www.organic-chemistry.org/abstracts/li... 1-Methyl-1-vinylsilacyclobutanes undergo rapid and high yielding cross-coupling with aromatic halides. Btw: Elucidation of the reaction intermediates led to: www.organic-chemistry.org/namedreactio...

www.organic-chemistry.org/abstracts/li... N-Trifluoromethoxyphthalimide (PhthN-OCF3) is a stable and solid trifluoromethoxylating reagent, that releases an OCF3 anion under mild reaction conditions.

www.organic-chemistry.org/abstracts/li... Commercially available [(PPh3)2NiCl2] is an efficient catalyst for the mono-N-alkylation of (hetero)aromatic amines with alcohols

www.organic-chemistry.org/abstracts/li... Air and moisture stable potassium allyl- and crotyltrifluoroborates react with a variety of alkyl, α- or β-substituted alkyl, and aryl aldehydes

www.organic-chemistry.org/abstracts/li... A chemoselective heterodimerization of weak electrophilic ortho-diisocyanoarenes and common isocyanides

www.organic-chemistry.org/abstracts/li... A unique Rh(III)-catalyzed C-H activation of N-phenoxyacetamides followed by carbooxygenation of 1,3-dienes enables the construction of dihydrobenzofurans

www.organic-chemistry.org/Highlights/2... Douglass features Alkaloid Synthesis: Lysergine (Bisai), 10-Demethoxyvincorine (Wei/Xie), Melonine (Yokoshima), Melodinine E (Li/Dong), Rhazinilam (Yoshimitsu), Corynoxine A (Zhang/Tu)

Molecule of the Week: Corynoxine A Isolated from the kratom tree Mitragyna speciosa, Corynoxine A is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via the Akt/mTOR pathway. More Info: www.organic-chemistry.org/Highlights/2...

www.organic-chemistry.org/abstracts/li... A β-boron effect accounts for high regioselectivity in electrophilic addition reactions to allylic MIDA (N-methyliminodiacetic acid) boronates.

www.organic-chemistry.org/abstracts/li... A highly enantioselective silicon-directed Nazarov reaction is cooperatively catalyzed by a Lewis acid and a chiral Brønsted acid.

www.organic-chemistry.org/abstracts/li... Quantitative oxidative conversion of thiols to disulfides was effected by aqueous 30% H2O2 in trifluoroethanol

www.organic-chemistry.org/abstracts/li... An operationally simple and efficient strategy for the synthesis of substituted tetrahydrofurans from readily available cis-butene-1,4-diol

www.organic-chemistry.org/abstracts/li... A Julia-Kocienski reaction of 2,2-dimethoxyethyl 1-phenyl-1H-tetrazol-5-yl (PT) sulfone with various aldehydes

www.organic-chemistry.org/abstracts/li... A microwave-promoted, solvent-free Biginelli three-component cyclocondensation

www.organic-chemistry.org/abstracts/li... Excited-state palladium-catalyzed alkylations of quinoxalinones

www.organic-chemistry.org/abstracts/li... A metal-free CH [5 + 1] carbonylative annulation of 2-alkenyl/pyrrolylanilines with dioxazolones

www.organic-chemistry.org/abstracts/li... Several alcohols were smoothly and practically sulfonylated.

www.organic-chemistry.org/abstracts/li... An organo-photocatalytic sulfonylimination of alkenes using readily available N-sulfonyl ketimines

www.organic-chemistry.org/abstracts/li... Eu(OTf)3 catalyzes a transsulfinamidation of primary sulfinamides with alkyl, aryl, and heterocyclic amines

www.organic-chemistry.org/abstracts/li... Various aromatic and aliphatic nitriles were prepared in high yields in a direct one-pot process

www.organic-chemistry.org/abstracts/li... Low loadings of commercially available lithium triethylborohydride catalyze the hydroamination of various carbodiimides.

www.organic-chemistry.org/abstracts/li... An iridium complex catalyzes an environmentally friendly, efficient, and facile one-pot transfer hydrogenation of C=C bond of enones and reductive amination

