𝗳𝗠𝗥𝗜 (𝗕𝗢𝗟𝗗) 𝘁𝗿𝗼𝘂𝗯𝗹𝗲𝘀 𝗮𝗴𝗮𝗶𝗻? Something that everyone using fMRI will be hoping is not very solid, please please... Please BOLD don't go down if oxygen metabolism (neurons?) goes up... And it had to affect "default" regions??? doi.org/10.1038/s415... #neuroskyence

This is an important study but psilocybin potentially promoting brain tumor growth is consistent with human studies suggesting SSRIs may worsen survival outcomes in glioma

You will find this paper interesting and relevant too: www.biorxiv.org/content/10.1...

New ENIGMA-CHR study examining network topology differences in 1282 controls and 1582 individuals with clinical high risk for psychosis, led by Drs Siwei Liu, Helen Juan Zhou, Jimmy Lee with @dhernaus.bsky.social, Maria Jalbrzikowski and colleagues. Link to article: www.nature.com/articles/s41...

A new take on the limitations of "psychometric networks" now out in Nature Human Behavior. You don't want to put too much confidence in individual edges. Something we cautioned against in 2017. 1/2 www.nature.com/articles/s41...

Published now (after long last & 10 citations). Although tVNS does not alter food reward ratings in healthy people, it acutely improved liking ratings in patients with MDD (also correlated with anhedonia). #neuroskyence 🩺 Work w/ @akuehnel.bsky.social www.sciencedirect.com/science/arti...

With over 7000 participants @ecnp.eu annual meeting in Amsterdam is kicked off by President @martienkas.bsky.social - Congrats to program chair Barbara Franke on an excellent program starting with an impactful keynote from Eveline Crone on the mysterious adolescent brain. #ecnp2025

This one looks intriguing. Arousal "embedding" whole-brain dynamics. 🤯 #neuroskyence #compneurosky doi.org/10.1038/s415...

'Memento', but it's every plot you make in R

somehow I missed this! Dopamine represents a domain-general teaching signal: www.science.org/doi/full/10....

Lab’s latest is out in Imaging Neuroscience, led by Kirsten Peterson: “Regularized partial correlation provides reliable functional connectivity estimates while correcting for widespread confounding”, where we demonstrate a major improvement to standard fMRI functional connectivity (correlation) 1/n

New preprint...and this one is truly EPIC 🚨. Using a large group of patients with depression and healthy controls (N>800), we show differences in the functional segregation of insular subnetworks. And we can use it to classify! Led by @glassybrain.bsky.social #neuroskyence 🩺 osf.io/preprints/ps...

Discovery of a brain center (BNST) that controls consumption (including sweets, fats, salt and other foods) in mice www.cell.com/cell/fulltex...

This was a fun piece to write

In our new paper 📖🔥, we conducted a pooled analysis (n=443; 5 studies) to test if state affect (momentary mood) or trait dispositions (approach/avoidance) predict cortisol reactivity beyond biological & contextual factors. (1/4) #neuroscience #Neuroskyence #cogpsyc #AffectSci #psychscisky

Hello hivemind! I haven't seen one of these in a while but I know that back-in-the-day they were all the rage: does anyone have a funky spreadsheet of MH/psych/neuro-relevant grants/fellowships for ECRs that they wouldn't mind me sharing with my lab?

check out Jake Russin's new paper on how the interplay between in-context and in-weight learning in neural nets can explain tradeoffs in human learning! pnas.org/doi/epdf/10....

My latest: a short review on latent variable models to help uncover trial-to-trial structure in perceptual decision-making strategies authors.elsevier.com/a/1lMiv4sIRv...

I am delighted to announce registration and abstract submission is open for "The Mechanistic Basis of Foraging 2025" to be held at the Edgbaston Park Hotel, University of Birmingham, UK on 3-5th November 2025. uobevents.eventsair.com/the-mechanis...

Alert!!!! “An Action Networks Model for Pain” We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it. 👉 thread below 🧵 osf.io/preprints/ps...

Our big behavioral precision mapping preprint is out. Based on 1,486,950 observed choices in a reward learning task, we show that BMI is associated with higher and more variable learning rates. Binge eating was associated with lower reward sensitivity. #neuroskyence 🩺 www.medrxiv.org/content/10.1...

An Analysis of 200 pairwise statistics for functional brain connectivity in tasks such as hub mapping, distance relationships, structure-function coupling and behavior prediction highlights their effectiveness for neurophysiological applications. www.nature.com/articles/s41...

When I first started working with resting state fMRI as a postdoc, there was a lot of skepticism about what we could learn from it. 20 years later, it's hard to imagine where the field of neuroscience would be without it. Here's a summary 🧠 www.nature.com/articles/s41...

Still open for expressions of interest until June 15th! Do reach out directly (or see link) if you're interested in developing an MSCA-Postdoc. Fellowship application on the (cognitive) neuroscience of motivation/goal-directed behaviour 🧠 👇 #cognitiveneuroscience #Neuroscience #postdoc #cogsci

A Reinforcement Learning and Decision-Making framework for understanding Mental Disorders: https://osf.io/s58jh

Transcutaneous auricular vagus nerve stimulation (taVNS) and fMRI: a great combination to test the mechanism of action driving stimulation effects 🧠 But how to use the stimulation safely within the magnetic field? We looked into this! #neuroskyence doi.org/10.31234/osf...

