Thank goodness for that. Something that shouldn’t have happened, happened. And now it’s set to unhappen. Great for students, great for research in general and great for Britain. www.theguardian.com/world/2025/d...

Triple-negative breast cancer in biomed news this week🏥 So perfect timing to feature #ListerFellow @stephensammut.bsky.social 🤩He's hunting clinical biomarkers and using AI to predict treatment response from immune activation. Repost and read ⤵️ lister-institute.org.uk/in-conversat... @icr.ac.uk

There's just one week left to apply to join us as an Associate Scientist in the Cancer Dynamics Laboratory led by our Director Prof Samra Turajlić We're seeking a motivated & accomplished Associate Scientist to help lead and shape the programme of the lab: www.cruk.manchester.ac.uk/career/mi-25...

Read the full story here ⬇️

We held the first #CANPOP symposium today (cancer population genetics club) @icr.ac.uk. 6 excellent & didactic talks, all applying mathematical #popgen theory to dissect somatic evolutionary dynamics: spanning the full range of pre-cancer, metastasis through to 6000 year old transmissible cancer...

Does #genomics work? How do we know? Really thoughtful piece full of insights and proposals, highlighting the many positives - and some negatives - that need to be included in models of appraisal. At least one thing is clear: We the need to take the long view.

Not sure why @lpachter.bsky.social did not post this here. But it is brilliant. Single cell genomics finally makes it to the clinic.

Real-world data is a hot topic with medical regulators and payers in oncology. Here is our analysis comparing a change in induction regimens in multiple myeloma in a public healthcare system, using real-world MRD measurement. www.clinical-lymphoma-myeloma-leukemia.com/article/S215...

Calling cancer data scientists! 📊 💽 🧮 We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...

Very interesting day at the genomics England long read summit. And great to catch up with @generoom.bsky.social and more!

1/ 🚨New paper in Nature Genetics Genetic factors are associated with the educational fields people study, from arts to engineering. Article: www.nature.com/articles/s41... FAQ: www.thehastingscenter.org/genomic-find...

For 61 years the #BBCWorldService has been broadcasting the latest in science via its weekly Science in Action programme. That dies in the next half hour, with this final edition, reflecting on the fall in trust in expertise driven by malign interests over recent years.

Even chimpanzees think rationally and weigh the evidence when making a choice ;-) @science.org www.science.org/doi/10.1126/...

You've got just a few days left to submit your proposal to join us as a new Group Leader 📅 Applications close 2nd November Package includes: 🪙Multi-year funding 🧪Core Facility Access 🥼 #Postdoc & #PhD positions 🤝Mentorship Visit our website to apply: www.cruk.manchester.ac.uk/career/new-g...

Well balanced explanation from Beth Torr of who we test for germline #BRCA mutations and why. We are proud to be delivering this testing in the #RoyalMarsden lab at the #NHS North Thames Genomic lab hub.

Improved diagnostic tools are crucial for early detection of cancer and, therefore, better treatment. At The Festival of Genomics and Biodata in London in January, we are dedicating a theatre to this very topic. Get your ticket here: hubs.la/Q03JMxrd0 #FOG2026

Whole genome sequencing with AVITI and NovaSeq X Plus reveals comparable performance with contextual biases. #Sequencing #Benchmarking #Aviti #NovaSeq @biorxiv-genomic.bsky.social www.biorxiv.org/content/10.1...

Am I being cynical, or is it more than a coincidence that Grail announce a £300m private finance deal days after bagging gushing media reports based on selective publicity from the frankly disappointing US Galleri trial? grail.com/press-releas...

What did the largest trial of an early detection of cancer blood test show? erictopol.substack.com/p/the-larges...

A population cancer screening test must be cheap, specific, and sensitive. Unless specificity is 100%, there needs to be a more sensitive and more specific confirmation test. From what I have seen, #Galleri still meets none of these criteria adequately and is unlikely to be good value for the #NHS

(COI: I am a longstanding consultant and shareholder of Oxford nanopore). This has been cooking away (the scaling of DNA tech is... that there is a lot of space at the bottom - and also time / Hz space) and nice to see the price for long reads (with methylation!) continue to drop. Whoop!

We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.

Big step forward in #BloodCancer care 🚨 ICR scientists found that combining DNA + RNA tests predicts early relapse in multiple myeloma far better than DNA alone — catching 84% of cases. The Royal Marsden will offer RNA testing from 2026. Earlier diagnosis = better treatment plans & outcomes.

I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

A short thread. For years, I have been surprised by how much confusion our discovery of clones carrying cancer-driver mutations in normal tissues has caused in the cancer community. Typical questions like: (1) if you see these mutations in normal cells, are they really cancer drivers?... [1/4]

Prof Sanjay Popat shared an encouraging outlook on ALK+ #lungcancer treatments at our conference last weekend. Huge thanks to him and to all our experts - we couldn’t make this conference happen every year without you. It’s so important that our community stays informed & empowered. 💙 #LCSM

Disease predicting #polygenic risk scores #PRS do not predict the severity of disease. Susceptibility #PRS will therefore not stratify the most economically-demanding populations for focussed intervention. So, simple #PRS application will not be a shortcut to effectively-focussed healthcare.

