Andrew Maclean
@macleanlab.bsky.social
📤 267
📥 319
📝 11
MRC research fellow at the University of Edinburgh working on parasite metabolism.
reposted by
Andrew Maclean
Jiménez-Ruiz Lab
3 days ago
Our new paper is out in Nature Communications! 🎉 We explore how Toxoplasma gondii organizes parasite development, combining cell biology and expansion microscopy to reveal new structural insights.
#Toxoplasma
@meissnerlab.bsky.social
@natcomms.nature.com
www.nature.com/articles/s41...
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reposted by
Andrew Maclean
Ross Waller
4 days ago
Excited to release the Herculean efforts of
@scottchisholm.bsky.social
&Co. defining the subcellular
#hyperLOPIT
spatial proteome of
#Plasmodium
schizonts. Proteomes defining 24 subcellular niches, including exported compartments in the blood cell, are identified.
www.biorxiv.org/content/10.1...
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Andrew Maclean
bishara marzook
5 days ago
There's still time to register for CoccidiaUK in London - it's going to be a jam-packed two days of talks by early-career parasitologists, a knowledge transfer session, plus trivia and prizes! It's
@crick.ac.uk
(very central) & we're cooking up some fun swag :)
www.eventbrite.co.uk/e/coccidiauk...
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CoccidiaUK 2025
A biannual gathering of parasitologists from across the UK to discuss all things coccidian!
https://www.eventbrite.co.uk/e/coccidiauk-2025-tickets-1967671128313
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reposted by
Andrew Maclean
7 days ago
Looking to start a PhD in October 2026 and learn about bioinformatics and the regulation of TGF-beta signalling in macrophages? Check out this PhD opportunity with a multidisciplinary team at the University of Edinburgh:
www.findaphd.com/phds/project...
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Precision Medicine DTP - Towards precision therapeutics for macrophages: developing a multi-organ understanding of macrophage control by TGF-β at University of Edinburgh on FindAPhD.com
PhD Project - Precision Medicine DTP - Towards precision therapeutics for macrophages: developing a multi-organ understanding of macrophage control by TGF-β at University of Edinburgh, listed on ...
https://www.findaphd.com/phds/project/precision-medicine-dtp-towards-precision-therapeutics-for-macrophages-developing-a-multi-organ-understanding-of-macrophage-control-by-tgf/?p191419
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reposted by
Andrew Maclean
Bungo Akiyoshi
20 days ago
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK)
www.findaphd.com/phds/project...
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reposted by
Andrew Maclean
SPPIRIT Network
27 days ago
Coming up: Postdoctoral fellowship mini-workshop as a part of the SPPIRIT Forum series. EMBO, Marie Curie, and Wellcome Early Career fellows will share their advice on fellowship applications. Join us at 12 noon on Thursday 14th November! Register at
docs.google.com/forms/d/e/1F...
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reposted by
Andrew Maclean
DrPrernaVohra
29 days ago
If you’re interested in solving bacterial mysteries, this PhD project is for you!
www.findaphd.com/phds/project...
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Investigating the role of the Vi antigen in Salmonella pathogenesis. at University of Edinburgh on FindAPhD.com
PhD Project - Investigating the role of the Vi antigen in Salmonella pathogenesis. at University of Edinburgh, listed on FindAPhD.com
https://www.findaphd.com/phds/project/investigating-the-role-of-the-vi-antigen-in-salmonella-pathogenesis/?p189589
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Andrew Maclean
Dr. Mattie Christine Pawlowic
about 1 month ago
Incredibly proud to share that our work on Cryptosporidium Oocyst Wall Proteins is published in @PLOSPathogens
journals.plos.org/plospathogen...
Led by previous PhD student @BacchettiRoss and carried on by current PhD student, Sarah Stevens.
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Cryptosporidium oocyst wall proteins are true components of the oocyst wall and COWP8 is not required for parasite transmission
Author summary Infection with Cryptosporidium causes diarrhoea, which can be fatal for malnourished children or people who are immunocompromised. There is no vaccine or effective medicines available t...
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1013561
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reposted by
Andrew Maclean
Chi-Min Ho
about 1 month ago
Learn how our hunt for the native structure of top antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now!
