Calling all Developmental Biologists! We're accepting self-funded PhD students to work on Wnt and Notch signalling using Gastruloids! Spread the word! www.liverpool.ac.uk/courses/mole...

To find out more about this work and the people behind it, we spoke to first author Tina Balayo, and to co-corresponding authors André Dias @dias-andre.bsky.social and David Turner @gastruloids.bsky.social: journals.biologists.com/dev/article/...

Delighted that this article is now out journals.biologists.com/dmm/article/... Great team work with Dharani Hapangama, Chris Hill and first author Dimas Rahmana from @livuni-ilcams.bsky.social @livunihls.bsky.social With generous funding from the Indonesian government.

Listening to David Lammy on @BBCr4today attempting to justify abolishing trial by jury, it is increasingly and terrifyingly clear that he simply does not understand the issues.

As set out in this thread, the causes of the court backlog are chronic lack of funding and absurd inefficiency. The government has made no proposals to address either. Their answer is to remove juries. Rather than fix the leaking roof, their solution is to burn the house down.

Now out in @dev-journal.bsky.social Lots of new results! Check it out!! journals.biologists.com/dev/article/...

There's increasing evidence that in organoid/embryoids conditions of cells at start of experiments is crucial/ determines outcome. Much to be learnt still. Taking advantage of mouse #gastruloids, two groups explore this here. Important work to calibrate the field www.biorxiv.org/content/10.1...

Now out in @dev-journal.bsky.social journals.biologists.com/dev/article/...

I do like the @dev-journal.bsky.social "Research Report" format for shortish papers This one is valuable. "Is it the N2B27?" is the stem cell biologist version of "Is it the magnesium?" Congrats Tina Balayo @dias-andre.bsky.social David Turner & all authors journals.biologists.com/dev/article/...

Like Wnt signalling? How about Notch? How about both together (Wntch!)... in gastruloids? Come and and apply for a PhD studentship with us in Liverpool! Applications open 30th October! tinyurl.com/3bpx3y2b

This year's Crick @crick.ac.uk PhD programme is open for applications - £27,715 tax-free student stipend per year for 4 years - Tuition fees paid - Student visa fee & health surcharges covered Deadline 5 Nov We have a project available. For all the details visit: www.crick.ac.uk/careers-stud...

New insights directly link WT1 and smooth muscle cell lineages Read this Research Highlight showcasing work from Suad Alsukari, Huei Teng Ng, @gastruloids.bsky.social, Bettina Wilm @bwilm.bsky.social and colleagues: journals.biologists.com/dev/article/...

Very happy to announce that this article is now published @dev-journal.bsky.social @biologists.bsky.social journals.biologists.com/dev/article/... With Suad Alsukari and Huei Teng Ng and @gastruloids.bsky.social

An englishman, down and out in Paris…..trying to read the news and laughing....at a french joke? @gastruloids.bsky.social‬

Look at this amount of work that has gone into the analysis of these beautiful (yes, we are biased) images of rods and rings. Now you can automatically classify these structures which is rather tedious to do manually. 🔬📷🖼️💻📄 bmcbiol.biomedcentral.com/articles/10....

I cannot help but think of these rod-rings as oh so pretty. amazing work by some of our @cci-liv.bsky.social users.

Great preprint out from the MicroAge team in @livuni-ilcams.bsky.social! www.biorxiv.org/content/10.1...

Excellent work supporting #modularity of the mammalian #embryo, a role for #hypoxia & how development exploits these features. It shows what we can learn from assemblies of #gastruloids @ spatio-temporal coordination of the modules in AP organization. Putting modules together, extremely informative

The modularity of the mammalian #embryo in display. Controlled assembly of classic #gastruloids and uncommitted precursors in #hypoxia, patterns the AP axis www.biorxiv.org/content/10.1... Beautiful & insightful from @bulutkarslioglu.bsky.social‬ group. Building models to learn and learning.

This was a fabulous collaboration! Thanks @gastruloids.bsky.social and to Suad and Huei who worked incredibly hard to make it happen!

Also, an interesting reflection from Bob Edwards on the contrast between Research Institutes and Universities. Having spent my academic life in the latter, I can relate. From "A matter of life" a first hand account of the path to IVF that I suggest as a read for those interested in human #DevBio

Great to see our article published in @dev-journal.bsky.social! Wonderfull collaboration with @bwilm.bsky.social to understand how Wt1 guides cell fate in the early gastrulating embryo! journals.biologists.com/dev/article/...

We previously showed that DNA Typewriter can record high-resolution lineage trees in cultured cells (HEK293T). www.nature.com/articles/s41... But could we use it to study how clonal memory shapes cell fate decisions during development? (2/13)

New preprint with the Shendure lab @jshendure.bsky.social ! We apply the DNA Typewriter lineage recorder to mouse 3D gastruloids, a powerful model of early mammalian development. Led by Sam Regalado and CX Qiu @cxqiu.bsky.social : www.biorxiv.org/content/10.1... (1/13)

We've just updated our manuscript to a more 'publishable' version! www.biorxiv.org/content/10.1... New details about the role of Wnt in suppressing neural differentiation and fostering a posterior epiblast state, and the temporal effect of Nodal signalling in driving mesendodermal fates

Our new paper just arrived! Fun collaborative effort led by Sam Ball and Meagan Hennessy to develop an AI tool to segment and classify #IMPDH2 rod-rings in mouse ESCs doi.org/10.1186/s129...

Great fun at last night's Gala Dinner at the stunning St Georges Hall. #biologists100

Right after the spanish edition of #TheMasterBuilder comes the Portuguese one, thanks to www.temasedebates.pt Have a look for a cell’s eye view of Biology in contrast with the widespread gene’s eye. #CellsRUs #NotInTheGenes

Wonderful evening in #Barcelona w/ friends sharing memories, science and hope in these troubled times.

In the wake of Barcelona #Gastruloid meeting, we can say w/ some confidence that this is a system w/ potential in several areas of biomedical research: models, rather than replicas, are useful &also teach. For details linkinghub.elsevier.com/retrieve/pii... onlinelibrary.wiley.com/doi/10.1002/...

Delighted to announce our preprint on modelling of the peritoneum in endometriosis research, by Dimas Rahmana, with Dharani Hapangama's group, Liverpool Women's Hospital, with essential contribution from Chris Hill www.biorxiv.org/content/10.1... @livunihls.bsky.social @liverpooluni.bsky.social

First day of our Gastruloid Meeting in Barcelona kicking off with amazing talks and discussion and a room filled with gastruloid enthusiasts! #gastruloids #conference

Fun collaboration! All the nitty-gritty about N2B27 and gastruloids. Kudos to all the authors, particularly Tina Balayo (¡que va de primero!)

New Gastruloid preprint just landed... nice collaboration between our lab, @dias-andre.bsky.social, and @amartinezarias.bsky.social www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.1... Here we explore the role of #Wnt and #Nodal signalling during mammalian gastrulation using #gastruloids. Building on the work of many labs, we propose that antagonistic signalling-dependent #modularity in the PS establishes the early mammalian body plan.

This is probably the future of science. But to set it up? @gastruloids.bsky.social @dwilkinsonlab.bsky.social

A remonder we have a MRC funded PhD studentship open for application. Supported by a great multidisciplinary team, with Biomedical and engineering methods to explore how sex and menopause affect osteoarthritis. Please share! www.findaphd.com/phds/project...