Paradoxically, heart failure involves both cell death and growth. How does a cell decide? In a paper at JMCC Plus led by Bryan Chun and Lavie Ngo, we find that rather than dying following hypertrophy, stressed cardiomyocytes commit early to either grow or die. www.sciencedirect.com/science/arti...

Nearing sunset, Shenandoah NP #cville

@j-muncie-vasic.bsky.social and @benoitbruneau.bsky.social show that MEF2C is not a one trick pony- it distinctly regulates different regions of heart tube formation. Glad @aclark.bsky.social and I could contribute gene regulatory networks that predict mechanisms.

Nice to walk out of my backyard onto the #Crozet Connector Trail. #cville

Happy to share our latest preprint, "Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury", in collaboration with Matthew Wolf's lab, led by Bryce Murillo and Alex Young! www.biorxiv.org/content/10.1...

Cooling off at Sugar Hollow #cville

Sunset showers at Shenandoah NP

Do large language models understand how cells work? To find out, we built a pipeline that generates logic-based models of signaling networks using general purpose LLMs GPT, Gemini, or Claude. We benchmarked LLM-generated networks against 3 large-scale literature-curated and validated networks. 1/

Great interactions, crabcakes, and science at #BCVS2025 in Baltimore

On my way to AHA #BCVS25 in Baltimore! Come see Bryce Murillo present on a drug for DYRK1A that induces cardiomyocyte cell cycling in network models, isolated cardiomyocytes, and after myocardial infarction. Wed 9:39 am.

A few pics from my trip to Egypt. Cairo, Luxor, Alexandria

So many storms, but also the 4th rainbow this week! #Crozet #cville

"The Faculty Senate expresses no confidence in the Board of Visitors for not protecting the University and its president from outside interference, ..." www.forbes.com/sites/michae...

Public comment on this new "no animal only studies" is open here: www.fda.gov/news-events/... It closes next Monday.

On June 17, 2012, following the unjustified forced resignation of an effective university president, the University of Virginia’s Faculty Senate voted 68 to 2 to demand her reinstatement. Nine days later, the president was reinstated. Today the Faculty Senate votes on the same issue again.

End to end rainbow in Crozet. #cville

Appreciating finally being back home, hiking in the Blue Ridge with my dog, an A+ burrito (Alex's), and thunderstorms.

Sad to see the Trump admin force resignation of UVA President Ryan. No due process, just hurried political attacks to undermine values of free expression and knowledge on which Thomas Jefferson founded UVA. www.nytimes.com/2025/06/27/u...

I'm thrilled to share the newest paper from the Yang Lab! Ever wonder how bacterial metabolism affects antibiotic resistance #AMR? In this study, Barry Li, a former MD/PhD student in the lab, took on this question using a systems and #synthetic_biology approach. 1/n www.nature.com/articles/s41...

Really enjoyed my first cardiovascular development @weinsteinconf.bsky.social, followed by a trip to the Milwaukee Art Museum

Afternoon kayak to Ragged Mountain "Island" #cville

I appreciate UVA Today featuring our recent paper on logic-based machine learning for drug repurposing, validated in cells, mice, and electronic health records. news.virginia.edu/content/uva-...

Just behind the storm front in #Crozet. Neighbors pulled over to ask why I was taking a pic in the rain 😂.

Sunset at Sunset State Beach, CA

Walking among redwood giants at Muir Woods, north of San Francisco.

Do you tip your AI driver? #waymo (video 4x) in #SF

Rising from the ashes at Big Basin

Great to be back #hiking in the redwoods! Henry Cowell State Park.

Undergrads: come to UVA *this summer* for our NSF-funded REU program in multi-scale bioengineering! Apply by 4/30. engineering.virginia.edu/department/b...

Terrific paper by post-doc @aclark.bsky.social in @plos.org Comp Biol. This tutorial enables students and biologists to simulate biological networks with our tool Netflux, no programming required! #sysbio #cardiosky 🧪

Reflections while kayaking at Ragged Mountain Reservoir #cville

We appreciate the thoughtful commentary article by Cristobal Rodero and Steve Niederer, highlighting our recent paper "Logic-based machine learning predicts how escitalopram attenuates cardiomyocyte hypertrophy" in PNAS. www.pnas.org/doi/10.1073/...

Nice segment on ABC Richmond on our recent AI drug discovery paper. Our tool LogiRx found Lexapro attenuates cardiomyocyte hypertrophy, validated in cells, mice and electronic health records. 🧪 #cardiosky www.wric.com/news/virgini...

Thanks for featuring our latest paper! With our AI tool LogiRx, we discovered that the antidepressant Lexapro attenuates cardiomyocyte hypertrophy. Validated in cells, mice, and 2 patient observational cohorts. 🧪 #cardiosky

I recently attended the Netflux and Logic-Based Network Biology virtual conference organized by @jsauce7.bsky.social . Here's my first attempt at logic-based simulations. I've exported the simulation data to customize the graph further using R. Excited to explore more!

Dawn of the myocyte

Happy to share our latest paper, "Logic-based machine learning predicts how escitalopram attenuates cardiomyocyte hypertrophy" in PNAS led by Taylor Eggertsen. Great collab with Travers, McKinsey and Wolf to validate in mice and patient outcomes! 🧪https://www.pnas.org/doi/10.1073/pnas.2420499122

Snow is gone and Shenandoah NP is open! Ridge hikes are great in the winter.

Do I work in the Death Star?

Rep. Alexandria Ocasio-Cortez: "What expertise does (Elon) have in biomedical engineering devices?" #BME #AIMBE

Dynamic map illuminates Hippo-cMyc module crosstalk driving cardiomyocyte proliferation Read this @reviewcommons.org transfer Research Article by Bryana Harris, @jsauce7.bsky.social & colleagues: https://doi.org/10.1242/dev.204397

Quick video summary of my research: We develop computational and experimental methods to discover drugs for heart disease 🧪 youtu.be/nmpFDiE4GSg

Strolling around a snowy UVA Grounds with my dog, thinking about the principles that inspired democracy and public education...

Get in dorks, we're going protesting! STAND UP FOR SCIENCE WITH US ON MARCH 7TH, 2025 WASHINGTON DC AND EVERY STATE CAPITOL Because science is for everyone! Find us at standupforscience2025.org #standupforscience2025 #scienceforall #sciencenotsilence

BREAKING: Federal judge temporarily blocks NIH indirect costs rate cap issued Friday as applied to states that sued over the act this morning. Judge Angel Kelley, a Biden appointee, ordered further briefing as well, and set a hearing on Feb 21 in the case. storage.courtlistener.com/recap/gov.us...

I'm happy to share Bryana Harris's paper on the first computational model of cardiomyocyte proliferation, now out at Development! We found that YAP induces cardiomyocyte proliferation via cMyc, which we validate in primary cells and public in vivo data. 1/n🧪 journals.biologists.com/dev/article/...

Another fun ❄️ day, this time at Wintergreen 🏂. #recharge

Back among the white blazes, pondering what if I just kept going to Maine or Georgia? #hiking

Hiking along Moorman's River ❄️ #cville

Fun hiking in the snow around Sugar Hollow Reservoir #cville