New paper in @natcomms.nature.com! We show how the Clostridia peptide CliM acts as a molecular handbrake to monitor YidC activity. Cryo-EM & MD show it stalls the ribosome using diverse mechanisms until membrane insertion releases it. Paper: www.nature.com/articles/s41...

Are you interested in understanding protein dynamics and allostery in biomedically relevant "loopy" enzymes? We are looking for postdocs to join our group at GT for both applied and method development work. If you are interested, please email me your CV, cover letter, and details of 2-3 referees.

🎗️ Final reminder! This Sunday 31st May is the deadline: 💰 Early-bird registration 🗣️ Oral presentation abstract submission ➡️ bioexcel.eu/hzr0 #ComputerSimulation #conference #community

Mitochondrial ribosomes follow a precisely timed 🕺choreography to coordinate protein production, folding & insertion. 👉 About the collab between Peter Rehling (University Medical Center Göttingen) & our project group leader @niels-fischer.bsky.social & their teams: www.mpinat.mpg.de/5263150/pr_2...

Over the past 5 years, 50 structures of full-length HECT-type ligase constructs have been deposited in the PDB. What have we learned from these studies, and what key questions remain open? Check out our new review on this exciting and fast-moving field: www.jbc.org/article/S002...

I am organising a 2 day workshop on explainable AI as applied to (bio)chemistry in Copenhagen, June 15-16, 2026. Everyone is invited. No need to register, but lunch is at your own expense. #compchem

We are happy to share our latest publication with you that just appeared in J. #Proteome Res. @pubs.acs.org pubs.acs.org/doi/10.1021/... 🙏 Many thanks for the great collaboration with our colleagues @mpibiochem.bsky.social in Martinsried! #proteomics #IMS #MD #peptides

We open up to two Junior PI positions at UCT Prague, Czechia @vschtpraha.bsky.social. Broadly defined chemistry-related projects will be considered. A support from any department must be negotiated prior application. Feel free to contact me for further info or visit www.vscht.cz/research/dag....

We just preprinted one of my favorite studies @FlatironInst . I was lucky to be part of an amazing team studying the effects of rapid cooling to preserve samples in cryoEM. Read on to learn about the limits of cryoEM for biophysics and how to overcome them www.biorxiv.org/content/10.6...

Our latest contribution is out! In this highly collaborative paper, we show that tRNAs with a 4-base-pair anticodon stem are surprisingly frequent across organisms. Our atomistic MD simulations reveal the role of the 5th base pair. academic.oup.com/nar/article/...

#KeinVergessen: Heute vor zwei Jahren, am 25. März 2024, verübt ein Rechtsextremer einen rassistischen Brandanschlag in Solingen, bei dem İsmail (Kancho) Zhilov & Kıymet (Katya) Zhilova sowie ihre Töchter Elis (Emily) & Gizem (Galia) ums Leben kommen. https://f.mtr.cool/zfvsjdkdak

Our new FEP sampling engine GrandFEP is now on GitHub and Chemrxvi. We implemented GCMC, Water-Swap MC, REST2, and terminal-flip MC in OpenMM. Github github.com/deGrootLab/G... Chemrxiv doi.org/10.26434/che...

🚨 Preprint alert! We solved the structure of human NSUN2 bound to Asp tRNA, revealing how it installs m⁵C and recognizes RNAs #CryoEM #RNABiology A collab between Casañal & Gullerova labs, with @miclass.bsky.social and me working side by side as co-first authors 🔗 doi.org/10.64898/202... (0/7🧵)

Our recent investigation of the constriction in the bacterial ribosomal tunnel is online. Unbiased all-atom MD simulations of the entire ribosome and PDB analysis show, how flexible the constriction is. The flexibility is modulated by short nascent polypetides.

We are looking for RNA enthusiasts to join us at the @uniregensburg.bsky.social as a junior group leader! Our university offer excellent infrastructure and collaboration opportunities for ground breaking RNA research. Please RT @jrrnascientists.bsky.social @rnasociety.bsky.social

We are recruiting a computational scientist for a postdoc position to work on detecting RNA modifications using nanopore sequencing: tinyurl.com/RiboComp Deadline March 4th. Please share and repost! More on the group: www.bric.ku.dk/research-gro...

The Faculty of Physics @uni-goettingen.de annually awards the Berliner-Ungewitter Prizes. Congratulations to Annke de Maeyer who receives this award for her exceptional master’s degree👏! We are happy she continues her PhD with us @compbiophys.bsky.social

#PhDPosition open — #RibosomeBiology & #Translation QC 📍 JGU Mainz, Germany 🗓️ Apply by 10 Mar 2026 (or until filled) 🔗 Full details + project options: 👉 ak-winz.pharmazie.uni-mainz.de/jobs/

🧐 You are a physicist or chemist who wants to reveal how life works at the molecular level? 🤓 You know how to combine computer power and theory to solve biological problems? ❤️ You just love doing science? 👉 Send us your application! 🔗 Current job adverts www.mpinat.mpg.de/grubmueller

😲 #Deadline is approaching... Don't miss your chance to join the @bioexcelcoe.bsky.social #summer#school on #biomolecular #simulations in #sardinia 🇮🇹 @gromacs.bsky.social #pmx #hadddock #biobb

This is Alex Pretti. This morning he was murdered by ICE. Six ICE agents held him down and shot him at point blank range. Alex was a nurse and researcher at the VA. Our thoughts are with his loved ones and we stand united in action calling for the abolishment of ICE. #ScientistsAgainstICE

Did you miss our 2025 scientific lecture series at the Literaturherbst in Göttingen? Stream most German & English talks in full-length on our website💻. From baby talk to democracy and the vaccines of the future; there is something interesting for everybody! www.mpinat.mpg.de/4758909/media

Listen to this if you bear. Phone call from #Iran. I will transcript (pardon typos). "You cannot even imagine. Not even in your imaginations, what is happening in Iran. Thousands and thousands of people have been killed. 1/ www.instagram.com/reel/DTgIUBt...

