While BioNtech & Moderna become household names because of their Covid vaccines, those emerged from different projects: finding ways to treat the most challenging cancers. They hypothesized that we could vaccinate patients against their own tumors, & evidence is mounting that they were right! 1/n 🧪

If you are interested in PARP inhibitors and history, this might be of interest to you. www.nature.com/articles/s41.... An attempt to cover the work of thousands and their immense contributions to the development of a targeted approach to treating cancers.

NHS data should be driving innovation & improvement – it’s an amazing resource We just published the sequel to our 2021 "Road to Hell" paper on using NHS data for research... things are worse! Buckle up for a long 🧵about *how COMPLETELY mad* system is for accessing NHS data for research 1/20

Very important thread about accessing NHS data for scientific progress. We (our processes, not our researchers) need to get better at this.

My Hotel room for the #genomics meeting in Cardiff tonight. #ifyouknowyouknow

I’m excited to share our new paper in Genome Biology, where we show SMARCA4 protects against genome instability at G4 sites, using analysis of double-strand break mapping and whole genome sequencing. It has been a really interesting and collaborative project! link.springer.com/article/10.1...

Sound advice on grant writing from Ewan. Bookmark it!

Invite is a verb. Invitation is a noun. You may invite me to a genomics meeting by sending me an invitation. Here endeth the lesson. #grumpyoldman

I posted on LinkedIn about my reflections on the genome, 25 years on. www.linkedin.com/posts/ewan-b...

At the ICR, we discover more prototype cancer drugs than any other academic institution in the world. One drug we discovered, abiraterone, has helped to give thousands of men with advanced #ProstateCancer, many more years with their loved ones. www.icr.ac.uk/about-us/icr...

@4130chromo.bsky.social Ouch. Port Vale might be bottom of league 1, but there are still 3 divisions higher than Macclesfield. Less said about the Cup this season, the better 🙈

We were honoured to welcome legendary West Indies cricketer Sir Clive Lloyd to The Institute of Cancer Research, London, today, as he visited Professor Ros Eeles’ lab to learn more about our world‑leading research into prostate cancer genetics.

Thats our lab done that 😀 And we ran #BRCADirect too. Royal Marsden and North Thames GLH, improving options for people at higher risk of #Cancer.

In honour of the Sunday Telegraph's editor and offical maddest columnist, we have created the Allister Heath headline generator... stirring-fox-7e1fab.netlify.app

BTOG's response to England’s 10-Year National Cancer Plan welcomes the ambition — particularly lung cancer screening rollout — but raises concerns about diagnostic capacity, workforce pressures and smoking cessation integration. Delivery must match ambition: https://ow.ly/YCN150Yk8qI

How does he sleep at night?

142,000 participants! The largest randomized trial of a multi-cancer early detection (MCED) test failed its primary endpoint genomeweb.com/cancer/grail... Had the enrollment been risk-based instead of age 50, it would likely have been very positive.

Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC. #BioNTech www.nature.com/articles/s41...

A Technical Report published in Nature Cancer presents M-PACT: a deep neural network leveraging low-input cell-free DNA methylation profiles to achieve robust classification of pediatric brain tumors. 🧪

Liquid biopsies hold promise as companion diagnostics or surrogate endpoints in clinical trials. How does the current regulatory landscape pose challenges for pharma? Read the recent developments in our latest edition of the Liquid Biopsy Playbook. Download now: hubs.la/Q03PFMSp0 #liquidbiopsy

This Is Just To Say I have eaten the delicious cooked ham that was in the cooked meat fridge at the local coop and which Lynn was probably saving for her husband Tony Forgive me it was delicious so local and so ham

I made a map of 3.4 million Bluesky users - see if you can find yourself! bluesky-map.theo.io I've seen some similar projects, but IMO this seems to better capture some of the fine-grained detail

📣New from Nisselle & co! 📄Variant interpretation training for the #genomics era: Learning outcomes to inform professional competencies and education

Led by Aviva Capital Partners and Socius, the new development will bring one million square feet of brand-new labs and research space to The London Cancer Hub, which is already home to the ICR, The Royal Marsden NHS Foundation Trust, and the Innovation Gateway. Find out more ⬇️

A modern-day tragedy, BUT YOU CAN HELP. 1 Like = 1 Pray 1 Share = 10,000 Prays

Angela George makes the case for faster testing for #ovarian #cancer to get patients onto time restricted treatment #FOG2026 #genomics

Getting the Prees in for FOG2026 😁🍻

Some @fogenomics.bsky.social 'pre-drinks' with @generoom.bsky.social & Chris Watson 🧬🧬🍺🍺🍺