@natcomms.nature.com
👉
rdcu.be/eLRlH
🦠🔬❄️ A team effort led by
@mehsehret.bsky.social
& Anurag Shukla
@akhilvaidya.bsky.social
!
#cryoEM
#malaria
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Endogenous structure of antimalarial target PfATP4 reveals an apicomplexan-specific P-type ATPase modulator
Nature Communications - Here, the authors present the 3.7 Å cryoEM structure of native sodium efflux pump PfATP4 from Plasmodium falciparum, revealing a bound protein that they term...
https://rdcu.be/eLRlH
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reposted by
Andrew Maclean
Jiménez-Ruiz Lab
about 1 month ago
Excited to share our new paper! Tepsin and AP4 mediate transport from the trans-Golgi to the plant-like vacuole in Toxoplasma gondii. A great collaboration between the Meissner, Jiménez-Ruiz, and Dacks labs 🙌
#Toxoplasma
#Apicomplexa
#Golgi
#CellBiology
#Parasites
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reposted by
Andrew Maclean
Keith Matthews
about 2 months ago
We have a 3+ year post doc available in our lab to study trypanosome transmission and virulence. Combined wet lab and bioinformatics expertise preferred. Please apply via the HR link (
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
). Find out more about us in the link below.
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The Matthews Lab | Biology
The Matthews Lab
https://biology.ed.ac.uk/the-matthews-lab
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reposted by
Andrew Maclean
Vivien Shek
2 months ago
Delighted to share this story from my PhD! 🎉 🪱
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reposted by
Andrew Maclean
Sateriale Lab
2 months ago
From nutrient acquisition to drug resistance, membrane transport is especially important for intracellular parasites! This review will help you stay up-to-date on the latest transport research for crypto/malaria/toxo:
www.sciencedirect.com/science/arti...
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reposted by
Andrew Maclean
Henry McSorley
2 months ago
Latest McSorley lab paper is out! Led by Vivien
@vshek.bsky.social
, this is a story about the immunomodulators from H. polygyrus bakeri (Hpb), and how their analysis led to the identification of HpBoRB, a secreted protein which binds host RELM-beta
www.sciencedirect.com/science/arti...
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reposted by
Andrew Maclean
Tea Tomita
2 months ago
[We are Hiring!] The Weiss Lab at Albert Einstein College of Medicine (NY) is hiring a Postdoc Scientist to explore the Toxoplasma gondii cyst wall using XL-MS, Split TurboID, & U-ExM. This project aims to unlock new strategies for treating toxoplasmosis. DM for more info!
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reposted by
Andrew Maclean
Annis Richardson
2 months ago
The Plant Shape Lab is hiring! Are you interested in supporting cutting edge cereal research? We are looking for an enthusiastic and dedicated technician to join us for 2 years, setting up and running cereal transformation. Find out more, and apply here:
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
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reposted by
Andrew Maclean
SPPIRIT Network
3 months ago
📢 7 weeks to go until our SPPIRIT symposium A fantastic opportunity for ECR parasitologists across Scotland to network and showcase their research. 🗓️ 31 October 2025 | 📍 Roslin Institute, Edinburgh 🎟️ Free to attend →
tinyurl.com/3yzjnm5h
Secure your spot today!
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Hostbusters: SPPIRITed to Roslin
Bringing together ECR parasitologists from across Scotland to network and showcase their science.
https://tinyurl.com/3yzjnm5h
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reposted by
Andrew Maclean
Dr Joanne Power
3 months ago
Save the dates!!
@bspparasitology.bsky.social
Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026! Keep an eye on the BSP website for registration and abstract submission! Logo by
@shannaraeilean.bsky.social
! 🦟
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reposted by
Andrew Maclean
SPPIRIT Network
3 months ago
Don't miss the chance to learn from an industry expert in drug discovery and connect with the Tryps Club community! 🌍✨
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reposted by
Andrew Maclean
André Schneider, University of Bern
3 months ago
The trypanosomal TAC is required for mitochondrial DNA segregation. We provide insight into TAC assembly: one of the most extreme sorting event for any mitochondrion. Congratulations to Philip, Salome and Bernd
#mitochondria
#mtDNA
#Trypanosoma
journals.plos.org/plospathogen...
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Assembly of the mitochondrial outer membrane module of the trypanosomal tripartite attachment complex
Author summary Mitochondria are essential for nearly all eukaryotes. This requires proper segregation of the organelles and their genomes to the daughter cells during cell division. For Trypanosomes a...
