Blocking extracellular glycine uptake mediated by GlyT1 mitigates protoporphyria @marcliesa.bsky.social provides a Commentary on Ducamp et al. (buff.ly/W67oexo) buff.ly/9TuVOy3

Thank you @jclinical-invest.bsky.social for inviting me to write a commentary about the original study published yesterday by Ducamp and colleagues, which shows a metabolic strategy to treat protoporphyrias. Commentary: www.jci.org/articles/vie.... Article: www.jci.org/articles/vie....

Irene Hernando-Herráez, a researcher at the IBMB-CSIC, has been awarded a Starting Grant from the European Research Council (@erc.europa.eu), funded with €1.5 million. These prestigious grants support young scientists leading outstanding research projects. #ERCStG

🚨 Join us for the @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!

We had an amazing time with the ABC family and already miss you all! Can’t wait to hear your exciting talks, have great discussions, and hit the slopes of the Alps again. #ABC2025 See you next time!🗻⛷️🚠🧬🧫🧪💙

Maria Zoghbi says she's in "ABC transporter heaven" at #ABC2025 🥰 A closer look at ABCB10 transporter dynamics may well keep you on cloud number nine... ☁️⭐️

Moving into mitochondria with Marc Liesa! ABCB10, heme and redox stress: Some projects are literally a blood.bath... maybe sounds familiar to some other researchers out there? 😅🩸

Educació i innovació www.elpuntavui.cat/opinio/artic... @epons.bsky.social @jordivitria.bsky.social @pcb-ub.bsky.social @abadal.bsky.social @aristides-lopez.bsky.social @maricarmenb.bsky.social @kutandalkim.bsky.social @gaiaub.bsky.social @vcliments.bsky.social @marcliesa.bsky.social

Preprint alert!! How zonated hepatocytes adapt to changes in lipid influx due to fasting or a Western diet (WD). We developed a microscopy-based phenotyping method called single-cell phenomics (scPhenomics) to measure the features of mitochondria and lipid droplets (LDs).

Join your fellow #ABC friends in the lecture hall and on the slopes for ABC2025 in Innsbruck Feb 27-Mar03! Register abc2025meeting.org and see our invited speakers´list below! See you in Innsbruck!🧬⛰️🏂🧪

Last @mitotalks.bsky.social by @marcliesa.bsky.social See mitotalks.org for a link to join

SHADES OF BLUE Blue zones, supposed havens of longevity, have become a global brand. But skeptics think they rest on shaky science www.science.org/content/arti...

Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”. doi.org/10.1038/s422... A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social

Do you know who Douglas Prasher is? Many don't, even though he is the person who cloned the original #GFP gene in the late 1980s. In my short history of plant light #microscopy I also cover a bit of his story - & why he is relatively unknown today, despite the importance of his work. See this 🧵👇

“The product of your education is not your thesis, it’s yourself“ @annarogers.bsky.social on why not to rely on LLM AI to write for you in graduate school. hackingsemantics.xyz/2024/writing/

2 days left to register and present a poster to the 10th MetNet meeting on mitochondria and metabolism. The final program with the selected short talks is now available. Looking forward to see you! @EMBO @IBMB_CSIC @IBUB_UB @IRBBarcelona @ciberdem @idibaps @VHIR_ @UABBarcelona

Deadline for registration to the Mitochondria and Metabolism meeting October 24-25th in Barcelona is soon! Sept 15 for oral presentation and Oct 3rd to secure your spot! With an @EMBO keynote lecture! Registration link:

Do not miss the most special Mitochondria Meeting in Barcelona, Oct 24-25th, with @OrianShirihai @GenoxphosLab @SWculek @FormentiniLaura @AlbertPol10 @QuintanaLab @mitodynamics @avlecvie @LabScorrano @AntonioZorzano ..., incl. short talks & posters. Registration & Program👇 .

Highly motivated after the kick-off meeting with @CSIC colleagues and president @delPinoE for the preparation of a Science 4 Policy report about Metabolic Diseases, together with @DiabetesLabIBGM, María Monsalve, Angela M Valverde, María Angeles Martín and Yolanda Sanz.

Very excited with our new study just published in Redox Biology! We show that mitochondrial redox in hepatocytes determines the pro-inflammatory capacity of infiltrated neutrophils in alcohol-induced hepatitis.

It is out! Here we describe a new method to isolate peridroplet mitochondria (PDM) from white adipose tissue (WAT), revealing unique functional characteristics in WAT PDM determined by lipid droplet size.

