Marketa Novotna
@marketanovotna.bsky.social
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Interested in kinetoplastids | Genetics enthusiast | Postdoc in David Horn's group
reposted by
Marketa Novotna
SPPIRIT Network
7 days ago
Coming up: Postdoctoral fellowship mini-workshop as a part of the SPPIRIT Forum series. EMBO, Marie Curie, and Wellcome Early Career fellows will share their advice on fellowship applications. Join us at 12 noon on Thursday 14th November! Register at
docs.google.com/forms/d/e/1F...
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Another piece of the VSG expression control puzzle: Active VSG transcript is required for allelic exclusion, acting as both, non-coding and coding RNA. Shout out to Douglas Escrivani and the team!
academic.oup.com/nar/article/53/19/gkaf1011/8294349
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A non-coding role for trypanosome VSG transcripts in allelic exclusion
Abstract. Bloodstream-form African trypanosomes display antigenic variation. This requires mono-telomeric but switchable expression of a Variant Surface Gl
https://academic.oup.com/nar/article/53/19/gkaf1011/8294349
18 days ago
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Marketa Novotna
Manu De Rycker
about 2 months ago
#Chagas
disease remains very neglected, and not only in the US, in spite of an estimated 8 million people being infected with T. cruzi. We, and our collaborators, aim to develop new medicines, but this is becoming increasingly challenging due to lack of funding.
www.theguardian.com/us-news/2025...
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‘Kissing bug’ disease should be treated as endemic in US, scientists say
People in at least eight states have been infected with Chagas, new report says, amid low awareness of disease
https://www.theguardian.com/us-news/2025/sep/13/kissing-bug-chagas-disease
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Save the date and join us on 22nd of August for a parasitology journal club, 1st session of the SPPIRIT Forum series.
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3 months ago
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reposted by
Marketa Novotna
Faria Tryps Lab
4 months ago
www.nature.com/articles/s41...
Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!
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Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes - Nature Communications
Transcription in trypanosomatids, such as Trypanosoma brucei, is predominantly polycistronic and involves unconventional RNA polymerase II promoters. This study uses precision gene editing, site-satur...
https://www.nature.com/articles/s41467-025-61480-z
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I used inducible CRISPR/Cas9 to make Trypanosoma brucei cell line that allowed me to edit originally muti-copy histone gene. We uncovered a novel role of H4 histone tail in gene regulation. I enjoyed working on this exciting project with
@joanarcf.bsky.social
, a great mentor.
doi.org/10.1038/s414...
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Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes - Nature Communications
Transcription in trypanosomatids, such as Trypanosoma brucei, is predominantly polycistronic and involves unconventional RNA polymerase II promoters. This study uses precision gene editing, site-satur...
https://www.nature.com/articles/s41467-025-61480-z
4 months ago
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reposted by
Marketa Novotna
Faria Tryps Lab
6 months ago
So happy to share the first preprint from our lab on post-transcriptional regulation at the VSG expression-site body in trypanosomes.
@ybri-uoy.bsky.social
@york.ac.uk
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Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes
Antigenic variation is a sophisticated immune evasion strategy employed by many pathogens. Trypanosoma brucei expresses a single Variant-Surface-Glycoprotein (VSG) from a large genetic repertoire, whi...
https://www.biorxiv.org/content/10.1101/2025.05.24.654301v1
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reposted by
Marketa Novotna
Dr. Mattie Christine Pawlowic
6 months ago
If you have ever wanted to know "Where is the gut is the parasite?" this pre-print is for you. 🐮 Led by Peyton, with thanks to our wonderful collaborators at
@moredunfoundation.bsky.social
Frank Katzer,
@geordieparasit.bsky.social
and EMs by
@lemgruber.bsky.social
www.biorxiv.org/content/10.1...
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Tissue atlas of Cryptosporidium parvum infection reveals contrasts between the natural neonatal calf model and laboratory mouse models
Cryptosporidium is an apicomplexan parasite that causes diarrhoeal disease. The species C. parvum is zoonotic and causes significant morbidity and mortality for both humans and farm animals; most comm...
https://www.biorxiv.org/content/10.1101/2025.05.05.652177v1.full.pdf+html
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I am delighted that the preprint of my PhD work is out! We used Cas9-based method to edit essential polycistronic histone H4 gene in T. brucei for the first time. A big thanks to
@fariatrypslab.bsky.social
who was a fantastic mentor during my PhD
www.biorxiv.org/content/10.1...
