Stand up for science - stand up for the NIH! I just signed the support letter for the #BethesdaDeclaration. Please consider signing as well: www.standupforscience.net/bethesda-dec...

New CRISPR technology developed by @stanleyqilab.bsky.social‬, Mengting Han & team could pave the way for potential treatments for neurodegenerative diseases like ALS and spinal muscular dystrophy:

Thrilled to share our paper in @nature.com led by @MengtingHan123 on CRISPR-TO technology, which paves the way for treatments for neurodegenerative diseases by precisely delivering therapeutic RNA to the damaged sites. A 🧵@Stanford_ChEMH, @bioe_stanford, @Stanford

Institute Scholar Stanley Qi @stanleyqilab.bsky.social discusses the importance of scientific research and his long-term goal of using the genetic engineering technologies developed in his lab to address unmet medical needs in diseases like cancer and Alzheimer’s:

“Research is like a chemical reaction – it takes time to reach completion. If we ever slow down in training the next generation of scientists, we risk falling behind other competitors in the world – even if we have the better solution.” #ResearchMatters

Excited to share our latest manuscript, a collaboration with @justinperryphd.bsky.social led by Weill Cornell Neuroscience PhD student @annbaako.bsky.social. Ann developed a new, improved mouse PSC model for studying tissue-resident macrophage differentiation. www.biorxiv.org/content/10.1...

www.alz.org/news/2025/ke...

Grant freezes versus terminations feel different, but they have the same practical effect. We should start treating freezes as terminations, both of which can be undone by HHS / NIH whenever they want—or by court order if they refuse. They’re all illegal.

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

No bottlenecks with binseq... github.com/ArcInstitute...

LA trash haulers are bringing their loads up to the Antelope Valley and dumping it. I saw a river canyon filled -- 30 feet deep and about 60 acres in area -- of solid trash. www.latimes.com/science/stor...

🎉 Excited to share my postdoc work in the Bernstein lab now online @cp-molcell.bsky.social! 🔎We explored the unique functions of the SWI/SNF PBAF complex and its relationship with TFs, and unveiled a PBAF/REST-controlled neuronal-like signature with potential implications in #melanoma brain mets🧬

Game 1, WON.

Our latest work now online in Cell: Rewriting regulatory DNA to dissect and reprogram gene expression Our new method (Variant-EFFECTS) uses high-throughput prime editing + flow sorting + sequencing to precisely measure effects of noncoding variants on gene expression Thread 👇

Losing sleep over #iPSC transgene silencing after differentiation? Same here — too many times😭 So we built a PiggyBac construct that resists silencing. Expression stays ON, even after differentiation. Our #preprint is out👇 🔗 www.biorxiv.org/content/10.1... Supported by @cziscience.bsky.social

Glad to share our paper, in collaboration with Prof W.E. Moerner lab and Prof. Andrew Spakowitz lab on developing a high-resolution DNA imaging technology Oligo-LiveFISH, which is online in Cell this week.

Silencing of transgenes during iPSC differentiation is a frequent problem. 🧬🫢 Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪 Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!

Thrilled to share our paper, led by Dr. Yanyu Zhu @yanyuzhu.bsky.social in collaboration with Prof. W.E. Moerner and Prof. Andrew J. Spakowitz, on developing Oligo-LiveFISH technology, in Cell @cellcellpress.bsky.social. A🧵 @stanford-chemh.bsky.social @bioe-stanford.bsky.social

I'm excited to release what I've been cooking up the past few months at @arcinstitute.org BINSEQ is a family of binary file formats for sequencing data built with paired records and parallel processing in mind with big performance gains (2x-40x) over gzip-fastq with similar storage

They’re destroying federal science capacity & California needs to step up & expand science capacity at the state level. I introduced SB 829 to create the California Institute for Scientific Research & authorize the State of California to produce vaccines. It just passed the Senate Health Committee.

As Trump & Musk tear down our federal science agencies & jeopardize U.S. global science leadership, CA needs to step up. I introduced legislation (SB 829) to create the California Institute for Scientific Research & solidify CA’s global science leadership in the absence of federal leadership.🧵

Now we’re finally talking! www.politico.com/news/2025/03...

