Andrew Maclean
@macleanlab.bsky.social
📤 302
📥 335
📝 15
MRC research fellow at the University of Edinburgh working on parasite metabolism.
reposted by
Andrew Maclean
Liz Cooney
about 1 month ago
Meet Holdonia, a new member of the chrompodellid clade. Found clinging to a polychaete, this little guy reveals that similar patterns in plastid reduction have occurred independently across chrompodellid and related lineages.
@rhizalyssa.bsky.social
@pjkeelinglab.bsky.social
tinyurl.com/2t25xb6z
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The evolutionary transition from alga to parasite in the sister lineage of apicomplexans
The chrompodellids are a collection of photosynthetic “chromerids” and heterotrophic “colpodellids,” which are together the sister lineage to the apic…
https://tinyurl.com/2t25xb6z
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reposted by
Andrew Maclean
University of Glasgow School of Infection & Immunity
about 1 month ago
🆕 |
@uofgsii.bsky.social
Research Fellow Dr Megan Sloan has been awarded a 2026
@sulsa.bsky.social
Postdoctoral Prize for work showing excellent potential to make an impact in the field of life sciences. 🔗 Full story:
www.gla.ac.uk/schools/infe...
📺 SULSA video:
youtu.be/nJASKkxqMpA?...
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Andrew Maclean
bishara marzook
3 months ago
Hi all, I'd like to share some news - I will soon be moving to Lisbon, Portugal to start my very own lab
@gimminstitute.bsky.social
! The Epithelial Biology of Apicomplexan Infections lab (Epi-Api lab for short) will focus on the special relationship between
#epithelial
cells and
#Cryptosporidium
.
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reposted by
Andrew Maclean
3 months ago
This week, our paper came out in
@jem.org
showing that: This week, our paper came out in @JEM showing that: 1. Long-lived Tim-4+ macrophages are present in the lamina propria and submucosa/muscularis. 2. Macrophage-derived TGF-beta is key to instructing macrophage identity in the lamina propria.
add a skeleton here at some point
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reposted by
Andrew Maclean
Jon Boyle
3 months ago
Our work just came out today in print form in Nat Micro. Really a tour de force from Hisham Alrubaye on sexual development in Toxoplasma gondii. Well done!
rdcu.be/feOj6
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A single-cell atlas of Toxoplasma sexual development in the feline intestinal tract
Nature Microbiology - Single-cell RNA sequencing is used to study the sexual development of Toxoplasma gondii in cats, generating a transcriptional atlas and showing that the female-specific gene...
https://rdcu.be/feOj6
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Andrew Maclean
Sara MaciasRNA
3 months ago
Our last manuscript is out! 🚨 We identify double stranded RNAs in embryonic stem cells - full of transposons, especially young LINEs and LTRs 🧐 🧬Happy Friday Reading🧬
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https://www.biorxiv.org/content/10.64898/2026.04.13.718158v1
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Andrew Maclean
Dr Joanne Power
3 months ago
Thank you so much to everyone who made it to
#BSP2026
in beautiful, sunny Glasgow!!! (We asked the weather to behave while everyone was around)! The
@bspparasitology.bsky.social
2027 meeting will be in Cardiff! I hope everyone enjoyed themselves! Like Glasgow, People Make
#Parasitology
! 🥳🧬🧫🔬
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reposted by
Andrew Maclean
SPPIRIT Network
3 months ago
Come and find us at
@bspparasitology.bsky.social
#BSP2026
! 👋 Find out about our upcoming events, share your feedback, and see how you can get involved with the committee. And if nothing else... our goodies might just tempt you 😉
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reposted by
Andrew Maclean
Megan Sloan
3 months ago
We open with
@sheinerlab.bsky.social
introducing a scientist who needs no introduction - Dominique Soldati-Favre. Dominique was awarded lifetime membership to the
@bspparasitology.bsky.social
for her immeasurable contributions to the field.
#bsp
#parasites
#peoplemakeglasgow
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reposted by
Andrew Maclean
Helen Price
3 months ago
Our Spring meeting starts today in Glasgow! All the best to all those presenting
@bspparasitology.bsky.social
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reposted by
Andrew Maclean
Bungo Akiyoshi
4 months ago
New preprint! We identified many components that localize to the structure involved in "eating" in a marine organism.