Happy to share our manuscript in its final form! Fantastic collaboration with Bantam Pharma. Targeting aggressive B-cell lymphomas through pharmacological activation of the mitochondrial protease OMA1 | American Association for Cancer Research

Very excited to see where biliverdin binds to ABCB10 for the first time! Cryo-EM structures of mitochondrial ABC transporter ABCB10 in apo and biliverdin-bound form ⁦@NatureComms⁩ ⁦@mikeshum22⁩

Very excited to share our new study @embojournal with @OrianShirihai⁩ and led by ⁦@R_AcinPerez⁩ and ⁦@CrisBenincaPhD⁩. We find that inhibiting mitochondrial complex V reverse activity restores energy homeostasis in mito pathologies.

Congratulations to Joe and Andrew. Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity

Congratulations to Manu and Susana. ISG15 Is a Novel Regulator of Lipid Metabolism during Vaccinia Virus Infection | Microbiology Spectrum

Very happy to share our latest collaboration with Janssen: The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR ⁦@OrianShirihai⁩ ⁦@JNgo1412⁩

Today @JNgo1412 is presenting two posters from our lab at #ADA2022 showing how mitochondrial dynamics regulate fat utilization and counteract NASH (12-13h)⁦.⁩

Very happy with today’s presentations and the engaging audience in the Fuel Energetics in Islet Hormone. Looking forward to the afternoon sessions! #ADA2022 @AmDiabetesAssn

If you are attending the 82nd Scientific Sessions of the American Diabetes Association (ADA), come to see my talk on Saturday June 4th 2022 in New Orleans! @ADA_Pubs @AmDiabetesAssn

Had a great time reading the paper and writing the news and views. Congrats to @tom_mcphagy lab! The EMBO Journal | The goodies of chelated fat: iron‐regulated lipid droplet biogenesis precedes and preserves mitophagy

Very excited to see this paper out @MolMetab! We show that ABCB10 actions in beta cells contribute to insulin resistance. Congrats to @mikeshum22 and all co-authors. Thanks to @bcorkey @JimJohnsonSci for their previous studies guiding our work.

Very happy to share our latest publication led by @mikeshum22, defining that ABCB10 exports biliverdin outside mitochondria, which induces a redox state in hepatocytes that promotes insulin resistance and steatosis.

Happy to share the final version of our @MolMetab review . We propose that the co-existence of 3 functionally independent sub-populations of mitochondria can clarify the conundrum of the role of mitochondria function and ROS in NAFLD (pic by @JNgo1412)

Congratulations to @JNgo1412, @IlanBenador , Alex, Laurent, @MichaelaVeliova , @mikeshum22, Karen Reue and @OrianShirihai for our publication in @STARProtocols describing in detail the isolation of peridroplet mitochondria from BAT. .

Great day for the lab. Matheus’ review related to one of his projects in the lab is published. The Role of Mitochondrial Fat Oxidation in Cancer Cell Proliferation and Survival #mdpicells via @MDPIOpenAccess

#SinCienciaNoHayFuturo #NoScienceNoFuture

Pyruvate kinase controls signal strength in the insulin secretory pathway | bioRxiv

Why does a mitochondrion need its individual cristae to be functionally autonomous?

Very happy with our new paper with @OrianShirihai showing how excess nutrients increase basal insulin secretion. Mitochondrial Proton Leak Regulated by Cyclophilin D elevates Insulin Secretion in Islets at Non-Stimulatory Glucose Levels

A new preprint from our labs. Congratulations to all, specially to Michaela. Blocking mitochondrial pyruvate import causes energy wasting via futile lipid cycling in brown fat | bioRxiv

Registration is now open for The Mitochondrial Biogenesis and Dynamics in Health and Disease Conference-May 19-24, 2019 | Palm Springs, California co-organized by Toño Enriquez (CNIC), Pere Puigserver (Dana Farber), Orian Shirihai (UCLA) and myself.

Elamipretide Promotes Mitophagosome Formation and Prevents Its Reduction Induced by Nutrient Excess in INS1 β-cells

OMF Sponsors Second Annual Community Symposium on the Molecular Basis of ME/CFS at Stanford University

Metabolism-focused startup aims to shorten time between scientific insight and therapies

Congrats Ajit! Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion @Cell_Metabolism

Non Sequitur by Wiley Miller via @GoComics