Andrew Maclean
@macleanlab.bsky.social
📤 282
📥 328
📝 14
MRC research fellow at the University of Edinburgh working on parasite metabolism.
reposted by
Andrew Maclean
David Bhella
about 15 hours ago
I am excited to share our latest preprint - An evolutionarily divergent herpesvirus with a giant tail. Featuring symmetry breaking and genome annotation from structure using ModelAngelo.
doi.org/10.64898/202...
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Andrew Maclean
Spoel Lab
6 days ago
Plants use cell-surface and intracellular receptors that collaborate to detect pathogens🦠. We discovered that a key
#ubiquitin
recognition event recruits both receptor types into an unexpected dual receptor complex that boost the translation of defence proteins and establishes robust
#PlantImmunity👇🏾
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Andrew Maclean
Ross Waller
8 days ago
Spatial Proteomics Workshop for Protists (see more in thread below) Registration Early Bird Monday 22nd June 2026. Regular Monday 10th August 2026. There will be a conference dinner on day 1. To register visit
protistology.org.uk/autumn-meeti...
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Congratulations to Barrack, we are very excited to welcome him here in Edinburgh.
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12 days ago
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Andrew Maclean
Dewar Lab
13 days ago
🧬Fully Funded PhD Mitochondria|Protein Homeostasis|Antibody Technologies 🤝In collaboration with
@menzieslab.bsky.social
and Nick Robinson
@blslancasteruni.bsky.social
🎓UK students only ⏰6th March 2026 📩Enquiries:
[email protected]
www.findaphd.com/phds/project...
#phdopportunity
#mitochondria
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Safeguarding the powerhouse: antibody-based characterisation of trypanosome mitochondrial quality control proteins at Lancaster University on FindAPhD.com
PhD Project - Safeguarding the powerhouse: antibody-based characterisation of trypanosome mitochondrial quality control proteins at Lancaster University, listed on FindAPhD.com
https://www.findaphd.com/phds/project/safeguarding-the-powerhouse-antibody-based-characterisation-of-trypanosome-mitochondrial-quality-control-proteins/?p193962
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Andrew Maclean
SheinerLab
15 days ago
If you are a committed scientist who wishes to work with Toxoplasma or with organelles (or both!!) - come work with us:
www.jobs.gla.ac.uk/job/research...
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Andrew Maclean
Juan Carlos De la Concepcion
15 days ago
Please share! PhD position (4 years) available in my group
@zmbp-tuebingen.bsky.social
. We look for candidates with solid aptitude in computer science to cross disciplines and use cutting edge imaging to understand host infection by destructive plant pathogens.
uni-tuebingen.de/universitaet...
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Andrew Maclean
Victor Tobiasson
17 days ago
LAST CALL! Come join me at Glasgow University for evolutionary structural biology! We have fully positions. Computational Postdoc:
www.jobs.gla.ac.uk/job/research...
Structural Postdoc:
www.jobs.gla.ac.uk/job/research...
Technician:
www.jobs.gla.ac.uk/job/technici...
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Technician
Job PurposeThe post holder will join the School of Infection and Immunity, supporting structural biology research under the supervision of Dr Victor Tobiasson (Principal Investigator). The applican...
https://www.jobs.gla.ac.uk/job/technician-5770250?source=gla.ac.uk
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Andrew Maclean
Victor Tobiasson
27 days ago
FYI were starting weird structure/evolution/biology stuff at Glasgow University! If you're interested let me know! Tell your friends! CRYO
www.jobs.gla.ac.uk/job/research...
BIOINFO
www.jobs.gla.ac.uk/job/research...
TECHNICIAN
www.jobs.gla.ac.uk/job/technici...
