Starting next Monday (January 12th), we will resume our normal number of updates, both on social media and on the abstracts page: www.organic-chemistry.org/abstracts/ Thank you for your patience!

www.organic-chemistry.org/Highlights/2... Douglass features The Gui Synthesis of Swinhoeisterol A

Molecule of the week: Swinhoeisterol A Swinhoeisterol A (3), isolated from the Xisha marine sponge Theonella swinhoei, showed remarkable inhibitory activity against histone acetyltransferase p300 (IC50 = 2.9 μM). More Info: www.organic-chemistry.org/Highlights/2...

www.organic-chemistry.org/Highlights/2... Douglass features Other Methods for Carbocyclic Construction: Azorellolide (Trauner), Aphanamol I (Zi), Crinipellin A (Tu), Daphnepapytone A (Li/She), Wallichanol A (Dethe), Ambiguine P (Yang/Li)

Molecule of the week: Crinipellin A The crinipellins, represented by crinipellin A, isolated from the North American mushroom Crinipellis stipitaria, have antibacterial and anti-cancer activity. More Info: www.organic-chemistry.org/Highlights/2...

www.organic-chemistry.org/Highlights/2... Douglass features Diels-Alder Cycloaddition: Lugdunomycin (Huang), Fortimicin B (Cai), Cephanolide A (Li/Wang), Berkeleyacetal D (Li), Macrocalin B (Zhao/Ma), Veratramine (Trauner)

Molecule of the Week: Lugdunomycin Lugdunomycin, isolated from Streptomyces sp. QL37, showed antibacterial activity. Jun Huang assembled the molecule by a photochemically-promoted intermolecular Diels-Alder cycloaddition More Info: www.organic-chemistry.org/Highlights/2...

www.organic-chemistry.org/Highlights/2... Douglass features Organocatalyzed C-C Ring Construction: The Shi Synthesis of Alstoscholarinoid B

Due to an accident, I have to take this feed offline for about two months. Please follow us on www.linkedin.com/company/orga... or visit www.organic-chemistry.org/abstracts/ regularly. I'm scheduling now for both feeds in advance and will then have surgery. I hope to be back by Feb at the latest.

www.organic-chemistry.org/abstracts/li... Palladium-imidazol-2-ylidene complexes are efficient catalysts for Suzuki cross-coupling of aryl chlorides with arylboronic acids.

www.organic-chemistry.org/abstracts/li... A Chan-Lam-type sulfur-arylation of sulfenamides with commercially abundant boronic acids

www.organic-chemistry.org/abstracts/li... A diastereoselective addition of carbamoyl anions to azirines affords synthetically useful 2-aziridinyl amide building blocks.

www.organic-chemistry.org/abstracts/li... Palladium-imidazol-2-ylidene complexes are efficient catalysts for Suzuki cross-coupling of aryl chlorides with arylboronic acids

www.organic-chemistry.org/abstracts/li... The combination of Pd(PCy3)2Cl2 and di-2-pyridyl ketone catalyzes a reductive formylation of aryl iodides

www.organic-chemistry.org/abstracts/li... 1,3-Dienes undergo pyrrole formation in the presence of inexpensive chloramine-T trihydrate

www.organic-chemistry.org/abstracts/li... A mild, operationally simple Minisci C-H acetylation of N-heteroarenes.

www.organic-chemistry.org/abstracts/li... Halogenated Azidopyridines: Under-Reported Synthons for Medicinal Chemistry

www.organic-chemistry.org/abstracts/li... Hypervalent azido- and cyanosilicate derivatives, prepared in situ by the reaction of trimethylsilyl azide or trimethylsilyl cyanide with tetrabutylammonium fluoride, are effective sources of nucleophilic azide or cyanide.

www.organic-chemistry.org/abstracts/li... Rh complexes of methylene-bridged P-chiral diphosphines exhibit excellent to almost perfect levels of enantioselectivity in asymmetric hydrogenation of various dehydroamino acid esters

www.organic-chemistry.org/abstracts/li... A direct metal- and oxidant-free photochemical decarboxylative formylation of indoles with 50% aqueous glyoxylic acid

www.organic-chemistry.org/abstracts/li... Tungsten hexacarbonyl catalyzes an unprecedented cycloaddition between acyclic CF3-ketimines and a N-benzyl azomethine ylide

www.organic-chemistry.org/Highlights/2... Douglass features Metal-Mediated C-C Ring Construction: The Ueda Synthesis of Incarvillateine

Molecule of the week: Incarvillateine Incarvillateine, isolated from the flowering Chinese plant Incarvillea sinensis, demonstrated significant analgesic activity. More Info: www.organic-chemistry.org/Highlights/2...

