💊 🧬 Insightful dive into in-host bacterial evolution under antimicrobial pressure, a work from @csavin.bsky.social and @pierrelebury.bsky.social in our lab at @pasteur.fr

Time for some insights into our latest #preprint Using cryo–electron tomography, we peeked inside different #Mtuberculosis strains, and a couple of other mycobacteria.🧐 Surprise: some species, especially the host-adapted ones, build intracytoplasmic membranes (we call them MIMs)! 🦠

More outstanding maps in this Mercator / 'Correct The Map' explainer by Reuters 😍 www.reuters.com/graphics/AFR...

Mycobacterium tuberculosis forms nitrate-induced intracytoplasmic membranes (MIMs) that rewire metabolism & dampen inflammation during infection, uncovering a new layer of bacterial adaptation! ✍️ @camimille.bsky.social @enningalab.bsky.social @pasteur.fr 📖 shorturl.at/9kbDM

Registration & abstract submissions are open for the #Shigella meeting! Travel grants available too! All are welcomed, whether you are active in #Shigella research or interested in the 21st century perspective on this formidable pathogen! 🦠 🧫 #Microsky www.shigella2026.conferences-pasteur.org/home

Come and join us in Paris 2026 to talk all about Shigella!

After years of hard work and months of growing MTB @camimille.bsky.social submitted her story ! Check this out if you wanna discover new intrabacterial structures and their function ! 🦠🔬✨

🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫 Thread coming soon!

New preprint from the lab! Great work led by @camimille.bsky.social #mycobacterium #TB #cryoET

There are half a million cases of invasive non-Typhoidal Salmonella (iNTS) every year and while you might know S. Typhimurim and Enteritidis, you may not have heard of S. Panama 💩 🩸 🧫 💊 Check out our latest in @lancetmicrobe.bsky.social doi.org/10.1016/j.la... and the 🧵 below to find out more 1/n

Win £200 for your post on the Node! Do you have an idea for a post on the Node that you have been postponing for a while? Post your piece by 30 September. One winner will be randomly selected for a prize of £200 and an interview with the Node. Find out more: thenode.biologists.com/the-node-wri...

Focusing on something other than Salmonella for a minute, because my wife’s paper is just out and it is AMAZING! www.nature.com/articles/s41... Congrats to all the authors, great work from the @dfachinetti.bsky.social @naltemose.bsky.social labs!

Trouble imaging actin in ExM? Meet HAK-Actin, a probe for U-ExM, cryo-ExM & iU-ExM. Enables post-expansion labeling for max signal. www.biorxiv.org/content/10.1... Soon at @spirochrome.com Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social

Want 1,000 more steps a day? Don’t buy a Fitbit. Move to a walkable city. A US-wide natural experiment shows people who moved to high-walkability areas added ~1,100 steps/day on average, regardless of age, gender, or BMI. www.nature.com/articles/s41...

Una vez golpista, siempre golpista ☝🏼

Con estos incendios forestales seguramente escucharéis a gente decir que hay que limpiar el monte En esta entrada de mi blog os explico por qué limpiar el monte no sólo no ayuda sino que empeora la situación

Check out 🧐 our new preprint 📜: www.biorxiv.org/content/10.1... Congrats🎉 to @vasilgaisin.bsky.social and Corina Hadjicharalambous, who studied contractile injection systems directly in hot spring♨️ bacterial mats🦠 #microsky #teamtomo #Chloroflexota

France faces unprecedented chikungunya outbreak with first locally acquired cases detected in June - earliest on record. #chikungunya ↘️

Postdoc program at the MDC in Berlin, @mdc-berlin.bsky.social : take a look 👇👇 For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too! www.mdc-berlin.de/postdocs#t-g...

📣 I'm recruiting a postdoc researcher to join my team for a project on mosquito-specific viruses and host interactions. Peep the job description & how to apply below. Perfect for soon-to-be or recent PhD graduates in mosquito vector biology 🦟 or arbovirology 🦠 🗓️ Application deadline 31 August 2025

📢New job posting!📢 Are you excited by the idea of building global infrastructure to make pathogen sequencing more accessible, interpretable, and equitable? 🧑🏻‍💻🧬 My group at @swisstph.ch has an opening working with ARTIC2, @pathoplexus.org, & Loculus - read on! 1/5

🦠🧍‍♀️From bacterial to human immunity. We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social www.science.org/doi/10.1126/...

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...

Long-term #MusicalTraining can provide neural resources to help cope with effects of #aging, but how? @leicogsci.bsky.social &co show that cognitive reserve acquired via music training holds back age-related neural recruitment during speech-in-noise perception @plosbiology.org 🧪 plos.io/44NIkxZ

Here's the link to the companion paper: journals.asm.org/doi/10.1128/... - together, our studies show that PgtE enables Salmonella to evade innate immunity and cause bacteremia.

Happy that our manuscript showing that PgtE protease enables Salmonella to evade C3-mediated serum and neutrophil killing is published in mBio journals.asm.org/doi/10.1128/... - check out the companion paper from @rtsolis.bsky.social and team, focused on PgtE in the African Salmonella strain ST313

www.youtube.com/watch?v=hMH1... I am very thankful to the @ec.europa.eu for highlighting my research at @institutpasteur.bsky.social . It is a privilege for me to have the opportunity of developing my professional life here.

I am recruiting - if you have a background in plant mol cell bio, a keen interest in sustainability and planetary health and are looking to move away from the bench, this may be for you! Have a 👀 and please reach out if Qs 1yr FTC, remote in the UK job-boards.eu.greenhouse.io/plos/jobs/46...