#science
#hiring
#evolution
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Andrew Maclean
Mathieu Gissot
about 1 month ago
We are actively recruiting a Post doc to work on the regulation of Toxoplasma différenciation. Please send a CV and cover letter if interested.
ciil.fr/teams/apicompl…
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Accueil - Université de LilleAccueil - Université de Lille
L’Université de Lille a obtenu la labellisation DD&RS – Développement durable et Responsabilité sociétale pour une durée de quatre ans.
https://ciil.fr/teams/apicompl…
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Andrew Maclean
Sara MaciasRNA
about 1 month ago
Happy to share with you our work on how the interferon response impacts embryonic development 🦠Mammalian embryos contain endogenous dsRNAs that resemble viruses and can be misrecognised by the dsRNA sensor MDA5. Thanks to all collaborators, we could not have done it without you 🤩
rdcu.be/eWMfA
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Double stranded RNA sensing is silenced during early embryonic development
Nature Communications - The type I interferon response is suppressed during early development, making embryos susceptible to pathogens. Here, the authors show that this suppression contributes to...
https://rdcu.be/eWMfA
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Andrew Maclean
Nath Jones
about 1 month ago
I am pleased to share our latest preprint, detailing the characterisation of BDF7 in Leishmania. This non-canonical bromodomain factor is essential for the parasite to live inside the host macrophage and has a parasite specific function compared to the host ortholog , ATAD2. Details in the link:
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Andrew Maclean
Paul Sigala
about 2 months ago
Happy to share a new preprint exploring the unusual biochemistry of a "weirdly" diverged cytochrome c in malaria parasites that exemplifies a lineage common to many apicomplexan parasites.
@uofubiochem.bsky.social
@uuhsresearch.bsky.social
@uofutahcihd.bsky.social
www.biorxiv.org/content/10.6...
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A Divergent Cytochrome c in Malaria Parasites with an Anomalously Low Redox Potential
Eukaryotic cytochrome (cyt) c is a highly conserved mitochondrial protein central to cellular respiration, featuring a covalently attached hexacoordinate heme whose redox potential is tuned by axial H...
https://www.biorxiv.org/content/10.64898/2025.12.23.696199v1
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Was a lot of fun working with
@sheinerlab.bsky.social
and Julius Lukes and his lab to explore the weird mitochondria of these under explored parasites. Thanks to all the authors.
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about 2 months ago
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Andrew Maclean
André Schneider, University of Bern
2 months ago
In the early 1980ies the labs of Cordingley, Boothroyd and Borst discovered that the LSU rRNA of T. brucei is processed into 6 fragment. Now more than 30 years later Simona Amodeo at al. found the factors that mediate these trypanosomatid-specific processing events.
academic.oup.com/nar/article/...
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A trypanosome-specific complex mediates late-stage processing of cytosolic LSU rRNA
Abstract. Unlike most eukaryotes, Trypanosoma brucei processes its cytosolic large subunit (LSU) RNA into six fragments. The factors responsible for these
https://academic.oup.com/nar/article/53/22/gkaf1327/8378191
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Andrew Maclean
Courtney Stairs
2 months ago
Save the date! The next instalment of Comparative Genomics of Unicellular Eukaryotes is a GO! Join us next year for a programme of talks, posters, ECR/networking activities. Website and registration details to follow in the coming weeks. See you October 5-10 2026 in beautiful San Feliu!!
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Interested in parasitology? Looking to do a PhD? Cone join me and
@geordieparasit.bsky.social
in Edinburgh as we try and work out how human parasites get their vitamins.
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2 months ago
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Andrew Maclean
Jiménez-Ruiz Lab
3 months ago
Our new paper is out in Nature Communications! 🎉 We explore how Toxoplasma gondii organizes parasite development, combining cell biology and expansion microscopy to reveal new structural insights.
#Toxoplasma
@meissnerlab.bsky.social
@natcomms.nature.com
www.nature.com/articles/s41...
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Andrew Maclean
Ross Waller
3 months ago
Excited to release the Herculean efforts of
@scottchisholm.bsky.social
&Co. defining the subcellular
#hyperLOPIT
spatial proteome of
#Plasmodium
schizonts. Proteomes defining 24 subcellular niches, including exported compartments in the blood cell, are identified.
www.biorxiv.org/content/10.1...