www.organic-chemistry.org/abstracts/li... Cesium fluoride catalyzes a nucleophilic trifluoromethylation of esters to give the silyl ether intermediates

www.organic-chemistry.org/abstracts/li... Sulfur mediates a synthesis of acyl fluorides from carboxylic acids using Selectfluor.

www.organic-chemistry.org/abstracts/li... A Pd-catalyzed annulation of enaminones and alkenes provides various NH-free pyrroles

www.organic-chemistry.org/abstracts/li... In situ generated zinc hydride catalyzes an economical, safe, and industrially interesting hydrosilylation-reduction of aldehydes, ketones, esters...

www.organic-chemistry.org/abstracts/li... Cheap and readily available formic acid is an effective reductant for the reductive cyclization of o-nitrostyrenes

www.organic-chemistry.org/abstracts/li... A chiral catalyst based on nickel, an earth-abundant metal, can achieve the enantioconvergent coupling of readily available racemic alkyl electrophiles with a wide variety of alkylzinc reagents

www.organic-chemistry.org/abstracts/li... An efficient and environmentally benign oxidation of primary alcohols to carboxylic acids

www.organic-chemistry.org/abstracts/li... 1,4-Pentadiene and 1,5-hexadiene can serve as allylmetal pronucleophiles in regio-, anti-diastereo-, and enantioselective carbonyl additions

www.organic-chemistry.org/abstracts/li... Readily accessible N'-nitro-2-hydrocarbylidene-hydrazinecarboximidamides can be cyclized to disubstituted 1H- and 4H-1,2,4-triazoles

www.organic-chemistry.org/abstracts/li... Oxidation of alcohols into aldehydes and ketones can be efficiently performed in the presence of oxygen or air using catalytic amounts of CuCl·Phen and azo derivatives.

www.organic-chemistry.org/abstracts/li... In situ formation of highly unsaturated alkylidene ketenes from propargyl alcohol derivatives.

www.organic-chemistry.org/abstracts/li... A general aminoalkylation of aryl halides with α-silylamines overcomes intolerance of free amines in nickel-mediated C-C coupling.

www.organic-chemistry.org/abstracts/li... Rh-PennPhos catalyzes an asymmetric hydrogenation of cyclic enamides.

www.organic-chemistry.org/abstracts/li... (PPh3)2CuBH4 catalyzes a convenient, efficient, and inexpensive palladium-free Sonogashira cross-coupling of o-iodoanilines

www.organic-chemistry.org/abstracts/li... The use of a simple stilbene ligand enables a stereospecific Suzuki-Miyaura cross-coupling of chiral tertiary benzylic carboxylates

www.organic-chemistry.org/abstracts/li... Synthesis of Enantiomerically Pure N-tert-Butanesulfinyl Imines

www.organic-chemistry.org/abstracts/li... Visible light and KOtBu promote a dehydrogenative C-H carbonylative lactamization of 2-arylanilines with DMF as the sole carbonyl source.

www.organic-chemistry.org/abstracts/li... A Ni-catalyzed acceptorless dehydrogenative coupling of alcohols with nitriles followed by decyanation

www.organic-chemistry.org/abstracts/li... Coumarin-3-carboxylic acids could be synthesized in high yields and selectivities from salicylic aldehydes and malonic acid

www.organic-chemistry.org/abstracts/li... The use of Si(OMe)4 as a nonmetallic regenerable reagent and DBU as a CO2 capture agent and catalyst enables the direct conversion of low-concentration CO2 into carbamates.

www.organic-chemistry.org/abstracts/li... A remote functionalization strategy enables a Z-selective synthesis of silyl enol ethers of (hetero)aromatic and aliphatic ketones

www.organic-chemistry.org/abstracts/li... Ullmann condensations are rapid and clean at temperatures of 50-100 °C lower than was heretofore required 1,10-phenanthroline as ligand

www.organic-chemistry.org/abstracts/li... Sulfuryl chlorofluoride is a versatile reagent for controllable chlorination and chlorooxidation of simple unprotected indoles.

www.organic-chemistry.org/abstracts/li... A facile photocatalyzed strategy for difunctionalization of styrenes in the presence of CS2 and amines

www.organic-chemistry.org/abstracts/li... Two catalysts were found to be effective in peracid oxidations of alcohols: TEMPO with Bu4NBr or TMP-HBr.

www.organic-chemistry.org/abstracts/li... A C2-symmetric borinic acid can achieve highly enantioselective desymmetrization of 2,2-disubstituted-1,3-propanediols

www.organic-chemistry.org/abstracts/li... Planar chiral [2.2]paracyclophane-based isothiourea catalysts catalyze a highly efficient enantioselective fluorination of carboxylic acids