#ProtistOnSky
#diplonemid
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.03.30.714256v1
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reposted by
Andrew Maclean
Clinton Lau
4 months ago
Check out our first lab preprint: A real team effort to understand the Plasmodium GAPM proteins, which form part of a essential bridge between the parasite's cytoskeleton and motility apparatus. Below is a sneak peek of some beautiful microscopy - light and electron!
www.biorxiv.org/content/10.6...
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reposted by
Andrew Maclean
Perona Lab, Edinburgh, UK
4 months ago
Job opportunity for a
#FlowCytometry
technician, School of Biology, University of Edinburgh, UK. We do cool flow with fungi, bacteria, diatoms, space particles, as well as mammalian cells. Spectral, conventional and sorts. Join us! Details here:
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
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Flow Cytometry Technician
We are looking for an enthusiastic person to join the flow cytometry facility in the King’s Buildings campus at the School of Biological Sciences in the University of Edinburgh. This role involves pro...
https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/13843
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reposted by
Andrew Maclean
Maryse Lebrun
4 months ago
Honored and proud to be elected EAM member. Huge thanks to mentors, my amazing team (past&present), the great parasitology community
@parasitesrule.org
@parafrap.bsky.social
for support throughout this journey
@inserm.fr
@cnrs.fr
@umontpellier.bsky.social
@erc.europa.eu
@frm-officiel.bsky.social
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reposted by
Andrew Maclean
John Steele
4 months ago
It feels cheesy when people say this but it really was a privilege to be part of this work. Our recent paper (led by the fantastic Ben Royer
@swallacelab.bsky.social
) shows how engineered Ecoli can turn the main product of PET plastic breakdown it into an anti-Parkinsons drug (L-DOPA)
rdcu.be/e84ZO
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Microbial upcycling of plastic waste to levodopa
Nature Sustainability - The production of high-value chemicals can involve energy-intensive processes, necessitating sustainable production strategies. Here the authors present a circular...
https://rdcu.be/e84ZO
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reposted by
Andrew Maclean
University of Glasgow School of Infection & Immunity
4 months ago
🆕 | Sii's Dr Mariana Ferreira Silva has been awarded a Young Investigator Grant from FAPESP to establish a research group at the University of São Paulo. The group will investigate how the ubiquitination system contributes to the Toxoplasma gondii life cycle. 🔗 More:
www.gla.ac.uk/schools/infe...
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reposted by
Andrew Maclean
Jenny Regan
4 months ago
Like
#hemocytes
? I'm advertising a 3 year, BBSRC
#postdoc
position, in
#Edinburgh
, using
#Drosophila
& human cells to understand sex differences in the regulation of
#macrophage
function, an exciting collaboration with the Bénézech and Wood labs. Please share! 🪰🏴
www.jobs.ac.uk/job/DQU604/p...
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Postdoctoral Research Associate at The University of Edinburgh
Discover an exciting academic career path as a Postdoctoral Research Associate at jobs.ac.uk. Don't miss out on this job opportunity - apply today!
https://www.jobs.ac.uk/job/DQU604/postdoctoral-research-associate
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reposted by
Andrew Maclean
Marketa Novotna
4 months ago
Join us next Friday to learn about working with different parasites and enhance your parasitology network!
add a skeleton here at some point
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reposted by
Andrew Maclean
SPPIRIT Network
4 months ago
docs.google.com/forms/d/e/1F...
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reposted by
Andrew Maclean
Paul Sigala
4 months ago
Happy to announce a new review article by MD/PhD student Kade Loveridge on iron metabolism in
#malaria
#parasites
.
@uofubiochem.bsky.social
@uuhsresearch.bsky.social
@uofutahcihd.bsky.social
@parasitesrule.org
journals.plos.org/plospathogen...
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Fifty shades of iron: Unorthodox mechanisms of iron acquisition and utilization in blood-stage Plasmodium parasites
Plasmodium falciparum parasites cause severe human malaria and depend on iron for essential metabolic processes during all phases of their complicated lifecycle, including when growing in human red bl...
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1014030#references
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reposted by
Andrew Maclean
LabEx ParaFrap
4 months ago
📆 Join us for the scientific session of the ParaFrap Next Generation in Parasitology Workshop (May 18-21, 2026, Montpellier) ! 🧑🔬 Junior PIs will present their work. Registration is free but mandatory (includes lunch & coffee breaks). Spots are limited, register now! 👉
forms.gle/bYsb47iZG7pR...
