We are pleased to announce the publication of our STEMM sector-wide survey The report highlights our findings & suggests recommendations. Now available to download here carersinstemm.co.uk Please share especially w/ institutions, funders & allies @laurawolz.bsky.social @carterlj.bsky.social

NEW: Nature trained AI to predict which NIH grants from 2014 would have been cut if the Trump admin had its way back then — and what science would have been lost to history. "The results show the damage that cuts in funding can do to research, and the unpredictable nature of the research process."

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Very pleased to say DETECTION2 has just randomised it's 50th patient! Awesome work by patient groups @melanomafocus.bsky.social , UK clinical teams @christieinstitute.bsky.social R+I and SCTU funded by @cancerresearchuk.org

v1.108 is rolling out today 🚚 Now live, at long last: Bookmarks, aka Saved Posts. For all those posts you'll definitely plan to come back to! Update the app and give it a try. The button is right down there 👇

The Lee lab is expanding! We are really interested in mechanisms of local and systemic immune tolerance particularly in liver metastases - X2 research technicians 💡 Creative fun environment 🌱 Opportunities to grow 🫂 Highly collaborative with clinical+basic research 📢 Please spread word!

Calling all ECRs in cancer and metastasis research. Don't forget to register for the upcoming ECR Virtual Symposium in November (FREE for MRS members). More details here metastasis-research.org/2025/08/06/2...

⭐We have a clinical fellow opportunity with the melanoma team! ⭐ Very friendly and supportive team Lots of learning opportunities including clinical trials and immune therapy Apply here👇 urldefense.com/v3/__https:/...

🚨 Exciting new paper alert 🚨 From the Marie lab ⭐They have identified new melanoblast cell states which are reawakened in metastasizing and immunotherapy resistant melanoma ⭐ Can target using hdac inhibitors #melsm #melanoma #cancer www.biorxiv.org/content/10.1...

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) www.nature.com/articles/s41...

Mathematical models and ctdna have reached the clinic - the ultimate personalised trial testing adaptive targeted therapy highlighted in the news today! #EBEcancer25 www.express.co.uk/life-style/h...

Absolutely loving this course - fantastic discussions between all and the delegates and faculty. So many exciting Q's coming out of this!

Excited to share our new study on how resistance to AKT inhibition is linked to lineage differences within breast cancer 👇🏽 Stellar work @colindhratcliffe.bsky.social www.biorxiv.org/content/10.1... and also surprisingly/worryingly good AI generated podcast 🎧 notebooklm.google.com/notebook/28e...

The deadline for early bird registration for the 5th Crick Cancer Conference has been extended. See the full programme and book by 15 July to take advantage of reduced ticket rates for early bookers ⤵️ www.crick.ac.uk/whats-on/5th...

Super proud of our fellow Tomasso Bosetti presenting his poster at #ASCO25 on the impact of timing of immune therapy and outcomes across cancers - the early 🐦catches the 🪱!

Our data and the lung cancer trial also presented are very compelling for early time of day immune therapy treatment urldefense.com/v3/__https:/...

Single cell whizz with green fingers for molecular genomics? Want to develop and apply new technologies for profiling #cancer #evolution? Like single cell WGS + ATAC: www.biorxiv.org/content/10.1... Perhaps our senior scientific officer role is for you? jobs.icr.ac.uk/vacancies/12... @icr.ac.uk

Happy international trials day! Bit more info on one of the trials we have developed from research done @cruk-mi.bsky.social and now bringing to patients thanks to CRUK and @southamptonctu.bsky.social

The Department of Integrated Mathematical Oncology @mathonco.bsky.social (Moffitt Cancer Center, Tampa, Florida) is also advertising an Open Rank Tenure-earning Faculty Position in Mathematical Oncology. For this and other openings see mathematical-oncology.org/jobs

Review @cp-immunity.bsky.social Role of specialized sensory neuron subtypes in modulating peripheral immune responses www.cell.com/immunity/ful...

Fantastic news for Europe - does anyone know what this means for the UK and whether we are part of it now we are back in Horizon?

We are recruiting - two exciting positions to check out this Bank Holiday weekend: 🥼 #Postdoctoral Scientist with @sylvaindelaunay.bsky.social 🥼 Amit Patel #Leukaemia Research Fellowship & Cancer Research UK Manchester Institute Senior Clinical Institute Fellow www.cruk.manchester.ac.uk/careers/

A new Science summary spotlights a paper by CSHL’s Tobias Janowitz and colleagues that uncovers a neural circuit linking inflammation to reduced motivation in a mouse model of cancer cachexia. Check out the Science summary here: www.science.org/doi/10.1126/... #Cachexia #ScienceMagazine

Review @annualreviews.bsky.social @lindavsinclair.bsky.social @cantrell-lab.bsky.social Protein Synthesis and Metabolism in T Cells www.annualreviews.org/content/jour...

