Hi bsky! How do cells coordinate fate with migration during development? 🐣 Turns out EMT doesn't just drive cell behaviour changes... it actively primes BMP signalling competence, creating a reciprocal coupling that drives collective invasion! (@bensteventon.bsky.social lab) tinyurl.com/2ncc8zap

Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis: Molecular Cell www.cell.com/molecular-ce...

Our study, just published in #ScienceAdvances and funded by @hfspo.bsky.social, explores the post metamorphic cell composition of the sea urchin juvenile, revealing that its body is head-like. Long considered brainless creatures, they’re all brain instead! www.science.org/doi/10.1126/...

Hi bsky! Do embryonic tissues have backup plans🔀? Gastruloids (model of body elongation) can build an axis through different cellular mechanisms when on adherent substrates instead of free floating. A case of developmental plasticity! w/ A. Delahaye & ‪@bensteventon.bsky.social‬ shorturl.at/v01DO

Which features of tissue flows are most robust and how do they emerge from #EpithelialMechanics? I’m @alex-plum.bsky.social (@mattiaserra.bsky.social group) and I’ll be sharing some papers on characterizing and controlling avian gastrulation flows.

Speaking of time, @osvaldo-chara.bsky.social 's lab recently developed a new method, ForSys, that uses all available dynamic information. It also tracks the elements of the tissue over time and uses their movement to further inform the stress inference algorithm. bsky.app/profile/epim...

Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors - @niakanlab.bsky.social @loke-ctr.bsky.social go.nature.com/3JdRdu8

Congratulations Ahmed and colleagues in the @niakanlab.bsky.social on this beautiful work tracking mitotic errors by live imaging the human embryos!

Like Wnt signalling? How about Notch? How about both together (Wntch!)... in gastruloids? Come and and apply for a PhD studentship with us in Liverpool! Applications open 30th October! tinyurl.com/3bpx3y2b

A developmental atlas of zebrafish gills links early vascular patterning to adult architecture Read this #LifelongDevSI #OA Research Article by Mathieu Preußner @mathpreu.bsky.social, Virginie Lecaudey @vlecaudey.bsky.social and colleagues: journals.biologists.com/dev/article/...

Congratulations @vlecaudey.bsky.social @mathpreu.bsky.social

1🧵 Excited to share my first PhD paper, published in @dev-journal.bsky.social What if fish gills —often overlook —hold secrets about development, patterning, and function? We uncovered how early patterning shapes adult gill architecture. journals.biologists.com/dev/article/... #DevBio #Zebrafish

New preprint from the Lecaudey lab by first authors Anna Mertens and Nicola Moratscheck, with the help of other former members including @chaitanyadingare.bsky.social uncovering the role of integrin-laminin interactions during epithelial collective cell migration!

(1/8) Very Happy to share our lab’s 3D post-implantation human embryo model, made via signalling reprograming! 🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis). www.cell.com/cell-stem-ce...

www.biorxiv.org/content/10.1... late post! Parts of my PhD thesis are now in a preprint. Just imagine if each cell of your organs decides to undergo some extra divisions while being formed, how would they look and what prevents that from happening? This is exactly what I have shown in my work.

Patterned integrin-laminin adhesion coordinates epithelial collective cell migration https://www.biorxiv.org/content/10.1101/2025.09.12.675859v1

@vlecaudey.bsky.social !

Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social

Nerve-to-cancer transfer of mitochondria during cancer metastasis www.nature.com/articles/s41...

GATA6 Mediates Endoderm and Mesoderm Progenitor Fate Driven by WNT and NODAL Signaling https://www.biorxiv.org/content/10.1101/2025.06.20.660704v1

An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning https://www.biorxiv.org/content/10.1101/2025.06.17.660116v1

It’s out! 🥳 www.science.org/doi/10.1126/...

The weekly Metabolites-driven PTMs focusing on cancer Biomed News is out ☺️ biomed.news/bims-prolim/...

If you’ve ever wondered how those intricate gill structures emerge—and how gills develop throughout a zebrafish’s lifespan—check out my new preprint! We dive into the development of gills and their vasculature in detail. Huge thanks to @vlecaudey.bsky.social for the support🐟 #zebrafish #microscopy

New preprint from the lab! Beautiful work by @mathpreu.bsky.social, who delved into the early development of gills and their intricate vasculature. Thanks to the Clusterproject ENABLE and @goetheuni.bsky.social for the funding! www.biorxiv.org/content/10.1...