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reposted by
Andrew Maclean
Sara MaciasRNA
5 months ago
A great collaboration of my group with
@herassr.bsky.social
and
@heick.bsky.social
groups searching for mammalian dsRNAs and their importance to human disease 🧬
add a skeleton here at some point
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reposted by
Andrew Maclean
Sebastian Shaw
5 months ago
🚨 Postdoc position 🚨 I’m moving back to Switzerland this summer to launch my lab at the University of Zurich and am recruiting a Postdoctoral Fellow (start: late 2026). Details & application:
jobs.uzh.ch/job-vacancie...
. Please share! 😊
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UZH: Postdoc
The newly founded Cryptosporidium lab at the Institute of Parasitology focuses on the genetic and transcriptomic basis of parasite virulence and persistence in Cryptosporidium and is committed to incl...
https://jobs.uzh.ch/job-vacancies/postdoc/e639e72a-6302-42f7-9a1e-cbcb2f2c4a57
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reposted by
Andrew Maclean
Richard Wheeler
5 months ago
Want to computationally analyse a genome's-worth of protein localisations? Have data for 4.5 million cells at your fingertips using this Python tool to access
TrypTag.org
data
www.biorxiv.org/content/10.6...
(we're out of beta and releasing on time 🎂)
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https://www.biorxiv.org/content/10.64898/2026.02.17.706163v1
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reposted by
Andrew Maclean
Amit Meir
5 months ago
Very excited to share our work, a fish herpesvirus' cryo EM structure. It features a long PVAT tail, with new and host-like proteins discovered using modelAngelo, Dali, and Viro3D, including a host-like macrodomain
doi.org/10.64898/202...
@dbhella.bsky.social
@grovearmada.bsky.social
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https://doi.org/10.64898/2026.02.13.705735
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reposted by
Andrew Maclean
David Bhella
5 months ago
I am excited to share our latest preprint - An evolutionarily divergent herpesvirus with a giant tail. Featuring symmetry breaking and genome annotation from structure using ModelAngelo.
doi.org/10.64898/202...
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reposted by
Andrew Maclean
Spoel Lab
5 months ago
Plants use cell-surface and intracellular receptors that collaborate to detect pathogens🦠. We discovered that a key
#ubiquitin
recognition event recruits both receptor types into an unexpected dual receptor complex that boost the translation of defence proteins and establishes robust
#PlantImmunity👇🏾
add a skeleton here at some point
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reposted by
Andrew Maclean
Ross Waller
5 months ago
Spatial Proteomics Workshop for Protists (see more in thread below) Registration Early Bird Monday 22nd June 2026. Regular Monday 10th August 2026. There will be a conference dinner on day 1. To register visit
protistology.org.uk/autumn-meeti...
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Congratulations to Barrack, we are very excited to welcome him here in Edinburgh.
add a skeleton here at some point
6 months ago
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reposted by
Andrew Maclean
Dewar Lab
6 months ago
🧬Fully Funded PhD Mitochondria|Protein Homeostasis|Antibody Technologies 🤝In collaboration with
@menzieslab.bsky.social
and Nick Robinson
@blslancasteruni.bsky.social
🎓UK students only ⏰6th March 2026 📩Enquiries:
[email protected]
www.findaphd.com/phds/project...
#phdopportunity
#mitochondria
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Safeguarding the powerhouse: antibody-based characterisation of trypanosome mitochondrial quality control proteins at Lancaster University on FindAPhD.com
PhD Project - Safeguarding the powerhouse: antibody-based characterisation of trypanosome mitochondrial quality control proteins at Lancaster University, listed on FindAPhD.com
https://www.findaphd.com/phds/project/safeguarding-the-powerhouse-antibody-based-characterisation-of-trypanosome-mitochondrial-quality-control-proteins/?p193962
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reposted by
Andrew Maclean
SheinerLab
6 months ago
If you are a committed scientist who wishes to work with Toxoplasma or with organelles (or both!!) - come work with us:
www.jobs.gla.ac.uk/job/research...
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reposted by
Andrew Maclean
Juan Carlos De la Concepcion
6 months ago
Please share! PhD position (4 years) available in my group
@zmbp-tuebingen.bsky.social
. We look for candidates with solid aptitude in computer science to cross disciplines and use cutting edge imaging to understand host infection by destructive plant pathogens.
uni-tuebingen.de/universitaet...
