“cathepsin K…uniquely degrades cell-surface mucins, proteoglycans, and polysialylated glycoproteins, and…reduces total glycocalyx thickness…a promising starting point for the development of a glycocalyx-debulking enzyme for cancer therapeutics.” #glycotime @carolynbertozzi.bskyverified.social 👏

Sheddase Targeting Chimeras (SHEDTACs) catalyze membrane target proteolysis https://www.biorxiv.org/content/10.64898/2026.02.06.703938v1

Dear friends and colleagues, I am excited to share a preprint describing my take on extracellular targeted protein degradation (eTPD) - a proximity modality termed Sheddase-Targeting Chimeras (SHEDTACs). www.biorxiv.org/content/10.6... 👀

This a word cloud from the titles of ~1100 terminated NSF grants. It is hard not to see these grant terminations as an attack on the training of the future United States scientific workforce.

Amazing Checkpoint blockade dependence on time of day (ToD) “After…28.7 months, the median PFS was 11.3 months…in the early ToD group and 5.7 months…in the late ToD group”

On #WorldCancerDay 🎗️, our review on Writers and Readers of Sialylation in Immunoregulation in Cancer is out today in #JBiolChem: 🔗 www.jbc.org/article/S002... Follow for future experimental glyco-work from the @siglecdude.bsky.social lab 🔬🧫 #glycotime

Desialylation potentiating immune escape #Glycotime “We demonstrate… complement components (IgG, C1q, C4, and C5) and regulators (Factor I, Factor H, and C4bp) are sialylated, and that bacterial… desialylation suppresses complement activation…, thereby enabling complement evasion.”

The time of day for cancer immunotherapy is associated with major outcomes. Early is better. Results from a randomized trial of lung cancer, backs up the importance of our circadian rhythm and immune system www.nature.com/articles/s41...

Apple & Google removed ICE tracking apps in their app stores. TikTok reportedly suppressed videos criticizing ICE & the shooting of Alex Pretti. Meta blocked Facebook groups tracking ICE & links to a database of agents that the government wants to keep secret. Big Tech is enabling Trump's regime.

qualifying exam shenanigans

My weekly update (Grants with Notice of Award dates up to 1/23/26) All projects 1/3

I thought it was because it’s cold and flu season 😷

New #glycotime discovery from @raflynn5.bsky.social’s lab @bostonchildrens.bsky.social @harvard.edu, cell surface glycoRNA-RBP complexes organized by heparan sulfate PG nanoclusters that modulate VEGF signaling www.nature.com/articles/s41...

Target stiffness influences T cell polarization and gene expression through distinct Ca2+ channels www.science.org/doi/10.1126/...

Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX

It would e a *very good idea* to get your measles antibody titer checked, particularly if you were vaccinated as a child before 1967. The old vaccine doesn’t last as long! Or just skip that step and get the current vaccine if you have any doubts at all.

He treats it like a family photo www.thetimes.com/article/e9fd...

As mentioned in my post today, here's the US measles situation. What will the rest of 2026 bring?

A look across the vaccine regulatory landscape in the US. There's a lot going on, and very little of it should be cause for optimism:

“Sustained, strong science, as with all public goods, requires government investment if it is to deliver long-term societal benefit.” donmoynihan.substack.com/p/american-b...

Point blank. 10-shots. Execution. A US citizen, a VA ICU Nurse. Then lying. Blocking a real investigation.

“…LCMS-based approach enabling the analysis of serum IgG4 clonal repertoires, we show that widespread Fab-arm exchange occurs in serum of healthy donors and leads to a massive explosion in the molecular diversity of the IgG4 clonal repertoire”

The final version of our new paper is out now - and open access @acs.org Central Science!! Such a fun collaboration! pubs.acs.org/doi/10.1021/...

Breaking NYT: The FBI agent who sought to investigate the federal immigration officer who fatally shot Renee Good has resigned from the bureau, according to two people familiar with the matter, after leadership pressured her to discontinue a civil rights inquiry into the officer.

