Motion to stop referring to it as Next Generation Sequencing. That's like saying The Matrix is a recent movie

If you want concentration camps in the UK, people being grabbed off the streets, or murdered on them, five year olds being separated from their parents and locked up #VoteReform

This is what it is.

This is great news, and I hope all vendors continue to support THE vendor neutral option for MS data. Regardless, it was a shame that Skyline went without funding for a year from SCIEX My dream is that Skyline is funded by all vendors continuously. All of #teammassspec benefits from the arrangement

I love #zotero (@zotero.org). The newish phone app is good. What I would really like though is a little widget with my next three papers to read. Would really help replace doom scrolling with more productive reading.

Today's job required colecting and combining info from @ebi.embl.org, #KEGG and #NCBI. Integrating with #bioinformatics tools in #Rstats and @bioconductor.bsky.social These biological data resources and tools must surely be amongst the greatest achievements of modern science.

Actually sounds like a useful use case for #AI / #LLM. Tell me what the code I wrote 2 months ago in a hurry actually does. Where the variables on this line come from. What the variables on this line are used for. Get me back in build/edit/write mode faster.

This is obvs doing the rounds and is very cool. I come out close to Mass Spec and Proteomics. Surprised I'm not closer to #Rstats community. Does makes sence that Mass Spec / #Proteomics and #Rstats should be next to each other though.

Just working on a paper, writing with Quarto in Positron IDE. Trying the split view of a file. Have a method section where I'm writing code for figures and exlaining analysis - and the results where I'm plotting figures with captions etc, both open next to each other. Neet.

I am very pleased to announce that we have finalised the program for the @eupaproteomics.bsky.social Brixen Proteomics Summer School 2026 now also a @febsj.bsky.social advance lecture course. www.brixenproteomics.org

Years as a biologist and these brilliant visualisations still give me "cosmic vertigo" The individually the molecular machines as in the "comets" are not alive, yet somehow all together, they are. Put enough of them together and they can watch a video and start typing...

Todays job involves finding every example of a spesific measurement in a spesific setting in the literature for comparison. It would be nice if that could be somthing like a database query, and less like a literature review.

One of the great insights (to me) of The Emperor of All Maladies was Siddartha's exposition of how each advance in science, anasthetic and surgery, chemical synthesis, radiation, were all applied to cancer in turn. Of course AI will take its turn and of course it will not definitivly end cancer.

Computer science needs more biologists. They are used to: - study systems that are mindbogglingly complex and complicated, - use reductionism to study and describe such systems, using famously clumsy and fiddly tools to collect noisy and incomplete data, (1/2)

Most science and engineering research is just people sitting frustrated at a computer for hours on end

The way to accelerate science is to SLOW it down. Fewer papers please! We’re drowning in meaningless text. One GREAT paper per lab per decade is more than enough. q.e.d 👇

Zotero 8 is out, and we are very lucky to have such great open source software

Great piece on prioritizing quality over quantity in scientific publication. For those of us with labs, this necessarily involves shrinking our group size. After I got tenure I started to downsize my lab and have not regretted it one iota. More time for each student & more time to think & write.

Writing is thinking Outsourcing the entire task of writing to LLMs will deprive us of the essential creative task of interpreting our findings and generating a deeper theoretical understanding of the world.

Maybe one question #LLMs and #AI really pose academic #science is: What exactly are we trying to do?

I have a paper on Biorxiv: www.biorxiv.org/content/10.6... My first preprint! An instrument capablity comparison for #proteomics for #biomanufacturing. Working towards the economical appliction of #omics technologies to industrial life science.

To me, science is about trying to figure out WTF is going on.

Experience in #archaeological #proteomics? Interested in #Roman economy / organic artefacts? Background in data analysis for #ZooMS? Then apply for a 3-year RA post working to join PELLIS project with the wonderful @gtaylortu.bsky.social to investigate Roman leather economy Apply by 12/01/2026

#proteomics people, this figure has been around for some years. I'm trying to track the original source to give credit. Any idea? Found this publication pubs.rsc.org/en/content/a... www.crownbio.com/hs-fs/hubfs/...

