Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪 www.richmondscientific.com/how-a-discov...

NIH's work saves lives—& Trump is gutting it. Straight from D.C. I headed to Seattle Children's to hear from researchers & patients alike about the importance of NIH funding—it's not just about lines in a budget, it's about lifesaving discoveries. We ALL need to speak up to save it.

Excited to share work led by Preston Anderson and Peng Xiao in collaboration with Jinpeng Sun (just like old times when we were postdocs in Lefko lab). We find that beta-arrestins form biomolecular condensates to regulate GPCR function - www.biorxiv.org/content/10.1...

Wow. This is really stunning . www.science.org/doi/10.1126/...

NEW: NIH slashes overhead payments for research, sparking outrage | Science | AAAS www.science.org/content/arti...

'Speeds things up, you know. Move fast and break things, amIright? Problem is, in biomedicine some of the things you break are human beings.' @dereklowe.bsky.social www.science.org/content/blog...

Merck stopped the Phase 3 Hyperion trial of its pulmonary arterial hypertension (PAH) treatment Winrevair early due to strong efficacy data & fiercepharma.com/pharma/effic... all study participants will be offered access to the drug. #biosky 1/n

American science and medicine has been thrown into chaos and uncertainty over the past week. Here are some stories to get up to speed. 1/12

Started off this morning emailing my Senators and Congressman about the NIH and the potential damage being done by unnecessary disruptions. They need to hear from us loud and clear. Constituents matter to them as one of the primary purposes of a politician is to get re-elected (and its their job).

Bluetorial: When the leadership of Science magazine does not seem to care about getting the facts right in a news story... A very troubling incident occurred some years ago and I think the concerns and lessons are important. My apologies for the length, but it is a complicated story.

Can we design allosteric modulators that change a GPCR's preferred G protein? Yes!💥 BAMs at the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design. The lab's 1st preprint! Check it out! 🧪💊🧠🟦https://doi.org/10.1101/2024.11.20.624209 🧵👇

We have updated and expanded our database of fellowships for POSTDOCS in neuroscience/neurology/cog science. For each fellowship, we provide a description, $ amount, deadline, link, and eligibility criteria. Download our database freely here: research.jhu.edu/rdt/funding-... pic.x.com/eEhXhlOzEj