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Andrew Maclean
bishara marzook
3 months ago
There's still time to register for CoccidiaUK in London - it's going to be a jam-packed two days of talks by early-career parasitologists, a knowledge transfer session, plus trivia and prizes! It's
@crick.ac.uk
(very central) & we're cooking up some fun swag :)
www.eventbrite.co.uk/e/coccidiauk...
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CoccidiaUK 2025
A biannual gathering of parasitologists from across the UK to discuss all things coccidian!
https://www.eventbrite.co.uk/e/coccidiauk-2025-tickets-1967671128313
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reposted by
Andrew Maclean
3 months ago
Looking to start a PhD in October 2026 and learn about bioinformatics and the regulation of TGF-beta signalling in macrophages? Check out this PhD opportunity with a multidisciplinary team at the University of Edinburgh:
www.findaphd.com/phds/project...
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Precision Medicine DTP - Towards precision therapeutics for macrophages: developing a multi-organ understanding of macrophage control by TGF-β at University of Edinburgh on FindAPhD.com
PhD Project - Precision Medicine DTP - Towards precision therapeutics for macrophages: developing a multi-organ understanding of macrophage control by TGF-β at University of Edinburgh, listed on ...
https://www.findaphd.com/phds/project/precision-medicine-dtp-towards-precision-therapeutics-for-macrophages-developing-a-multi-organ-understanding-of-macrophage-control-by-tgf/?p191419
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Andrew Maclean
Bungo Akiyoshi
3 months ago
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK)
www.findaphd.com/phds/project...
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Andrew Maclean
SPPIRIT Network
3 months ago
Coming up: Postdoctoral fellowship mini-workshop as a part of the SPPIRIT Forum series. EMBO, Marie Curie, and Wellcome Early Career fellows will share their advice on fellowship applications. Join us at 12 noon on Thursday 14th November! Register at
docs.google.com/forms/d/e/1F...
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Andrew Maclean
DrPrernaVohra
3 months ago
If you’re interested in solving bacterial mysteries, this PhD project is for you!
www.findaphd.com/phds/project...
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Investigating the role of the Vi antigen in Salmonella pathogenesis. at University of Edinburgh on FindAPhD.com
PhD Project - Investigating the role of the Vi antigen in Salmonella pathogenesis. at University of Edinburgh, listed on FindAPhD.com
https://www.findaphd.com/phds/project/investigating-the-role-of-the-vi-antigen-in-salmonella-pathogenesis/?p189589
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Andrew Maclean
Dr. Mattie Christine Pawlowic
4 months ago
Incredibly proud to share that our work on Cryptosporidium Oocyst Wall Proteins is published in @PLOSPathogens
journals.plos.org/plospathogen...
Led by previous PhD student @BacchettiRoss and carried on by current PhD student, Sarah Stevens.
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Cryptosporidium oocyst wall proteins are true components of the oocyst wall and COWP8 is not required for parasite transmission
Author summary Infection with Cryptosporidium causes diarrhoea, which can be fatal for malnourished children or people who are immunocompromised. There is no vaccine or effective medicines available t...
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1013561
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Andrew Maclean
Chi-Min Ho
4 months ago
Learn how our hunt for the native structure of top antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now!
@natcomms.nature.com
👉
rdcu.be/eLRlH
🦠🔬❄️ A team effort led by
@mehsehret.bsky.social
& Anurag Shukla
@akhilvaidya.bsky.social
!
#cryoEM
#malaria
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Endogenous structure of antimalarial target PfATP4 reveals an apicomplexan-specific P-type ATPase modulator
Nature Communications - Here, the authors present the 3.7 Å cryoEM structure of native sodium efflux pump PfATP4 from Plasmodium falciparum, revealing a bound protein that they term...
https://rdcu.be/eLRlH
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Andrew Maclean
Jiménez-Ruiz Lab
4 months ago
Excited to share our new paper! Tepsin and AP4 mediate transport from the trans-Golgi to the plant-like vacuole in Toxoplasma gondii. A great collaboration between the Meissner, Jiménez-Ruiz, and Dacks labs 🙌
#Toxoplasma
#Apicomplexa
#Golgi
#CellBiology
#Parasites
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Andrew Maclean
Keith Matthews
4 months ago
We have a 3+ year post doc available in our lab to study trypanosome transmission and virulence. Combined wet lab and bioinformatics expertise preferred. Please apply via the HR link (
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
). Find out more about us in the link below.
