This is a landmark paper showing a predictive test for #ALS #MND up to 40 years before onset and able to predict age of onset. Huge implications www.nature.com/articles/s41...

🌍 Be part of the global effort to tackle #ALS. The £7.5m (~$10m) #LongitudePrizeOnALS is searching for innovators in #AI, #data, #biotech, and #neurology. 🧠 Meet the teams already registered, and find out how you can partner with them below. 🔗https://bit.ly/4mdHxxX

🧠 The @ukmndri.bsky.social is an #MND powerhouse, accelerating progress towards new treatments and, ultimately, a cure. Read their article about how the #LongitudePrizeOnALS could be a game-changer for drug discovery in neurodegenerative diseases. 🔗 bit.ly/40Tmmsh @ammaralchalabi.bsky.social

Postdoc Research Assistant in Dr Arpan Mehta’s lab at University of Dundee, using CRISPR screens in iPSC-derived motor neurons to study ALS mechanisms. Closing date: 4th August www.dementiaresearcher.nihr.ac.uk/job/postdoc-...

“MND is one of the most scientifically and biologically challenging diseases to tackle. That said, no mountain is insurmountable…” Dr. Mike Rogers (@mndassoc.bsky.social) shares why the #LongitudePrizeOnALS is key to creating new opportunities for #ALS & #MND 📰 longevity.technology/news/climbin...

Tagging 🧪 🧬🖥️

New research has examined how disrupted sleep patterns may signal the early stages of #MND / #ALS or FTD, providing clues to earlier detection. Read more ⬇️ 🔗 ukmndri.org/2025/07/16/r... This post is part of our Research Snapshot series, powered by Readable Research at @sheffielduni.bsky.social

Researchers reveal that structural variants disrupting the 3D genome can drive diseases like cancer by altering gene expression. by Sreenivasan VKA, Yumiceba V and Spielmann M in Nat Rev Genet #MedSky 👉 get more here 📖 read the article:

⏰ Reminder: Our first Welcome Webinar is tomorrow, Tuesday 9th of July at 09:00 BST. 💻 Register below to learn everything you need to know about the #LongitudePrizeOnALS, including how to apply, how the Prize works, and what support is available.

Research Fellow vacancy at UCL MND Centre. Join Prof Andrea Malaspina’s team to study immune responses and neoantigens in ALS using proteomics and cell phenotyping. Closing date: 20th July www.dementiaresearcher.nihr.ac.uk/job/research...

🧠 As the principal funder, the @mndassoc.bsky.social has been instrumental in bringing the #LongitudePrizeOnALS to life. We were joined by Dr Usman Khan last week, who spoke on the power of cross-specialism collaboration. Learn more about the Prize: bit.ly/4kD3tSh #AIforGood #MND #ALS

Want to learn more about the £7.5M #LongitudePrizeOnALS? Join one of our welcome webinars to find out how the Prize works and how to get involved. Register here: 📅 9 July, 09:00 BST: bit.ly/4nzJuWA 📅 10 July, 17:00 BST: bit.ly/3Tl4u5u #AIForGood #MND #ALS

Check out this article from Dr Brian Dickie (@mndassoc.bsky.social), exploring how #AI and quality data can transform treatment progress—and how the £7.5M #LongitudePrizeonALS aims to support #innovation through global collaboration. 🧠 Read here: bit.ly/4nqi4lN #ALS #MND

Apply now for the NIHR Senior Investigator award! £15K per year for 4 years to support top researchers shaping the future of health and social care in the UK. @nihr.bsky.social www.dementiaresearcher.nihr.ac.uk/funding/nihr...

What a week for the #LongitudePrizeOnALS 🧠 Thank you to everyone who made it possible! 🎥 Watch the segment on BBC News here: bit.ly/4eoGyaR This is just the beginning. Entries close 3 Dec → Learn more on our website: bit.ly/4kD3tSh @trisdyson.bsky.social @ammaralchalabi.bsky.social #AIforGood

Join Dr Arpan Mehta's lab at MRC PPU, Dundee, for a 12-month postdoc using CRISPR screens to explore ALS in iPSC-derived motor neurons. Closing date: 18th July www.dementiaresearcher.nihr.ac.uk/job/postdoc-...

Today is #MNDAwarenessDay, a moment to highlight the hidden realities of living with #MND. Our translational research projects aim to find treatments for MND through a national, coordinated approach. 👉 Discover more: ukmndri.org/2025/06/20/f...

Professor Sir Simon Wessely is a world-renowned academic psychiatrist and epidemiologist and has been awarded this GBE in recognition of his distinguished position as 'the pre-eminent psychiatrist of his generation in the UK.' ⬇️ www.kcl.ac.uk/news/profess...

We are delighted to announce that Professor Sir Simon Wessely has been awarded a Knight Grand Cross of the Order of the British Empire (GBE) in this year's King’s 2025 Birthday Honours. 🎉 🧵⬇️ @kingsioppn.bsky.social

Join a leading dementia research team as a Clinical Research Fellow at UCL. Work on trials for novel Alzheimer’s and FTD therapies. Closing date: 2nd July www.dementiaresearcher.nihr.ac.uk/job/clinical...

Back from Torino where I was able to hear hundreds of smart young ALS investigators from all corners of Europe. (This pic was taken at the very last session on a Friday afternoon. They stayed.) 1/

Day 3

Read about our latest findings from the @MNDRegister showcased at the @ENCALS Meeting 2025.🌍 Findings ranged from a new #MND/#ALS incidence and prevalence analysis to clinical characteristics and outcomes. Read more here⬇️ ukmndri.org/2025/06/04/m...

