Professors: we must start teaching the creative scientific process to PhD students and postdocs! Register for our April 24 train-the-trainer event in New York to learn from us how to teach it. night-science.org/train-the-tr... Register by Jan. 30th for a free Night Science Podcast T-shirt!

With all the excitement about AI giving us answers, we often forget that the real trick is to figure out what is the question.

ISCO (Innovations in Single-Cell OMICS) will be back in beautiful Barcelona! 🗓️ 28th/29th of May 2026 📍Barcelona Biomedical Research Park @prbb.org (beachfront!) Keynotes: @bartdeplancke.bsky.social and @bocklab.bsky.social Submit your abstract and present your research! www.isco-conference.eu

@yusufroohani.bsky.social @rberrens.bsky.social @timcoorens.bsky.social @hsiuchuanlin.bsky.social @albarmeira.bsky.social @ferrannadeu.bsky.social @alejofraticelli.bsky.social @elimereu.bsky.social @simonhaas.bsky.social @leifludwig.bsky.social @stefaniegrosswendt.bsky.social

Not sure why @lpachter.bsky.social did not post this here. But it is brilliant. Single cell genomics finally makes it to the clinic.

🚀The Human Pancreas Atlas is here! With profiles of >4M cells and nuclei from 57 donors, this outstanding work is part of the @humancellatlas.org, led by @bihatcharite.bsky.social and @elimereu.bsky.social, with contributions from @hoheyn.bsky.social (CNAG) www.biorxiv.org/content/10.1... #ESPACE

The Berlin crew Ashley Sanders @simonhaas.bsky.social @leifludwig.bsky.social @stefaniegrosswendt.bsky.social is passing the torch to our co-organizers and partners in crime @elimereu.bsky.social @larsplus.bsky.social @alejofraticelli.bsky.social for ISCO 2026 in Barcelona www.isco-conference.eu

The Innovations in Single Cell Omics conference in Berlin was amazing! Great talks and we even had a Night Science workshop! 🙏 @stefaniegrosswendt.bsky.social, Ashley Sanders, @simonhaas.bsky.social, @leifludwig.bsky.social, @elimereu.bsky.social, @larsplus.bsky.social & @alejofraticelli.bsky.social

Meet Alessia Buratin 👩‍🔬 She focuses on Single Cell Multi Omics and Deep Learning Approach to reverse immunosuppression in Multiple Myeloma, under the supervision of Dra @elimereu.bsky.social at @carrerasijc.bsky.social. Read about Alessia and her project: carrerasleaders.eu/postdoctoral...

We're pleased to announce that Dr Ari Melnick has been appointed new Director of the Josep Carreras Institute. Dr Melnick will lead IJC in our mission to advance #research in #leukaemia and other malignant blood diseases. Read the full release here: www.carrerasresearch.org/en/news/dr-a...

Proud of our new perspective describing the role of mathematical biology for immunotherapy www.nature.com/articles/s41... @natbiotech.nature.com

Epigenetic enhancement of adoptive T cell immunotherapy www.cell.com/cancer-cell...

On my way to #Ascona in Switzerland) for this exciting congress, where we will discuss about modern benchmarking strategies to advance molecular biology!! Happy also to present our findings on the latest systematic evaluation of #singlecell multimodal data integrations in complex tissues. 🧬🔬👩🏻‍💻👩🏻‍🔬

🔬 Curious about the impact of #singlecell multimodal data on cell-type discovery? Check out our latest study: www.mereulab.org/post/do-we-r... . 📖 Too tired to read? No problem! 🎧 Listen to the NotebookLM #podcast included at the end of the post instead!

Join us at "Innovations in Single Cell Omics" in Berlin 5.12-13 (+ night science workshop!) www.isco-conference.eu Organizers: @stefaniegrosswendt.bsky.social, @simonhaas.bsky.social @leifludwig.bsky.social, Ashley Sanders, @larsplus.bsky.social, @elimereu.bsky.social, @alejofraticelli.bsky.social

🚀 Join the #ISCO2025 community at @mdc-berlin.bsky.social on May 12-13! 🚀 Don't miss this incredible opportunity to connect with top #singlecell & #spatial omics experts and participate in a special Workshop led by @itaiyanai.bsky.social. ⏳Abstract submissions: March 21) www.isco-conference.eu

🚀 Join the #ISCO2025 community at @mdc-berlin.bsky.social on May 12-13! 🚀 Don't miss this incredible opportunity to connect with top #singlecell & #spatial omics experts and participate in a special Workshop led by @itaiyanai.bsky.social. ⏳Abstract submissions: March 21) www.isco-conference.eu

📖 Too tired to read? No problem! 🎧 Listen to the #NotebookLM podcast at the end of the post here: www.mereulab.org/post/do-we-r...

🔬 Curious about the impact of #singlecell multimodal data on cell-type discovery? Check out our latest study: www.mereulab.org/post/do-we-r... . 📖 Too tired to read? No problem! 🎧 Listen to the NotebookLM #podcast included at the end of the post instead!

Ever wondered why we do all these #Omics? Here is your answer: biorxiv.org/content/10.1... 📜 Multi-Omics integration of a Human Cell Atlas @humancellatlas.org of the Kidney, coordinated by the #HCA Standards and Technology Working Group and co-led by @elimereu.bsky.social.

🚀 New Preprint Alert! 🚀 With the Standards and Technology Working Group of the @humancellatlas.org, we present a new preprint guiding multimodal #singlecell data integration and human organ atlas generation! 📄 Read the preprint: www.biorxiv.org/content/10.1...

