And here is the PDF of the 4th course @college-de-france.fr. You will find the justification and presentation of geometric representation of cell decisions, a parsimonious mathematical model for signalling and cell state transitions tinyurl.com/yc7u296j

Very excited to share our latest paper, in which we developed an approach to answer a central question: Is cell fate more dependent on a cell lineage or a cell direct neighbors? Surprisingly, when analyzing single cell trajectories, we showed that C. elegans exhibit both

Very happy to share our 'Evoscape' paper, now published in PNAS ! www.pnas.org/doi/10.1073/...

#LivingArchitectures We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay. www.musee-orsay.fr/fr/agenda/ev... Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night. -> Two shows on the 24th and 25th of January.

📣 New review! Dynamical systems and low-dimensional geometric structures in phase space help rationalize how embryos develop form and function, from large datasets. We focus on morphogenesis, cell differentiation, and their interconnection. @alex-plum.bsky.social sciencedirect.com/science/arti...

Very happy to share video of 1st lecture @college-de-france.fr on Biological computation 😊. I defend the necessity to access Algorithmic & Computational levels of analysis in cell & developmental biol. proposed by David Marr in neuroscience. Logic & Function matter 🤩. Video: tinyurl.com/55yejk5f

Are you passionate about the mathematics of data science, computational geometry and topology and want to apply your skills to a beautiful biological question? Come do a PhD with us! You will help us understand of how boundaries are established and maintained in early heart development.

Are you passionate about the mathematics of data science, computational geometry and topology and want to apply your skills to a beautiful biological question? Come do a PhD with us! You will help us understand of how boundaries are established and maintained in early heart development.

Felix Zhou's u-Segment3D is out: www.nature.com/articles/s41... It leverages 2D cell segmentations from orthoviews to generate a ‘consensus’ 3D segmentation. It does a great job on segmenting densely packed samples, and we have used the algorithm in many applications.

Congratulations to Dr @baalberti.bsky.social !! 🎉 And many thanks to his jury members @randersson.bsky.social @arnausebe.bsky.social @olivier-gandrillon.mastodon.social.ap.brid.gy Marie Sémon Anouck Necsulea and co-supervizor @paulvilloutreix.bsky.social

Excited to be in Paris later this week!

#Agenda With @batistaruan.bsky.social, Valentin Rineau, @ignacioq.bsky.social, Aleksandra Walczak, Guillaume Achaz, @k4tj4.bsky.social - @r3rto.bsky.social, Maël Montévil, @paulvilloutreix.bsky.social, Barbara Bravi, Cyril Rauch, Giuseppe Longo, Anton Robert, @charbelelhani.bsky.social , Ana Soto

Happy to share STORIES out now on Nature Methods STORIES learns cell fate landscapes from spatial tramscripromics data profiled at several time points, thus allowing prediction of future cell states. Led by Geert-Jan Huizing and Jules Samaran www.nature.com/articles/s41... @pasteur.fr

Great program, amazing scientists and beautiful facilities!! I visited for 6 months in 2023, a unique place in Europe at the intersection of maths, computer science and developmental biology

🧬 Excited to share Nicheformer out now in Nature Methods! A transformer foundation model linking single-cell & spatial omics, learning spatial context from gene expression to map tissue organization. Led by Ale Tejada & Anna Schaar 👏 👉 www.nature.com/articles/s41...

Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions 🧵👇 www.biorxiv.org/content/10.1...

Had a very nice time visiting Granada for the annual heart ICDAR meeting! We presented Harshit Pateria's current work in collaboration with Robert Kelly following up from our recent publication on the second heart field www.nature.com/articles/s41...

Wow @gioelelamanno.bsky.social & @giodang.bsky.social

Pleasure to announce the program of my new series of lectures at the College de France in Nov-Dec. Continuing on the theme of Biological information. I will focus on the computational aspects, building on David Marr's tri-level of analysis in biological systems. YouTube link sent when it starts.

🤩👍🏼💪🏼 Meet #TopoSPAM - a high-performance simulation platform for biological morphogenesis with a friendly Python interface. @tudresden.bsky.social @csbdresden.bsky.social @mpi-cbg.de. Solve both continuous and discrete active mechanics! Released today: arxiv.org/abs/2509.24905

Very elegant and efficient methodology to recover spatial patterns from multi-modal spatial datasets 👌!! Many congratulations @paulvilloutreix.bsky.social and to all authors👏😀!!

Very happy to introduce jsPCA, a fast and interpretable computational framework for spatial transcriptomics that simultaneously identifies spatial domains and variable genes across multi-slice and multi-sample data.

Are digits modified fins, or evolutionary innovations? Read how we tackled this old question from a new angle🧪 A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today! #InHoxWeTrust

Very happy to share MODIS - a new Multi-Omics Data Integration method for Small and unpaired datasets! We solve a long-standing problem in the field: how to perform data integration for small unpaired datasets Our solution: learning with class imbalance on both reference and target datasets!

