The AFDB50 is now also searchable at search.foldseek.com/folddisco Happy Motif Hunting!

Remember the current NIH director going on about protecting researchers from government censorship? Today his people called the police in to forcibly remove my colleagues from their own society meeting for sharing an editorial published in their flagship journal that was critical of him. Gift link

@neildegrassetyson.com: "The relationship of the executive branch and science has never been as devastating as it has been under the current administration... We will sink lower economically, in our health, our wealth & our security, until everyone wakes up and is reminded how important science is."

The largest and most diverse collection of Indigenous American genomes 👉🏻 “The evolutionary history and unique genetic diversity of Indigenous Americans” @macscastro.bsky.social @hunemeier.bsky.social @chiarabarbieri.bsky.social @jrockdrigo.bsky.social 🔗 www.nature.com/articles/s41...

Spread the word! We are recruiting for 6 new research professors at UC Davis' California National Primate Research Center. Open rank, open area, but must leverage 🐒 resources. recruit.ucdavis.edu/JPF07561

This is amazing news! And I just heard BioEYES is coming to Kings College London as well 👀

It's online! In this series of perspectives @dev-journal.bsky.social, yours truly talks about the exciting open questions and many things to do in the field of dev bio and neuroscience #DevBio🧪 #PIsOfTomorrow journals.biologists.com/dev/article/...

The conference (agreement between House and Senate) appropriations bill that includes HHS and NIH was released this morning. www.appropriations.senate.gov/news/majorit... 1/5

I’ve been quiet for a while, cleaning up my social media and quietly doing the work that has to be done in order to persist. Maybe I’m looking at this from the perspective of someone who doesn’t fully understand the capabilities or higher-level decision making within universities. 1/4

Last week I had the pleasure of hosting Dr Marianne Bronner for our CReM seminar series. Through this series, we’re committed to giving our mentees and trainees exposure to 🤯 science from those pushing the boundaries in their field, and extraordinary mentors , and Marianne checks every single box.

Reaffirming the value of model organisms in training scientific minds | @natcellbio.nature.com www.nature.com/articles/s41...

We have a bunch of new job ads out @arcadiascience.com. If you haven’t checked them out, take a look! www.arcadiascience.com/careers

Yesterday, October 7, Sir John Gurdon passed away. Dr. Gurdon was awarded the Nobel Prize in Physiology or Medicine in 2012, together with Shinya Yamanaka. Through a series of experiments using Xenopus eggs, Gurdon showed that the nucleus of a mature cell can be reprogrammed to a pluripotent state.

EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬 The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓

Assistant or Associate Professor of Microbiology at the University of Kentucky: ukjobs.uky.edu/postings/601... #academic jobs #edusky

Despite their high rigidity, microtubules (MTs) dynamically bend and buckle in cells. MT-self repair is inherent to their metastable nature, but it remains unclear whether just inherent repair mechanisms are sufficient to maintain MT integrity🧵 (1/9) www.biorxiv.org/content/10.1...

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/... Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle

The new NIH grant review format and the iron law of unintended consequences drugmonkey.wordpress.com/2025/08/27/t...

#zebrafish genome update, our T2T assembly of the inbred strain of AB (M-AB) generated by my buddy Nori Sakai has now been released at NCBI and will be a second reference genome for zebrafish (GRCz12ab):

My team has updated our free database of POSTDOC fellowships. This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria. Download this updated and expanded database here: research.jhu.edu/rdt/funding-...

Key advice for scientists writing grants…

What's the best software for making and styling a protein sequence alignment? Please tell me there's something better than MS Word?

🚨 If you haven’t seen it yet… 📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition. Check it out at bioart.niaid.nih.gov

Still accepting late-breaking abstracts for #ZDM18, for those finterested! More details at the conference website: www.zdmsociety.org/zdm18-abstra...

My quote of the day If future generations are to remember us more with gratitude than sorrow, we must achieve more than just the miracles of technology. We must also leave them a glimpse of the world as it was created, not just as it looked when we got through with it. Lyndon B. Johnson

An amazing clinical triumph for regenerative medicine! A great example of how federal funding results in patient cures. Let’s keep these stories going, America! “World's First Patient Treated with Personalized CRISPR Therapy” #helpisontheway! www.pennmedicine.org/news/news-re...

