When is the last time you felt you can replicate (generate the data and do analysis) a CNS paper in your lab?

Deadline is 8th of April. #phdposition

Happy pi (RNA) day everyone! And what better way to enjoy than to revisit the unusual features of nematode piRNAs: www.cell.com/developmenta...

Is anyone here aware of any research into the impact (e.g. changing ranking) and effectiveness (picking the best candidates, without biases) of interviews in grant application peer review process?

Buying used electric cars is already a big gamble and now the cars might not even gave the fedtures you think they have . www.theguardian.com/environment/...

PhD position in our lab - 4-year funded by BBSRC and @nrpdtp.bsky.social in collaboration with @earlhaminst.bsky.social and Inspiralis Ltd. Open to UK fee qualifying students - UK citizens and citizens of Ireland (residency requirement), etc biodtp.norwichresearchpark.ac.uk/projects/how...

£40m funding to setup an AI lab, expression of interest in two weeks and full application deadline in 4 weeks from advert. Can @jamesdracott.bsky.social explain why the rush? Why not give people more time? Grants costing less than £1m take easily 2-3x longer to prepare. @ukri.org

Some molecular machines, like ribosomes, can persist for long periods of time in cells. Could molecular aging of ribosomes shape how proteins are made? In our new preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10) www.biorxiv.org/content/10.6...

Are you a biological sciences or bioinformatics/computing graduate with home fee status, interested in a funded #PhD starting in October? If so, look 🔽 Application deadline 8 April 2026 www.uea.ac.uk/course/phd-d...

We are seeing a large number of papers being published on new AI models in biology, disease, genomics. What should we look for in these papers before committing our time to test their use? I really wonder how they are reviewed as well.

This is ridiculous but not surprising! Obviously, EPSRC must have people/organisations in mind and I wouldn’t be surprised if they have been in contact with some groups in advance. Some hard questions about why £40m is spent as such www.researchprofessionalnews.com/rr-news-uk-r...

⭐ #NARBreakthrough! ⭐ 🧬 New study uncovers how #RNAstructures control stochastic exon selection in Dscam1 genes. #Balancer RNA structures and a #multi-subunit RNA architecture coordinate spatial and temporal splicing 🔬✨ Read the full article here: doi.org/10.1093/nar/... #AlternativeSplicing

PhD position in our lab - 4-year funded by BBSRC and @nrpdtp.bsky.social in collaboration with @earlhaminst.bsky.social and Inspiralis Ltd. Open to UK fee qualifying students - UK citizens and citizens of Ireland (residency requirement), etc biodtp.norwichresearchpark.ac.uk/projects/how...

🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41... RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10 #RNA #IDR #RBP

I hope people of Gorton & Denton vote for a party that stands up for humanity and against genocide. Don’t believe in the lies of many politicians claiming they care about you while turning a blind eye to worst crimes of humanity of our times. apple.news/ATgPSimpARKC...

I suppose if you are still organising an “international” conference in the US, you are effectively helping ICE. apple.news/AgpcB41ERTmu...

Sarajevo sniper tourists ‘killed children by day, then partied at night’ - The Times and The Sunday Times apple.news/AP_CGjIiiS26...

Following an open letter on 1 February, our Chief Executive Professor Sir Ian Chapman has responded to feedback and provides an update on the changes to UKRI investment approach. Read his letter here: www.ukri.org/news/ukri-ce...

There are a lot of similarities between how UK universities and UKRI are run. In both cases, big decisions are taken and changes made without consultation and often with dire consequences for the academic community and with little to no transparency around decisions, their impact or alternatives.

Ian Chapman makes the case that he would not be doing his job properly if he didn't deal with the cost overruns at STFC, which are causing so much grief to physicists Physics groups are calling on ministers to intervene (presumably with more cash) And there is now a response from a minister ...

“The goal is to break the Palestinian resistance by affecting the social base that embraces it” (...) Israel aimed to “re-engineer the Palestinian human” into a being whose sole cognitive focus is basic survival, rendering them incapable of political thought."

The way UK govt funds science is in the midst of a major transition, with creation of a much more direct link between government priorities & UKRI research funding. My attempt to set in context the biggest upheaval in UK science funding policy since the 1980s: softmachines.org?p=3252

The last EU Horizon programme lost £330m from UK science funding

Last week, RPN broke a string of stories on significant changes to funding across a number of research councils (see thread below) This morning, UKRI chief executive is appearing at the Commons science committee, where he is being asked about them by MPs Here are some key moments so far 🧵

We cannot rely on “science corrects itself”. We need national independent research integrity offices with powers everywhere. Here is another story about research misconduct——Did a Celebrated Researcher Obscure a Baby’s Poisoning? - The New Yorker apple.news/AO91lC8YBT-K...

The Holocaust survivor judge who issued Netanyahu’s arrest warrant - The Times and The Sunday Times apple.news/AIrDM9zZ1RCK...

