Paul Sigala
@sigalalab.bsky.social
๐ค 47
๐ฅ 33
๐ 14
biochemist, parasitologist, mentor, student
https://sigala.biochem.utah.edu
Happy to share a new preprint exploring the unusual biochemistry of a "weirdly" diverged cytochrome c in malaria parasites that exemplifies a lineage common to many apicomplexan parasites.
@uofubiochem.bsky.social
@uuhsresearch.bsky.social
@uofutahcihd.bsky.social
www.biorxiv.org/content/10.6...
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A Divergent Cytochrome c in Malaria Parasites with an Anomalously Low Redox Potential
Eukaryotic cytochrome (cyt) c is a highly conserved mitochondrial protein central to cellular respiration, featuring a covalently attached hexacoordinate heme whose redox potential is tuned by axial H...
https://www.biorxiv.org/content/10.64898/2025.12.23.696199v1
11 days ago
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@uofuhealth.bsky.social
put out a gracious highlight on our manuscript
@pnas.org
#malaria
@uofubiochem.bsky.social
@uofutahcihd.bsky.social
healthcare.utah.edu/newsroom/new...
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Malaria Parasites are Full of Wildly Spinning Iron Crystals. Scientists Finally Know Why.
The first known metallic nanomotor in biology is powered by rocket fuel.
https://healthcare.utah.edu/newsroom/news/2025/10/malaria-parasites-are-full-of-wildly-spinning-iron-crystals-scientists
2 months ago
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Thrilled our study on heme crystal motion in
#malaria
@parasitesrule.org
is now published
@pnas.org
, support from NIH,
@bwfund.bsky.social
,
@uofutahcihd.bsky.social
, UofU 3i. With Fu and Bidone labs
@price.utah.edu
,
@uofubiochem.bsky.social
,
@uofuhealth.bsky.social
www.pnas.org/doi/10.1073/...
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Chemical propulsion of hemozoin crystal motion in malaria parasites | PNAS
Malaria parasites infect red blood cells where they digest host hemoglobin and release free heme inside a lysosome-like organelle called the food v...
https://www.pnas.org/doi/10.1073/pnas.2513845122
2 months ago
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It was a pleasure to host these speakers for our 2025
#Postdoc
Rising Stars event! Great science and terrific symposium.
@uofubiochem.bsky.social
@uuhsresearch.bsky.social
3 months ago
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Very excited to welcome these
#postdoc
speakers to our annual
@utah.edu
Rising Stars Symposium cohosted by
@uofubiochem.bsky.social
and Med Chem
@uuhsresearch.bsky.social
with keynote address by Ryan Watts at Denali
3 months ago
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We're thrilled to announce the 2025 Postdoctoral Rising Stars Symposium cohosted
@uofuhealth.bsky.social
by
@uofubiochem.bsky.social
and MedChem with keynote by Ryan Watts at Denali Therapeutics
4 months ago
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Congratulations to lab members Aldo Garcรญa-Guerrero and Erica Hastings for winning the
@uofubiochem.bsky.social
Evelyn Bruenger and Marjorie Riches Gunn Awards for Postdoctoral and Graduate Student Research Excellence, respectively!
#malaria
@uofutahcihd.bsky.social
@uuhsresearch.bsky.social
7 months ago
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Happening today!
@uofubiochem.bsky.social
@uofutahcihd.bsky.social
@parasitesrule.org
#malaria
#biophysics
www.biorxiv.org/content/10.1...
add a skeleton here at some point
8 months ago
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reposted by
Paul Sigala
U of Utah Dept of Biochemistry
8 months ago
Congrats to our chair, Wes Sundquist, on being awarded the Bhaumik Breakthrough of the Year Award for work on lenacapavir!
add a skeleton here at some point
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It's an honor to announce the upcoming PhD thesis defense of Erica Hastings, who will present her work on
#malaria
parasites and the biophysics of hemozoin motion
@uofubiochem.bsky.social
ky.social
@uofutahcihd.bsky.social
@parasitesrule.org
8 months ago
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Thrilled to announce a new collaborative preprint from PhD student Erica Hastings unraveling the nature and mechanism of fascinating hemozoin crystal motion inside
#malaria
parasites
@uofubiochem.bsky.social
@uofutahcihd.bsky.social
@bwfund.bsky.social
@parasitesrule.org
t.co/zLPgIS1rig
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https://www.biorxiv.org/content/10.1101/2025.04.25.650681v1
https://t.co/zLPgIS1rig
8 months ago
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Thanks to
@pubs.acs.org
for featuring our work on cyt c biogenesis in
#malaria
parasites on the front cover!
@uofubiochem.bsky.social
@uofutahcihd.bsky.social
pubs.acs.org/doi/10.1021/...
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ACS Infectious Diseases
Predicted structure of the key complex from malaria parasites that attaches heme to mitochondrial cytochrome c to support the critical function of the electron transport chain. This structure was predicted using the AlphaFold 3 server and rendered using PyMOL. View the article.
https://pubs.acs.org/toc/aidcbc/11/4
9 months ago
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Very proud of PhD student Erica Hastings who gave a talk and poster at the American Physical Society meeting on collaborative work to understand hemozoin crystal motion in
#malaria
parasites
@uofubiochem.bsky.social
@uofutahcihd.bsky.social
@bwfund.bsky.social
Paper coming soon!
10 months ago
0
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