What if part of Huntington's disease wasn't just damage, but a circuit stuck in the wrong pattern? Our new paper, out today in Nature, tests that idea.

NEW! Explore @thetransmitter.bsky.social’s newest tool, Neuro Funding Finder. Discover grants, fellowships and funding opportunities for neuroscience research at all career stages. Find your next funding source and apply, all in one place: thetransmitter.org/neuroscience... #neuroskyence

I’m very excited to share that our paper is now out in Neuron! 🎉

HHMI’s Janelia Research Campus will close two of its programs dedicated to rodent work, @thetransmitter.bsky.social has learned. #neuroskyence By @callimcflurry.bsky.social www.thetransmitter.org/community/ex...

It will never stop being funny to me that the street fighter subreddit has a much better, well reasoned ai policy vis a vis literally all universities.

Where do ideas come from? We founded the Night Science Institute with the mission of training in the creative scientific process every early-career scientist in the world. Help us to spread the word with this clip! www.youtube.com/watch?v=0c1V... @nightsciencepod.bsky.social

If you use this, ask yourself: do you really like your job? 🧪

Janelia is built for this moment. Starting today, we're taking on 2 big bets: cracking how a vertebrate brain generates behavior, & building AI-in-the-Loop Discovery — a new way of doing biology. Tiny transparent fish + one of neuroscience’s biggest questions? Let's go: hhmi.news/2BigBets

1/11 Excited to share my postdoc work from @schierlab.bsky.social and Rainer Friedrich! 🐟👃 How does the brain decide whether an odor is good or bad? In larval zebrafish, we find that odor preference is reflected in spatially cohesive neuronal domains of the olfactory bulb. 🧵

Goodness me what bollocks. Of both kinds. Neuro- and AI-bollocks. Tell me how the 30 neurons in the lobster‘s stomach do what they do, lads - dig out the “core algorithm” of that and we might be getting somewhere...

Now published - the #BANC! A full central nervous system (CNS) connectome of a limbed animal at single-synapse resolution, enabling us to follow sensory-motor arcs and understand how the CNS controls the body. rdcu.be/fncjS. #neuroscience. Video by @quorumetrix.bsky.social 1/18

Mice produce interneurons in the septum as a response to aversive experiences and antidepressant treatment. www.science.org/doi/10.1126/...

There's a persistent fantasy that maybe some other nice countries will start mass-hiring US scientists. That's not going to happen. A few high-profile, big name researchers will get poached, sure. But most countries, including some very nice ones, are underemploying their own scientists already.

Loved sharing my thoughts about Hopfield’s seminal paper with @thetransmitter.bsky.social @franciscorr25.bsky.social . It’s so important to be reminded of the beauty and impact of free scientific investigation in these uncertain times.

Prediction without understanding sustained astronomy through a thousand years of epicycles, writes @tonyzador.bsky.social. AI is now offering neuroscience the same deal. #neuroskyence www.thetransmitter.org/machine-lear...

Many regions code for impact factor. Very cool!

In totally unsurprising news, Richard Dawkins is developing AI psychosis. Paywall bypass: archive.is/6RdK9

I have this *insane* idea that AI being shoved down our throats WILL result in a renaissance. A RENAISSANCE OF THE ARTS AND HUMANITIES! To which I say: LFG.

🎉 We’re delighted to announce Professor Erin Schuman, will become Director of the UCL Queen Square Institute (@uclqsion.bsky.social) from 1 Jan 2027. www.ucl.ac.uk/news/2026/ap...

It was nice knowing you, central dogma.

Hungary has chosen Europe. Europe has always chosen Hungary. A country reclaims its European path. The Union grows stronger.

Our digital sphinx shows that DRL is so powerful that it finds a solution even when the constraints are completely wrong: worm brain, fly body, zero cellular and circuit compatibility. Give it a target behavior, it fits. It doesn't care about biology Code: github.com/Brunton-Lab/DigitalSphinx2026

🧵 New preprint led by @bingbrunton.bsky.social, @elliottabe.bsky.social, @lawrencehu.bsky.social We gave a worm brain control of a fly body and it walked What did we learn? Nothing, other than deep reinforcement learning is effective We call it the digital sphinx www.biorxiv.org/content/10.6...

The whole "AI" industry is just based on the hope that they can deskill people fast enough that they'll have to rent back cognitive support systems. Forever. It's like Uber. Just that they don't try to break existing transportation infrastructures but your brain.

How does the brain build a memory? A common assumption is that the neurons activated during an experience collectively form the memory engram. In our new Nature Neuroscience paper (finally out!), we show that this is not the case. www.nature.com/articles/s41...

