Happy Fluorescence Friday :-)

New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function. www.nature.com/articles/s41...

Mercury was only 50 arcminutes (0.8°) above a very young waxing crescent Moon this evening. KAS member Pete Mumbower captured this image from his home in Vicksburg, MI.

As Fran was nice enough to highlight this, I thought I'd put up a brief thread. 3 in 10 proteins that our cells make are either embedded in membranes (ion channels, adhesion molecules, etc.) or secreted (insulin, antibodies). They move through the secretory pathway. 1/

BIG FIGHT AT POLAND’S WROCLAW ZOO!!!

your second moment of calm

We are hiring new faculty!! Come join our amazing community in the Department of Molecular Microbiology at Washington University School of Medicine! The deadline for applications is 2/21, but applications will be reviewed on a rolling basis. facultyopportunities.wustl.edu/Posting/Deta...

Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance? www.nature.com/articles/s41... More info 👇

Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6... Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet

Huge shoutout to all the NIH scientific review officers and external academics who stepped up after the government shutdown to help reschedule hundreds of study sections. Thanks to this great community, my fellowship review was rescheduled within two months of its original review date 🧪

This--my SRO and her colleagues are doing heroic work AND keeping me informed--THANK YOU!

Thrilled to share our new paper! With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste. Link @nature.com: www.nature.com/articles/s41...

@drugmonkey.bsky.social timely.

How is the persistence of compartmentalized inflammation sustained in MS? Our new study in @cp-immunity.bsky.social offers some hints. cell.com/immunity/ful... Thanks and congratulations to all contributors

New tenure track faculty position in glia and/or neurovascular coupling! Please come join us! academicjobsonline.org/ajo/jobs/30864 #neurosky #neuroskyence #glia #neurojobs

It’s so exciting to see this. These tools will be game changing.

If you think your field needs a collection of curated reviews and protocols, let me know! Let's create it and help the community.

Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years? A 30-year long mystery unraveled @ScienceMagazine today! Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation www.science.org/doi/10.1126/...

The first (of hopefully many) reports to come from our collaboration with @hjp.bsky.social We present a new type of cell fitness assay that allows you to both quantify and explain differences across human donors in cell proliferation and sensitivity to environmental toxicants.

Wow! This is really exciting!

UCLA research is amazing ✨✨ newsroom.ucla.edu/stories/ucla...

🚨 New Preprint! Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons. ▶️ www.biorxiv.org/content/10.1...

It was great to co-teach today’s Academic Skills workshop with the amazing @debiaselm.bsky.social 🧪✨

Check out our recent progress using 🧬 PAINT kinetics to decode molecular tension in super-resolution force imaging! 🔬 Great team effort from Seongho, Adam, Irving, and Kevin! 👏 #DNA-PAINT #tension #integrin #superresolution #adhesion doi.org/10.1002/advs...

Please spread the word about the glia networks world-wide 🙃 @astrocytenet.bsky.social @astrocytecafe.bsky.social @ukglia.bsky.social @glialclub.bsky.social @gliameeting.bsky.social @warsawgliacomm.bsky.social @italianglianetwork.bsky.social @canglia.bsky.social

Come join our lab as Postdoctoral Fellow! The project will investigate the maturation of spinal circuits and their plasticity within chronic widespread pain states. Apply here: www.ucl.ac.uk/work-at-ucl/... until 11th April. @ucllifesciences.bsky.social @uclnpp.bsky.social @jobrxiv.bsky.social

It was a pleasure hosting Ritchie Ho for this weeks Neural Repair seminar and hearing about his amazing work to understand pathogenic mechanisms of ALS @ucla @ritchieholab.bsky.social

UCLA scientists led by Dr. Hilary Coller have found that quiescent cells express transcription factors that act as "master switches" to regulate genes that suppress cell cycle progression, prevent the adoption of irreversible fates and reorganize their metabolism. www.nature.com/articles/s41...

✨UCLA is an amazing place for science! ✨ 📢 Tenure Track position open at UCLA! This is a very broad search in the Biomathematics, Biological Chemistry, Human Genetics, Molecular & Medical Pharmacology, Neurobiology, Physiology departments. 🔬✨ recruit.apo.ucla.edu/JPF10062

✨Tenure Track position open at UCLA! This is a very broad search in the Biomathematics, Biological Chemistry, Human Genetics, Molecular & Medical Pharmacology, Neurobiology, Physiology departments. 🧪🔬 recruit.apo.ucla.edu/JPF10062

Check out this paper and tool that we worked on with @sloanlab.bsky.social and Ye Zhang. Think of it as 'the Barres datasets 2.0' Lots of input and feedback from the amazing #Glia community.

📢UCLA is recruiting an open rank, tenure-track/tenured faculty position in the basic sciences! (see link below) #AcademicSky 💫✨ recruit.apo.ucla.edu/JPF10062

📢UCLA is recruiting an open rank, tenure-track/tenured faculty position in the basic sciences! (see link below) #AcademicTwitter 💫✨ recruit.apo.ucla.edu/JPF10062

so nice to see this amazing study out - huge congrats to @franckp.bsky.social & coll.!

📢UCLA is recruiting an open rank, tenure-track/tenured faculty position in the basic sciences! (see link below) #AcademicTwitter 💫✨ recruit.apo.ucla.edu/JPF10062 🧪🔬

Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵

New results! Visual adaptation changes the geometry of V1 population activity: frequent stimuli elicit smaller responses but become more discriminable. Similar results are seen in ANNs trained with metabolic constraints, suggesting these changes emerge from efficient coding. bit.ly/3VJHXRn

Yup

fantastic resources here. any neuroscientists considering single-cell work should read these reviews. I am thrilled to have them to cite when I review grants and papers.

Viral tracing (yellow) in the mouse adult spinal cord (cyan, nuclei; magenta, axons). Image by the very talented Soizic Riche. #fluorescencefriday #fluorescentfriday

Late addition for #fluorescencefriday Cultured neurons (red/yellow) interacting with glia (green). Imaged by the talented undergraduate researcher Grace Haroun.

The Vilcek Foundation has opened its grantmaking. #Nonprofit organizations are encouraged to apply for a grant of up to $20,000. The deadline to apply for a grant is June 30, 2025. vilcek.org/grants/?utm_...

⭐️ @rogiermin.bsky.social , Yi Qin, Sven Kerst, M. Hadi Saiepour, Mariska van Lier, Christiaan N. Levelt: Inhibitory maturation and ocular dominance plasticity in mouse visual cortex require astrocyte CB1 receptors ⭐️ www.cell.com/iscience/ful...

5-year-old Jakob Guziak born with ADA-SCID, a deadly immune disorder, received gene therapy developed by Dr. Donald Kohn and is ready to live life outside the bubble. “It’s not just a new life for Jakob, but it's a new life for us as parents,” his mother said.

Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41... We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties. Threads will follow!

Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/ G. Napolitano,A. Esposito, and A. Ballabio.

How do hibernators survive for months without water? Reduced neuronal activity in the CVOs is key! www.science.org/doi/10.1126/...