Excited for the ASPET Annual Meeting next week! The Blythe Lab will be presenting three posters -- stop by to meet the team and see what we've been working on.

New publication! Here, we explore how endocytosis differentially sculpts signaling downstream of three endogenously co-expressed GPCRs: www.sciencedirect.com/science/arti...

Members of the UMN Twin Cities AAUP voted unanimously to endorse this Statement of Solidarity with Somali and Immigrant Communities drive.google.com/file/d/1WDWq...

ATTN: Two faculty positions are available in my department (neuroscience) at the University of Minnesota. This is a general search with no topic focus. November 20th application deadline. Apply here: hr.umn.edu/jobs/Find-Job Assistant Prof job code: 364920 Associate/Full Prof job code: 364921

Now online @nature.com! Want to change the consequences of receptor activation? Small molecules binding the GPCR-transducer interface change G protein subtype preference in predictable ways, enabling rational drug design 💥 So many new possibilities! 🧪🧠🟦 www.nature.com/articles/s41... 🧵👇

@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"

🚀 Hey #GPCR community on #bluesky! 🌍 The 2nd GPCR Forum Virtual Conference is taking place!🧬 📅 Nov 12–14, 2025 This 3-day virtual event will bring together scientists and researchers from around the world to explore the latest breakthroughs in GPCR! #GPCRforum #ScienceTogether

A new special issue entitled “Emerging Voices in GPCR Biology” is now available in Molecular Pharmacology, highlighting innovative research led by early-career investigators (ECIs) across key areas of G protein-coupled receptor (GPCR) science. www.sciencedirect.com/science/arti...

My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology: postdocs.stanford.edu/prospective/... #TeamMassSpec #Proteomics #GPCR #Postdoc

"Talent and grit matter, but so do structure, transparency, and care." #ScienceWorkingLife https://scim.ag/4nCiPYg

Applying to the NSF-GRFP (or another fellowship) on a tight deadline? We built a 7-week guide + timeline to get you from draft to submission. It’s not too late — you’ve got this! ✨ 🔗 cientificolatino.com/apply-in-7-weeks #NSFGRFP #GradSchool #Fellowship

New NYT article detailing new requirements for the COVID-19 vaccine across US. This is all very preliminary information, but I suggest if you live in these states that may require a prescription, you acquire a script from your family doctor asap.

Our preprint “GPCR endocytosis rewires neuronal gene expression and cellular architecture” is now live on bioRxiv. 🔗 doi.org/10.1101/2025... We uncover how GPCR trafficking shapes protein content and neuronal structure. Congratulations to our team members, Katherine Hall and Matt Klauer! A short🧵

The Blythe Lab is growing! This summer we welcomed our first lab members: junior researcher Eamon Cole and postdoc Dr. Chantel Mastos.

A new paper proposes an ‘intracrine’ signaling mechanism whereby a G protein-coupled receptor (FFA4) senses locally released fatty acids on intracellular membranes associated with lipid droplets to efficiently regulate lipolysis in adipocytes www.nature.com/articles/s41...

🚨 New preprint alert! 🚨 Excited to share my latest work, now on bioRxiv: “Altered striatal dopamine regulation in ADGRL3 knockout mice” 🔗 www.biorxiv.org/content/10.1...

“If you cut out these diversity measures, you're going to make science full of people that are very elite…Full of people who have grown up with a large amount of privilege, who were able to work in a lab in high school because their dad was a prof at Cornell.” 🧪 www.nytimes.com/2025/07/10/u...

BOOM! Last nite we blew through the 20K mark and already @ 21K and counting. Wanna feel what it feels like to stand together w/ 20,000+ other science stans supporting the heroes of the #BethesdaDeclaration? CLICK to sign our #NIHLoveLetter here actionnetwork.org/forms/add-na... #StandUpForScience

If you weren't angry enough already, here are the rates of non-competitive renewals through May. 4008 Non-competitive renewals were due to be funded in May. The total funded was 99! Some is due to terminations, but most is due to slow grant making due to DOGE review and other impediments. 1/2

The Trump administration is unlawfully seeking to destroy higher education in the United States. It now demands that we sacrifice our international students in the process. Universities cannot acquiesce to such extortion.

Three new papers in Science report that astrocytes are indispensable for neuromodulatory signaling across diverse neural circuits, behavioral contexts, and species. Learn more in a new #SciencePerspective: scim.ag/43iprSX

The NIH has dropped its research funding by $2.7 billion so far this year. Cancer research funding has declined 31%. And new NIH research grants fell to the lowest level in more than a decade. Eye-opening findings in today's HELP committee minority report: www.sanders.senate.gov/wp-content/u...

New report from Bernie Sanders, ranking member on the HELP committee www.sanders.senate.gov/wp-content/u... Lots of substance in here. Some highlights... 1/n

Unlawful grant terminations are harming young scientists and threatening innovation. ASCB joins leaders calling for immediate funding restoration. www.ascb.org/society-news...

