Spatiotemporal NAIL-MS analysis shows that ALKBH5 does not affect global m6A turnover in human mRNA across subcellular compartments under standard growth conditions bit.ly/4lvVtC6

We’re moving in! Posters are going up, coffee is being ordered, and the countdown is real. Final prep before minds meet in Frankfurt. 2 days until we start #ConferenceVibes #RNAmods #HRP2025

The conference print materials have arrived — and so has the excitement! 🧭 Our goal? To build the foundation for reproducible RNA mass spectrometry, where labs worldwide can trust and compare results. #HRP2025 #RNAstandards #SciModom

In only 4 days, we’re combining theory and practice: the training module of HRP 2025 covers protocols, tools, and expert insights — from digestion to data analysis. Perfect for anyone entering the field or refreshing their skills. Hashtag#RNAtraining Hashtag#MassSpec Hashtag#HRP2025

Three instruments, one goal: the Kaiser Lab Agilent setup is now ready to contribute to our harmonization mission. Side by side with Thermo and Bruker, this is harmonization in action. #Agilent #HRP2025 #LCMS 5 days left!

6 days to go! Precision incoming: The Bruker instrument is now in set-up and ready for action! Thanks for everyone who made this possible! Can three platforms agree on what modified RNA looks like? Follow us and find out. #Bruker #LCMSMS #RNAmodification #HRP2025 (picture by Dirk Wunderlich)

Behind every workshop, there’s serious logistics: last week we welcomed the Thermo system that will power part of our experimental module. Big thanks to everyone who made this happen! #MassSpec #ThermoFisher #RNAanalytics #HRP2025

Our experimental module is the heart of the workshop: 3 platforms, 1 benchmark dataset, and a clear mission — harmonize how we measure modified RNA. Get ready to generate data that shapes the future. #Benchmarking #HRP2025 #RNAmods

only 9 days left until the HRP Workshop 2025! Here’s a first look at our talks and breakout sessions: the program reflects the full diversity of the RNA modification field. Designed for discussion, connection, and community progress. #HRP2025 #OpenScience #Epitranscriptome #RNA

This new preprint was designed so poorly that it provides absolutely no proof that mRNA vaccines caused cancer/other diseases. It compared 10 (!) handpicked sick patients to 803 healthy patients. And behold, they show different RNA expression profiles. Because they were sick. Link in alt.

1st Workshop of the Human RNome Project - Scientific Revolution Begins in Frankfurt! #HRP2025 @goetheuni.bsky.social 10 days to go!

Another great RNA modification-mass spec paper from @kaiserlab.bsky.social which we were very happy to contribute! @biouea.bsky.social @norwichrnaclub.bsky.social www.sciencedirect.com/science/arti...

Join us in Frankfurt, Aug 4–9, for the 2025 Human RNome Project Workshop! Focus: RNA modifications, mass spec, direct RNA seq & more. Help shape the roadmap to decode the human RNome. 🔗 humanrnomeproject.org/2025-workshop-in-germany #RNA #HumanRNomeProject

🎉 We’re absolutely thrilled: SCALE has been selected as a DFG Excellence Cluster! A huge thank you to our incredible team—this would not have been possible without your dedication and talent. 🙌 @dfg.de #ClustersOfExcellence #SCALEcluster 🧵

Die #Exzellenzcluster stehen fest: Heute hat die Exzellenzkommission 70 Projekte zur Förderung ausgewählt. 45 Cluster werden fortgesetzt, 25 neu eingerichtet. Die Förderung beginnt ab 1. Jan. 2026 für 7 Jahre, die Fördersumme beträgt insg. 539 Mio. €/Jahr. Die Liste: www.dfg.de/resource/blo... 1/3

What better way to start things off than with a throwback to our ALL-tRNAseq paper?! genesdev.cshlp.org/content/37/5...

You thought Glu/Asp don't like RNA or DNA? Maybe you even introduced them into your protein to stop such interactions? 😱🧪 Think again! New paper @angewandtechemie.bsky.social with Wöhnert lab shows structural context matters for phosphodiester interactions! onlinelibrary.wiley.com/doi/10.1002/...

Thank you #MIT

Postdoc position mass spectrometry/ chemical proteomics in Geneva, Switzerland 🇨🇭 with my colleague Sascha. Deadline is coming soon ⤵️

Are you a postdoc ready for transition to an independent position? You connect infection biology with cutting-edge structural biology or multimodal imaging? Are you aware of such a colleague? I am seeking speakers for "The Next Generation in Infection Biology" microsymposium on June 6 2025.

Come join our team! We have an opening for a research associate ("Ratsstelle"). Expertise in nucleotide chemistry and LC-MS is required. 👉 job-portal.lmu.de/jobposting/b... Deadline for application is June 01, 2025.

Heat stress impacts RNA modification levels in E. coi !🦠 #microsky #rnasky academic.oup.com/nar/article/...

RNA Salon in mRNA Translation We have an exciting lineup with Keynote by: Marvin Tanenbaum (Hubrecht/ Delft) Please RT @goetheuni.bsky.social @cpi-exstra.bsky.social

We are happy to announce that we will host the 1st workshop of the human RNome project consortium in Frankfurt am Main this August. More information can be found at kaiser-lab.de

The third is from Hagen, who studied artificial nucleases and their potential for rRNA removal. you can read up his work in PlosOne. Well done Hagen! journals.plos.org/plosone/arti...

The second is from Nur. She originally wanted to use hydrazine for detection of pseudouridine in oligonucleotide mass spectrometry. Along her way, she uncovered an impressive reactivity towards 8 modified nucleosides and determined the reaction products. Well done Nur! www.nature.com/articles/s42...

2025 is treating us well. We have 3 papers from the Kaiser Lab accepted until now. The first is a study on the impact of 5-fluoruracil (5FU) on tRNA and rRNA modifications. Well done Max! academic.oup.com/nar/article/...

Look forward to welcoming all participants in Frankfurt for some exciting science, building networks and having a good time 🤗🍀

Miao and colleagues show that tRNA m1A modification regulates cholesterol biosynthesis to promote antitumor immunity of CD8+ T cells. Deletion of RNA m1A “writer” gene Trmt61a enhances the tumor-killing capacity of CD8+ T cells. doi.org/10.1084/jem....

Hello Everyone! 👋 Nucleic Acids Research is excited to be on Bluesky! Please follow us for the latest #Research, #Breakthrough articles, journal issues and more. Also, please consider adding us to your starter packs!

My NUS Yong Loo Lin School of Medicine Helathy Longevity Webinar is online now. I am very grateful to Brian Kennedy for the invitation to share our latest research on #RNAmodifications and for the excellent discussion. youtu.be/fFAr5RF_2vs?...

"YTHDF2 functions as a dual reader where it stabilizes mRNAs as a 5-methylcytosine (m5C) reader ..." doi.org/10.1016/j.ce... #RNA #RNAsky #RNAbiology

Please RS/RT. #GordonConference "Histone and DNA Modifications" Program is now online 🍾 #epigenetics #chromatin #histones 20.-25. July. Il Ciocco 🇮🇹 Register now: ➡️ shorturl.at/AtAjz Exciting speaker lineup, many slots for talks selected from abstracts

The Kaiser Lab is migrating to bluesky. Follow us for updates on our ongoing RNA modification research using mass spectrometry tools.