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1013506&?utm_id=plos111&utm_source=internal&utm_medium=email&utm_campaign=author
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reposted by
Andrew Maclean
John Steele
3 months ago
SULSA is running an Industry Academia conference on 28th & 29th October. Looks fantastic for researchers working in Scotland- particularly good for students interested in learning more about industry & working on skill development!
sulsa.ac.uk/indac/
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IndAc Conference - SULSA
https://sulsa.ac.uk/indac/
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reposted by
Andrew Maclean
Sateriale Lab
3 months ago
Now available in a polished format! An important step toward accelerated functional genomics for the Cryptosporidium parasite. Brought to you by the incomparable
@lucy-watson.bsky.social
www.nature.com/articles/s41...
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Targeted CRISPR screens reveal genes essential for Cryptosporidium survival in the host intestine - Nature Communications
Cryptosporidium is an important threat to public health, yet it lacks a robust genetic toolkit. Here, Watson et al. introduce a targeted CRISPR-based screening method to identify parasite genes that a...
https://www.nature.com/articles/s41467-025-63012-1
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reposted by
Andrew Maclean
SPPIRIT Network
4 months ago
Only one week left until SPPIRIT Forum meeting! Join us to discuss recent work on mosquito tissue ultrastructure-expansion microscopy for malaria research, and ask questions to the 1st author,
@benliffner.bsky.social
, who will join us! For meeting link fill in:
tinyurl.com/3j5ewezv
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reposted by
Andrew Maclean
The Reece Lab
4 months ago
🚨NEW PAPER🚨 We've already shown mosquito infections vary by time-of-day, here we test whether infection of mice FROM mosquitoes vary in a rhythmic manner. We test this in untreated & drug treated mice as some fitness consequences are only apparent in stressful environments
doi.org/10.1186/s130...
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reposted by
Andrew Maclean
Richard McCulloch
4 months ago
We’re pleased to share our new study, led by
@jezieldamasceno.bsky.social
, that used long-read, single molecule sequencing to reveal the full (?) picture of Leishmania DNA replication. Thanks, Mike Boemo and helpful reviewers
@uofgsii.bsky.social
www.sciencedirect.com/science/arti...
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Leishmania major chromosomes are replicated from a single high-efficiency locus supplemented by thousands of lower efficiency initiation events
DNA replication initiates at genome sites termed origins. Previous origin mapping approaches in the populations of the protozoan parasite Leishmania m…
https://www.sciencedirect.com/science/article/pii/S2211124725008654?ssrnid=5045705&dgcid=SSRN_redirect_SD
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reposted by
Andrew Maclean
4 months ago
I am recruiting for a postdoc that wants to work on an exciting project on gut macrophages, TGFb signalling, and colon cancer! Please see the link for details -
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
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Postdoctoral Research Associate
We are looking for a talented and enthusiastic postdoctoral researcher to join the Shaw lab to investigate identify the regulatory function of NRROS/LRRC33 in gastrointestinal macrophage development a...
https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/12934
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reposted by
Andrew Maclean
Jiménez-Ruiz Lab
4 months ago
Hi there! Our group at LMU Munich is hiring a postdoc to work on Toxoplasma and Plasmodium. Start: from Oct 1, 2025 | Location: Munich, Germany 1-year contract with extension possible Apply by Aug 31:
bit.ly/LMUpostdoc
Contact:
[email protected]
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https://bit.ly/LMUpostdoc
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reposted by
Andrew Maclean
Bungo Akiyoshi
4 months ago
My attempt to become a professor was unsuccessful again but the diplonema tagging paper is now published in Open Biology.
royalsocietypublishing.org/doi/10.1098/...
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reposted by
Andrew Maclean
Seb Besteiro
4 months ago
🚨 2-year post-doc position available in my lab. More details below. Please repost!
acrobat.adobe.com/id/urn:aaid:...
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reposted by
Andrew Maclean
bishara marzook
4 months ago
Our paper has finally graduated from pre-print to peer-reviewed, pretty much unscathed, and is out now!
www.cell.com/cell/fulltex...