The @eleanormorton.bsky.social‬ Tolkien - CS Lewis skits are some of the best things on the internet.

#AminoAcidAdvent Day 7: Argenine (Arg; R) What's a pirate's favorite amino acid? ARRRgenine! This basic residue is a fav for heavy isotope fans, with a storied history from SILAC to SRM, and of course most famous for trypsin cutting after it giving us the 175 m/z y1 we all know and love.

We are hiring for a web developer position, ideally with some experience in bioinformatics. This position is aimed at helping us turn our research in human genetics into useful tools. A background in either bioinformatics or web development is required. jobs.ethz.ch/job/view/JOP...

"It’s hard, but struggling is the only way to learn anything. Once you’ve gotten these skills, you have enough knowledge and expertise to use LLMs & fight & argue with them & speed things up. But before that point, you’re in danger-land." I love that this is from the perspective of stats & coding.

Totally agree. Better than endnote, better than Mendeley.

We are delighted to release 𝐃𝐈𝐀-𝐍𝐍 𝟐.𝟑.𝟏, with a groundbreaking 𝐈𝐧𝐟𝐢𝐧𝐃𝐈𝐀 module for fast searches against huge databases and support for 𝐃𝐃𝐀 data. Release notes: github.com/vdemichev/Di...

#notion I have loved you as a notebook but load times are getting too long. My notebook has to be available faster than I can think. Don’t know if its growing sophistication of my connected databases, formula or integrated AI. But it's getting to be unusable.

I've been "nearly there" with a paper submission to bioRxiv and accompanying data submission to pride for about a week. It's the tension between wanting to check everything is correct (good) and not wanting to let go (bad).

The philosophers were so preoccupied with whether they should that they didn't stop to think if they could.

An important list of things that are nessisary, but no sufficient, and not magic!

Does anyone want a survivorship bias shortbread

Americans make great biologists because we are forged by the hardest challenge in all of biotech: getting flavor from a turkey

This post says it very well. I guess transparancy is supposed to enable the quality of work to be better judged after the fact, but agree that may do little to improve quality of the work in the first place.

@jameshiggins on UK budget news for what it concerns to #biotech and #diagnostics

that list of four potential peer reviewers you gave your acquisitions editor? one of them is retired, another is chairing their department and simply can't, the third is on leave and has an autoreply up for months, and the fourth replied within 20 seconds to say "no."

So much this, I have long wondered why jounals what spesific citations formats. Also, if they do, why not just ask for the doi / pubmed IDs and automate citation formatting to their taste during typsetting.

And we warned them with our new 2025 State of the Climate Report which you can check out here: doi.org/10.1093/bios...

Thinking Like a Scientist, Part Two: The Omics Illusion network.febs.org/posts/thinki... #FEBSnet

One little bonus of using #git for version control with #quarto for scientific writing is the psycological boost from seeing the git graph fill up as a little progress chart.

I had a wonderful run this morning and beautiful walk this afternoon in the north of England. Both of course were curtasy of the ongoing catastraphy of climate change.

Oh, amzing tool in #Positron with #Quarto for #Rstats scientific publishing. The gitlense extention allows you to compare any pair of previous commits in a single diff view. Am currently rescuing a few ideas lost to an earlier over zelious condensing effort.

Amazing Halloween decoration up in #Manchester #UK near the Gay Village. A giant pink spider climbing down wall! The wall belongs to an Alice in Wonderland / Through the Looking Glass themed tea room. I love this city.

So I'm working on revisions from co-authors to a paper drafted in #quarto. Co-authors quite reasonably prefer familiarity of word. So I've been trying markitdown (pypi.org/project/mark...) to convert docx back to md and comparing files in notepad++

My lucky lucky barber got a lecture on #proteomics and #biomanufacturing this week for this very reason.

A super useful #tidyverse function for #bioinformatics in #rstats with deframe(). Get a named vector of linking protein/gene/kegg identifiers and then attach to a table from elsewhere to translate the new tables ids:

This is the way.