How do cells assess mtDNA quality? Local ATP and membrane-potential gradients reflect mtDNA integrity and drive intracellular purifying selection. We introduce FAST, a scalable mtDNA QC assay in S. cerevisiae. Great collaboration with the Schmoller Lab. journals.plos.org/plosgenetics... 🧬⚡

Drosophila models have been highly useful in dissecting the physiological roles of PINK1 and Parkin in #mitophagy Led by 3 talented PhD students, we wrote a review summarising recent exciting discoveries and discussed these in context of current in vitro studies portlandpress.com/biochemj/art...

☕Zhang et al. characterize the #mitochondrial inner membrane subdomain organizer (MISO) protein, which responds to inner #mitochondria membrane stress by inducing membrane subdomains promoting homeostatic fission and mtDNA degradation. 👉https://rdcu.be/eXjMB bit.ly/3YZ0PNj

The mitochondria in a cell are weirder than you think. Not just “the powerhouse of the cell,” but more like a shape-shifting, constantly remodeling, mildly unhinged energy blob. #CellBiology

MISO: An MTFP1 interactor that regulates inner mitochondrial membrane fusion and quality control MISO regulates mitochondrial dynamics and mtDNA homeostasis by establishing membrane subdomains | Nature Cell Biology

Huge congratulations to Abigail Giles whose paper has just come out in Nature Cardiovascular Research - from a great collaboration with Bob Balaban, along with Thomas Krieg and Tish Murphy. doi.org/10.1038/s441...

Our latest now published in @natcomms.nature.com, where we found a new role for mitochondrial programming of SC-β cell fate through PPARα. We're excited for the potential to target mitochondria to improve SC-islets to treat #T1D! www.nature.com/articles/s41...

Our new paper is out now in Nature Communications! We uncovered the function of XBP1 in beta cells of a preclinical model of T1D and identified unique and shared gene regulatory networks driven by IRE1 and XBP1. www.nature.com/articles/s41...

Monitoring the complexity and dynamics of mitochondrial translation

A new carrier-drug conjugate fuses a TGR5-targeting compound for type 2 #diabetes to silicon particles to limit intestinal absorption, enabling safe and extended blood sugar control in mice and pigs without typical systemic toxicity. #ScienceTranslationalMedicine https://scim.ag/48opIrf

Measuring mitochondrial membrane potential | The EMBO Journal www.embopress.org/doi/full/10....

A new #ScienceImmunology study finds that mice and humans have pancreatic islet-resident macrophages with elevated antioxidant profiles, which could shield β cells from oxidative stress. https://scim.ag/49cqs3M

Extremely happy to see this out in @embojournal.org! Here we provide a guide on how to accurately determine mitochondrial membrane potential. Thanks to @marcliesa.bsky.social for the opportunity and to everyone involved! We hope you find it useful! @ibmb-csic.bsky.social

Measuring mitochondrial membrane potential @marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells www.embopress.org/doi/full/10....