Science article with perspectives from NIH insiders www.science.org/content/arti... 1/n

Excited to share my first paper from my postdoc! In this study, we demonstrate that the mu opioid receptor produces a second wave of G protein activity on endosomes in a manner that doesn’t require receptor internalization. Check it out! www.pnas.org/doi/10.1073/...

Happy to have this out there! I had a lot of fun working with (and learning from) @akshitg.bsky.social on this mini-review on microdiversity in microbial populations and how current ecological theory fails to quantitatively explain the observations. doi.org/10.1111/1462...

Ever wonder how many lives have been saved by NIH-funded research - including your own? Enter any medical condition and instantly see how your tax dollars transformed science into survival. www.ourhealthroi.com

Hello Community! Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)

Happy to see my Postdoc work out @natbiotech.nature.com. Using HaloTag and synthetic fluorophores instead of FPs enables us to shift the spectral properties of kinase activity reporters (KARs) to the far-red 🔬. Huge thanks to everyone involved @jinzhanglab.bsky.social! www.nature.com/articles/s41...

Hey GPCRs, GRKs and Arrestins Scientists, I know these are troubling times but science makes us thrive. Check out the FASEB summer conference in Niagara Falls June 22-26 - great line of up outstanding speakers - we have a few slots open, register now. Abstracts due April 27th!

Looking forward to engaging presentations and discussions at #ASBMB25! I’ll be by poster 270 (Abstract 2651) on Sunday highlighting some of our work on the biological function of the strongest known genetic risk factor for fatty liver disease worldwide, PNPLA3-I148M — stop by if you’re interested

While I understand why NCI is adding this, I bothers me that it is another mechanism for the rich to get richer I did my postdoc (with foundation support) with a starting faculty member who did not yet have substantial NIH funding It was a great experience (and he was subsequently very successful)

Excited to share work led by Preston Anderson and Peng Xiao in collaboration with Jinpeng Sun (just like old times when we were postdocs in Lefko lab). We find that beta-arrestins form biomolecular condensates to regulate GPCR function - www.biorxiv.org/content/10.1...

Join us for the FASEB meeting on G Protein-coupled Receptor Kinases and Arrestins in Niagara Falls, NY June 22 -26, 2025. Abstracts due April 27th, Hotel reservation by May 25th. See Program Agenda below. Register by June 2 to save $150! events.faseb.org/event/gprk-a...

so sad for so many who have benefitted from this incredible program. this is a tragedy for every scholar, but more importantly for academic science as a whole

"We spent all this money on this research and we’re not even going to be able to give taxpayers the outcomes." DOGE's cuts to NIH grants may save money on paper, but terminating studies without notice ultimately wastes money, our analysis shows. @science.org www.science.org/content/arti...

In a landmark commentary last year, 24 scientists from around the globe—all of whom either identify as trans or have trans family members—called for recognition and support from the research community. #TransDayOfVisibility scim.ag/4l8LK5O

🚨 Over 70 graduate programs in the biological and biomedical sciences have frozen or slashed admissions. The consequences are profound—how many brilliant minds are being shut out of research entirely? How much future discovery is being lost before it even begins? docs.google.com/spreadsheets...

Check out our new review!

A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved

We're hiring! Join the Blythe lab as a full-time junior researcher starting Summer 2025. Explore GPCR trafficking and signaling using biochemistry, cell biology, and proteomics. Mentorship, hands-on experience, and career growth await! Apply now: hr.myu.umn.edu/jobs/ext/367... (UMN job ID #367053)

New preprint! Here, we explore how endocytosis encodes receptor-specific cAMP/PKA signaling downstream of three endogenously coexpressed GPCRs. www.biorxiv.org/content/10.1...

Almost all grant-review meetings under Trump 2.0 remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget. https://go.nature.com/4gM6oW4

More and more scientists are joining the ranks of fired federal workers—and fighting back through protests, appeals, and legal challenges.

I’ve been warning people about this despite people pointing out that some study sections have gone on. My study section is still on hold for this exact reason 🤦🏾‍♀️

Excited to share the publication of our latest #NIH funded work led by Matt Klauer where we determine how #GPCRs shape the translational landscape of cells: www.pnas.org/doi/10.1073/...

As a hard pivot from the dog/child action, here's some science to share with ya'll. Excited to share our work on developing a practical approach to resolving intact GPCR proteoforms: go.shr.lc/416MyyQ A short 🧵

Just boosting this post from a couple weeks ago. If you are interested in these openings or know of folks who might be interested, please reach out to me! TL;DR looking for a lab tech/manager and postdoc fellow. Please repost!

And now back to our regularly scheduled $hitshow The dismantling of NIH programs to increase diversity in the biomedical workforce and the abhorrent treatment of talented young scientists