EVERY ALS MND scientific conference needs to allow for those with ALS MND who want to attend to be there in person or virtually. It is simply wrong to exclude them.

We are pleased to announce that the @ucl Queen Square Motor Neuron Disease Centre Sixth Hybrid #ALS/#MND International Symposium in Partnership will be held on Friday 5/9/25. The theme is Translating Targets to Therapies. To register, click below⬇️ www.eventbrite.co.uk/e/ucl-queen-...

This week, we launched our brand new and redesigned website for the @MNDRegister.🗺️ But why is it so important? Find out how this vital resource is helping researchers understand who is affected by #MND/#ALS and why. 📖Read more below. ukmndri.org/2025/05/28/m...

Our paper on the theoretical properties of SNP heritability in admixed populations is out in Genetics: academic.oup.com/genetics/adv... with @jinguohuang.bsky.social, @nicole-kleman.bsky.social , Saonli Basu, and Mark Shriver

So lucky to have the best lab. Will miss @kittybmurphy.bsky.social so much 😢❤️ but excited to see her future successes in ancient genome research!

📄The UK MND Clinical Studies Group has released an official statement in response to the MIROCALS study results. Find out what it means for future research into #MND / #ALS 🔗 ukmndri.org/2025/05/15/uk-mnd-clinical-studies-group-issues-statement-on-mirocals-trial-findings/

The #MIROCALS study has now been assessed by the UK MND Clinical Studies Group. Their consensus statement can be found here: ukmndri.org/2025/05/15/u... #ALS #MND #clinicaltrials @ukmndri.bsky.social @mndassoc.bsky.social @mndoddie5.bsky.social @mndscotland.bsky.social

We may be closer to treating motor neuron disease (or #ALS) thanks to a new clinical trial involving Sheffield University scientists. We've a primer 🧵 from the MIROCALS trial, published in @thelancet.bsky.social, below, or jump to the story on our website 👇 1/5 www.sheffield.ac.uk/news/landmar...

Our paper describing the results of the MIROCALS trial of low-dose interleukin-2 in #ALS #MND is out in the Lancet @thelancet.bsky.social Open access Read it here: www.thelancet.com/journals/lan...

ALL ALS scientific conferences should think like this... pactalscongress.com/nina-buscomb...

If your condition is getting worse very quickly, your health and social care team may recommend you complete the Fast-track Pathway Tool. This must be completed by a doctor or a registered health professional. #MND #KennedysDisease Find out more www.mndassociation.org/chc

I recenty did a podcast about our work in the lab @ukdri.ac.uk @uclqsion.bsky.social to understand the mechanisms that cause FTD/ALS check it out here: SoundCloud on.soundcloud.com/xs6j9EcMbTRW... - Apple Podcasts podcasts.apple.com/it/podcast/n... - Spotify open.spotify.com/episode/7cnY...

We’re working to shape the UK’s research environment for MND to accelerate the search for a cure.🔬 Our goals: ✅ Accelerate drug discovery ✅ Better understand MND ✅ Support research participation ✅ Coordinate a national strategy Learn more 👉 ukmndri.org/ourstory

THIS is how it's supposed to work... People living w ALS and caregivers welcomed to every ALS scientific meeting. Thanks, PACTALS.

Introducing our new Research snapshot series. Where we highlight the latest #MND studies reported by Readable Research @sheffielduni.bsky.social 🔬 First up: a look at toxic proteins in a mouse model of C9orf72-related MND and what it tells us about future treatments. ukmndri.org/2025/04/14/r...

Catch up with the @mndassoc.bsky.social Political Snapshot - a round-up of some of our recent influencing work in #westminster #senedd and #stormont on behalf of people affected by motor neurone disease. www.mndassociation.org/media/latest... #mnd #mndcampaigns

Tanya Curry, CEO of the @mndassoc.bsky.social has written to the Department of Health & Social Care raising urgent concerns about access to Tofersen. We’re calling for immediate intervention and extra funding to ensure all eligible #mnd patients can access Tofersen via the Early Access Programme.

April's issue of Brain is now online! academic.oup.com/brain/issue/...

Does reldesemtiv, the a fast skeletal troponin activator, slow ALS progression? Spoiler alert: nope. What will we learn from this failure? Will sartor resartus – the tailor re-tailor, and build on the failure? Shefner and colleagues just published in JAMA Neurology. jamanetwork.com/journals/jam...

CREB3 gain of function variants protect against ALS www.nature.com/articles/s41...

A huge thank you to everyone who took part in and supported the Darby Rimmer Foundation’s #MarchOfTheDayII🙌 Your incredible efforts help fund vital #MND research and support those affected by the disease. Thank you to all who sponsored us.

NIH's NINDS had been planning to issue grants to academic scientists to study blood- and brain-scan markers of non-Alzheimer’s dementia & ALS. “we will not be able to run that kind of program.” Instead, he said, “we will have to do simpler things.” www.nytimes.com/2025/03/24/h...

Did the ground just shift under our feet in Huntington's disease? Handsake and colleagues performed a series of experiments. 3 incisive questions? 1- what is toxic to cells ? Why is toxicity cell type specific? Why does Huntington’s disease stay latent for years before unmasking? Somatic mutations.

Delighted to have been reappointed as an NIHR Senior Investigator

Please invite your MP to meet us about #mnd in Parliament on 1 April and to share this with your networks. Many thanks! 🙂 ecampaigns.mndassociation.org/page/165792/...