How are human brain regions connected? Are the connecting axons thicker and more myelinated the longer these connecting fibers are? In our recent paper we find that indeed, they are! Read the skeetorial below ⬇️⬇️⬇️ plos.io/4mq5tOy #neuroscience #neuroskyence #whitematter #deeplearning

#LISH25 day 10 ushered in by Claudia Gerri from @mpi-cbg.de introducing us to the wonderful world of mammalian early embryo development, implantation and #placenta interactions. Showing light sheet data from ex #LoPaT - Michi Burkon 💕. Walk-up song with Italian flair came with sweets.

It’s Sunday, but #LISH25 goes on with Matteo Rauzi presentation on using light sheet to study #Morphogenesis of #flies and #sea_urchins. Matteo had not one but two walk-up songs! #RockyBalboa 🥊

a second rendering for #fluorescencefriday

Love these names 😆

For the day five of #LISH25 Jan Huisken comes home, to @mpi-cbg.de, to show us what his latest project, the #Flamingo microscope can do. Walk up song featured stunning photography of birds - all taken by Jan who is the imager all the way.

An AD mouse brain with therapeutic antibody (in blue) and smooth muscle cells (in yellow).The first attempt, but quite successful. Thanks to @dvonwangenheim.bsky.social #LISH25

Pan-ASLM: a high-resolution and large field-of-view light sheet microscope for Expansion Microscopy www.biorxiv.org/content/10.1...

My undergrad Inword got some really cool data this week, and I can't think of a better way to celebrate #fluorescencefriday than to share it. She injected oligomeric amyloid-B (red) and it caused these pulses of tracer leakage throughout the brain (turquoise) 1.5 days later. #BBB #zebrafish

Excited to share our new research in @cp-iscience.bsky.social! We reveal that tortoise head scales are sculpted through two distinct developmental processes - chemical signalling and mechanical folding 🐢🔬🧪 @lanevol.bsky.social @genevunige.bsky.social www.cell.com/iscience/ful...

Beautiful 💙🩵

When microscopy meets MRI at MINDs with @neuroak.bsky.social #fluorescenceFriday

OmiCLIP #Visualomics An amazing Histology (HE) - #SpatialTranscriptomics foundation model An ST-bank 2.2 M image-Visium pairs 1007 tissue samples 32 organs Loki PredEx HE-to-spatial gene expression vs Hist2ST HisToGene BLEEP mclSTExp @natmethods.nature.com 2025 www.nature.com/articles/s41...

The @embo.org practical course on #lightsheet #microscopy is back! Join us in #Dresden for 2 weeks with #your #samples, try the complete line-up of #lightsheet microscopes, tackle big data image analysis, sample prep, OA hardware & much more Apply now! Repost 🙏 meetings.embo.org/event/25-lsm

#legoptical Episode 3: An italian twist. In 1997, Franco Quercioli and his colleagues published in SPIE an article entitled: “Play optics with Lego” introducing for the first tie the use of LEGO bricks in setting up an optical instrument! opg.optica.org/ao/abstract....

After the course, some of these microscopes stay in the beautiful @pasteuredu.bsky.social for a week, and the companies will welcome you on request to organize demos. Interested? All information on how to book a demo is here: research.pasteur.fr/en/event/sym...

Loving this series!! Got to show off this miniMOC that my friend built 😊🥰

Sugars labeled in a zebrafish embryo. Credit to Holly Aaron & @carolynbertozzi.bskyverified.social. #ZebrafishZunday 🧪

@john-haug.bsky.social and I are getting ready to announce a DIY, open-source light-sheet microscope designed for high-resolution, sub-cellular imaging. Here is one sneak peak of some raw data! #COMPASS

1-2μm/°C is a good 'rule of thumb' for the axial shift of the focal plane of an objective with temperature, or ~1-2 depths of field (DOF) at high numerical aperture. -> Here's a typical lab trace with a swing of 1-2°C over 1-2h. This is ~1-4 DOF of drift per hour! So continuous autofocus is needed!

Just a gorgeous #Purkinje neuron all by itself in the cerebellum. Only with #lightsheet #microscopy on a whole #cleared sample could you ever hope to catch a lone reporter expressing cell in it’s entirety. #science 🧪

Please welcome our official #mesoSPIM channel on this platform, @mesospim.bsky.social. Repost is appreciated!

Microscopy Nodes is now up on bioRxiv! 🚀 This is a Blender extension that seamlessly integrates and visualizes 3D microscopy data (TIF & @zarr.dev). High-quality volume rendering for anyone, in both EM and fluorescence, regardless of computational expertise! 🔬 www.biorxiv.org/content/10.1...

Ok here’s a first go at looking at the previously acquired sample in 3D space. Still some work to do before we have a final product. 🧪

If you need to load a large CZI file quickly, look no further... pypi.org/project/pyli...

Where did our neck muscles come from?🧪 Here's our #evodevo #devbio deep dive feat. #zebrafish, mouse, axolotls, & more! Led by Eglantine Heude & Tajbakhsh lab at Pasteur, the team at National Museum of Natural History France, & lab alumni Karin Prummel & Rob Lalonde. www.nature.com/articles/s41...

It's even more fun and collaborative when it's the correct link to apply: www.jobs.ac.uk/job/DKU906/p...

An early Christmas present if you like Fluorescence Lifetime Imaging Microscopy, data analysis and pho-ho-ho-tons (sorry not sorry) - another postdoc position open in my group! Deadline 16th December -> www.kcl.ac.uk/jobs/100785-... Part of a super fun and collaborative Wellcome Bioimaging project 🔬

🥳

#Vanderbilt Neurovisualization lab specializes in #lightsheet #Microscopy. 🧪 Here we see a wave of c-fos positive cells in blue and tyrosine hydroxylase in gold. If you need help with lightsheet let me know!

Precious!! 🐢🥺

😉 can confirm haha