🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

Nobel laureate Jennifer Doudna tells Jeffrey Goldberg that vaccinations have been so successful that "there's been a collective forgetting that measles, and mumps, and rubella—these used to be diseases that would kill people in fairly large numbers." #TAF25 bit.ly/46a5DUE

Today’s work, aside from meetings.

@embl.org Heidelberg is looking for a new Head of Scientific Instrumentation! This is an exciting opportunity at the interface between scientific research and technology development, overseeing our mechanical and electronic workshops! embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

Beautiful work led by @oliveringe.bsky.social. It was great fun to be involved with this project. See Ollie’s paper and thread 👇

Thanks Misha for the shout-out! It has been a truly mind-opening journey. WHOLISTIC is one step towards whole-organism neuroscience and a true physiological observatory - with extensions on the way! I am continually amazed by what the data reveals - so much remains to be discovered and mined.

We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)

Results so stunningly clear they inspired this classic xkcd (xkcd.com/2400/):

This is absolutely the most significant glycobiology paper so far this year. Increasing cell surface N-glycosylation makes viable allo CAR-T cells without deleting the endogenous TCR #glycotime

Vaccines save lives, pass it on.

(1/n) A simple, ultrastable, and cost-effective oxygen-scavenging system for long-term DNA-PAINT imaging Please check out our new study on the benefits of sodium sulfite as oxygen scavenging system for DNA-PAINT. 👇🧵 #SuperResolution #DNAPAINT #SMLM #Microscopy

A new 25-camera multifocus microscope can capture 3D volumes of living organisms at high speeds. Using the microscope, the researchers were able to view a fruit-fly larva’s heart beating at about 2 Hz. Read the OPN story: bit.ly/4muEQbx #imaging #microscopy 💡⚛️🧪

One of the people I'm indebted the most for creating stunningly beautiful #mesoSPIM samples was Martina Schaettin - who tragically passed away in March this year. To honor her memory, Elkhan Yusifov created an award - submit your best #microscopy images & videos! www.linkedin.com/company/mart...

Clever mug :-)

Today, I would like to honor the memory of Roger Y. Tsien, who died on August 24, 2016. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! #FluorescenceFriday www.nature.com/articles/nme...

Wim Wenders war bei Alles gesagt? Der bedeutendste deutsche Filmregisseur unserer Zeit wird heute, am 14. August 2025, 80 Jahre alt.

We’re excited to welcome @kevin-dean.bsky.social to the #mesoSPIM2025 Symposium! Explore his innovations in Multiscale Cleared-Tissue Axially Swept Light-Sheet Microscopy for imaging from organ to subcellular levels. 🗺️Oct 13–15 | Zurich & hybrid Interested? Register now: t.uzh.ch/1Ss

I have some BIG NEWS to share today! Today I begin my next adventure as Chief Editor of Nature Biomedical Engineering!! (a thread) @natmethods.nature.com @natbiomedeng.nature.com @natureportfolio.nature.com

I still can’t believe that all NIH grants to my colleagues at Harvard and Harvard Medical School have been nullified. And that, as a nation, we’re somehow okay with this illegal, arbitrary, and petty act. Just think of the consequences: scientists, students, and patients will all suffer.

Nature Methods is hiring! We are seeking a new editor with expertise in microscopy, imaging technology, and/or cell biology. The position is available in NYC/Jersey City or Shanghai/Beijing on a hybrid working model. Apply by August 3! springernature.wd3.myworkdayjobs.com/SpringerNatu...

Fantastic talk by @hhmijanelia.bsky.social alumna and @embl.org group leader Dr. Claire Deo (@clairedeo.bsky.social). Stay tuned for her HHMI YouTube recording youtube.com/playlist?lis... #openscience @prevedel-lab.bsky.social @markkitti.bsky.social @kaydanych.bsky.social @rhodamine110.bsky.social

A big mission of @crick.ac.uk is to bring Science to everyone. Thank you chris agathangelou and Clare green for your help with making our latest work on a new stem cell model of the human amnion accessible to all 🙏

A gem from @xkcd.com

Big congratulations Kiryl 🎉

Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...

Quantitative comparison of fluorescent proteins using protein nanocages in live cells, from @microtubule.bsky.social pubmed.ncbi.nlm.nih.gov/40326462/

Great News & Views article by Ben Campbell covering recent development in FP field with focus on mScralet3-H (aka mYongHong) www.nature.com/articles/s41...

Dr. Eric Schreiter demo at @hhmijanelia.bsky.social #bioluminescence #luciferase

👁⚕️✔️ #AnnualEyeExam

Brian I #otisstreetartsproject #DavidMordini

Installation view of my performance over the weekend at VisArts. Deep love & gratitude to everyone who came out, played & danced!!! 💙📚 Thank you as well to all of the other artists, to @heloisarts.bsky.social for gathering us all together & to @sciencethecat.bsky.social for taking awesome pics ♥️

#MicroscopyMonday! #microscopycommunity, join @bioimagingna.bsky.social March 25 to hear from 5 talented Scientists about their experiences in a variety of different careers, in academia & industry. It is free & online, so register for the zoom details at buff.ly/FQbTu6m @ritastrack.bsky.social

decided to write an op-ed for our local journal to support federally funded research - I encourage you to spread the good word! riverjournalonline.com/letters/op-e... thanks @drannecarpenter.bsky.social and @sean-ryder-music.bsky.social for the inspiration

I know that the mRNA is larger than the protein it codes for but I don't believe it

Hey #chemsky and beyond, with all that is going on, I am curious what expensive, high margin molecules we could provide to the community for free. What things do you use all the time, cost way too much, and would make a difference? Alexa Fluor 488 NHS? Other dyes? Other molecule?

Just a start! Who's missing? go.bsky.app/LAA7Sdx

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15) www.biorxiv.org/content/10.1...

2025 = 45^2 It's a perfect square. It will probably be the only perfect square year you ever get to live in. The last time that occurred was in 1936. The next will be in 2116. So, make 2025 a perfect year for you.

artist D.Y. Begay derives her dyes from flowers, roots, barks, and lichens harvested from rocks around Diné bíkéyah #dyes #dybegay #tapestries #SmithsonianNMAI

🎉Congratulations to Luke Lavis (@rhodamine110.bsky.social), recipient of the 2025 Gregorio Weber Award for Excellence in Fluorescence Theory and Applications from ISS for his pioneering work on the design & synthesis of small-molecule fluorescent dyes.🧪

hand-made silver #Janelia ChemisTree erlenmeyer flask ornaments @rhodamine110.bsky.social @hhmijanelia.bsky.social #TollensTest #chemsky

In honor of our annual ChemisTree event @hhmi.bsky.social @hhmijanelia.bsky.social today, here's a repost of a little video I made a few years back to demonstrate how the ornament silver plating works! #chemsky

Relatively straightforward integration into an OPM, much better long term imaging stability.

We are looking for exceptional #AIScientist|s to join our #AI@HHMI initiative at #HHMIJanelia. We want to uncover fundamental principles underlying complex biological systems that are inaccessible without new innovations that combine #AI with experimental design. ai.hhmi.org#join-our-team 1/4

It's woefully incomplete, but I've made the start of a starter pack for folks interested in microscopy. Suggestions for who else to include (including yourself!) are very welcome. go.bsky.app/SaYfAX3

✈️ + ☄️#CometC2023A3

#northernlights from DC

Becky Osten McFall/ Genesis Project at Brentwood Arts Exchange

waterdrop lens 💧🔎

🌱 #ScienceOnTap with @hhmi.bsky.social's David Stern #OldOxBrewery #Aphids