We have a 3-year funded postdoc position to work on structures of #amyloid filaments. If you are an expert in protein biochemistry, structural biology or #cryoEM / #cryoET, this could be for you! Feel free to email me with any questions. Come join us! 🤩 www.nature.com/naturecareer...

Sexually transmissible shigellosis has gone from an obscure cause of sporadic outbreaks to a sustained endemic AMR priority in only two decades! 🧫💊 Check out our latest preprint to understand how this happened 1/11 www.medrxiv.org/content/10.1...

Big news in #GlobalHealthHistory today. A species of bacterium that causes leprosy, discovered in 2008 in modern patients, has been proven to have been present in the Americas well before European arrival. More details in 🧵 below: www.science.org/content/arti... #GlobalMiddleAges #histmed #aDNA 🧪

Only 328 days to go! We're very busy behind the scenes getting thigns ready for the meeting! In the meantime you can add your email address for updates here: coming-soon.embo.org/w26-04

Zoom into a human cell infected by Shigella, the bacteria behind dysentery. Using cryo-EM, @leaswistak.bsky.social and team revealed how it pierces cells with molecular syringes. Stunning science at the nanoscale. @enningalab.bsky.social @jytinevez.bsky.social @nanoimaging.bsky.social #CryoEM

New pre-print in the lab! Beautiful work by Francisco Garcia-Rodriguez in collab with @kamovalenz.bsky.social and @joaquinbernal.bsky.social : when macrophages are provided with specific nutrients, Salmonella can bypass its requirement of the T3SS to replicate, a process that occurs within the SCV

Another very cool story I was lucky enough to be involved in! Congrats @pescoll.bsky.social and Francisco! Now let’s hope for a smooth submission!

Provision of Preferred Nutrients to Macrophages Enables Salmonella to Replicate Intracellularly Without Relying on Type III Secretion Systems https://www.biorxiv.org/content/10.1101/2025.05.15.653970v1

If you would like to attend a #microscopy or #bioimageanalysis training course in the next 6 months but don’t have funding, check out our Microscopy Training Grant from @jcellsci.bsky.social and @focalplane.bsky.social. Next deadline: 6 June 2025 www.biologists.com/grants/jcs-f... #Training

Really proud to see this story finally published! #Shigella #T3SS

How do intracellular #bacteria breach vacuoles to enter the host cytosol? @leaswistak.bsky.social @matthijnvos.bsky.social @enningalab.bsky.social &co show that #Shigella uses its T3SS system to damage endomembranes via mechanoporation to initiate cytosolic access @plosbiology.org 🧪 plos.io/4jXrr9Z

Shout-out to @pierredupuy.bsky.social and colleagues! Excited to share our latest study, where we uncovered a previously unknown bacterial defense system in M. #tuberculosis: effluxosomes — dynamic membrane clusters that coordinate resistance to multiple toxic metals. shorturl.at/Ek0HD #MicroSky

Happy to share the latest work from the lab @crick.ac.uk. Outstanding work from Di Chen and Tony Fearns showing the link between Mtb membrane damage, calcium leakage and ATG8/LC3 lipidation in macrophages. Congratulations Di and Tony! www.science.org/doi/10.1126/...

🧬23andMe is bankrupt 🧬To delete your genetic data and your actual DNA sample before it is sold to another company, follow instructions from the Atty Gen of California: buff.ly/Qmg4Vy1 1. Start by destroying your DNA sample. 2. Then revoke permission for research. 3. Then DELETE account. #medsky 🧪

Interested in predicting AMR in bacteria? We show ignoring phylogenetic structure in genome collections leads to overly optimistic evaluations of machine learning methods for AMR prediction. With @nwheeler443.bsky.social and former PhD student Yanying Yu. 🦠🧫🧬🖥️🧪 www.biorxiv.org/content/10.1...

Job alert ‼️ 2x professorships available @uniofmanchester.bsky.social - ecology www.jobs.manchester.ac.uk/Job/JobDetai... - organismal biology (inc genomics, evolution etc.) www.jobs.ac.uk/job/DMI506/s...

🚀 Join the IBDM as a Group Leader! We are looking for innovative researchers in developmental and cell biology. 🔬 Open to junior & senior scientists 📅 Deadline: March 30, 2025 📍 Marseille, France 🔗 More info:

THE MOST PROMISING TREATMENT TO SAVE MY LIFE IS A VACINE. For those of you that voted for this man- my death is on you. I have fought to stay alive for nearly 6 years only to see the train get derailed now.

Please Please call your congresspeople, and your senators. I called mine. They need to put a stop to this pseudoscientific bullshit.

Hearing from a source: "A friend at NCI lost 3 outstanding staff (their words) and tweeted about it. She was suspended for 2 days. No idea how her tweet was flagged." This is for all the people asking us why it's hard to tell what's happening at NIH. Retaliation is real.

Last Friday, thousands attended rallies across the US (and internationally - check out this map!) in opposition to antiscience policies. I had the privilege of interviewing the organisers! Read more here (in their own words): www.nature.com/articles/s41... #standupforscience2025 #scienceforall

#StandUpForScience a rassemblé près de 15 000 personnes partout en France. Des scientifiques, équipes, laboratoires, ou des associations citoyennes ont affiché leur soutien par des photographies prises sur leur lieu de réunion ou de travail. Nous les avons assemblées 👇 standupforscience.fr/photos/