ICYMI: New Online! Discovery of a human gene encoding a cyclin-dependent kinase

We have a fully funded and exciting opportunity for a PhD project led by @conradn.bsky.social and the Biofoundry group to advance synthetic genomics @earlhaminst.bsky.social

We have a 4 year fully-funded PhD opportunity to join our group @earlhaminst.bsky.social on an Eng Bio project: Engineering stable synthetic chromosomes. Jointly with the BioFoundry and @cgrandel.bsky.social. Read more about the project shorturl.at/GZMbB and about our research shorturl.at/HR6p5

PHD: Building on recent research to develop the first "designer" eukaryotic chromosome, this fully-funded #PhDproject with @conradn.bsky.social and @cgrandel.bsky.social will clarify and test the design principles for stable maintenance of fully synthetic chromosomes. buff.ly/l3dTmAf #synbio

From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes www.nature.com/articles/s41... 🧬🖥️🧪 github.com/HaploTeam/10...

Congratulations Aykut & Alper!

📣 Applications have just opened for our 2026 #PhD programme as part of the @nrpdtp.bsky.social and @aries-dtp.bsky.social! Begin your academic career with the expert scientists, technology, and facilities at the Earlham Institute in Norwich. buff.ly/327FNrX #genomics #findaphd #AcademicSky

New BBSRC funded PhD opportunity in my group with Inspiralis Ltd and @conradn.bsky.social. If you are interested in RNA - protein interactions and RNA modifications check the details below for how to apply. @nrpdtp.bsky.social @biouea.bsky.social @earlhaminst.bsky.social tinyurl.com/bdzvn4dr

Fantastic to welcome researchers for another Norwich #Nanopore Day at the Earlham Institute - bringing together the research community using @nanoporetech.com! 🧬

📣 We're pleased to open applications for a new Group Leader in Artificial Intelligence (#AI) in Biology. Join our collaborative and inter-disciplinary research environment, exploring the natural world through the lens of #genomics. 🗓️ Applications close: 24 Oct ➡️ buff.ly/YRz3YLe #machinelearning

Our preprint on Pol-η usage during genome replication has been uploaded. It addresses the biased use of Pol-η in the lagging strand and late-replicating regions, which may be correlated with cancer mutagenesis. www.biorxiv.org/content/10.1...

Checkout our latest research in @natcomms.nature.com rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team

how (yeast) cells re-climb the fitness landscape when they are reprogrammed to a different telomere DNA sequences (human-like)? read the latest from @melaniadangiolo.bsky.social etal , with great help and insights from Eric Gilson, Jonas Warringer and @juliamuenzner.bsky.social (& Ralser lab)

@davideanne.bsky.social showing off our new protocol with the Opentrons 👏🏼🤖 @earlhaminst.bsky.social

Ready for #Yeast2025 in Paris tomorrow. Looking forward to the science and to seeing colleagues and friends.

Next week at #Yeast2025 Dr Sathish Thiyagarajan will be presenting work from the @conradn.bsky.social group at the Earlham Institute using #nanopore #sequencing to identify pause sites in DNA replication. 📄 Plenary session 4 🗓️ Wednesday, 23 July 2025 🕤 9:30am - 11:00am

Our new review on how the initiation of DNA replication is coordinated with transcription is now online! Congratulations to @syedshahidmusvi.bsky.social! www.sciencedirect.com/science/arti...

It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...

📢 New paper out in Mol Syst Biol! During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬 🔗 www.embopress.org/doi/full/10....

💬 "These technologies have the power to remove breeding bottlenecks that have stymied development of new and improved #crops." A new project - funded by a £8.5M from @aria-research.bsky.social - will leverage advances in #engineeringbiology to establish #synthetic #plant chromosome technologies.

Modern agriculture faces significant challenges, from climate change to soil degradation and food security. Scientists at the Earlham Institute are part of a new multi-million project developing #synthetic #plant #chromosome technologies to speed up the introduction of novel traits to plants.

Here ends our foray into rDNA variation in model organisms—w/ Christine Queitsch, Bonnie Brewer, and many others. Especially Ashley Hall and Elizabeth Morton. tl;dr: In natural ranges of rDNA copy number, phenotypes are rare (yeast + C. elegans). But outside those ranges? Some things happen. 1/3

Very excited to be part of this project and to continue working with our longstanding collaborator, the amazing Yizhi (Patrick) Cai from @uommib.bsky.social

Great to welcome @adrianramsay.bsky.social MP for Waveney Valley, to the Earlham Institute and Norwich Research Park today.

💬 “When we looked at the replication start sites we’d identified, we discovered only 20% of them had been reported previously. The majority were newly discovered with this approach." 📃 Researchers use ultra #longreads to reveal #DNAreplication sites in the #humangenome. ‪@conradn.bsky.social

Basically molecular biologists can either use incorporation (eg, BrdU) or modification (eg, bacterial enzymes tethered to antibodies) or chemical modification (eg, radicals etc) and then the read out is the DNA (or RNA, see below).