Is there a gene for selective hardware store amnesia? I really love wandering around the shop, putting new tools, bits of wood and hardware components into the basket. Its only when I get it home that I remember I am utterly crap at DIY and dont know what to do with all the stuff I have bought. 🧐

More #Genomics than the SoL can handle 🫡 At the match with @generoom.bsky.social today #suncry 🧬🧬🍺⚽👌🏼 #HawayTheLads ♥️🤍 3 PTS 🥳

Are you fascinated by cancer biology and also ❤️ 💻 ? Feel like this ->😻<- at the thought of exploring oodles of cancer genomes, single cells and spatial multiomics data? Then our core Data Science Team at @icr.ac.uk might be the place for you. Vacancy here: jobs.icr.ac.uk/vacancies/14...

New research looks at why ALK+ #LungCancer targeted treatments can stop working over time. Resistance is not always a new mutation. Cells around the tumour can help ALK positive cancer cells survive, even when ALK inhibitors are working. www.science.org/doi/10.1126/... #LCSM

I am hiring - I am looking for a senior research technician to work in the busy sequencing team, with a particular focus on our long-read platforms @pacbio.bsky.social & @nanoporetech.com Appy here: lnkd.in/eCEeb_3b Closing 16th Jan 2026

I’m excited to be speaking at #FOGLondon this January on The Future of Cancer Management: Genomics, Monitoring and Realities Registration is FREE for over 90% of attendees, so don’t miss out. Reserve your spot now: hubs.la/Q03JMvwd0 #FOG2026 #genomics #biodata

Pssst! I have a PhD position available. Please pass it on www.findaphd.com/phds/project...

Thank goodness for that. Something that shouldn’t have happened, happened. And now it’s set to unhappen. Great for students, great for research in general and great for Britain. www.theguardian.com/world/2025/d...

Triple-negative breast cancer in biomed news this week🏥 So perfect timing to feature #ListerFellow @stephensammut.bsky.social 🤩He's hunting clinical biomarkers and using AI to predict treatment response from immune activation. Repost and read ⤵️ lister-institute.org.uk/in-conversat... @icr.ac.uk

There's just one week left to apply to join us as an Associate Scientist in the Cancer Dynamics Laboratory led by our Director Prof Samra Turajlić We're seeking a motivated & accomplished Associate Scientist to help lead and shape the programme of the lab: www.cruk.manchester.ac.uk/career/mi-25...

Read the full story here ⬇️

We held the first #CANPOP symposium today (cancer population genetics club) @icr.ac.uk. 6 excellent & didactic talks, all applying mathematical #popgen theory to dissect somatic evolutionary dynamics: spanning the full range of pre-cancer, metastasis through to 6000 year old transmissible cancer...

Does #genomics work? How do we know? Really thoughtful piece full of insights and proposals, highlighting the many positives - and some negatives - that need to be included in models of appraisal. At least one thing is clear: We the need to take the long view.

Not sure why @lpachter.bsky.social did not post this here. But it is brilliant. Single cell genomics finally makes it to the clinic.

Real-world data is a hot topic with medical regulators and payers in oncology. Here is our analysis comparing a change in induction regimens in multiple myeloma in a public healthcare system, using real-world MRD measurement. www.clinical-lymphoma-myeloma-leukemia.com/article/S215...

Calling cancer data scientists! 📊 💽 🧮 We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...

Very interesting day at the genomics England long read summit. And great to catch up with @generoom.bsky.social and more!

1/ 🚨New paper in Nature Genetics Genetic factors are associated with the educational fields people study, from arts to engineering. Article: www.nature.com/articles/s41... FAQ: www.thehastingscenter.org/genomic-find...

For 61 years the #BBCWorldService has been broadcasting the latest in science via its weekly Science in Action programme. That dies in the next half hour, with this final edition, reflecting on the fall in trust in expertise driven by malign interests over recent years.

Even chimpanzees think rationally and weigh the evidence when making a choice ;-) @science.org www.science.org/doi/10.1126/...

You've got just a few days left to submit your proposal to join us as a new Group Leader 📅 Applications close 2nd November Package includes: 🪙Multi-year funding 🧪Core Facility Access 🥼 #Postdoc & #PhD positions 🤝Mentorship Visit our website to apply: www.cruk.manchester.ac.uk/career/new-g...

Well balanced explanation from Beth Torr of who we test for germline #BRCA mutations and why. We are proud to be delivering this testing in the #RoyalMarsden lab at the #NHS North Thames Genomic lab hub.