COMMENT | KS Li, X Su & T Huan (Rutgers U, UBC): Metabolites are not genes — avoiding the misuse of pathway analysis in #metabolomics. https://bit.ly/4kIGbtI#metabolomics?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab

A lipid metabolism defect is an underlying contributor to Diamond Blackfan anemia syndrome https://www.biorxiv.org/content/10.1101/2025.05.22.654334v1

Signaling and Mechanics influence the number and size of epithelial rosettes in the migrating zebrafish Posterior Lateral Line primordium https://www.biorxiv.org/content/10.1101/2025.05.17.650326v1

Experimental embryology postdoc available in my lab at the @biology.ox.ac.uk @ox.ac.uk working on the evolution of vertebral counts. Reach out if you’re passionate about EvoDevo, enjoy lab work and microscopy and are into or could get into cichlid fishes. Deadline on the 16th June. Please share!

Interesting work on #morphogen (BMP4, Wnt8) mobility and HSPGs in Xenopus🐸

“We propose a model in which Yap1, together with Tead proteins, ensures that the [posterior lateral line primordium] contains a sufficient number of cells before migration begins.” New work from @vlecaudey.bsky.social 👩‍🔬

Vgll4 Proteins limit Organ Size in Zebrafish through Yap1-Dependent and -Independent Mechanisms https://www.biorxiv.org/content/10.1101/2025.05.08.652796v1

New preprint from the lab!! Project was initiated by @chaitanyadingare.bsky.social and continued by Alicia Lardennois with quite some people involved on the way 🤗

Two transcriptional modules that control mammalian #gastrulation that are functionally linked through their GRNs www.biorxiv.org/content/10.1... and paced by interactions between Wnt and Nodal signalling Great collaboration with S Arnold and K McDole's labs #gastruloids

Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...

I'm excited to share our latest story from the @lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/

📢 Fresh off the press and featuring new exciting experiments! 🧪 We show how glycolytic activity instructs germ layer proportions through regulation of Nodal and Wnt signaling - happy to finally share this 😊 doi.org/10.1016/j.st... B2B with @jesseveenvliet.bsky.social lab: doi.org/10.1016/j.st... 🤩

Online Now! Glycolytic activity instructs germ layer proportions through regulation of Nodal and Wnt signaling #stemcells

Embryo-scale single-cell chemical transcriptomics reveals dependencies between cell types and signaling pathways https://www.biorxiv.org/content/10.1101/2025.04.03.646423v1

🎉Congratulations to PoL PI and group leader at @mpi-cbg.de Rita Mateus @ritamateus.bsky.social and collaborators for being awarded a HFSP Early Career Grant! Their project is titled 'MetaCrystal: Metabolic principles of intracellular crystallization'. Learn more on our website: tud.link/y56cmr

Are you interested in being involved with the undergraduate practical teaching we offer? We are looking for a Technician to come and join our team. 📅Apply by 02 March ➡️https://www.jobs.cam.ac.uk/job/50264/

This is Charlie. He has literal heart-eyes. 14/10 would be an honor to pet (IG: charlie.the.dalmatian)

This is my first every pre-print! Yes I am late to the party - but happy to make this entrance. Congrats to all my co-authors on their lovely work. www.biorxiv.org/content/10.1...

Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production https://www.biorxiv.org/content/10.1101/2025.02.07.637120v1

Here’s a story about actual Nazis, the Original Gastruloid, and the lengths scientists will go for other scientists and for science itself. Welcome to Episode Two of the #LongBibliography #DevBiol #SciHist 🧵. 1/13

Thrilled to share our new preprint from Ye Zhu in the lab. www.biorxiv.org/content/10.1... . We look at the cell fate potential and degree of cadherin switching of human ES cells differentiated to different primitive streak coordinates.

Birth defects are the #1 cause of death in the first year of life (🧵). Birth defects kill more than twice as many children as cancer. Birth defects are diseases of developmental biology. Here are CDC statistics for 2021. 1/5 wisqars.cdc.gov/pdfs/leading...

Birth defects are diseases of development and are the #1 cause of death in the first year of life. And birth defects kill more than twice as many children as cancer. 4% of ALL hospitalizations (for all ages) are due to birth defects. Economic impact of birth defects is > 22 billion dollars per year.

Despite challenging times delighted to see our preprint on how stem cell-specific sphingolipid metabolism controls fate trajectories in the hair follicle published🎉 congratulations Franziska &team and thank you @dfg.de @maxplanckpress.de and UniHelsinki for support! rupress.org/jcb/article/...

So, what do YOU make of these pictures of embryos drawn in 17th Century Tibet? New episode of The Long Bibliography drops soon, right here (no matter what happens....).