On Friday, my son stayed home from school because he had a sore throat and wasn’t feeling well. He went with my husband to his office for the morning while I handled our daughter. When he came back at lunch, he was not interested in eating, saying his throat hurt too much. 1/n

So incredibly stoked that my hero Ray Keller was elected to the National Academy of Sciences for his pioneering work on the cell biology and biophysics of embryo morphogenesis. Well earned, Ray!! www.nasonline.org/news/2025-na...

The do’s and don’ts of scientific image editing Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies. @sarareardon.bsky.social reports www.nature.com/articles/d41...

Here's the background story on how I vibe coded a web extension for "Painless Preprint Posting": thenode.biologists.com/painless-pre...

It has been a while since I advertised some of the tools we have released to help researchers analyze the zebrafish genome. So a brief Bluetorial on our zebrafish genomics UCSC public data hub and the bigger effort led by @ferencmueller.bsky.social to create a zebrafish ENCODE project (Danio-CODE):

to visualize and then click the "submit" button to add them to your web browser.

Looking to enhance your timeline? Add a bit of fishiness with our Group Leader & Senior Scientists Starter Packs from the #zebrafish community! 🧪 Volume 1: go.bsky.app/2cHYybY Volume 2: go.bsky.app/4zBuxAF Volume 3: go.bsky.app/JvjuSZg Check out our other Starter Packs located under our profile!

This 👇🏻. There is SO MUCH uncertainty…but one thing is 100% certain: We will do what has to be done to support our mentees.

Adapted from: www.linkedin.com/posts/kristy...

#NIHFunding Template: download, adapt, share! Let me know if you need pdf format or other.

I got laid off today, with the rest of 18F. 18F was an elite federal software shop. We made gov't websites work better, more efficiently for the American people. We saved taxpayers from getting screwed over by contractors. And were fired for it. We made this website to tell our story: 18f.org

And for all the scientists asking “what can we do?”, here’s an interesting suggestion: call your local TV stations and newspapers and tell them you’d be happy to be interviewed. if you do that, please let us know and we’ll share so others can learn.

Senior scientists who will be reviewing tenure & promotion files in the future - please remember that the effects of many of these executive orders will disproportionately affect researchers from marginalized groups - often the same folks penalized by COVID-related delays, childcare issues, etc. 🧪

This week is an opportunity to explain things about how NIH works to your friends, family, etc that aren’t in the biz. This is the last available data from NIH, Fiscal Year 2023. The percentile rank is the relative merit score voted by various study section. Lower is better in the NIH parlance.

The kind of work that represents a major turning point in the pursuit of knowledge!

for those interested in time-lapse imaging and quantitative 4D tracking of live mouse (or other) embryos, here is our detailed protocol, with all the computational pipelines available in one portable drive, ready to roll. Martin Dominguez's brilliance here! star-protocols.cell.com/protocols/3936

It is that time of the year again when @odedrechavi.bsky.social and I do our annual “your favorite paper of the year” thread. Now only on Bluesky! Please link to your favorite paper in the comments and say a few words why you loved it so much. Happy holidays and happy reading!

Happy Saturday. If you're working on your NIH specific Aims for a February submission, don't include a figure. grants.nih.gov/grants-proce....

A fully 3D-printed optical microscope for low-cost histological imaging https://www.biorxiv.org/content/10.1101/2024.12.16.628684v1

I am so excited to see this! Thank you so much for putting this together! I’ll try to build 1 for our library! If anyone in Boston wants to help me build this (I am slightly intimidated 😅) for #Dorchester #Matapan neighbourhoods, please let me know! #AccessibleScience #KnowledgeWithoutBorders

We built on the @openflexure.bsky.social platform to combine a 3D printed microscope chassis with both a 3D printed condenser and objective lens. Now we have the entire microscope, including the optics, printed for less than £7.00… and it works! (2/N)

Infamous paper that popularized unproven COVID-19 treatment finally retracted Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds @cathleenogrady.bsky.social reports. www.science.org/content/arti...