Today, 2 postdoctoral researchers from #CarrerasLeaders have led our Young Researcher Seminars🙌 🧑‍🔬👩‍🔬 Gerard Martínez (@scuartero.bsky.social lab) has presented his work on myeloid leukemia of Down syndrome and Alessia Buratin ( @elimereu.bsky.social lab) on machine learning to enhance CAR-T therapies

ResolVI - addressing noise and bias in spatial transcriptomics www.biorxiv.org/content/10....

🚨 New paper alert 🚨 Our Human Microglia Atlas (HuMicA) characterizes #microglia subpopulations across 6 distinct #neurologic diseases. www.nature.com/articles/s41...

Great work on characterizing human microglia in 6 😱 neurological disorders! In collaboration with my next door colleagues at @eballestar.bsky.social’s lab!!

Made a #short about my internal conflicts on academic publishing #AcademicSky #PhDlife "Stop asking me where I want to publish our paper. I don't care...I just want people to read it. And maybe learn from it. Even build on it. Ok?" Is this #hopecore or #hopelesscore youtube.com/shorts/GV7NJ...

Researchers from the Crick have found that over 40% of variation in the way kidney cancer behaves is due to non-genetic factors. The findings were led by Angel Fernandez Sanroman with senior author Samra Turajlic www.crick.ac.uk/news-and-rep...

Excited to share our new study of #genomics🧬, #EHR📈 + treatment outcomes of 78K patients across 20 #cancers! We identified >700 mutations predicting which drugs💊 are effective for individual patients. Our #ML model predicts who responds well to immunotherapies. #precisioncancer

scRepertoire 2: Enhanced and Efficient Toolkit for Single-Cell Immune Profiling www.biorxiv.org/content/10.1...

Join us to decode the immune system with AI and advance immunotherapy research. 🌍 Part of RAMON LLULL - AIRA: 33 prestigious international postdoc fellowships. 📅 Apply by Feb 20. Start June 2025. 🔗 ramonllull-aira.eu 📩 [email protected] #AI #Postdoc #Genomics #Immunotherapy #Research

"Polls have shown that principal investigator biologists now spend up to 40 percent of their time—it’s a shocking number, 40 percent of their time—writing grants." www.harvardmagazine.com/2025/01/harv...

1/🚀 Excited to share RegVelo, our new cell model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇 biorxiv.org/content/10.1101/2024.12.11.627935v1

Last minute call !! Join us soon for the first Single-cell and spatial metabolomics online day! We have more than 700 registrations! Zoom, doors open 14.30 CET = 8.30 Boston, registration (mandatory) below. It's time for the program reveal! 1/4

Modeling and predicting single-cell multi-gene perturbation responses with scLAMBDA www.biorxiv.org/content/10.1...

Have you been thinking hard about statistical modelling of scATAC-seq data? (No.) Luckily for you, @aaronkwc.bsky.social has! Aaron will help you grok: What's going on? What is TF-IDF? Is there really single-cell level chromatin information? Check it out 👇 www.biorxiv.org/content/10.1... 🧪🧬💻

Quantifiable TCR repertoire changes in prediagnostic blood specimens among patients with high-grade ovarian cancer www.cell.com/cell-report...

Allogeneic CD19-targeted CAR-T therapy in patients with severe myositis and systemic sclerosis www.sciencedirect.com/science/arti... With commentary: Off-the-shelf CAR-T cells could prove paradigm shifting for autoimmune diseases www.sciencedirect.com/science/arti... in @cellpress.bsky.social

Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation www.nature.com/articles/s41... in @naturecellbiology.bsky.social by @steinaerts.bsky.social

tcrBLOSUM: an amino acid substitution matrix for sensitive alignment of distant epitope-specific TCRs academic.oup.com/bib/article...

Researchers at the Crick and @uclofficial.bsky.social have developed an algorithm that can identify which cell populations within a tumour are growing the fastest. The findings are part of the @cancerresearchuk.org-funded TRACERx study www.crick.ac.uk/news-and-rep...

Only a subset of patients respond to immunotherapy Why? Which ones? We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response. www.nature.com/articles/s41...

Hi! I just compiled some of the new Barcelona cancer labs! Many more missing, so let me know if anyone needs to be added! go.bsky.app/AkCGugm

A new approach helps examine the proportion of cancerous and healthy stem cells in patients with chronic myeloid leukaemia and how this influences treatment outcomes. https://buff.ly/3ULmWp6

Would you prefer to lead a lab alone or together with a science buddy? How interesting would be a research institute where joint labs are the standard?!

1/ 🧬 Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dim’s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces. biorxiv.org/content/10.1101/2024.11.06.622266v1

More than 40 @natureportfolio.bsky.social papers on the Human Cell Atlas.. Biology is changing so fast.. www.humancellatlas.org

Out today in Nature: "The Human Cell Atlas"! In my News and Views, I compare the cell atlas to early naturalists creating an atlas of South America. Researchers mining this cell atlas can now make big discoveries, just as the next naturalists then discovered evolution. www.nature.com/articles/d41...

Hello world!! 🌍I’m happy to join this community with new and old scientists friends! Stay tuned if you want to know more about our science in #singlecell applications to biomedical research! Soon a new benchmarking of sc multiomics integrations in reference data!

Vacancy: @bsc-cns.bsky.social is looking for #AI Institute Director We are establishing a new Institute of #ArtificialIntelligence The selected candidate will lead the Institute's operations & strategic vision, driving research at the intersection of #HPC & #AI ➡bsc.es/Z9Z #trabajo #feina #job