Women are twice as likely to develop Alzheimer’s disease as men. A feature in Nature Medicine reports how the changes to the female brain during menopause, along with social and cultural factors, might affect disease risk. #medsky #alzsky 🧪

Despite @governor.ca.gov 's past concern about #plastic, #styrofoam can still be purchased in stores and online throughout CA. It was banned on Jan. 1. But the gov's office still has not acknowledged it, leaving some stores and producers confused. 🤷‍♀️ #SB54 www.latimes.com/environment/...

I miss when the biggest controversy about mRNA was whether it correlated with protein or not.

Huge thanks to all co-authors and our funding support!

Thrilled to share our preprint led by @xinyi-chen.bsky.social on programmable molecule delivery via engineered trogocytosis called TRANSFER! a 🧵 @stanford-chemh.bsky.social @bioe-stanford.bsky.social

Since @stephanieaw.bsky.social left the lab to start her group at Vanderbilt, we've been talking regularly on the ups and downs of academic science. We started recording... The Tortured Proteins Department open.spotify.com/show/10PHVou... (science with a small dose of running and Taylor Swift)

These cuts are ruining people’s careers. This is not efficiency - capricious changes to funding damage science for generations. www.nature.com/articles/d41...

#US Working #Canines are the latest victims in the Elon/Trump dumpster fire “ALL requests for everything," for the pups, including "vet visits, kenneling, dog food, etc" have been "put on hold until we receive guidance” These #dogs save lives. There needs can not just be “put on hold”

This is a super clear and helpful article explaining why the 15% indirect cost rate is unfair, hurts science, and does NOT increase $ for research: www.science.org/doi/10.1126/...

Our collaborative project with Matthias Stadtfeld and Jason Mezey labs has now been published. We examined how genetic variation impacts regulation of DNA methylation at the control regions of imprinted genes in naive pluripotent stem cells. www.cell.com/stem-cell-re...

🚨🚨 Concerning genetic mutation found in #H5N1 #BirdFlu dairy cows -- likely 4 herds in San Bernardino County: www.latimes.com/environment/...

note this is a log scale - five logs, 10^5, a 100000 fold decrease in the measles death rate thanks to vaccination. it’s hard to understand why anyone would undermine such a successful vaccination program absent equally compelling data, which certainly doesn’t exist

USDA finally added the #H5N1 #BirdFlu infected herds I'd heard about (2 weeks ago) to its list, bringing CA's total to 754; 983 across 17 states. Meanwhile domestic cats are getting pummeled -- APHIS' list shows last 10 entries were all cats.

Excited for our iAssembloid work, led by @emmyli.bsky.social to be featured on the cover of today's issue of @cp-neuron.bsky.social

Thank you Alzforum for featuring our work! CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions - project led by @emmyli.bsky.social www.alzforum.org/news/researc...

The Lawrence Lab website (lawrence-lab.org) is live and we are hiring for our launch in Jan 2025! We combine high resolution structure 🔬 and cell biology 🧪🧫 approaches to define mechanisms of stress response signaling in health and disease. Live postings below--Please RT and send to recent grads!

Spending a minute today admiring my favorite spiky swirly cells (hiPSC-derived iAstrocytes, serum-free, in bi-polar process-bearing phase). One day I will make this into a Starry Night-esque painting. 🧪 🧠 #neuroskyence

Our latest paper, led by Emmy Li, is out on Neuron today: CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions www.cell.com/neuron/fullt...

We are opening in January of 2025 at UCLA: SamelsonLab.org We combined classic biophysical techniques with systems genetics in iPSC-derived cell types to explore how proteins aggregate and how cells control protein aggregation. Multiple positions are open: SamelsonLab.org/join/ Join us!!

Our updated preprint is live! www.biorxiv.org/content/10.1... @kampmann.bsky.social We add new data: 1. A new CRL5 complex that targets tau for degradation 2. CUL5 as a marker of vulnerability in Alzheimer's Disease 3. Oxidative stress-derived tau fragments change in vitro tau aggregation