Paul Sigala
@sigalalab.bsky.social
📤 52
📥 33
📝 17
biochemist, parasitologist, mentor, student
https://sigala.biochem.utah.edu
Thrilled to share a new collaborative preprint, joint with Sean Prigge
@johnshopkinssph.bsky.social
, on the apicoplast ACP in
#malaria
parasites.
@uofubiochem.bsky.social
@uuhsresearch.bsky.social
@parasitesrule.org
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.03.29.713301v1
21 days ago
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Happy to announce a new review article by MD/PhD student Kade Loveridge on iron metabolism in
#malaria
#parasites
.
@uofubiochem.bsky.social
@uuhsresearch.bsky.social
@uofutahcihd.bsky.social
@parasitesrule.org
journals.plos.org/plospathogen...
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Fifty shades of iron: Unorthodox mechanisms of iron acquisition and utilization in blood-stage Plasmodium parasites
Plasmodium falciparum parasites cause severe human malaria and depend on iron for essential metabolic processes during all phases of their complicated lifecycle, including when growing in human red bl...
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1014030#references
about 1 month ago
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reposted by
Paul Sigala
SACNAS Utah Chapter
about 2 months ago
Come and learn more about Dr. McReynolds's journey to science while enjoying a warm and delicious breakfast! This event is open to all, and everyone is welcome, so bring a friend and help spread the word!
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reposted by
Paul Sigala
SACNAS Utah Chapter
3 months ago
We’re excited to invite you to support our SACNAS student chapter through a fundraising event at Space Tea! 🧋🧋 To make your purchase count toward the fundraiser, please mention SACNAS at checkout!! Please join us! 🧸
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Happy to share a new preprint exploring the unusual biochemistry of a "weirdly" diverged cytochrome c in malaria parasites that exemplifies a lineage common to many apicomplexan parasites.
@uofubiochem.bsky.social
@uuhsresearch.bsky.social
@uofutahcihd.bsky.social
www.biorxiv.org/content/10.6...
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A Divergent Cytochrome c in Malaria Parasites with an Anomalously Low Redox Potential
Eukaryotic cytochrome (cyt) c is a highly conserved mitochondrial protein central to cellular respiration, featuring a covalently attached hexacoordinate heme whose redox potential is tuned by axial H...
https://www.biorxiv.org/content/10.64898/2025.12.23.696199v1
4 months ago
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@uofuhealth.bsky.social
put out a gracious highlight on our manuscript
@pnas.org
#malaria
@uofubiochem.bsky.social
@uofutahcihd.bsky.social
healthcare.utah.edu/newsroom/new...
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Malaria Parasites are Full of Wildly Spinning Iron Crystals. Scientists Finally Know Why.
The first known metallic nanomotor in biology is powered by rocket fuel.
https://healthcare.utah.edu/newsroom/news/2025/10/malaria-parasites-are-full-of-wildly-spinning-iron-crystals-scientists
6 months ago
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Thrilled our study on heme crystal motion in
#malaria
@parasitesrule.org
is now published
@pnas.org
, support from NIH,
@bwfund.bsky.social
,
@uofutahcihd.bsky.social
, UofU 3i. With Fu and Bidone labs
@price.utah.edu
,
@uofubiochem.bsky.social
,
@uofuhealth.bsky.social
www.pnas.org/doi/10.1073/...
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Chemical propulsion of hemozoin crystal motion in malaria parasites | PNAS
Malaria parasites infect red blood cells where they digest host hemoglobin and release free heme inside a lysosome-like organelle called the food v...
https://www.pnas.org/doi/10.1073/pnas.2513845122
6 months ago
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It was a pleasure to host these speakers for our 2025
#Postdoc
Rising Stars event! Great science and terrific symposium.
@uofubiochem.bsky.social
@uuhsresearch.bsky.social
7 months ago
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Very excited to welcome these
#postdoc
speakers to our annual
@utah.edu
Rising Stars Symposium cohosted by
@uofubiochem.bsky.social
and Med Chem
@uuhsresearch.bsky.social
with keynote address by Ryan Watts at Denali
7 months ago
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We're thrilled to announce the 2025 Postdoctoral Rising Stars Symposium cohosted
@uofuhealth.bsky.social
by
@uofubiochem.bsky.social
and MedChem with keynote by Ryan Watts at Denali Therapeutics
7 months ago
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Congratulations to lab members Aldo García-Guerrero and Erica Hastings for winning the
@uofubiochem.bsky.social
Evelyn Bruenger and Marjorie Riches Gunn Awards for Postdoctoral and Graduate Student Research Excellence, respectively!
#malaria
@uofutahcihd.bsky.social
@uuhsresearch.bsky.social
10 months ago
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Happening today!
@uofubiochem.bsky.social
@uofutahcihd.bsky.social
@parasitesrule.org
#malaria
#biophysics
www.biorxiv.org/content/10.1...
add a skeleton here at some point
11 months ago
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reposted by
Paul Sigala
U of Utah Dept of Biochemistry
12 months ago
Congrats to our chair, Wes Sundquist, on being awarded the Bhaumik Breakthrough of the Year Award for work on lenacapavir!
add a skeleton here at some point
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It's an honor to announce the upcoming PhD thesis defense of Erica Hastings, who will present her work on
#malaria
parasites and the biophysics of hemozoin motion
@uofubiochem.bsky.social
ky.social
@uofutahcihd.bsky.social
@parasitesrule.org
12 months ago
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Thrilled to announce a new collaborative preprint from PhD student Erica Hastings unraveling the nature and mechanism of fascinating hemozoin crystal motion inside
#malaria
parasites
@uofubiochem.bsky.social
@uofutahcihd.bsky.social
@bwfund.bsky.social
@parasitesrule.org
t.co/zLPgIS1rig
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https://www.biorxiv.org/content/10.1101/2025.04.25.650681v1
https://t.co/zLPgIS1rig
12 months ago
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Thanks to
@pubs.acs.org
for featuring our work on cyt c biogenesis in
#malaria
parasites on the front cover!
@uofubiochem.bsky.social
@uofutahcihd.bsky.social
pubs.acs.org/doi/10.1021/...
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ACS Infectious Diseases
Predicted structure of the key complex from malaria parasites that attaches heme to mitochondrial cytochrome c to support the critical function of the electron transport chain. This structure was predicted using the AlphaFold 3 server and rendered using PyMOL. View the article.
https://pubs.acs.org/toc/aidcbc/11/4
about 1 year ago
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Very proud of PhD student Erica Hastings who gave a talk and poster at the American Physical Society meeting on collaborative work to understand hemozoin crystal motion in
#malaria
parasites
@uofubiochem.bsky.social
@uofutahcihd.bsky.social
@bwfund.bsky.social
Paper coming soon!
about 1 year ago
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