New preprint from the lab! @findunmun1.bsky.social @chemsley.bsky.social We looked at new protein synthesis and genetic fitness during starvation in P. aeruginosa. Resources are dynamically redistributed to support ongoing activity, even over days of total starvation: www.biorxiv.org/content/10.1...

''including ORFs within tRNA loci.'' 🤷🏻‍♀️🧐 study detects significant ORF hits at 10 distinct tRNA loci under high chloramphenicol selection 🦠

Dual transposon sequencing profiles the genetic interaction landscape in bacteria | Science https://www.science.org/doi/full/10.1126/science.adt7685?af=R

Huge opportunity - super exciting lab to work in

A systemic screen using programmable antisense oligomers to silence genes of DNA and RNA phages identifies proteins essential for phage propagation. This tool offers potential for optimizing phage therapy. #NBThighlight www.nature.com/articles/s41...

Super cool Pseudomonas-Bacillus interaction paper in @natmicrobiol.nature.com from Yun Chen with @gabrieleberg.bsky.social Phenazines shape Gram+ abundance & influence Bacillus cell biology Phenazines contribute to microbiome dynamics by targeting topoisomerase IV www.nature.com/articles/s41...

Efficient sequence alignment against millions of prokaryotic genomes with LexicMap - @shenwei356.bsky.social @zaminiqbal.bsky.social go.nature.com/3K09TgJ

New in JB: There are many ways to regulate transcription. Jayasinghe and Babitzke review the role of RNA polymerase pausing in the control of gene expression in several microbes. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology

Postdoc position available - pls share- to investigate molecular mechanisms of protein homeostasis during S. during infection. Send a CV, list of publications, and a statement about why you would like to join the laboratory. Eduardo Groisman Yale Med [email protected]

Pseudomonas aeruginosa senses exopolysaccharide trails using type IV pili and adhesins during biofilm formation by O'Toole, Parsek, & Wong groups www.nature.com/articles/s41...

So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!

journals.plos.org/plosbiology/... #MicroSky

www.cell.com/cell-host-mi... #MicroSky

academic.oup.com/nar/article/... #MicroSky

www.sciencedirect.com/science/arti... #MicroSky

www.science.org/doi/10.1126/... #MicroSky

New in JB: Yigit and Chien review the role of the Lon protease in oxidative stress, including regulation of Lon activity by such stress. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology

Pls share: Distributing this advertisement from EMBL for a group leader position at their Hamburg, Germany site: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Genome-wide screening using TraDIS accelerates identification of key adaptive mutations of longer-term evolution experiment in Escherichia coli. https://www.biorxiv.org/content/10.1101/2025.09.02.673662v1

The Company of Biologists @biologists.bsky.social has a strong commitment to sustainability including our sustainability hub www.biologists.com/sustainabili... & event carbon calculator www.biologists.com/sustainabili... Find out more about what our initiatives & the carbon footprint of your event

Effectiveness of a novel selective medium ‘Modified MacConkey Agar for Burkholderia’ for isolation of Burkholderia pseudomallei from contaminated specimen By Md. Shariful Alam Jilani and co workers www.sciencedirect.com/science/arti...

Pseudomonads coordinate innate defense against viruses and bacteria with a single regulatory system: Cell Host & Microbe www.cell.com/cell-host-mi... #MicroSky

www.nature.com/articles/s41... #MicroSky

@jrchandler.bsky.social: #Burkholdaria thailandensis AHLs activate transcription of many genes in #Chromobacterium subtsugae, including the hcnABC genes coding for production of hydrogen cyanide, providing Csubtsugae a competitive advantage #phages2025 🦠 www.microbiologyresearch.org/content/jour...

@paczkowskilab.bsky.social: luxR type receptor RhlR integrates multiple regulatory pathways in #Pseudomonas QS network; accessory protein PqsE slows RhlI proteolysis #phages2025 🦠 journals.asm.org/doi/full/10....

A biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells url: rupress.org/jcb/article-...

Roughly 10% of all living organisms lack superoxide scavenging enzymes (SOSEs). How do they survive superoxide stress? Research in #mBio suggests redox-based metabolic reprogramming may compensate for loss of SOSEs in pathogenic bacteria. Get the story: asm.social/2wV

Amino acid competition shapes Acinetobacter baumannii gut carriage: Cell Host & Microbe www.cell.com/cell-host-mi... #MicroSky

📢Our review of the impact of bacterial purine synthesis on antibiotic tolerance and resistance expression is now out! A lot of food for thought and contrasting data from E. coli and S. aureus... 🤔 Read it here: rdcu.be/ezfQ7

journals.plos.org/plosbiology/... #MicroSky

What is the role of extracellular polymeric substances (EPS) in carbon exchange among microbial species? @sammy-pontrelli.bsky.social &co show that #EPS, formed via #chitin degradation, drives #MicrobialDiversity by acting as a sequentially degraded #CarbonSource @plosbiology.org 🧪 plos.io/3J9kbuu

#Review A discussion on the processes driving bacterial evolution and emergence of pathogenesis within hosts, the importance of understanding within-host genetic diversity, and the implications for transmission analysis and infectious disease control. #MicroSky 🦠 www.nature.com/articles/s41...

