Bored over the holidays? Give our new preprint on how #microtubule lattice alteration by taxols can regulate #RhoA #signalling via GEF-H1 a read! Perhaps a new mechanism of action for taxol #chemotherapeutics during interphase. www.biorxiv.org/content/10.6... Happy holidays ✨🎄

Now online! Structural basis of microtubule-mediated signal transduction

PhD Position in Biophysics #ScienceJobs #AcademicSky

📢Internships on cellular nematics! 🔬Come for the pretty images, stay for the cool physics: each project combines in vitro experiments with advanced microscopy and image analysis. 📧Feel free to DM or email me with any questions.

I like this movie, but a friend of mine likes to complain about the obvious stitching artifacts. I'll try harder next time, Michael. Vimentin (orange) and ER (blue) in an overnight acquisition.

😍😍😍

iPS cell-derived cardiac myocytes (heart muscle cells) typically beat about once per second, so I usually speed up the movies I post; otherwise, scrollers might miss the action. But every now and then, a cell looks like this in real time. #CellBiology

Go right or left? A question that we encounter very often in our daily lives, and while our decision may sometimes be hindered by the fear of making a mistake, cells DO NOT HESITATE!!! They swirl with the confidence of someone who’s always RIGHT… or LEFT!!!

Vimentin promotes actin assembly by stabilizing ATP-actin subunits at the barbed end https://www.biorxiv.org/content/10.1101/2025.11.17.688760v1

Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase. www.nature.com/articles/s41...

Dick is one of the most thoughtful folks in cell biology--this is a must read for anyone interested in microtubules!

Playing around with @kwolbachia.bsky.social 's LUT manager plugin. Absolutely love the campfire LUT🔥 😍#microtubulemonday

Expression of vimentin intermediate filaments in epithelial cells promotes cell migration and cell matrix interaction in 3D https://www.biorxiv.org/content/10.1101/2025.09.18.677142v1

Have you ever wondered how microtubules withstand and respond to mechanical stress in cells? Here we show by in vitro reconstitution assays that MAP65-1 and PRC1 promote microtubule nucleation on existing lattices, especially on those with structural irregularities linked to mechanical stress.

Here's some more exciting new news from the microtubule world ✨Great work from @marianattom.bsky.social the @schaedellab.bsky.social showing how MAP65-1/PRC-1 reinforce microtubules under mechanical stress. Look at them microtubule arrays in plant cells 😍 ( To quote Verstappen, "Simply lovely")

Despite their high rigidity, microtubules (MTs) dynamically bend and buckle in cells. MT-self repair is inherent to their metastable nature, but it remains unclear whether just inherent repair mechanisms are sufficient to maintain MT integrity🧵 (1/9) www.biorxiv.org/content/10.1...

Congratulations, Subham 🎉🎉🎉 Great study and uber cool microtubule self-repair images that I can stare at for hours 😍😍😍

Upcoming interdisciplinary meeting: Cell Physics 2025 When? October 7-9, 2025 Where? Saarbruecken, Germany Relevant dates? Early-bird deadline: June 30, regular registration by August 31 Several opportunities for short-talks selected from abstracts More info at: cell-physics.uni-saarland.de