Serotonin neurons are known for their puzzling responses to rewards and punishments that don't quite fit with simple theories based on reward, punishment, surprise, salience, or uncertainty. Theories of serotonergic function seem to be diverging over time. efharkin.com/blog/2024-07... 3/6

Out today in American Journal of Psychiatry: psychiatryonline.org/doi/10.1176/... @kurtfraser.bsky.social and I evaluate the Aberrant Salience hypothesis of psychosis in light of the work it inspired over the last 20 years. We still find it ambitious and beautiful, but the devil is in the details

Interested in dopamine? Have fMRI data? We’ve identified a temporal BOLD feature that carries rich information about dopamine physiology. This measure, obtainable from resting-state and task fMRI, opens new ways to indirectly probe dopamine’s role in cognition and disease. 1/n tinyurl.com/bddyz67b

🥂 IT'S A WRAP !!! 💡ENIGMA's 2024 End-of-Year VIDEO ( youtube.com/watch?v=lJ9E... ) highlights discoveries by 2,000+ scientists from 45 countries, investigating 30+ brain diseases through brain mapping, genomics, environmental studies, treatments, neurostimulation, prevention across cultures (1/n)..

A detailed new look at dopamine signaling suggests neuroscientists’ model of reinforcement learning may need to be revised. #MIT "Dopamine release plateau and outcome signals in dorsal striatum contrast with classic reinforcement learning formulations" #NatureCom www.nature.com/articles/s41...

Nothing says cozy reading by the fireplace like our new review, “Molecular heterogeneity and development of the VTA” Thanks @bensaunders.bsky.social and @bellonec.bsky.social for the invitation to contribute to this special issue on #Dopamine! authors.elsevier.com/a/1kIwj8MqMi...

OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019). The renamed: Bluesky-sized history of neuroscience (biased by my interests)

My paper is out!! 🎉 "Opponent control of reinforcement by striatal dopamine and serotonin", @Nature Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain THREAD ⬇️ 1/n

🚨Out in Nature Human Behaviour!🚨 Effort is costly - how can we learn to value doing effortful things? Reward effort, not outcomes/performance! Registered report led by the incomparable Hause Lin shows people can learn to prefer doing effortful tasks doi.org/10.1038/s415...

Dynamic representation of appetitive and aversive stimuli in nucleus accumbens shell D1- and D2-medium spiny neurons https://www.biorxiv.org/content/10.1101/2024.02.22.581563v1

How do the LC and VTA systems respond to rewards and valence? Our study used high-res fMRI to explore their activation during a reward-emotion recognition task www.biorxiv.org/content/10.1...

We submitted a revised version today, thanks to @akuehnel.bsky.social's work. I hope it will be published soon. #neuroscience 🩺

I'm elated to share my PhD keystone paper published @PNAS www.pnas.org/doi/10.1073/... I've poured my heart & soul into this project since 2016 (8 yrs!) & I'm happy to introduce the Effort Foraging Task to the world #CognitivePsychology #Motivation #Effort #Foraging #DecisionMaking 🧵

New paper day! "Multiband acquisition sequences for fMRI: Proceed with caution" apertureneuro.org/article/9129... VERY proud of this one as it's my first editorial piece. Big thanks to @layerfmri.bsky.social and @fmri-today.bsky.social for asking me to do it. #neuroskyence

New paper out led by Xavier Job at @elife.bsky.social !!! elifesciences.org/articles/90912 We tested two opposing hypotheses of how action influences somatosensory perception! We show that action does not enhance but attenuates self-touch compared to identical touch in the absence of action

Locus Coeruleus Norepinephrine Neurons Facilitate Orbitofrontal Cortex Remapping and Behavioral Flexibility https://www.biorxiv.org/content/10.1101/2023.12.15.571858v1

Anxiety researchers - has anyone tried to recruit hypo-anxious population? (people with very low anxiety) If so, what were your selection criteria? Is there a specific diagnostic tool for this?

First pre-print thread here on bsky! We investigated how the acute stress response impacts the allocation of resources (energy) towards safety-related goals. osf.io/preprints/ps... #neuroscience #Neuroskyence #cogpsyc #AffectSci #psychscisky (1/6)

The Drive to Survive: Acute Stress Promotes Aversive Motivation: http://osf.io/yhqbt/

After months of piloting and optimization, we are finally seeing high-quality recordings of tVNS-induced pupil dilation. @akuehnel.bsky.social also set up an automated QC report with several plots and is too humble to brag about it. Work w/ @cecivez.bsky.social #neuroscience

Is the vagus nerve primarily regulating 'rest & digest'? In our new TiCS review, we outline that it is time to expand our perspective on vagal signaling to include 'strive to survive' as a second survival mode. Work w/ @glassybrain.bsky.social #neuroscience authors.elsevier.com/a/1iALr4sIRv...

quick q for universities that require you to sign up to a website to submit your letter of rec: (1) how dare you

Great open access textbook on experiment design! (h/t @mcxfrank.bsky.social) experimentology.io

🔔New Postdoc Position 🔔 Do you love computational modelling and mental health? We're recruiting a postdoc on a Wellcome Trust-funded project to lead the development of a new open-source platform: Hypatia. w/ @alexandrapike.bsky.social, Lei Zhang and Catia Oliveira Read on 👇👇👇