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reposted by
Andrew Maclean
Victor Tobiasson
6 months ago
LAST CALL! Come join me at Glasgow University for evolutionary structural biology! We have fully positions. Computational Postdoc:
www.jobs.gla.ac.uk/job/research...
Structural Postdoc:
www.jobs.gla.ac.uk/job/research...
Technician:
www.jobs.gla.ac.uk/job/technici...
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Technician
Job PurposeThe post holder will join the School of Infection and Immunity, supporting structural biology research under the supervision of Dr Victor Tobiasson (Principal Investigator). The applican...
https://www.jobs.gla.ac.uk/job/technician-5770250?source=gla.ac.uk
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reposted by
Andrew Maclean
Victor Tobiasson
6 months ago
FYI were starting weird structure/evolution/biology stuff at Glasgow University! If you're interested let me know! Tell your friends! CRYO
www.jobs.gla.ac.uk/job/research...
BIOINFO
www.jobs.gla.ac.uk/job/research...
TECHNICIAN
www.jobs.gla.ac.uk/job/technici...
#science
#hiring
#evolution
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reposted by
Andrew Maclean
Mathieu Gissot
6 months ago
We are actively recruiting a Post doc to work on the regulation of Toxoplasma différenciation. Please send a CV and cover letter if interested.
ciil.fr/teams/apicompl…
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Accueil - Université de LilleAccueil - Université de Lille
L’Université de Lille a obtenu la labellisation DD&RS – Développement durable et Responsabilité sociétale pour une durée de quatre ans.
https://ciil.fr/teams/apicompl…
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reposted by
Andrew Maclean
Sara MaciasRNA
6 months ago
Happy to share with you our work on how the interferon response impacts embryonic development 🦠Mammalian embryos contain endogenous dsRNAs that resemble viruses and can be misrecognised by the dsRNA sensor MDA5. Thanks to all collaborators, we could not have done it without you 🤩
rdcu.be/eWMfA
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Double stranded RNA sensing is silenced during early embryonic development
Nature Communications - The type I interferon response is suppressed during early development, making embryos susceptible to pathogens. Here, the authors show that this suppression contributes to...
https://rdcu.be/eWMfA
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reposted by
Andrew Maclean
Nath Jones
7 months ago
I am pleased to share our latest preprint, detailing the characterisation of BDF7 in Leishmania. This non-canonical bromodomain factor is essential for the parasite to live inside the host macrophage and has a parasite specific function compared to the host ortholog , ATAD2. Details in the link:
add a skeleton here at some point
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Andrew Maclean
Paul Sigala
7 months ago
Happy to share a new preprint exploring the unusual biochemistry of a "weirdly" diverged cytochrome c in malaria parasites that exemplifies a lineage common to many apicomplexan parasites.
@uofubiochem.bsky.social
@uuhsresearch.bsky.social
@uofutahcihd.bsky.social
www.biorxiv.org/content/10.6...
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A Divergent Cytochrome c in Malaria Parasites with an Anomalously Low Redox Potential
Eukaryotic cytochrome (cyt) c is a highly conserved mitochondrial protein central to cellular respiration, featuring a covalently attached hexacoordinate heme whose redox potential is tuned by axial H...
https://www.biorxiv.org/content/10.64898/2025.12.23.696199v1
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Was a lot of fun working with
@sheinerlab.bsky.social
and Julius Lukes and his lab to explore the weird mitochondria of these under explored parasites. Thanks to all the authors.
add a skeleton here at some point
7 months ago
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reposted by
Andrew Maclean
André Schneider, University of Bern
7 months ago
In the early 1980ies the labs of Cordingley, Boothroyd and Borst discovered that the LSU rRNA of T. brucei is processed into 6 fragment. Now more than 30 years later Simona Amodeo at al. found the factors that mediate these trypanosomatid-specific processing events.
academic.oup.com/nar/article/...
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A trypanosome-specific complex mediates late-stage processing of cytosolic LSU rRNA
Abstract. Unlike most eukaryotes, Trypanosoma brucei processes its cytosolic large subunit (LSU) RNA into six fragments. The factors responsible for these
https://academic.oup.com/nar/article/53/22/gkaf1327/8378191
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Andrew Maclean
Courtney Stairs
7 months ago
Save the date! The next instalment of Comparative Genomics of Unicellular Eukaryotes is a GO! Join us next year for a programme of talks, posters, ECR/networking activities. Website and registration details to follow in the coming weeks. See you October 5-10 2026 in beautiful San Feliu!!
