@furkanoflaz.bsky.social
๐ค 26
๐ฅ 47
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Postdoc @Stanford. Interested in mitochondrial biology
pinned post!
Iโm happy to share that my latest PhD work is published in
@embojournal.org
! We demonstrate a fundamental role for Annexin A5 in regulating mitochondrial calcium signaling and apoptosis.
www.embopress.org/doi/full/10....
8 months ago
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reposted by
Ernst Schmid
about 2 months ago
Thrilled to share that the final piece of my PhD work is now on bioRxiv!
biorxiv.org/content/10.1...
With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at
predictomes.org/hp
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Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
http://biorxiv.org/content/10.1101/2025.11.10.687652v1
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reposted by
The EMBO Journal
about 2 months ago
Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons Tong Wang and coworkers
www.embopress.org/doi/full/10....
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reposted by
Claire Deo
2 months ago
Our photoswitchable HaloTag is out in Angewandte Chemie
@angewandtechemie.bsky.social
! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out:
onlinelibrary.wiley.com/doi/full/10....
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A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells
Photoswitchable fluorophores are critical for advanced bioimaging. Here, we develop a photoswitchable self-labeling HaloTag that can reversibly modulate the emission of a bound fluorogenic dye via a ....
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202424955
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reposted by
Cell Chemical Biology
3 months ago
Sensing within: Mitochondrial inside-out signal transduction
http://dlvr.it/TNkqLD
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reposted by
Joseph Gordon
3 months ago
www.cell.com/cell-metabol...
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Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as a key mediator of mitochondrial impo...
https://www.cell.com/cell-metabolism/abstract/S1550-4131(25)00434-6?dgcid=raven_jbs_aip_email
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reposted by
Avezov lab
3 months ago
New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Caยฒโบ store-refillโrevealing selective neuronal vulnerability to ER-structure problems. Thread to follow.๐ง โก๏ธ
www.biorxiv.org/content/10.1...
#Neurodegeneration
#NeuroCellBiology
#Calcium
#bioRxiv
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reposted by
Xinnan Wang Lab
3 months ago
Our new review is out! Likely once an independent organism, mitochondria have retained a striking degree of autonomy. We discuss their capacity to sense withinโa process we refer to as mitochondrial inside-out signaling. Written by talented
@furkanoflaz.bsky.social
@signscaztl.bsky.social
add a skeleton here at some point
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reposted by
Joachim Goedhart
4 months ago
We have updated our preprint "A green lifetime biosensor for calcium that remains bright over its full dynamic range" with some new data - including this photo showing the difference in color for the Turquoise and Green lifetime probe.
www.biorxiv.org/content/10.1...
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reposted by
Gerry Hammond
4 months ago
Announcing our new PA biosensor, PILS-Nir1 โ seen here in HeLa cells during PLC activation
#lipidtime
#phospholipids
Read the OA paper in JCB
add a skeleton here at some point
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reposted by
Journal of Cell Biology
8 months ago
Shun-ichi Yamashita, Ritsuko Arai, Tomotake Kanki, Satoshi Waguri et al. show that the
#mitophagy
receptors BNIP3 and NIX are required for tight attachment & expansion of the isolation membrane along the mitochondrial surface
rupress.org/jcb/article/...
#Autophagy
#Mitochondria
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Iโm happy to share that my latest PhD work is published in
@embojournal.org
! We demonstrate a fundamental role for Annexin A5 in regulating mitochondrial calcium signaling and apoptosis.
www.embopress.org/doi/full/10....
8 months ago
0
6
2
reposted by
Nature
9 months ago
A brain-reading implant that translates neural signals into audible speech has allowed a woman with paralysis to hear what she intends to say nearly instantly
https://go.nature.com/3QStZtI
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Brain implant translates thoughts to speech in an instant
Improvements to brainโcomputer interfaces are bringing the technology closer to natural conversation speed.
https://go.nature.com/3QStZtI
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reposted by
Joachim Goedhart
9 months ago
NitrOFF: An engineered fluorescent biosensor to illuminate nitrate transport in living cells by Sheel Dodani and team:
www.biorxiv.org/content/10.1...
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reposted by
Christian Frezza
10 months ago
In-cell architecture of the mitochondrial respiratory chain | Science
www.science.org/doi/10.1126/...
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In-cell architecture of the mitochondrial respiratory chain
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...
https://www.science.org/doi/10.1126/science.ads8738
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reposted by
Kai Johnsson
11 months ago
Check out our new fluorescent probe for imaging f-actin dynamics: ๐ฆ๐ถ๐ฅ-๐ซ๐๐ฐ๐๐ถ๐ป: ๐ ๐ณ๐น๐๐ผ๐ฟ๐ฒ๐๐ฐ๐ฒ๐ป๐ ๐ฝ๐ฟ๐ผ๐ฏ๐ฒ ๐ณ๐ผ๐ฟ ๐ถ๐บ๐ฎ๐ด๐ถ๐ป๐ด ๐ฎ๐ฐ๐๐ถ๐ป ๐ฑ๐๐ป๐ฎ๐บ๐ถ๐ฐ๐ ๐ถ๐ป ๐น๐ถ๐๐ฒ ๐ฐ๐ฒ๐น๐น๐
www.biorxiv.org/content/10.1...
Thank you
@veselin-nasufovic.bsky.social
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SiR-XActin: A fluorescent probe for imaging actin dynamics in live cells
Imaging actin-dependent processes in live cells is important for understanding numerous biological processes. However, currently used natural-product based fluorescent probes for actin filaments affec...
https://www.biorxiv.org/content/10.1101/2025.02.04.636537v1
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reposted by
Franck Polleux
about 1 year ago
Delighted to highlight our new paper in
@natureportfolio.bsky.social
entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below ๐):
www.nature.com/articles/s41...
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Synaptic basis of feature selectivity in hippocampal neurons - Nature
A temporally asymmetric synaptic plasticity kernel results from bidirectional modifications of synaptic weights around the induction of a place field.
https://www.nature.com/articles/s41586-024-08325-9
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reposted by
Xinnan Wang Lab
11 months ago
Beautiful paper on mitochondrial DNA (mtDNA) stress sensing, from our postdoc Alva Sainz
@signscaztl.bsky.social
of her Ph.D work in the Shadel lab!
add a skeleton here at some point
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