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The Matthews Lab | Biology
The Matthews Lab
https://biology.ed.ac.uk/the-matthews-lab
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Andrew Maclean
Vivien Shek
5 months ago
Delighted to share this story from my PhD! 🎉 🪱
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reposted by
Andrew Maclean
Sateriale Lab
5 months ago
From nutrient acquisition to drug resistance, membrane transport is especially important for intracellular parasites! This review will help you stay up-to-date on the latest transport research for crypto/malaria/toxo:
www.sciencedirect.com/science/arti...
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Andrew Maclean
Henry McSorley
5 months ago
Latest McSorley lab paper is out! Led by Vivien
@vshek.bsky.social
, this is a story about the immunomodulators from H. polygyrus bakeri (Hpb), and how their analysis led to the identification of HpBoRB, a secreted protein which binds host RELM-beta
www.sciencedirect.com/science/arti...
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Andrew Maclean
Tea Tomita
5 months ago
[We are Hiring!] The Weiss Lab at Albert Einstein College of Medicine (NY) is hiring a Postdoc Scientist to explore the Toxoplasma gondii cyst wall using XL-MS, Split TurboID, & U-ExM. This project aims to unlock new strategies for treating toxoplasmosis. DM for more info!
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Andrew Maclean
Annis Richardson
5 months ago
The Plant Shape Lab is hiring! Are you interested in supporting cutting edge cereal research? We are looking for an enthusiastic and dedicated technician to join us for 2 years, setting up and running cereal transformation. Find out more, and apply here:
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
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Andrew Maclean
SPPIRIT Network
5 months ago
📢 7 weeks to go until our SPPIRIT symposium A fantastic opportunity for ECR parasitologists across Scotland to network and showcase their research. 🗓️ 31 October 2025 | 📍 Roslin Institute, Edinburgh 🎟️ Free to attend →
tinyurl.com/3yzjnm5h
Secure your spot today!
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Hostbusters: SPPIRITed to Roslin
Bringing together ECR parasitologists from across Scotland to network and showcase their science.
https://tinyurl.com/3yzjnm5h
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Andrew Maclean
Dr Joanne Power
5 months ago
Save the dates!!
@bspparasitology.bsky.social
Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026! Keep an eye on the BSP website for registration and abstract submission! Logo by
@shannaraeilean.bsky.social
! 🦟
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Andrew Maclean
SPPIRIT Network
5 months ago
Don't miss the chance to learn from an industry expert in drug discovery and connect with the Tryps Club community! 🌍✨
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Andrew Maclean
André Schneider, University of Bern
5 months ago
The trypanosomal TAC is required for mitochondrial DNA segregation. We provide insight into TAC assembly: one of the most extreme sorting event for any mitochondrion. Congratulations to Philip, Salome and Bernd
#mitochondria
#mtDNA
#Trypanosoma
journals.plos.org/plospathogen...
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Assembly of the mitochondrial outer membrane module of the trypanosomal tripartite attachment complex
Author summary Mitochondria are essential for nearly all eukaryotes. This requires proper segregation of the organelles and their genomes to the daughter cells during cell division. For Trypanosomes a...
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1013506&?utm_id=plos111&utm_source=internal&utm_medium=email&utm_campaign=author
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Andrew Maclean
John Steele
6 months ago
SULSA is running an Industry Academia conference on 28th & 29th October. Looks fantastic for researchers working in Scotland- particularly good for students interested in learning more about industry & working on skill development!
sulsa.ac.uk/indac/
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IndAc Conference - SULSA
https://sulsa.ac.uk/indac/
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Andrew Maclean
Sateriale Lab
6 months ago
Now available in a polished format! An important step toward accelerated functional genomics for the Cryptosporidium parasite. Brought to you by the incomparable
@lucy-watson.bsky.social
www.nature.com/articles/s41...