🎉 Now also published in @pubs.acs.org #Photonics ⏩ pubs.acs.org/doi/10.1021/... #MINFLUX #microscopy #Bayes

Over 100 hours of Internet and phone blackout, as the regime commits crimes against humanity. The death toll is now in the thousands. If you care *at all* about human rights, do something. Contact your representatives. Demand accountability. History will not forgive you for looking away. #Iran

If anyone is interested in making bacterial ribosome-nascent chain complexes and studying them using HDX-MS, we have written up a detailed protocol. rdcu.be/eYFx4 Characterise the conformational dynamics of the ribosome, nascent polypeptide and bound chaperones, label-free and at peptide-level

Iran has been under communications blackout for over 60 hours now. Several thousand people have been killed (numbers vary by source, I have seen between 2 and 5000 this morning). Iranians abroad don't know if their loved ones are alive or dead, have absolutely no way to communicate 1/

As a reminder, in the 2019 protests, the Iranian regime killed about 1500 people in less than two weeks. They do this under the cover of cutting internet. This time, they have cut off the internet, phone lines, and closed airspace. This is a crisis. Don't look away.

📣 Talented PhD students wanted: The IMPRS for Genome Science @imprsgs.bsky.social and the DFG Research Training Group GönomiX are looking for you!

Exciting news! We have a new website: omsf.io/alchemistry Your one-stop shop for everything related to our conference community. 🎉 BTW, registration is now open, so head over to secure your spot! We'll be sharing updates and details about the event. Bookmark it as there's plenty more to come!

🚨Last chance to apply for two PhD projects in my lab, applying structural biology and single molecule biophysics to investigate gene expression in RNA viruses: www.findaphd.com/phds/?Keywor...

👉Applications will be reviewed on a rolling basis until the #postodc or #phd #position is filled. 📩 Send us your message to explain why you are a great candidate to join the group "Computational Biomolecular Dynamics" of Bert de Groot @mpi-nat.bsky.social 🔗 www.mpinat.mpg.de/degroot #compbiophys

anyone got any advice on the following situation? I wrote and did a big chunk of the admin for a large MRC grant which also also awarded. I am named in the Staff breakdown on the grant as "researcher co-lead" with 100%FTE, and I am mentioned by name as "postdoctoral researcher Maria Niedernhuber"

The Frankfurt Institute for Advanced Studies (FIAS) and the newly funded Cluster of Excellence SCALE are seeking several Independent Research Group Leaders to drive theoretical and computational research in molecular and cellular life science. fias.institute/de/das-fias/...

📜 New preprint! We developed PoGö, an algorithm to optimize the essential dynamics of GöMartini proteins based on all-atom simulations: www.biorxiv.org/content/10.1...

Awesome to see this epic piece of work, led by @cecclementi.bsky.social, finally appear in @natchem.nature.com. The development of a general coarse-grained protein forcefield to describe folding, binding and conformation changes without solvent and all-atom, has been long anticipated!

🐦 For the early birds and #ribosome #MD and #ML enthusiasts #EBSA2025: Don't miss 📌 Lars' @larsvbock.bsky.social oral presentation (O-16.1) tomorrow at 8:30 during session 16 in hall 1: "Combining #Simulations and Machine Learning with Experiments to Explore Ribosomal #Translation" 🔗 t1p.de/ccmwk

One day remaining before this closes! bsky.app/profile/benj...

🆕📣 Job alert: Our department @compbiophys.bsky.social is looking for a PhD student or Postdoc specializing in theory and methods for non-equilibrium theory and atomistic simulations of complex biomolecules. More information here: ⬇️

💭 Would you like to contribute to projects in the field of "Theory and Methods for Non-equilibrium #Theory and Atomistic Simulations of Complex# Biomolecules"? Join our department as #PhD student or #Postdoc at @mpi-nat.bsky.social in 🇩🇪 🔗 Here are more details www.mpinat.mpg.de/4965656/10-2... #job

Excited to share my latest research. In this paper in PNAS, I use #cryoEM and #crystallography to solve multiple new structures of a viral RNA motif that controls frameshifting. #virus #retrovirus #structuralbiology #science #biochemistry www.pnas.org/doi/10.1073/...

🧐 Are you a computational physicist and expert in probability theory? 👉 Contribute to our project "Theory and Algorithms for Structure Determination from Single Molecule X-Ray Scattering Images" as PhD student or Postdoc! 🔗 Check our job advert for more details www.mpinat.mpg.de/4988122/09-2...

Gemma Solomon and I are looking for a postdoc to work across the two groups on modelling biological systems with a view to applications for quantum computing More details about the project including how to apply in the link below. Deadline April 9 2025 candidate.hr-manager.net/ApplicationI...

I need y'all to sit with this headline and understand what is being done to our community. They're trying to criminalize our very existence. This is a campaign of eradication. www.nbcnews.com/nbc-out/rcna...

There was a lot of #AcademicFreedom, good scholarship, and independent thought in German universities before Hitler. After Hitler had risen to power, many academics fled the country. Some resisted the Nazi regime and were persecuted. Most adapted to a new situation. Here are some examples. 1/n

A friend included this anti-acknowledgement section on her PhD thesis. She also added the proposition: “Systematic bullying and undermining of girls and women in STEM starts early on and is the reason why they do not stay in science and related fields.” Absurd we still need to go through this 🧪👩‍🔬