First whole-brain recording of social sound processing in a vertebrate. Surprises start in the hindbrain; thalamus gates conspecific calls; male and female brains diverge downstream. Work by @joerghenninger.bsky.social, @mh123.bsky.social sky.social and team. www.biorxiv.org/content/10.6...

This is a very important story. Thank you @science.org for covering it. Two critical points: 1. SIMPLE INVESTIGATION! 2. Notice how not being desperate for money leads people to use good judgement? This is why philanthropy isn't going to fix what Trump has done to our scientific ecosystem.

I have a male friend who spent some time in Axel's lab. About the 3rd conversation he had with Axel, Axel broke the ice with "So, have you fucked [a female postdoc in the lab] yet?" My friend was horrified...

Breaking: Richard Axel, a Nobel Prize-winning scientist and professor, just announced that he was resigning as a co-director of a flagship neuroscience institute at Columbia University because of his friendship with Jeffery Epstein. www.nytimes.com/2026/02/25/n...

A new paper shows that less than 2 months of exposure to Twitter’s algorithmic feed significantly shifts people’s political views to the right. Moving from chronological feed to the algorithmic feed also increases engagement. This is one of the most concerning papers I’ve read in awhile.

“I don’t want to be in this place I want to go to my school.” - 7 year old imprisoned by ICE for 70 days in a concentration camp in Texas. Today, after @propublica.org published this story, the camp was raided to confiscate letters from the children. www.propublica.org/article/ice-...

Excited to launch Principia, a nonprofit research organisation at the intersection of deep learning theory and AI safety. Our goal is to develop theory for modern machine learning systems that can help us understand complex network behaviors, including those critical for AI safety and alignment. 1

In terms of what cures are being lost: - Epstein-Barr virus is perhaps the major trigger for multiple sclerosis - herpes simplex virus causes cold sores, genital herpes, infections in babies, deadly meningitis - shingles virus causes an intensely painful disease

Really nice work from the Holmes lab looking at amygdala astrocytes in fear memory and extinction! www.nature.com/articles/s41...

No joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition. Which just makes me want to share it again: www.nature.com/articles/d41...

“The human body is an obstacle to efficiency — the limited head, the distracted heart, the tired limbs. Taking things inside saps energy and time, retaining them takes up space; and all for occasional use, if at all.”

The only surprise is they admit it

hahahaha what

Save the date for the annual "Neural Circuits and Behaviour" satellite conference at the Canadian Association for Neuroscience annual meeting, cohosted by @franklandlab.bsky.social and myself on May 18, 2026. We have a great speaker lineup and will be selecting 4 trainees talks from our registrants!

Defending PhD student, looking over their thesis: “If I knew then what I know now, I could’ve done all of this in like 9 months.” A thread about my favorite pioneering cave explorers and why I don’t think AI will ever “solve” biology.

How does the brain control locomotion? In our new preprint, we uncover a brain circuit in Drosophila that controls forward walking independently of turning. This dedicated locomotor circuit enables flexible motor control and might reflect a shared principle across species. doi.org/10.64898/202...

What in the Gestapo is going on in Grand Rapids? Watch this activist get arrested *mid-interview* for speaking out against U.S. action in Venezuela.

Carolin Warnecke together with Hanna, Dennis, Bene & Kerstin from my lab show that re-exposure to reward diminishes multiple associated olfactory memories. We’re hiring 2 postdocs—DM/email me for details. #Postdoc #Hiring www.sciencedirect.com/science/arti...

📢 Please help spread the word: We’re hiring a Head of Student & Postdoc Affairs to coordinate our international PhD program, provide guidance & career counseling, lead training programs, collaborate on EDI initiatives, and manage alumni relations. Apply at www.fmi.ch/education-ca...

1/n: A new collaborative preprint from the lab to start the year: "A multi-ring shifter network computes head direction in zebrafish" together with Siyuan Mei, Martin Stemmler and Andreas Herz from the LMU, Munich.

That’s quite the pivot from LeCun who disagreed vigorously (let us say) with @garymarcus.bsky.social on this issue for quite some time…

"40 percent of MRI signals do not correspond to actual brain activity"; "Since tens of thousands of fMRI studies worldwide are based on this assumption, our results could lead to opposite interpretations in many of them.” www.tum.de/en/news-and-...

If the Romans had simply deported woke baby Jesus to South Sudan, a lot of trouble could have been avoided

This is exactly why people claiming "it came up with a new set of experiments/ideas/concepts" are carrying water for the weasels trying to put genAI on everything. This is how we get science defunded. This is how your colleagues lose their jobs 🧪

I wouldn't describe Jay as "man in the middle" unless I were making sort of human centipede analogy.