link.springer.com/article/10.1... The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells

Great work from @philouail.bsky.social 🙌 #xcms now fully integrated into @bioconductor.bsky.social 💪 👉 #metabolomics #MassSpectrometry #rstats

Measuring mitochondrial membrane potential @marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells www.embopress.org/doi/full/10....

Nature research paper: A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia go.nature.com/45Eb8te

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps:// www.sciencedirect.com/science/article/abs/pii/S1097276525008196 Congratulations @bensahralab.bsky.social !!

Great resource: doi.org/10.1038/s41467-025-63751-1

Still one of my favorite metabolite repair stories. doi.org/10.1002/jimd...

Exciting to see IC-MS getting more attention. It really does have excellent separation and coverage for central carbon metabolites, including those pesky sugar phosphates.

Check out our article in this issue on the metabolite repair role of CLYBL!

Some really nice points outlining the misuse of metabolomics in pathway analysis. To add, unless you have proof of gene/protein/pathway regulation, metabolomics data can only tell us that metabolite levels increase or decrease. This is not the same as up/down regulation. doi.org/10.1038/s422...

Non-canonical metabolites are continuously formed in primary metabolism & #MetaboliteRepair enzymes have evolved to eliminate these often toxic byproducts. Out today in @nchembio.bsky.social, we found that CLYBL repairs malyl-CoA, a TCA cycle side-product, to avert vitamin B12 depletion 🧪

I had the opportunity to give my perspective to The Analytical Scientist about recent events. With this article, I hope to give a voice to others who may not have the ability to speak out. #StandUpForScience theanalyticalscientist.com/business-edu...

Free access to 2,656 metabolites from 9 platforms measured at 56 time points and covering 6 challenges "suffered" by 15 healthy volunteers: The HuMet Repository - Watching human metabolism at work www.sciencedirect.com/science/arti... All data provided in an interactive repository: humet.org

The T32 training grant supported the interdisciplinary and multi-department design of the UC Riverside Environmental Toxicology Graduate Program. Funding from it gave me valuable time to focus on research and I am eternally grateful for the impact it has had on my career.

Thank you @jeremymberg.bsky.social for highlighting the special importance of T32s. This allowed me to launch an interdisciplinary chemistry/biology interface (CBI) graduate program at UCB in early 2000s. For the first time, due to this funding, chem PhD students were able to do rotations. 1/n

the rich and powerful want to destroy biomedical science, like they wanted to destroy climate science, and before that tobacco science and before that asbestos science -- because science and universities are an independent source of truth that can reduce the power and money of oligarchs.

Neat perspective on the connection between metabolism & PTMs. Cells spend a lot of effort combating reactive chemistry, but they also take advantage of it. The line between utility and toxicity must depend, at least partially, on metabolite/protein repair enzymes. www.nature.com/articles/s41...

I've noted some of the procedural things Democrats could be doing in Congress, but this point from @edgeofsports.bsky.social's great piece in the Nation deserves emphasis. This is basic politics, and it's baffling that every Democrat isn't doing it every day. www.thenation.com/article/poli...

Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠 sciencehomecoming.com

Yes, and this is super-important. People don’t know what’s happening. Most of the country has no idea that American science — cancer cures — are being shredded. They really don’t know! The job of all scientists 🧪 in this moment should be to get the word out.

Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC: www.cell.com/cell/fulltex...

Darby makes this point but I just want to reinforce it: These words are entirely legitimate to discuss science, accurately and correctly. This attack on "DEI" (🙄) is not only an attempt to resegregate science but also an attack on expertise, itself. Resisting it is a defense of science

A human metabolic map of pharmacological perturbations reveals drug modes of action - @zampierilab.bsky.social @depbiomedicine.bsky.social go.nature.com/3CreANg

CLYBL averts methylmalonyl-CoA mutase inhibition and loss of vitamin B12 by eliminating malyl-CoA https://www.biorxiv.org/content/10.1101/2024.09.25.614871v1