CODA for the masses! Valentina Matos-Romero, Ashley Kiemen and team have put together an ultra detailed protocol to use CODA for 3D single-cell mapping of tissues, organs, and organisms. Use CODA by downloading this protocol here: www.biorxiv.org/content/10.1...

Today at 4pm: Cancer Center Friday Seminar | Ashley Kiemen, PhD, Johns Hopkins Inst for NanoBioTechnology "Integration of histology and multiplex imaging for targeted understanding of pancreatic cancer progression" cancer.ucsf.edu/seminars Host: @shainlab.bsky.social @ucsanfrancisco.bsky.social

We used CODA to generate 3D single-cell immuno maps around pre-cancer lesions of the human pancreas. Highly heterogeneous. Work by Prof. Ashley Kiemen and colleagues. Read more about 3D immuno maps around pre-cancer lesions here: www.biorxiv.org/content/10.1...

Proud of our CA1 Anesthesiology Intensive Research Residency (AIRR) residents. These research scholars are in our research-intensive 5-year residency designed to produce independent and innovative investigators in anesthesiology. More: anesthesia.ucsf.edu/news/meet-ou... #research #anesthesiology

Was a pleasure to present this piece of my postdoctoral work at #bcvs2025! If you missed it or are looking for more, check out our preprint: www.biorxiv.org/content/10.1...

More to come soon, both in continuing to examine the genomic regulation, but also defining the cellular behaviors that are necessary for early heart tube formation. For now, huge thanks to @benoitbruneau.bsky.social for supporting me as we pursued this ambitious and open-ended project! (8/8)

In what @benoitbruneau.bsky.social aptly described as our “lets go nuts” experiment, we confirmed this interaction by demonstrating that reduced Nr2f2 dosage partially rescues the Mef2c KO heart tube phenotype. (7/n)

Excited to share that our manuscript “MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis” is now online @genesdev.bsky.social ! genesdev.cshlp.org/content/earl... (1/n)

nice to read a perspective in @genesdev.bsky.social on our recent paper genesdev.cshlp.org/content/earl...

This month’s cover of @genesdev.bsky.social has @j-muncie-vasic.bsky.social’s embryos all in a row! Paper and commentary in the issue genesdev.cshlp.org/content/39/2...

Now that the print issue is out, I'm excited to share that our manuscript is featured on the @genesdev.bsky.social cover! genesdev.cshlp.org/content/39/2...

New preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...

Always fun collaborating on networks of cardiac development with Irfan, @benoitbruneau.bsky.social, and team!

January issue of @natcardiovascres.nature.com has our image on the cover! Also a research highlight on our paper @irfankathiriya.bsky.social @gladstoneinst.bsky.social @ucsfanesthesia.bsky.social www.nature.com/natcardiovas...

Helping this mood is our latest now out in its final form! @irfankathiriya.bsky.social leading the teams with me. Thanks to the editors and reviewers (incl. @wythelab.bsky.social)for a pleasant and productive journey. More to come when the full issue is out. www.nature.com/articles/s44...

Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀 Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function now revised and journal accepted at www.science.org/doi/10.1126/... 🧵👇

truly amazing paper led by current postdoc Lisa Iwamoto-Stohl. "To our knowledge, this represents the first systematic evidence of proteomic asymmetry between sister blastomeres in the 2-cell mouse embryo." pubmed.ncbi.nlm.nih.gov/41344326/

Our 13th Annual Anesthesia Research Day featured a keynote address from Vivianne Tawfik, MD, PhD and presentations from our faculty and learners. There was also time to connect with colleagues while reviewing more than 45 poster presentations. More: anesthesia.ucsf.edu/ard25 #AnesthesiaResearch

RESEARCH PAPER: MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis By Muncie-Vasic et al. and Benoit Bruneau ➡️ https://genesdev.cshlp.org/content/39/23-24/1451.abstract Jon Muncie-Vasic Benoit Bruneau #transcriptionfactor #embryodevelopment #cardiactract

Accepted ms on modeling human atrial disease posted @dev-journal.bsky.social just now. Congratulations to @irfankathiriya.bsky.social @jsauce7.bsky.social and team! @gladstoneinst.bsky.social @ucsfanesthesia.bsky.social journals.biologists.com/dev/article-...

📽 G&D Tapes 📽 G&D Author, Jon Muncie-Vasic tells us about their new study in #genesdev that defines the role of MEF2C in cardiac tract development. Read the full story here: ➡️ https://genesdev.cshlp.org/content/39/23-24/1451.abstract Jon Muncie-Vasic Benoit Bruneau Gladstone Institutes#genesdev