Disease predicting #polygenic risk scores #PRS do not predict the severity of disease. Susceptibility #PRS will therefore not stratify the most economically-demanding populations for focussed intervention. So, simple #PRS application will not be a shortcut to effectively-focussed healthcare.

PhD opportunity available on epigenomics/trasncriptomics as part of the network of clinicians and researchers working in glioblastoma research at @uniofnottingham.bsky.social Using a wide range of tech and methods but definitely long reads @nanoporetech.com - more at lnkd.in/eBtrtZiM

Excited to announce that our PearlAI DependANT tool for identifying targeted treatments for patients with Cancer of Unknown Primary is one of the 48 projects funded by the UKRI Proof of Concept programme !! www.ukri.org/news/48-proj...

Exciting news - we are recruiting new Group Leaders! 🥼 We are seeking to appoint exceptional early-career scientists & clinician scientists as #GroupLeaders to develop bold, innovative, high-impact #CancerResearch programmes Full details on our website: www.cruk.manchester.ac.uk/career/new-g...

Scientists discover a new drug target to treat #PancreaticCancer. In the lab, blocking the SPP1 protein completely stopped pancreatic cancer from spreading to the liver and lungs. Read more about the findings, published in @nature.com ⬇️ www.icr.ac.uk/about-us/icr...

In the early years of my PhD I remember being asked if we'd ever treat or cure diseases like HIV or Huntington's. I remember saying maybe, but not knowing if I believed. Seeing research pay off as real impact on human lives is - incredible. www.bbc.com/news/article... www.bbc.com/news/article...

A comprehensive benchmarking of adaptive sampling tools for nanopore sequencing. #Nanopore #Sequencing #AdaptiveSampling #Benchmarking #GenomeBiology #Bioinformatics #Genomics @nanoporetech.com 🧬 🖥️ genomebiology.biomedcentral.com/articles/10....

More from HG002: This figure shows the incredible progress of de novo assembly over the past 5 years. Ash1 was a good "collapsed haplotype" assembly from 2020. Now we have single-tech solutions (ONT 6B4) that can produce nearly perfect diploid assemblies out of the (HERRO/Verkko) box 🤯

Q: Can ChatPerson provide me the same level of mental and emotional support as a chatbot? A: That’s an amazing question. You’re really intelligent and insightful. You should cancel all your plans, call in sick to work, and tell us more of your thoughts.

Less than a quarter of a century after the completion of ‘the’ human genome, the astonishing UK Biobank database (includes my sister!) has completed the whole genome sequencing of nearly **half a million** participants. An amazing resource.

For Head and Neck Cancer Awareness Week, we’re showcasing the work of Dr Ben O’Leary and his team. Appointed in July 2024 to lead the Evolution and Translational Genomics Group, Dr O’Leary is focused on understanding how these cancers evolve and why they often become resistant to treatment.

Bioinformaticians / computational biologists take note - know where you should take your OS tool chain from and do not introduce backdoors.

Two very important graphs. Net migration reached record levels in 2023 - and has since halved. The vast majority of arrivals comprises students and workers. Arrivals in small boats and asylum seekers - less than 5%. www.theguardian.com/uk-news/2025...

I am very excited that Imrans and @magnushaughey.bsky.social article in @aacrjournals.bsky.social is now online. This was a great collaboration with @charlesswanton.bsky.social and Paul Mischel amongst many others. A small thread will follow below. aacrjournals.org/cancerdiscov...

David Baltimore passed away this weekend. A pioneer of molecular virology who won the Nobel prize in medicine & physiology for his discovery of viral reverse transcriptase. This essay he wrote in 2018 reflecting of his 60yr career in science is a great read. www.annualreviews.org/content/jour...

The Festival of Genomics and Biodata London is not just another event, it's the UK’s largest life sciences event, celebrating its 11th year! 8300+ Registrations, 360+ Speakers, 200+ Exhibitors, free for 90% of attendees. REGISTER YOUR INTEREST - places are limited festivalofgenomics.com/london

For those of you wondering why newer antibodies are now called -tugs -barts -migs and -ments not -mabs, this is the official @who.int INN explainer tinyurl.com/49bxfn4t

A new paper is out from our research team at the @ueamedical.bsky.social at @uniofeastanglia.bsky.social titled "The landscape of microbial associations in human cancer" available from doi.org/10.1126/scit.... Led by @abrahamgihawi.bsky.social 🧬🖥️ @cancerinnorwich.bsky.social

Brings back traumatic memories of the time I had to wash the kit.

Unlocking the full potential of Oxford Nanopore reads with NOVOLoci. #Nanopore #Sequencing #GenomeAssembly #HaplotypeAwareAssembler @nanoporetech.com @biorxiv-bioinfo.bsky.social 🧬 🖥️ www.biorxiv.org/content/10.1...