Metal ions are universally required for life, and many of the foundational principles of metal homeostasis have emerged from studies of microbial systems. In this review, I provide a introductory overview targeted to those new to the field. #MicroSky #Metals rdcu.be/eycU2

#microsky tRNA modifications in Pseudomonas aeruginosa academic.oup.com/nar/article/...

journals.plos.org/plosbiology/... #MicroSky

🌑Goodbye bleaching, hello brightness! ☀️ We're thrilled to introduce two new Halotag ligands featuring @zhixingchen2.bsky.social fantastic photoresistant BD-dyes! ✅ Highly photoresistant, no photoblueing ✅ Outstanding brightness ✅ Cell permeable ✅ Outperform best in class fluorophores

New in JB: Conaway, Hogan et al. link QS and phosphate metabolism in P. aeruginosa, with implications of pathogenesis. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology

Repurposing a drug to punish carbapenem-resistant Acinetobacter baumannii | PNAS www.pnas.org/doi/10.1073/... #MicroSky

journals.plos.org/plosgenetics... #MicroSky

#NatMicroPicks Cell shape drives bacterial infections! 🦠🔷🟠⬛ Tissue geometry regulates bacterial infection patterns in epithelial layers by modulating cellular forces and Piezo1 localization, offering new mechanobiology-based strategies for infection control. #MicroSky www.cell.com/cell/abstrac...

#NatMicroPicks Vibrio in competition! 🦠💉 An orphan T6SS effector in non-toxigenic Vibrio cholerae targets susceptible strains by disrupting ion balance, shaping Vibrio population dynamics and offering a model for precision antimicrobials. #MicroSky www.cell.com/cell-host-mi...

Don't put all your eggs🥚 in the same basket🧺 𝙋𝙨𝙚𝙪𝙙𝙤𝙢𝙤𝙣𝙖𝙨 𝙖𝙚𝙧𝙪𝙜𝙞𝙣𝙤𝙨𝙖: epigenetic ON/OFF switching of 𝙜𝙡𝙥𝘿 gene → diverse subpopulations in the host Cells with high 𝙜𝙡𝙥𝘿 → increased toxin production and motility Low 𝙜𝙡𝙥𝘿 cells stay stealthy Balances attack and evasion www.pnas.org/doi/10.1073/...

The June issue of JB is out! Minireviews on the ribosome, Halofarex as a model microbe & riboswitches. Articles topics include CRISPRi methods, microbial interactions, biofilms & Ca, cell cycle, QS, and more! journals.asm.org/toc/jb/207/6 @asm.org #Jbacteriology

New in JB: Tchadi, Taylor et al. use a heterologous expression system to show that binding of PqsE to RhlR fine-tunes RhlR activity and does so in a promoter-specific fashion. journals.asm.org/doi/full/10.... @asm.org #JBacteriology

Lon protease, a highly conserved ATP-dependent protease, is thought to play a central role in mitigating oxidative stress by targeting damaged and misfolded proteins for degradation. This #JBacteriology review offers some insights: asm.social/2sV

New in JB: Oladosu and Sauer show that FleQ, SagS and BrlR contribute to fine tuning the expression of genes contributing to antibiotic tolerance in P. aeruginosa biofilms. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology

Shape of things to come? What if medical devices could passively repel bacteria with no drugs or coatings? Nat Comm: screen of 2,176 microtopographies finds different shapes that prevent Pseudomonas aeruginosa colonization up to 15-fold better than smooth plastic www.nature.com/articles/s41...

🚨Out now! #News&Views Different forms of bacterial persistence in Bacillus subtilis are driven by a common (p)ppGpp-mediated switch that depletes GTP, triggering a rapid transition from a sensitive to an antibiotic-recalcitrant state. #MicroSky www.nature.com/articles/s41...

🄰🅆🄴🅂🄾🄼🄴 Stubbusch et al 𝘚𝘊𝘐𝘌𝘕𝘊𝘌 Bacteria 🦠 repurpose Type VI Secretion Systems based on environmental cues: Nutrient-rich environments ➜ kill competitors Under starvation ➜ lyse neighbors to scavenge their nutrients Even “non-pathogens” shift from competition to predation as a survival strategy

Sharing the most significant work from my group, led by the @evolvingstem.bsky.social team. Come for the discoveries of how Pseudomonas adapts in biofilms, stay for the story of how they were discovered by thousands of young scientists in grades 9-12. 🧪🧫🧬🧵 www.biorxiv.org/content/10.1...