Ad: Vapourtec - Peptide-Builder More Info: www.organic-chemistry.org/info/present... Peptide-Builder is a compact, fully automated, lab-scale synthesizer that transforms solid-phase peptide synthesis (SPPS) through advanced flow chemistry technology

www.organic-chemistry.org/namedreactio... Pinacol Coupling Reaction - An overview and some recently published methods

www.organic-chemistry.org/abstracts/li... Primary and secondary trimethylsilyl and tetrahydropyranyl (THP) ethers are converted to their carbonyl compounds efficiently

www.organic-chemistry.org/abstracts/li... Pd/Cu-catalyzed coupling and boration of acyl chlorides with alkynes and B2pin2

www.organic-chemistry.org/abstracts/li... Using a cinchona squaramide-based organocatalyst for an enantioselective intramolecular oxa-Michael reaction of enones as well as α,β-unsaturated esters

www.organic-chemistry.org/abstracts/li... Chemoselective dithioacetalization of aromatic- and α,β-unsaturated aldehydes

www.organic-chemistry.org/abstracts/li... Visible light mediates a P-H insertion reaction between acylsilanes and H-phosphorus oxides

www.organic-chemistry.org/abstracts/li... A diaminocyclopentadienone ruthenium tricarbonyl complex catalyzes the synthesis of mono- or dialkylated acyl hydrazide compounds

www.organic-chemistry.org/abstracts/li... The combination of Fe(III)/NaI catalyzes a very simple and mild oxidative coupling of thiols

www.organic-chemistry.org/abstracts/li... A palladium(0)-catalyzed defluorosilylation of β,β-difluoroacrylates provides tetrasubstituted vinylsilanes

www.organic-chemistry.org/abstracts/li... The use of secondary amines and NXS (X = Cl, Br, I) enables an unprecedented copper-catalyzed oxidative aminohalogenation of electron-deficient maleimides.

www.organic-chemistry.org/abstracts/li... Highly tunable chiral thiazolium carbenes featuring bulky chiral flanking groups show catalytic efficacy in enantioselective SET-type three-component acyl-difluoroalkylations of olefins

www.organic-chemistry.org/abstracts/li... A cobalt-catalyzed [4,3]-hydroboration of 1,3-dienes with HBPin provides nearly enantiopure homoallylic boronate esters.

www.organic-chemistry.org/abstracts/li... The use of milled dry ice permitts a practical synthesis of arylcarboxylic acids with increased yields

www.organic-chemistry.org/abstracts/li... A transition-metal-free and redox-neutral 1°, 2°, or 3° C(sp3)-H carbonylative cyclization provides pyrazolones

www.organic-chemistry.org/abstracts/li... An iridium-catalyzed allylic alkylation of phosphonates followed by a Horner-Wadsworth-Emmons olefination

www.organic-chemistry.org/abstracts/li... An efficient palladium-catalyzed reaction of 2-iodostyrenes with di-t-butyldiaziridinone

www.organic-chemistry.org/Highlights/2... Douglass features C-N Ring Construction: The Zhu Synthesis of Mayumbine

Molecule of the Week: Mayumbine Mayumbine, isolated from the African poison devil's-pepper Rauvolfia vomitoria, potently inhibits in vitro binding of 3H-diazepams to the benzodiazepine sites within the rat GABAA receptor complex. More Info: www.organic-chemistry.org/Highlights/2...

www.organic-chemistry.org/abstracts/li... A visible-light-induced hydrodichloromethylation of unactivated alkenes with chloroform provides 1,1-dichloroalkanes

www.organic-chemistry.org/abstracts/li... An efficient and convenient electrochemical cross-dehydrogenative coupling reaction between isochroman and unactivated ketones

www.organic-chemistry.org/abstracts/li... Amino-substituted chalcones undergo a 1,7-hydride shift upon Lewis acid activation to form a zwitterionic iminium enolate, which collapses to dihydroquinoline-4-ones

www.organic-chemistry.org/abstracts/li... 2-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (DMT-TU) can be used for conversions of carboxylic acids and amines to their corresponding amides.

www.organic-chemistry.org/abstracts/li... A nickel-catalyzed enantioselective hydrofluoromethylation of enamides and enol esters with ICH2F

www.organic-chemistry.org/abstracts/li... The Ruppert-Prakash reagent acts as a bipolar CF2 building block

www.organic-chemistry.org/abstracts/li... Rongalite mediates a one-pot aminomethylation of heteroarenes using secondary amines/anilines

www.organic-chemistry.org/abstracts/li... A stereospecific Pd-catalyzed acylative cross-coupling of enantiomerically enriched alkylboron compounds

www.organic-chemistry.org/abstracts/li... A concerted metallophotoredox catalysis enables an efficient decarboxylative functionalization of α,β-unsaturated carboxylic acids