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The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment
An arrayed microscopy-based CRISPR screen revealed host genes affecting multiple infection phenotypes of the intracellular parasite Cryptosporidium. Hits in the host cholesterol biosynthesis pathway a...
https://www.cell.com/cell/fulltext/S0092-8674(25)00751-2
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📣 Open postdoc position in my lab to investigate how Toxoplasma acquires nutrients. Join me at the University of Edinburgh. Closing date 14th August. More details below ⬇️
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
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Postdoctoral Research Associate
We are looking for a talented and enthusiastic Postdoctoral researcher to join the Maclean lab to investigate the metabolism of the human parasite Toxoplasma gondii.
https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/12799/?utm_medium=jobshare&utm_source=External+Job+Share
4 months ago
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Great opportunity with a great supervisor.
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5 months ago
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reposted by
Andrew Maclean
Javier del Campo
5 months ago
Nutrient acquisition by intracellular parasitic
#protists
---
#symbiosis
#protistsonsky
www.sciencedirect.com/science/arti...
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reposted by
Andrew Maclean
Andrew S. MacDonald
5 months ago
Great to be a (small) part of this beautiful new study on global diversity of soil transmitted
#helminths
from
@stephenrdoyle.bsky.social
and colleagues 🧪
www.nature.com/articles/s41...
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Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets - Nature Communications
This study analysed genetic data of soil-transmitted helminths from 27 countries, revealing diversity impacting molecular test accuracy and highlighting the need to adapt diagnostics for effective STH...
https://www.nature.com/articles/s41467-025-61687-0
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reposted by
Andrew Maclean
Joanna Young
5 months ago
Postdoc position open to investigate chronic Toxoplasma infection!
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
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Postdoctoral Research Associate
We are looking for a talented and enthusiastic Postdoctoral researcher to join the Young lab to investigate secreted proteins during chronic Toxoplasma gondii infection.
https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/12738
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reposted by
Andrew Maclean
Andrew S. MacDonald
6 months ago
Delighted to share our paper on the role of SOX9 in liver
#fibrosis
and
#granuloma
formation during
#schistosome
infection - a really great collaboration over the past few years with the Piper Hanley lab!
#ImmunSky
🪱🧪
dx.plos.org/10.1371/jour...
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SOX9 plays an essential role in myofibroblast driven hepatic granuloma integrity and parenchymal repair during schistosomiasis-induced liver damage
Author summary Mammalian infection with schistosome worms results in the deposition of parasite eggs in the liver, where they secrete organ damaging toxins. In response, the liver generates a cellular...
https://dx.plos.org/10.1371/journal.ppat.1012928
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reposted by
Andrew Maclean
Richard McCulloch
6 months ago
We hope to see you at MPM in Woods Hole this year (again, or for the first time): registration and abstract submission is now open!
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Andrew Maclean
Sara MaciasRNA
6 months ago
In our last preprint we identify endogenous dsRNAs capable of activating the interferon response. Could these be relevant to our understanding of DiGeorge syndrome (22qDS)? In collaboration with
@herassr.bsky.social
and
@heick.bsky.social
labs
www.biorxiv.org/content/10.1...
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Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8
The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune respon...
https://www.biorxiv.org/content/10.1101/2025.05.28.656609v1
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Andrew Maclean
SheinerLab
7 months ago
Parasites need mitochondrial respiration to infect and spread. Effective anti-malaria and ani-toxoplasmosis drugs target respiratory complexes (e.g. atovaquone)! But how do the parasite complexes work and how do drugs inhibit them? Read Andrew Maclean and Alex Mühleip phenomenal work on this! 👇
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Andrew Maclean
Mohamed-Ali HAKIMI
7 months ago
🧵 Ever wondered what Toxoplasma is doing in your brain years after that undercooked steak 🥩 or a sip of contaminated water? Turns out, it's been hiding in your brain 🧠and we finally have a way to spot it. New study just dropped in EMBO Molecular Medicine 👇
doi.org/10.1038/s443...