NSF is open for feedback on their strategic plan, deadline is Jan 27!! www.nsf.gov/od/updates/n...

The conference (agreement between House and Senate) appropriations bill that includes HHS and NIH was released this morning. www.appropriations.senate.gov/news/majorit... 1/5

Dr. Martin Luther King, Jr. dedicated his life fighting for equity and justice. He taught us that even in the face of intimidation and discrimination, we must never stop working towards a better future – a lesson that feels especially relevant today.

JONATHAN ROSS-JONATHAN ROSS-JONATHAN ROSS- JONATHAN ROSS-JONATHAN ROSS-JONATHAN ROSS- JONATHAN ROSS-JONATHAN ROSS-JONATHAN ROSS-JONATHAN ROSS-JONATHAN ROSS-JONATHAN ROSS-JONATHAN ROSS-JONATHAN ROSS-JONATHAN ROSS-JONATHAN ROSS-JONATHAN ROSS-JONATHAN ROSS. #Justice4ReneeNicoleGood ⚖️

If tumor bearing mice fight and wound each other (ugh), I regularly observe wounded mice reject tumors at higher rates. Related? 🧐 also very annoying when this happens

www.biorxiv.org/content/10.6... #glycotime

Cartoon by Adam Zyglis

☢️ 🌙 www.nasa.gov/news-release...

#Glycans probably have more "copies/cell" than #proteins and changes in #glycosylation could potentially be remarkable biomarkers for diseases as well as targets for therapeutics. This post explores the abundance of glycans on the cell surface and it is worth a read to recognize these #biomolecules.

Epstein-Barr Virus #EBV was linked to #MultipleSclerosis - now a plausible cause has been found, misidentification by longterm memory T-cells that pick on the wrong protein, ANO2, instead of the EBV-antigen. Massive inflection towards the elimination of MS!!! 🧪🧠Cell www.cell.com/cell/fulltex...

I can’t possibly imagine what could go wrong. www.theguardian.com/technology/2...

this is a fascinating article, featuring a ton of analytical chemists arguing with one another #chemchat

Excited to share our new preprint in collaboration with Paul Cohen's lab at Rockefeller University and Ken Loh's lab at Yale University! We introduce TurboID-TMT for cell type-specific proximity labeling to profile organ secretomes and ER-resident proteomes in vivo. www.biorxiv.org/content/10.6...

“Please decide where your red line is so you can choose to act before the line is already behind you.”

Here's a summary of all the data that supports adding more red meat to your diet

In the new season of Autocracy in America, I will ask how the Trump White House is rewriting the rules of US politics. First episode: How ICE and the National Guard are being used not just to enforce immigration, but to project power open.spotify.com/episode/4Baj...

We saw Jan 6, 2021 and Jan 7, 2026 with our own eyes. This is not Orwell's 1984.

Authors use “Siglec-7 and -15…Fc chimera to demonstrate that CHST1-mediated 6-O-sulfation markedly enhanced binding to select O-glycoproteins, namely MAdCAM1, CD43, and PSGL-1” www.biorxiv.org/content/10.6...

Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance? www.nature.com/articles/s41... More info 👇

“#HIV infection reprograms… infected cells to increase… sialoglycan ligands for Siglec-3, −7, -9 … disruption of these interactions using 10-1074-SiaD, an … antibody conjugated to sialidase… enhances… (immune) killing of HIV-infected cells…” #glycotime www.nature.com/articles/s41...

I just stumbled upon featherbase, a database of feather pictures from a bunch of bird species.🪶 So pretty! www.featherbase.info/zh/home

The robots are not coming for your jobs, but bullshitters with robots ARE competing for your jobs, and unless we decouple publishing metrics from career paths (financial gain), we are going to lose both careers and our capacity to share information. doi.org/10.1126/science.adw3000

Yikes 🦠 #flu #influenza #glycotime www.cnn.com/2026/01/05/h...

With David Frum on Venezuela, spheres of influence, and the deeper implications of Trump's foreign policy www.youtube.com/watch?v=5oSR...