I can confirm this is accurate

So much chaos in the world and now this major scandal. How do these people even sleep at night? www.cbc.ca/news/canada/...

Advances in computational methods for PROTAC drug discovery

You asked, we listened. Millions of AI-predicted protein complex structures are now available in the #AlphaFold Database. This spans homodimers from 20 of the most studied species, including humans, as well as the World Health Organization’s priority pathogens list. www.ebi.ac.uk/about/news/t...

Evotec ending drug discovery in the UK :( good luck to all of those affected: some good people #chemsky

genuinely enjoyed this piece #chemsky

MAKAAAAARRRRRRRRRRRR!!!!!!! And we're...ALL.....TIED.....UP!!!!!

Let’s go Canada 🇨🇦🇨🇦🇨🇦🇨🇦

Group meeting needed to pause briefly since no one was paying attention anyway. Go Canada 🇨🇦🇨🇦🇨🇦

There’s nothing like a good ‘reply all’ first thing in the morning

Happy "reply all to the whole university" day to all that celebrate

The time has come, The College said, To empty your own trash. It's now ev'ry professor's job, For we are low on cash. There will still be a custodians So don't have any fear That you will have to mop the floors At least until next year.

The federal government is murdering our neighbors in broad daylight and carrying out a mission of terror against the Twin Cities. Schools and businesses are closed and people are staying home because they’re afraid of ICE. This is America in 2026: at war against its own people.

I’ve seen some weird drug molecules over the last 30 years but not many that I’d use as a synthetic intermediate (and store in a sealed vial) #ChemSky #ChemChat (h/t @drughunter.com for the screenshot)

Great news in the fight against antimicrobial resistance! Two oral antibiotics have been approved by the FDA for uncomplicated urogenital gonorrhea. As Neisseria gonorrhoeae is becoming resistant to all known antibiotics, such breakthroughs were urgently needed. (1/4) www.fda.gov/news-events/...

Especially in manuscript templates!!

When your spouse is the social one, and decides she doesn't want to go to a social obligation/event because she's tired from her marathon walk, it's important to modulate your response carefully: supportive but not to obviously enthusiastic and relieved

Everyone, stop being annoyed by "6-7". Instead START SAYING IT. Fastest way for it to become uncool 😆

I normally try to stay out of University rankings of any kind but this is encouraging for all of us pushing research at U of C www.ctvnews.ca/calgary/arti...

I found a flowchart which helps you navigate the IT landscape

Essentially every airline in Canada…🙂

Really excited to see this in print - super work here by the wonderful team here from the @uwyoongroup.bsky.social It was a real pleasure to watch this work evolve from a "what if" discussion to a @natsynth.nature.com paper I truly appreciate being included #Chemsky

I think about this post every day 🧪

I wonder if they saw that coming

Novartis is hiring a BS or MS synthetic / medicinal chemist to join the Synthesis Technologies Team - looks like a great early career opportunity #chemjobs www.novartis.com/careers/care...

Amazing

Professor Emeritus Axel D. Becke @dalhousieu.bsky.social has passed away at age 72.

Literally every kids dream at bat. Let’s go #BlueJays 🇨🇦🇨🇦🇨🇦

Explaining Canadian Thanksgiving to Americans

We have just published a vacancy for a Process Chemistry Senior Principal Scientist at Vertex, Boston, MA, USA: www.organic-chemistry.org/jobs/offers/... - Please check and share!

Come be my newest colleague! jobs.wisc.edu/jobs/assista...

Risking it all for a "shot of skimming immortality www.cbc.ca/radio/asitha...

Using a faster workflow for micro-electron diffraction discovery of new natural products. They’re hiding out there!

Simon Fraser University invites applications from world-renowned researchers for the Canada Excellence Research Chairs (CERC) 2026 competition, offering up to $8M over eight years to support innovative and impactful research. Learn more and apply by June 30: www.sfu.ca/vpacademic/a...

Great to see this paper out in print. We have been curious about changing the properties of borates and this collaboration with Jeff and Warren @wpiers.bsky.social crosses a few different disciplines to synthesize and characterize these intriguing molecules

Our pre-print on hypoxia-activated PROTACs (HAP-TACs) is now on ChemRvix: chemrxiv.org/engage/chemr... We used the indolequinone bioreductive group to protect VHL- or CRBN-recruiting BRD4 degraders rendering them inactive. This group is removed selectively in hypoxia, revealing the active PROTAC.

Dad's On The Dancefloor

Well this couldn’t have come at a better time www.bbc.com/news/article...

New on my CV: “Partially Successful Submission to Nature.”

In contrast to all the bad news in the world, kid 2 hit his first out-of-the-park home run today and it’s basically a perfect afternoon in the sunshine

As a practicing chemist, how often do you calculate the pH of a weak acid (or base) solution based on the initial concentration and Ka(b) value? Because that's like 75% of the acid/base chapter of most textbooks.

Very proud of the newest PhD from the lab! Huge congratulations to Dr. Leonie van de Wouw (O’Sullivan). It was a privilege to have her work in my lab and I know she will go on to do great things in science!! Thank you to @avenaross.bsky.social for being the external examiner 🙂

All 4 of my NIH research grants are terminated. These were grants on MDR-TB treatment & strategies for supporting adolescents living w/ HIV. This is a massive waste of resources. I am heartbroken for my Harvard team, my partners in Peru, the next generation of scientists & our country. Shame.

This is a noble goal, but I think policy is getting way ahead of reality on the ground here

📢The Chitnis group is moving!!! After 7 wonderful years on the east coast @dalchemistry.bsky.social, I'm thrilled to join University of Victoria on the west coast in July 2025. My Dal fam gave me the best start I could have imagined, and I'm proud to carry their torch on this new adventure at UVic!

New-preprint alert! We use chemoproteomic profiling to show MYST KAT inhibitors exhibit hierarchical target engagement (KAT6A/B > KAT7 >> KAT8). Reminiscent of Type I kinase inhibitors, the selectivity of these small molecules varies based on concentration. www.biorxiv.org/content/10.1...

I have friends and family in every corner of Alberta and many will absolutely vote Conservative every election just on principle. I don’t know a single one who has any interest in separation from Canada

New KRAS-G12V inhibitor RMC-5127 from Revolution Medicines next up at #AACR25 New Drugs on the Horizon