#tbrucei
#epigenetics
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Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes
Transcription of protein coding genes in trypanosomatids is atypical and almost exclusively polycistronic. In Trypanosoma brucei, approximately 150 polycistrons, and 8000 genes, are constitutively tra...
https://www.biorxiv.org/content/10.1101/2025.03.21.644654v1
8 months ago
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reposted by
Marketa Novotna
Emma Marie Briggs
8 months ago
Funded PhD project with myself, Prof. Paul Denny at Durham University and Dr Kalesh Karunakaran at Teeside University now open for applications!
www.findaphd.com/phds/project...
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Uncovering the adaptation mechanism that generate dormant forms of Leishmania microbes with omics approaches at Newcastle University on FindAPhD.com
PhD Project - Uncovering the adaptation mechanism that generate dormant forms of Leishmania microbes with omics approaches at Newcastle University, listed on FindAPhD.com
https://www.findaphd.com/phds/project/uncovering-the-adaptation-mechanism-that-generate-dormant-forms-of-leishmania-microbes-with-omics-approaches/?p182740
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reposted by
Marketa Novotna
Maria Bernabeu
9 months ago
Happy to announce that we are running the third edition of the EMBL-UNESCO residency on infection biology. If you are an African female scientist and would like to do a research stay at EMBL, my lab is a possible hosting group. Deadline March 31st!
www.embl.org/about/info/s...
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reposted by
Marketa Novotna
WHO
10 months ago
🧵 🙌🏾 Congratulations
#Guinea
for eliminating sleeping sickness (gambiense form) as a public health problem in the country!
bit.ly/3Cgp0zq
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reposted by
Marketa Novotna
Trends in Parasitology
10 months ago
Our Jan issue highlights
@sppirit-network.bsky.social
connecting
#Scottish
#parasitology
#ECRs
, written by R. Edgar
@jackhanna.bsky.social
@marketanovotna.bsky.social
@martacampillo.bsky.social
@mukul1190.bsky.social
@shikhas.bsky.social
@vfrank.bsky.social
& M.Ridgway
www.cell.com/trends/paras...
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reposted by
Marketa Novotna
Abhinay Ramaprasad
10 months ago
🥁🥁 Job alertttt!! Interested in weird biology of malaria parasites? Inducible genetic screens? Single-cell RNAseq? Come postdoc with us -
www.parafugelab.com
! International applicants or applicants just finishing up their PhD, both welcome!!
www.jobs.gla.ac.uk/job/research...
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Research Assistant/Associate
Job Purpose We are seeking to recruit a motivated and creative Research Assistant/Associate (postdoctoral researcher) to work within an MRC-funded research programme https://gtr.ukri.org/projects?...
https://www.jobs.gla.ac.uk/job/research-assistant-slash-associate-1
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reposted by
Marketa Novotna
Luisa Figueiredo
10 months ago
Have you finished your
#PhD
and are interested in exploring how
#parasites
cross the vasculature to colonize tissues? Do you fancy catching some
#waves
in the Atlantic? Or eating grilled fish by the beach? Join us in
#Lisbon
at GIMM, where science meets quality of life.
@parasitesrule.bsky.social
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If you are looking for a postdoc in tryps, check out this recent vacancy in the Faria lab in York. Great opportunity to work with a supportive mentor using cutting-edge techniques to address exciting questions.
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10 months ago
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If you are a budding parasitologist and you would like to spend a great summer full of science, networking, and fun with your peers, there is still time to apply for Biology of Parasitism course at
@mblscience.bsky.social
! Deadline 29th of January.
tinyurl.com/applyBoP
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Biology of Parasitism: Modern Approaches | Marine Biological Laboratory
A unique course for advanced graduate students, postdocs, and independent investigators, who are seeking in-depth training in modern approaches to the study of protozoan parasites and parasitic worms.
https://www.mbl.edu/education/advanced-research-training-courses/course-offerings/biology-parasitism-modern-approaches
10 months ago
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Have you heard of SPPIRIT (
@sppirit-network.bsky.social
)? In this article we explain how this ECR-led network of Scottish parasitologists was established, what impact it has already had and where it is heading!
www.cell.com/trends/paras...
10 months ago
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