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Targeted CRISPR screens reveal genes essential for Cryptosporidium survival in the host intestine - Nature Communications
Cryptosporidium is an important threat to public health, yet it lacks a robust genetic toolkit. Here, Watson et al. introduce a targeted CRISPR-based screening method to identify parasite genes that a...
https://www.nature.com/articles/s41467-025-63012-1
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Andrew Maclean
SPPIRIT Network
6 months ago
Only one week left until SPPIRIT Forum meeting! Join us to discuss recent work on mosquito tissue ultrastructure-expansion microscopy for malaria research, and ask questions to the 1st author,
@benliffner.bsky.social
, who will join us! For meeting link fill in:
tinyurl.com/3j5ewezv
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Andrew Maclean
The Reece Lab
6 months ago
🚨NEW PAPER🚨 We've already shown mosquito infections vary by time-of-day, here we test whether infection of mice FROM mosquitoes vary in a rhythmic manner. We test this in untreated & drug treated mice as some fitness consequences are only apparent in stressful environments
doi.org/10.1186/s130...
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reposted by
Andrew Maclean
Richard McCulloch
6 months ago
We’re pleased to share our new study, led by
@jezieldamasceno.bsky.social
, that used long-read, single molecule sequencing to reveal the full (?) picture of Leishmania DNA replication. Thanks, Mike Boemo and helpful reviewers
@uofgsii.bsky.social
www.sciencedirect.com/science/arti...
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Leishmania major chromosomes are replicated from a single high-efficiency locus supplemented by thousands of lower efficiency initiation events
DNA replication initiates at genome sites termed origins. Previous origin mapping approaches in the populations of the protozoan parasite Leishmania m…
https://www.sciencedirect.com/science/article/pii/S2211124725008654?ssrnid=5045705&dgcid=SSRN_redirect_SD
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reposted by
Andrew Maclean
6 months ago
I am recruiting for a postdoc that wants to work on an exciting project on gut macrophages, TGFb signalling, and colon cancer! Please see the link for details -
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
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Postdoctoral Research Associate
We are looking for a talented and enthusiastic postdoctoral researcher to join the Shaw lab to investigate identify the regulatory function of NRROS/LRRC33 in gastrointestinal macrophage development a...
https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/12934
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reposted by
Andrew Maclean
Jiménez-Ruiz Lab
6 months ago
Hi there! Our group at LMU Munich is hiring a postdoc to work on Toxoplasma and Plasmodium. Start: from Oct 1, 2025 | Location: Munich, Germany 1-year contract with extension possible Apply by Aug 31:
bit.ly/LMUpostdoc
Contact:
[email protected]
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https://bit.ly/LMUpostdoc
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Andrew Maclean
Bungo Akiyoshi
6 months ago
My attempt to become a professor was unsuccessful again but the diplonema tagging paper is now published in Open Biology.
royalsocietypublishing.org/doi/10.1098/...
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reposted by
Andrew Maclean
Seb Besteiro
7 months ago
🚨 2-year post-doc position available in my lab. More details below. Please repost!
acrobat.adobe.com/id/urn:aaid:...
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Andrew Maclean
bishara marzook
7 months ago
Our paper has finally graduated from pre-print to peer-reviewed, pretty much unscathed, and is out now!
www.cell.com/cell/fulltex...
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The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment
An arrayed microscopy-based CRISPR screen revealed host genes affecting multiple infection phenotypes of the intracellular parasite Cryptosporidium. Hits in the host cholesterol biosynthesis pathway a...
https://www.cell.com/cell/fulltext/S0092-8674(25)00751-2
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📣 Open postdoc position in my lab to investigate how Toxoplasma acquires nutrients. Join me at the University of Edinburgh. Closing date 14th August. More details below ⬇️
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
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Postdoctoral Research Associate
We are looking for a talented and enthusiastic Postdoctoral researcher to join the Maclean lab to investigate the metabolism of the human parasite Toxoplasma gondii.
https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/12799/?utm_medium=jobshare&utm_source=External+Job+Share
7 months ago
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Great opportunity with a great supervisor.
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7 months ago
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