#PressRelease 🗞️ The 2025 CNRS Gold Medal has been awarded to Stéphane Mallat, recognised the world over for his research on mathematics applied to signal processing and artificial intelligence. 👉 cnrs.fr/en/press/bet... #CNRStalents 🏅

Springboard for an international scientific career! 🧬🧪🔭⚛️🧠🌱 Call for #MaxPlanckResearchGroups launched; applications are possible until October 14, 2025 www.mpg.de/max-planck-r... #ScienceCareer

Become a Theory Fellow at Janelia. 🔍 Use computation & theory to tackle biological problems. 🖥️ Leverage state-of-the-art computational infrastructure 🤝 Collaborate across scientific disciplines Apply by Nov. 3 @ https://janelia.link/theoryfellowprogram

Are you an AI expert who wants to stay in academia and change the world by understanding the most complex things we know - living organisms? Want to lead your own group, based in Heidelberg DE, working language English? @embl.org is hiring in AI embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Places available in our online courses this autumn: @embo.org Project Management (17-19.09), Negotiation for Scientists (18-19.09), Lab Leadership for Postdocs (07-09.10) and for Group Leaders (04-06.11) + Self-Leadership (14-16.10). Register now: www.embolableadership.org/our-courses/ #EMBOLabLead

Dresden researchers @paveltomancak.bsky.social @bruvellu.bsky.social, Carl Modes, @cuencam15.bsky.social ‬ & colleagues published in @nature.com that a tissue fold in fruit fly embryos buffers mechanical stresses & may have evolved in response to mechanical forces. www.mpi-cbg.de/news-outreac...

📢We're #hiring Group Leaders! Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning. 🔹5-year renewable appointment 🔹Pioneer new tools & approaches 🔹Collaborate across disciplines Apply by Nov. 4👉 https://janelia.link/groupleader

🧬🔬🧪 🎉 Our team at @czbiohub is thrilled to share TWO companion papers out today in @NatureMethods! 📦 Ultrack — robust, scalable nD cell tracking 🌐 inTRACKtive — a beautiful, open-source web viewer for lineage exploration Let’s dive in! 👇 www.nature.com/articles/s41... www.nature.com/articles/s41...

We’re looking for curious, innovative science leaders at EMBL Heidelberg! 🔬🧬🦠 Join a vibrant, interdisciplinary community where collaboration and innovation are nurtured at all levels. Take a look at these four open positions 👇

🌐 EMBL’s new initiative is set to transform life science research through full AI integration – from genomics to drug discovery. 💡 Funding from the Hector Foundation is dedicated to attracting interdisciplinary talent, boosting infrastructure, training, & innovation. www.embl.org/news/connect...

#DBfeature #Celegans🪱 Left/right asymmetrically expressed ephrin and Flamingo proteins regulate lateralized axon growth in C. elegans by Khulganaa Buyannemekh, Paul Villoutreix, Vincent Bertrand www.sciencedirect.com/science/arti...

Très fier d'avoir pu contribuer à ce beau projet!

Great collaboration with fantastic colleagues :-) @paulvilloutreix.bsky.social, @cantinilab.bsky.social, Morgane Térézol, and Matthieu Vignes.

Excited to share David Hirst's PhD work! 🧬 When you only have a few datasets available for multi-omics integration, for instance because you work on rare diseases, one solution is Transfer Learning. Introducing #MOTL - now available in Genome Biology! doi.org/10.1186/s130...

🚨 Our paper is out! 🚨 Check how spatial-scERA can predict enhancer activity in a virtual Drosophila embryo. Very proud of this first step in the research world published in @narjournal.bsky.social Thanks to @yghavi.bsky.social, @paulvilloutreix.bsky.social and all the scientists who made it real!

Preprint alert! Want to hear more about the coolest new society on the block? You should check out our new preprint discussing @globias.bsky.social ! Hop into 🧵 for a couple quick highlights (1/x):

Spatial Transcript Omics DataBase (STOmics DB) is a comprehensive repository of literature and Datasets related to spatial transcriptomics topics, and provides convenient tools for Data analysis, search and visualization. db.cngb.org/stomics/

What a nice week at CIRM in Marseille for the workshop "Mathematics of Single-Cell Data Analysis", organized by PEPR Digital Health and PEPR MathVives. So many exciting mathematical approaches covering GRN inference, statistical testing and optimal transport. Looking forward to the next edition!

Very happy to see our paper on nested genes published! Very nice interdisciplinary collaboration with the Bertrand lab @ibdm.bsky.social - very combination of scRNASeq + smFISH to explore a fascinating question => www.sciencedirect.com/science/arti...

🥇Sham Tlili has been awarded the CNRS 2025 Bronze Medal! She studies how physical forces shape living tissues by using mouse stem cell models known as gastruloids. A unique blend of physics & biology. 🔗 Read more: www.ibdm.univ-amu.fr/sham-tlili-w...

Novel Research in Biological Artificial Intelligence: Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence @mpi-cbg.de and @csbdresden.bsky.social. More information: www.mpi-cbg.de/news-outreac...

Pas de Wikipédia, pas de chocolat 😉.

🚨 Calling all plant modelling enthusiasts! Plant Computational Biology Workshop Open to researchers at all levels Workshop is free. Participants cover own travel, food & accommodation 📅 8-12 Sept | 💻 Talks, tools & hand-on sessions 🔗 www.slcu.cam.ac.uk/computationa... #ComputationalBiology #PlantSci

Why wait for #FluorescenceFriday if you can have a neat #zebrafish right now. (pic credit Amanda Garfield @cudevbio.bsky.social) #devbio

What is possible in the space of organs, organoids and organisms? How can synthetic biology help designing new types of tissues and even novel organs? How can cognition be engineered from scratch? Check our paper @jordiplam.bsky.social @drmichaellevin.bsky.social www.nature.com/articles/s41...

Our latest work - MODIS: Multi-Omics Data Integration for Small and Unpaired Datasets - was in Singapore for the www.lmrl.org workshop at ICLR. Congrats Daniel Lepe-Soltero!! Preprint: arxiv.org/abs/2503.18856