20th patient recruited to DETECTION2! 🎉 Amazing work across the UK to get this study done!

Great paper from the Fairfax lab interrogating the effect of CMV status and immune therapy response www.nature.com/articles/s41...

IL-10 targets IRF transcription factors to suppress IFN and inflammatory response genes by epigenetic mechanisms @natimmunol.bsky.social www.nature.com/articles/s41...

Review @natbiotech.nature.com Engineering innate immune cells for cancer immunotherapy www.nature.com/articles/s41...

📢Happy to share our @natrevimmunol.bsky.social article; Result of #collaboration with @deadoc80.bsky.social @labliston.bsky.social & K Smith! 📑Read here: rdcu.be/ehm67 🔥Take🏠msg: Time to move away from narrow concept of #exhausted T cells to other #hypofunctional #states! 1/6🧵 @oncodaily.bsky.social

Melanoma team are out in force at EADO/WCM with some really interesting data on adjuvant therapy in old Vs young patients with melanoma

New video highlighting our work translating bench work to the clinic. It's exciting to see how liquid biopsies can be used to track cancer in real time enabling switching of treatments for patients- watch this space for the publication!

This is going to be so much fun! Get those applications in!

Sometimes you just got to take a day off and enjoy the view

Even my cat knows how important reading about science is! Thinking of all those standing up for science today and every day! #standupforscience2025 #sciencenotsilence #scienceforall

We are recruiting #postdoctoral scientists to join @giampazolias.bsky.social and our Cancer Immunosurveillance group 🧪🥼🧫🦠 For full details of the position, please visit our website: www.cruk.manchester.ac.uk/career/mi-24... Closing date: 4th April #OncoSky #CanSky #CancerResearch #microbiome

These are extremely challenging times for early-career faculty. Here is my office's small contribution to make their hard and important work a bit easier: Download our curated and comprehensive database of funding opportunities for early-career faculty. Here: research.jhu.edu/rdt/funding-...

Join us today by signing the Milan Declaration! The EACR, alongside 55 Nobel Laureates and 70+ organisations, has signed the Milan Declaration on the Crucial Role of Science in meeting Global Challenges: www.febs.org/milan-declar...

The new and emerging field of peripheral neuroimmunology is revealing how unique interactions between neurons and immune cells in various organs can profoundly impact mammalian health. Nice review in JLB. The peripheral neuroimmune system academic.oup.com/jleukbio/art...

Another great thread by @altmetric.com

Next Thu 13th March Ilaria Malanchi @ila07.bsky.social and I will host the next "Medicine at the Crick" event focusing on how tissues evolve over time and why this may initiate disease. Free in person/virtual registration @crick.ac.uk: www.eventbrite.co.uk/e/medicine-a...

Get ready for #WorldImmunologyDay2025! 🌎 Join us at The Francis Crick Institute on 24 April to explore "The immune system and your brain" 🧠 Hosted by @claudiahammond.bsky.social and run by @britsocimm.bsky.social, @natureportfolio.nature.com and @crick.ac.uk Register for FREE now: bit.ly/41m8kP9

CRUK Black Leaders in Cancer Non-Clinical PhD Opportunity in my lab using unique pt models ‘Phosphatases in melanoma metastasis +therapy resistance’ 📅 Deadline: 4 April 🔗https://www.crukcentre.manchester.ac.uk/opportunities/the-role-of-phosphatases-in-melanoma-metastasis-and-therapy-resistance/

An important paper from James Dooley in our lab, collaborating with the RSPCA and vets to implement the 3Rs in bone marrow chimera experiments in mice. Reduce the severity of your experiments while improving scientific reproducibility! onlinelibrary.wiley.com/doi/10.1111/...

We are now on BlueSky! 🥳 We're excited to be here, and engaging with people who care about psychiatry and mental health in the UK and around the world. Join us on our Bluesky journey - we'd love you to be part of it.

Pubmed being down really starts to make you realise how the ripple effects of the sabotage to science in the US affects the whole scientific community (not withstanding the awful impact on funding for colleagues)

The fellowship programme at The Christie is great!

Applications are open for the Workshop "formerly known as Vail": ASCO/AACR Methods in Clinical Cancer Research Workshop, July 20-25, 2025. A great experience for clinical fellows and junior faculty clinical researchers interested in effective clinical trial design. vailworkshop.org?utm_source=s...

Friends: Science is under threat! Worldwide, forces seek to make it corporate-like, focused on deliverables, or even the enemy of society. It's time to take a stand to celebrate the science we know and love. Introducing: Woodstock.Bio2 + Night Science June 10-13, Prague & Woods of Bohemia Join us!

Great to see one of our first patients on DETECTION2 in the news www.manchestereveningnews.co.uk/news/greater...

Fellowship opportunity for early career post docs - 3 years of funding - 30k consumables per year www.bmh.manchester.ac.uk/research/sup...