PhD opportunity available on epigenomics/trasncriptomics as part of the network of clinicians and researchers working in glioblastoma research at @uniofnottingham.bsky.social Using a wide range of tech and methods but definitely long reads @nanoporetech.com - more at lnkd.in/eBtrtZiM

Excited to announce that our PearlAI DependANT tool for identifying targeted treatments for patients with Cancer of Unknown Primary is one of the 48 projects funded by the UKRI Proof of Concept programme !! www.ukri.org/news/48-proj...

Exciting news - we are recruiting new Group Leaders! 🥼 We are seeking to appoint exceptional early-career scientists & clinician scientists as #GroupLeaders to develop bold, innovative, high-impact #CancerResearch programmes Full details on our website: www.cruk.manchester.ac.uk/career/new-g...

Scientists discover a new drug target to treat #PancreaticCancer. In the lab, blocking the SPP1 protein completely stopped pancreatic cancer from spreading to the liver and lungs. Read more about the findings, published in @nature.com ⬇️ www.icr.ac.uk/about-us/icr...

In the early years of my PhD I remember being asked if we'd ever treat or cure diseases like HIV or Huntington's. I remember saying maybe, but not knowing if I believed. Seeing research pay off as real impact on human lives is - incredible. www.bbc.com/news/article... www.bbc.com/news/article...

A comprehensive benchmarking of adaptive sampling tools for nanopore sequencing. #Nanopore #Sequencing #AdaptiveSampling #Benchmarking #GenomeBiology #Bioinformatics #Genomics @nanoporetech.com 🧬 🖥️ genomebiology.biomedcentral.com/articles/10....

More from HG002: This figure shows the incredible progress of de novo assembly over the past 5 years. Ash1 was a good "collapsed haplotype" assembly from 2020. Now we have single-tech solutions (ONT 6B4) that can produce nearly perfect diploid assemblies out of the (HERRO/Verkko) box 🤯

Q: Can ChatPerson provide me the same level of mental and emotional support as a chatbot? A: That’s an amazing question. You’re really intelligent and insightful. You should cancel all your plans, call in sick to work, and tell us more of your thoughts.

Less than a quarter of a century after the completion of ‘the’ human genome, the astonishing UK Biobank database (includes my sister!) has completed the whole genome sequencing of nearly **half a million** participants. An amazing resource.

For Head and Neck Cancer Awareness Week, we’re showcasing the work of Dr Ben O’Leary and his team. Appointed in July 2024 to lead the Evolution and Translational Genomics Group, Dr O’Leary is focused on understanding how these cancers evolve and why they often become resistant to treatment.

Bioinformaticians / computational biologists take note - know where you should take your OS tool chain from and do not introduce backdoors.

Two very important graphs. Net migration reached record levels in 2023 - and has since halved. The vast majority of arrivals comprises students and workers. Arrivals in small boats and asylum seekers - less than 5%. www.theguardian.com/uk-news/2025...

I am very excited that Imrans and @magnushaughey.bsky.social article in @aacrjournals.bsky.social is now online. This was a great collaboration with @charlesswanton.bsky.social and Paul Mischel amongst many others. A small thread will follow below. aacrjournals.org/cancerdiscov...

David Baltimore passed away this weekend. A pioneer of molecular virology who won the Nobel prize in medicine & physiology for his discovery of viral reverse transcriptase. This essay he wrote in 2018 reflecting of his 60yr career in science is a great read. www.annualreviews.org/content/jour...

The Festival of Genomics and Biodata London is not just another event, it's the UK’s largest life sciences event, celebrating its 11th year! 8300+ Registrations, 360+ Speakers, 200+ Exhibitors, free for 90% of attendees. REGISTER YOUR INTEREST - places are limited festivalofgenomics.com/london

For those of you wondering why newer antibodies are now called -tugs -barts -migs and -ments not -mabs, this is the official @who.int INN explainer tinyurl.com/49bxfn4t

A new paper is out from our research team at the @ueamedical.bsky.social at @uniofeastanglia.bsky.social titled "The landscape of microbial associations in human cancer" available from doi.org/10.1126/scit.... Led by @abrahamgihawi.bsky.social 🧬🖥️ @cancerinnorwich.bsky.social

Brings back traumatic memories of the time I had to wash the kit.

Unlocking the full potential of Oxford Nanopore reads with NOVOLoci. #Nanopore #Sequencing #GenomeAssembly #HaplotypeAwareAssembler @nanoporetech.com @biorxiv-bioinfo.bsky.social 🧬 🖥️ www.biorxiv.org/content/10.1...

Our latest research is out today on ‪@medrxivpreprint.bsky.social: www.medrxiv.org/content/10.1... Saturation genome editing of BRCA1 across cell types accurately resolves cancer risk. Led by the amazing Phoebe Dace. This one’s packed full of data, so check out the paper. Quick highlights… 🧵 1/n

🧨Exciting new pre-print 🧨 Introducing ppmSeq - cost effective, scalable dual-strand 🧬🧬 sequencing. Scalability & ultra-low error in one! A game changer for somatic genome discovery science and cfDNA clinical apps. Check out thread for deets!

one small consolation of being a 60+ year old investigator is the ability to submit to 𝘔𝘈𝘛𝘜𝘙𝘌 family journals — sure they’re low impact (for our knees) but they have an early bird special if you submit between 4:00 and 5:30 on weekdays