What's larger, a protein or its templating mRNA ? > The mRNA is much larger. ⬛ 𝐀 𝐬𝐞𝐧𝐬𝐞 𝐨𝐟 𝐬𝐜𝐚𝐥𝐞 -- 𝐪𝐮𝐚𝐧𝐭𝐢𝐭𝐚𝐭𝐢𝐯𝐞 𝐢𝐧𝐭𝐮𝐢𝐭𝐢𝐨𝐧 & 𝐜𝐨𝐧𝐬𝐭𝐫𝐚𝐢𝐧𝐭𝐬 -- 𝐢𝐬 𝐚 𝐩𝐨𝐰𝐞𝐫𝐟𝐮𝐥 𝐞𝐧𝐚𝐛𝐥𝐞𝐫 𝐨𝐟 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡. The figure shows myoglobin protein drawn to scale next to its mRNA template. The coding sequence of an mRNA ...

Neat RNA papers www.nature.com/articles/s41... (polyamine regulation of splicing by direct binding to U2 snRNP proteins) and www.nature.com/articles/s41... (impact of N1-methyl pseudo U on translation)

Just read an email about a 3 day conference organised by scientists well-known in their field with a capacity of 100 attendees, 33 invited speakers and only 10 slots for selected talks. Conferences are increasingly becoming closed circle meetings.

We've got ISSUES. Literally. We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do? arxiv.org/abs/2601.07563 A 🧵 1/n

"Results from experiments with N = 4 or less are shown to be highly misleading (...). For a cut-off of 2-fold expression differences, we find an N of 6-7 mice is required to consistently decrease the false positive rate to below 50%, and the detection sensitivity to above 50%"

Happy to share our latest work by Shivani Gahlot and Subodh, published in @febsj.bsky.social. We show that the amino acid Trp is highly toxic to C. elegans, and that this toxicity is driven by bacterial metabolism of Trp into indole. febs.onlinelibrary.wiley.com/doi/10.1111/...

2025 has been terrible with atrocities and indifference. I'm particularly disappointed in my scientific community. How can we claim to care about human life and health in papers and grants but stay silent when children are being killed daily? 1/2

Thanks to all lab members of the lab and our collaborators for a productive year. We had 4 papers, another successful PhD defence and some challenging methods established. Our first paper was in colab with @alexeimaklakov.bsky.social lab on ageing onlinelibrary.wiley.com/doi/full/10....

We are pleased to host Prof Ying Wang on Wednesday 3rd December 2pm @johninnescentre.bsky.social . Please join us for this exciting talk. @yiliangding.bsky.social @whaerty.bsky.social @alperakay.bsky.social @earlhaminst.bsky.social @biouea.bsky.social @rnasociety.bsky.social Lexogen

We are pleased to host Prof Danny Incarnato @incarnatolab.bsky.social on 5th December 9:30am @johninnescentre.bsky.social. Please join us for. @yiliangding.bsky.social @whaerty.bsky.social @alperakay.bsky.social @earlhaminst.bsky.social @biouea.bsky.social @rnasociety.bsky.social Lexogen

Can we *please* stop rewarding bullying behavior in academic social media?

It’s fellowship season in UK and many postdocs will be looking for host institutions. This is a very critical step. Approach at least 3-4 hosts. Make sure there is genuine interest in hiring you. Many institutions claim to support fellows into long term careers but most actually don’t. #UKRIFLF

Looking for a PhD in RNA biology? The deadline is approaching fast! This is a great opportunity to do a PhD together with an industry partner fully funded by @nrpdtp.bsky.social BBSRC Case studentship.

Katarzyna Hencel, @alperakay.bsky.social, @drsull.bsky.social & co demonstrate an accessible and affordable assay to measure #vitaminB12 in biological samples. doi.org/10.1242/bio....

“The Guardian reported on Tuesday that British military equipment licensed for export to the UAE had been used by the RSF and found on battlefields in Sudan, according to documents seen by the UN security council” www.theguardian.com/world/2025/n...

I can now vibe code, use HPC and analyse RNA sequencing data at large scale. LLMs are amazing for this. On the negative side, now I can see how bad some(most) of the published RNA-seq datasets are. We really need to insist that all sequencing datasets should come with their QC data.

This is a super interesting paper by @conradlab.bsky.social lab on METTL16. They separate METTL16 function on U6 and MAT2A allowing more accurate analysis. Their results cast serious doubt on hundreds of papers claiming METTL16 methylates vast number of mRNAs. www.cell.com/cell-reports...

This ceasefire or more accurately the “pause in genocide” will not last if the UN soldiers don’t get involved. Not that the UN has a great record in preventing genocides but thats still the best option. www.theguardian.com/world/2025/o...

“Many of my students are now dead” www.theguardian.com/global-devel...