I am delighted to announce that I am starting my lab next month in @oncology.ox.ac.uk @ox.ac.uk It is such a privilege to be a part of this storied institution! Also, we are hiring - if chromosomal instability and cancer biology excite you, come join the fun! Job Specification: lnkd.in/e8-3hyfr

Our latest research is out today on ‪@medrxivpreprint.bsky.social: www.medrxiv.org/content/10.1... Saturation genome editing of BRCA1 across cell types accurately resolves cancer risk. Led by the amazing Phoebe Dace. This one’s packed full of data, so check out the paper. Quick highlights… 🧵 1/n

🧨Exciting new pre-print 🧨 Introducing ppmSeq - cost effective, scalable dual-strand 🧬🧬 sequencing. Scalability & ultra-low error in one! A game changer for somatic genome discovery science and cfDNA clinical apps. Check out thread for deets!

one small consolation of being a 60+ year old investigator is the ability to submit to 𝘔𝘈𝘛𝘜𝘙𝘌 family journals — sure they’re low impact (for our knees) but they have an early bird special if you submit between 4:00 and 5:30 on weekdays

📣 We are recruiting! Please share!! Are you a bioinformatician / computational scientist who wants to apply your skills to understanding regulatory biology and improving rare disease diagnosis and treatment? 🧠 💻 🧬 🩺 We have two roles available 👇 🧵 1/4

📣 Fantastic opportunity to join Joris Veltman’s outstanding group at the Institute of Genetics and Cancer, the University of Edinburgh, advancing research in reproductive genomics and genomic medicine 🚀🖥️🧬 📅 Deadline: 1 Sept @jorisveltman.bsky.social @uoe-igc.bsky.social @edinburgh-uni.bsky.social

Even with long read technology, resolving complex structural variants is not easy! #clinical #genomics

En el camino de Antonio Machado.

The Perturbation Catalogue is here! A new platform unifying perturbation data from CRISPR screens, multiplexed variant effect assays and gene expression data in one place. The beta version is now live. Find out more and try the platform: www.ebi.ac.uk/about/news/u... 🧬🖥️

Please welcome @nickymcgranahan.bsky.social to Bluesky! I'm excited that he is here

Very glad to see this preprint by @lh3lh3.bsky.social and Meyerson labs www.biorxiv.org/content/10.1... confirming our finding of artifactual fold-back inv in long reads (Fig S1 in our @natmethods.nature.com‬ paper presenting SAVANA, which filters such artifacts to improve SV calling 👇

Damn....Utah clownin.😂😂

Just gave up watching the awful and incomprehensible #Tenet and found this @TheGuardian.com review from 5 years ago. "I’m not even sure that, in five years’ time, it’d be worth staying up to catch on telly" Obviously a message from the future www.theguardian.com/film/2020/au...

Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...

The UK BioBank continues to provide the "default human" baseline for the world - this has really stimulated research worldwide (UK included), crowded in a huge amount of additional investment into the UK BioBank from across the world and also means that research (basic+applied) is rooted in UK data

You've earned that pint! @4130chromo.bsky.social ##GenomeScience25

Huge thanks to John Coxhead @4130chromo.bsky.social and amazing team for organizing #GenomeScience25. #Genomics at its best. Super-interesting and great fun.

Wendy Bickmore closing #GenomeScience25 with a fascinating update on the latest thinking about how enhancers work in the #genome. Perfect end to a great meeting 😃

Genome Science Casuals ⚽ #GenomeScience25 @minomatt.bsky.social @pathogenomenick.bsky.social

We’ve also heard from 10X Genomics, Ultima Genomics and Single Genomics. Now the eagerly awaited talk about Roche SBX (Nanopore expandomer) sequencing from Bernd Timmerman. Showing we’ve come a long way from the early days of NGS. I still have fond memories of 454.

First Evolving Technologies session from Illumina, Element, Oxford Nanopore and PacBio. Strong push to integrated multi-omic sequencing methods with genomics, transcriptomics, single cell, spatial and proteomics.

Great start to #GenomeScience25 with a fascinating history of Crick and then @minomatt.bsky.social describing the amazing application of #nanopore in brain tumor classification. Now we have condensed updates from the tech companies.

Fabulous kick off talk at #GenomeScience25 from @matthewcobb.bsky.social discussing just a few of Francis Crick’s great conceptual leaps (and some less stellar moments) in the understanding of molecular biology and evolution as outlined in his new biography: get it on the Xmas list amzn.eu/d/fIPxARk

I strongly recommend reading Ewan's @ewanbirney.bsky.social summary of the state of play of #genomicmedicine in the UK and beyond. He beautifully summarises the achievements, the potential and the upcoming challenges. #NHS #genomics

This time next week Genome Science UK 2025 #GenomeScience25 will be well and truly underway 🧬🧬👩🏼‍💻👩🏼‍🔬 Really looking forward to welcoming everyone to Newcastle next week 😁 #Genomics

The government’s strong support for genomic healthcare in the 10 Year Health Plan is a vote of confidence in the power of genomics to transform lives. We are excited about the role we will play in bringing this to life. Read the 10 Year Health Plan here: www.gov.uk/government/p...

Yes. The time is now. Vaccines to treat and prevent cancer. www.jci.org/articles/vie...

NeoGenomics and Ultima Genomics collaborate to expand clinical test offerings in Oncology using the UG 100 sequencing platform www.prnewswire.com/news-release...

Yesterday I used this "AI -Free Statement" in a conference talk for the first time. Still trying to figure out the exact language. Feel free to borrow, modify, etc.

Today, we remember Dame Deborah James on the third anniversary of her passing 🤍 We're grateful for her tireless commitment in supporting #BowelCancer research. Her Bowel Babe Fund is helping ICR's Professor Trevor Graham to understand how bowel cancer cells change as they develop around the body.