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Uncovering biomarkers for chronic toxoplasmosis detection highlights alternative pathways shaping parasite dormancy | EMBO Molecular Medicine
imageimageDespite their clinical relevance, bradyzoite-filled cysts - the hallmark of chronic toxoplasmosis - are largely overlooked in current diagnostics. This study highlights bradyzoite serologica...
https://doi.org/10.1038/s44321-025-00252-0
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reposted by
Andrew Maclean
Shikha
7 months ago
Happy to have contributed to this wonderful study about
#Toxoplasma
#supercomplex
led by
@macleanlab.bsky.social
,
@sheinerlab.bsky.social
and Alex Mühleip. Parasite mitochondria never cease to amaze! Please go checkout 👇
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Happy to share our latest paper. Result of a great collaboration between
@sheinerlab.bsky.social
@oninopantsu.bsky.social
and Alexander Mühleip’s new group.
www.nature.com/articles/s41...
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Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex - Nature Structural & Molecular Biology
Here the authors demonstrate that the assembly of mitochondrial respiratory supercomplex (III2–IV) from Toxoplasma gondii is critical for parasite fitness. They reveal the basis for cytochrome b inhib...
https://www.nature.com/articles/s41594-025-01531-7
7 months ago
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reposted by
Andrew Maclean
Edinburgh Infectious Diseases
7 months ago
Richard Wheeler keeping us all awake in the post-lunch session with a great talk about swimming in trypanosomatid parasites
#EIDsymp25
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reposted by
Andrew Maclean
Keith Matthews
7 months ago
Please consider applying for a post doc in our lab if you have bioinformatics and wet lab skills, and are interested in parasites!
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
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Postdoctoral Research Associate
This project will seek to understand the basis of increased virulence after long term coinfection by a combination of genomic, transcriptomic and laboratory manipulation of the selected parasite lines...
https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/12490
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reposted by
Andrew Maclean
Dr. Mattie Christine Pawlowic
7 months ago
If you have ever wanted to know "Where is the gut is the parasite?" this pre-print is for you. 🐮 Led by Peyton, with thanks to our wonderful collaborators at
@moredunfoundation.bsky.social
Frank Katzer,
@geordieparasit.bsky.social
and EMs by
@lemgruber.bsky.social
www.biorxiv.org/content/10.1...
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Tissue atlas of Cryptosporidium parvum infection reveals contrasts between the natural neonatal calf model and laboratory mouse models
Cryptosporidium is an apicomplexan parasite that causes diarrhoeal disease. The species C. parvum is zoonotic and causes significant morbidity and mortality for both humans and farm animals; most comm...
https://www.biorxiv.org/content/10.1101/2025.05.05.652177v1.full.pdf+html
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Andrew Maclean
Keith Matthews
7 months ago
Exploring the chromatin proteome of Trypanosoma brucei repetitive elements (telomeres, centromeres, 70bp repeats, 177bp repeats) using TALEs. Another great collaboration with
@allshire-lab.bsky.social
www.biorxiv.org/cgi/content/...
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Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins
Kinetoplastids, such as Trypansoma brucei, are eukaryotes that likely separated from the main lineage at an exceptionally early point in evolution. Consequently, many aspects of kinetoplastid biology ...
https://www.biorxiv.org/cgi/content/short/2025.04.22.649942v1
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Andrew Maclean
Clare Harding
7 months ago
Please see the new tour de force from
@danaaghabi.bsky.social
PhD! We think that we have finally found the major Toxoplasma iron/zinc importer. Thanks to ID21 at the
@esrf.fr
, and help from UGs and the lab. This is what I wanted to find when I started my lab, and thanks to Dana we have it!
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Andrew Maclean
Dana Aghabi
7 months ago
New preprint alert 🔔🎉 We are so happy to share that our latest work “ZFT is the major iron and zinc transporter in Toxoplasma gondii” is now available online!
www.biorxiv.org/content/10.1...
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ZFT is the major iron and zinc transporter in Toxoplasma gondii
Transition metals, such as iron and zinc, are indispensable trace elements for eukaryotic life, acting as co-factors in essential processes ranging from respiration and metabolism to DNA replication. ...
https://www.biorxiv.org/content/10.1101/2025.04.17.649150v1
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Andrew Maclean
University of Glasgow School of Infection & Immunity
9 months ago
🏅 |
@uofgsii.bsky.social
's Professor Lilach Sheiner (
@sheinerlab.bsky.social
) was recently awarded the prestigious C.A. Wright Medal by the
@bspparasitology.bsky.social
for outstanding contributions to the discipline. Congratulations, Professor Sheiner! 🔗 Full story:
www.gla.ac.uk/schools/infe...
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