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Interested in parasitology? Looking to do a PhD? Cone join me and
@geordieparasit.bsky.social
in Edinburgh as we try and work out how human parasites get their vitamins.
add a skeleton here at some point
8 months ago
0
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reposted by
Andrew Maclean
Jiménez-Ruiz Lab
8 months ago
Our new paper is out in Nature Communications! 🎉 We explore how Toxoplasma gondii organizes parasite development, combining cell biology and expansion microscopy to reveal new structural insights.
#Toxoplasma
@meissnerlab.bsky.social
@natcomms.nature.com
www.nature.com/articles/s41...
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reposted by
Andrew Maclean
Ross Waller
8 months ago
Excited to release the Herculean efforts of
@scottchisholm.bsky.social
&Co. defining the subcellular
#hyperLOPIT
spatial proteome of
#Plasmodium
schizonts. Proteomes defining 24 subcellular niches, including exported compartments in the blood cell, are identified.
www.biorxiv.org/content/10.1...
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Andrew Maclean
bishara marzook
8 months ago
There's still time to register for CoccidiaUK in London - it's going to be a jam-packed two days of talks by early-career parasitologists, a knowledge transfer session, plus trivia and prizes! It's
@crick.ac.uk
(very central) & we're cooking up some fun swag :)
www.eventbrite.co.uk/e/coccidiauk...
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CoccidiaUK 2025
A biannual gathering of parasitologists from across the UK to discuss all things coccidian!
https://www.eventbrite.co.uk/e/coccidiauk-2025-tickets-1967671128313
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reposted by
Andrew Maclean
8 months ago
Looking to start a PhD in October 2026 and learn about bioinformatics and the regulation of TGF-beta signalling in macrophages? Check out this PhD opportunity with a multidisciplinary team at the University of Edinburgh:
www.findaphd.com/phds/project...
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Precision Medicine DTP - Towards precision therapeutics for macrophages: developing a multi-organ understanding of macrophage control by TGF-β at University of Edinburgh on FindAPhD.com
PhD Project - Precision Medicine DTP - Towards precision therapeutics for macrophages: developing a multi-organ understanding of macrophage control by TGF-β at University of Edinburgh, listed on ...
https://www.findaphd.com/phds/project/precision-medicine-dtp-towards-precision-therapeutics-for-macrophages-developing-a-multi-organ-understanding-of-macrophage-control-by-tgf/?p191419
0
2
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reposted by
Andrew Maclean
Bungo Akiyoshi
8 months ago
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK)
www.findaphd.com/phds/project...
add a skeleton here at some point
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Andrew Maclean
SPPIRIT Network
9 months ago
Coming up: Postdoctoral fellowship mini-workshop as a part of the SPPIRIT Forum series. EMBO, Marie Curie, and Wellcome Early Career fellows will share their advice on fellowship applications. Join us at 12 noon on Thursday 14th November! Register at
docs.google.com/forms/d/e/1F...
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reposted by
Andrew Maclean
DrPrernaVohra
9 months ago
If you’re interested in solving bacterial mysteries, this PhD project is for you!
www.findaphd.com/phds/project...
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Investigating the role of the Vi antigen in Salmonella pathogenesis. at University of Edinburgh on FindAPhD.com
PhD Project - Investigating the role of the Vi antigen in Salmonella pathogenesis. at University of Edinburgh, listed on FindAPhD.com
https://www.findaphd.com/phds/project/investigating-the-role-of-the-vi-antigen-in-salmonella-pathogenesis/?p189589
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Andrew Maclean
Dr. Mattie Christine Pawlowic
9 months ago
Incredibly proud to share that our work on Cryptosporidium Oocyst Wall Proteins is published in @PLOSPathogens
journals.plos.org/plospathogen...
Led by previous PhD student @BacchettiRoss and carried on by current PhD student, Sarah Stevens.
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Cryptosporidium oocyst wall proteins are true components of the oocyst wall and COWP8 is not required for parasite transmission
Author summary Infection with Cryptosporidium causes diarrhoea, which can be fatal for malnourished children or people who are immunocompromised. There is no vaccine or effective medicines available t...
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1013561
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