'Redefining dopaminergic synapses beyond the classical paradigm' Kenshiro Fujise, Jaya Mishra, Nasser Karmali & Nisha M. Rafiq @nishamrafiq.bsky.social www.cell.com/trends/neuro...

what a beauty!!

Looking forward to speak here!

Do you like following rules… but also breaking them? So does your dopaminergic synapse! 😎🧠 Our new Trends in Neurosciences review dives into the non-classical side of dopamine signaling, notably the tools reshaping how we see it (CLEM, cryo-CLEM, serial EM + more).

what an animation!

New paper alert! I’m very excited to share our paper published in @embojournal.org! @pdc-lab.bsky.social @yaleneuro.bsky.social

@anbangdai.bsky.social et al. @pdc-lab.bsky.social report the localization of BLTP2 in different human cell types & reveal binding partners that mediate its tethering to the PM & to PM-connected structures including certain #endosomes & #macropinosomes undergoing fusion rupress.org/jcb/article/...

Very happy that the first article from my postdoc work in the Tomancak lab is now published @PNAS! www.pnas.org/doi/10.1073/.... We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)

Cilia in the brain! Depiction on angular and orientation information across different parts of the mouse brain...

Did you know that Bioimage Archive has a specific database for people to share AI-ready imaging datasets? I did not until @yanlanmao.bsky.social told me! Please deposit! If people regularly submitted, it would have a huge collective impact on bioimage analysis. www.ebi.ac.uk/bioimage-arc...

EU augments opportunities for scientists around the world to launch or re-launch their careers in Europe.

Today, FutureHouse is releasing the first dedicated AI Agents for Science, via our Platform. These agents are able to perform a wide variety of scientific tasks better than humans. With the platform, we are bringing these capabilities to the wider community. 1/2

A package of research papers from the MICrONS (Machine Intelligence from Cortical Networks) consortium in Nature and Nature Methods provides a detailed map of mouse brain cell structure and connections, offering insights into how they relate to activity in the mouse brain. 🧪

We're live! @inikon.bsky.social used modular proximity labeling to identify ciliary EV cargo in #celegans. This EV-TurboID approach can be applied in cell- & tissue-specific manners to define the composition of distinct EV subtypes, a major challenge of the EV field. www.nature.com/articles/s41...

Eid Mubarak! May this special day bring peace, joy, and blessings to you and your loved ones. 😊

Post doc in Europe? 🇪🇺🔬💡 It’s open to anyone in the 🌍 Call open 9 April 25 marie-sklodowska-curie-actions.ec.europa.eu/actions/post...

Constrained roads to complex brains Neural development and brain circuit evolution converged in birds and mammals www.science.org/doi/10.1126/...

Very happy to share our last preprint where we investigated the vesicular organization of dopamine hub synapses with cryo-CLEM. It is a brain structure that emerges as an important regulator of striatal activity. Many thanks to David Perrais, Etienne Herzog and the lab of @fronzeslab.bsky.social !

"DA vesicles are bigger and less round" in synaptosomes, beautiful cryoEM images! We too showed this in iPSC-derived DA neurons, of course using just regular EM 😃 See link here: www.nature.com/articles/s41... Exciting times for non-classical synapse!

Neuronal cilia and ubiquitination

Our paper on the phase separation of synaptophysin+ and dopamine+ vesicles, as well as their co-existence in iPSC-derived DA neurons, is now online! 🤓 www.nature.com/articles/s41...

Our review on the emerging roles for primary cilia in synapses and neurological disorders is now online! 😃https://www.sciencedirect.com/science/article/pii/S0962892424002319