My amateur energy transition watching continues for GB grid. Reasonably windy days in the summer now have manageable gas peaks that could be replaced by batteries. I know there is a lot of battery storage going in so it will be interesting to see how this impacts the grid (from: grid.iamkate.com)

3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴󠁧󠁢󠁳󠁣󠁴󠁿 www.biochemistry.org/events-and-t...

Something a bit different from Comment is Freed - a guest post from Ilan Gur, the CEO of the UK government’s Advanced Research and Invention Agency (ARIA) on some of the technologies they ate exploring - on neurotechnologies, synthetic plants, and AI. (Free) samf.substack.com/p/three-tech...

A study from the Earlham Institute and @ox.ac.uk has generated ultra #longread @nanoporetech.com reads, to reveal the majority of the human #genome is replicated from dispersed initiation sites, with around 80% of the sites never reported before. 🖥️🧬 @conradn.bsky.social @drkarimgharbi.bsky.social

New paper! Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones genomebiology.biomedcentral.com/articles/10.... Identifying human DNA replication initiation sites on single molecules by @nanoporetech.com 1/7

Today we're looking forward to welcoming our Scientific Advisory Board - chaired by @katherinedenby.bsky.social - to a day of talks and presentations showcasing the latest from Earlham Institute scientists and technicians. Stay tuned as we share more throughout the day.

🚨 PhD project alert: Engineering a soil bacteria to sense and record soil health. 🦠 🪴 🥼 🧑‍💻 🌍 Fully funded PhD studenship in my group, open for international students. @earlhaminst.bsky.social Please share widely! Deadline: 14th of May www.earlham.ac.uk/studentship/...

I have a PhD project funded by the John Innes Foundation, "Uncovering Genetic Drivers of Gene Expression in Elite Wheat Varieties", from the 1st of October 2025. #wheat #bioinformatics Apply now www.earlham.ac.uk/studentship/...

MSCA postdoctoral fellowship applications are opening soon. If you are interested in applying and would like to join our lab to research RNA modifications and splicing, please get in touch by end of April. Check your eligibility at marie-sklodowska-curie-actions.ec.europa.eu/calls/msca-p...

We are advertising for a PhD position to study bacterial metabolites in C. elegans, funded by the MRC Microbes, Microbiomes and Bioinformatics training programme @uniofeastanglia.bsky.social @biouea.bsky.social. Open to UK and international students. www.findaphd.com/phds/project...

I've updated the introductory text on my nanopore notes page. These unstructured notes are a workaround for the Nanopore Community's shockingly bad search/discovery functions. If you'd like a nanopore notebook, please email / DM me so I can gauge interest. gringer.gitlab.io/presentation...

Make sure you join our NBRI Transformative Genomics User Meeting to hear @conradn.bsky.social discuss how ultra-long read sequencing reveals patterns of replication site initiation across the human genome. Join us here 👉 https://buff.ly/4blYAJl #genomics #sequencing @drkarimgharbi.bsky.social

Interesting and important Guardian piece. I’d recommend reading this before trying DeepSeek. I’m sure other important examples will emerge over the coming days.

Catch our scientists at the #FestivalofGenomics later this month where they'll be discussing overcoming data challenges in #singlecell biology, and ultra #longread #sequencing in #DNAreplication.👇🧬🖥️ @flgenomics.bsky.social @drkarimgharbi.bsky.social @conradn.bsky.social @whatchamacaulay.bsky.social

We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵 www.biorxiv.org/content/10.1...

We have been busing working on models to detect all 2'Ome-RNA modified nucleotides on top of PseudoU, m6A, m5C and Inosine using @nanoporetech.com direct RNA sequencing. This is still very preliminary but here are a few examples of what it looks like on Human #rRNA prepared with standard lib prep 🤩

A week left to apply for our MIBTP funded PhD program scholarship. DNA replication, structural biology, biochemistry… open to UK and international students. Supportive and international team 😀 www.findaphd.com/phds/project...

Some thoughts about what I am looking forward this year from my vantage point of computational molecular biology. One mega-trend for me; we will definitely see more AI methods of all sorts emerge.

Best holiday present: Our comprehensive review of triplex H-DNA has just come out in NAR Mol Medicine. I am indebted to two outstanding graduate students: Julia Hisey and Chiara Masnovo, whose enthusiasm, dedication and hard work made this review possible! academic.oup.com/narmolmed/ad...

2) The histone chaperone CAF1 promotes PRIMPOL recruitment to restart stalled forks through ssDNA gap formation. doi.org/10.1093/nar/...

Through a blend of lectures and hands-on sessions, this course, led by @conradn.bsky.social and team will provide you with the skills necessary to analyse base modification profiles in various contexts. 📍 Online, via Zoom 🗓️ Register by: 03 January 2025 @nanoporetech.com

Interested in a career in science or technology? This summer we’re offering hands-on experience alongside our talented teams with our 2025 internships. Click to see our availability here: nanoporetech.com/about/career...

💬 “This development will deliver the computational performance we need to support our science into the future." - @neilhall.bsky.social, Director. New #DataCentre at #NorwichResearchPark set to bolster UK’s #bioscience capability. @quadraminstitute.bsky.social @thesainsburylab.bsky.social

Group Christmas lunch 2024 with competition, secret Santa and more.