Late in the season but still the occasional breathtaking beauty…

Physical activity and risk of Alzheimer's disease. In older adults (mean age 72) with elevated Aβ amyloid, 5,000-7,500 steps/day (<-a plateau) were associated with less Tau accumulation, improved cognition @naturemedicine.bsky.social nature.com/articles/s41...

Tx for highlighting @nachristakis.bsky.social - this contributes to the present optimism and opportunity around healthy aging as I recently discussed in @wsj.com -> www.wsj.com/opinion/nobo...

"Everyone has won and all must have prizes." - The Dodo

In my latest TR column, I: - Go over new study of AI-vs-human hlth coaches for DM2 prevention (it was a tie); - Highlight value of AI approach (scale, continuous learning, supercharging promising local approaches); - Suggest top practitioners, FTF, still v best timmermanreport.com/2025/10/the-...

In my latest TR column, I: - Go over new study of AI-vs-human hlth coaches for DM2 prevention (it was a tie); - Highlight value of AI approach (scale, continuous learning, supercharging promising local approaches); - Suggest top practitioners, FTF, still v best timmermanreport.com/2025/10/the-...

In my latest TR column, I go over a just-published study comparing human and AI health coaches for DPP-based diabetes prevention, and discussion the implications for implementing health-promoting behavior change at scale. timmermanreport.com/2025/10/the-... @luketimmerman.bsky.social

"The marathon is glorious in no small part because the day represents an ideal of civic life: people striving to accomplish their goals while seeking connection…let us take solace from this model of civic participation that reveals all that we can accomplish together when we cheer one another on."

Thx for flagging, @erictopol.bsky.social! tl;dr: Why I see such hope in the longevity movement, despite the often-dubious science & frequently exaggerated claims. In short: we're embracing agency, recognizing that we have a measure of control over our long-term health. More: kindwellhealth.com.

If gift link not working for you, here's an accessible PDF: drive.google.com/file/d/1DaoF...

Just out: @wsj.com op-ed I wrote on why I see such hope in the longevity movement, despite often dubious science & frequently exaggerated claims; in short: we're embracing agency, recognizing that we have a measure of control over our long-term health. wsj.com/opinion/nobo... (gift link).

Looking for w/e reading on social connection, aging clocks, and longevity? TR has you covered -> timmermanreport.com/2025/10/the-... Incl: new book rec; two interesting new papers; reflections on this wk's biomarker & aging conf @harvardmed.bsky.social. @nachristakis.bsky.social @jvl.bsky.social

Latest TR on intersection of 2 topics: underappreciated importance of social connection as key driver of longevity & increased availability of easy-to-apply tools to assess "biological" aging: timmermanreport.com/2025/10/the-.... Bottom line ⬇️. @alicecallahan.bsky.social @sarahlongwell25.bsky.social

@nachristakis.bsky.social @ashishkjha.bsky.social @meganranney.bsky.social @thgoetz.bsky.social @jvl.bsky.social cc

Digital health tracks biometrics relentlessly. But human connection-a powerful evid-based driver of longevity-is harder to measure, & thus frequently overlooked. New studies (w/aging clocks) emphasize importance. Also: quick thoughts on 2025 aging bmx conf timmermanreport.com/2025/10/the-...

This LI post, summarizing recent panel discussion about AI in biopharma, triggered me b/c it seemed absolutely unmoored from reality. In particular, idea that "biotech now calculates success like NASA, not 'shots on goal'"= total fantasy. www.linkedin.com/posts/aaronb... @matthewherper.bsky.social

Another fantastic @nejm.org Not Otherwise Specified pcast ep from incomparable @lisarosenbaum.bsky.social; this season's topic is primary care, and today's focus=impact of AI - fascinating discussion w Stanford's Steven Lin. podcasts.apple.com/us/podcast/can… cc @meganranney.bsky.social

Wow. Even if anti-inflam mech would have thought degree of initial chronic inflammation, and consequently degree of cv benefit, might still have been correlated w baseline adipose and mag of wt loss.

Astonishing: The cost of health insurance for a family jumps to $27,000 from @tarabannow.bsky.social www.statnews.com/2025/10/22/h...

The beauty of autumn in New England

There is nothing like a great farmer's market

Hard agree! Key theme of my latest @wsj.com rev: wsj.com/arts-culture/b…, & impt overlooked oppy for digital platforms who have pivoted to longevity but are myopically fixated on optimization of performance metrics. Connection w others=vital for health, flourishing. https://www.kindwellhealth.com/

These large national cohorts provided data that supported healthcare policymaking across the public and private sectors. They were some of the most important works that only CDC was able to perform - and execute well - as a nationally representative survey. www.statnews.com/2025/10/14/c...

Aging well has increasingly focused on lab values & fitness scores. Often overlooked: engaging w other people. "Why Brains Need Friends" distills the science showing connection fuels resilience, enhances length, quality of life. My @wsj.com rev: www.wsj.com/arts-culture... @nachristakis.bsky.social

Final graf in my new @wsj.com book review of "Why Brains Need Friends," on the neuroscience+health value of social connection. www.wsj.com/arts-culture... @nachristakis.bsky.social @dereklowe.bsky.social @euanashley.bsky.social @thgoetz.bsky.social @hannahkuchler.bsky.social @jvl.bsky.social

Just out-my latest @wsj.com rev of new bk abt neuroscience underlying one of most impt - & most frequently overlooked (esp by would-be tech longevity platforms)-qualities associated w health & healthy aging: close social connection. www.wsj.com/arts-culture... (gift link) @alicecallahan.bsky.social

"More of a comment"

Incredibly powerful story from endocrinologist Dr. Caroline Fox candidly sharing her experience w an acute mental health crisis & her long, difficult, maddening, deeply inspiring journey towards recovery - & return to work as a senior biopharma R&D leader. www.youtube.com/watch?v=YVWS...

When 2 life science discoveries converge: solving a ~3 decade mystery of extraordinary longevity and healthspan + an essential cell danger sensor And related ongoing clinical trials! erictopol.substack.com/p/a-long-awa...

What @citizencohn.bsky.social said. Nicely done, @sonnybunch.bsky.social .

Who knew? Happy autumn!

Said on the local weather this morning: “It went from 80 to 55 like it saw a state trooper.”

TFW it sinks in that no one actually reads anything. Not when you cognitively recognize this, but when you viscerally understand it and know it to be true.

Finally got out three new TR pieces I've been working on: 1. Consumer Health's Digital Convergence - And What's Still Missing: timmermanreport.com/2025/10/cons... 2. Discussion of "Food Intelligence" book timmermanreport.com/2025/10/food... 3. AI Implementation: timmermanreport.com/2025/10/sili...

My latest TR column, discussing progress+ambition in consumer health-esp convergence around "personal health OS." Excited about much of this work, but disappointed by continued reductionist view of health as metric optimization timmermanreport.com/2025/10/consum… @alicecallahan.bsky.social

Each of these companies should be free to fire employees for performance. That can be subjective! No one is entitled to million-dollar paychecks for big news & entertainment jobs. But when decisions are made to hire and fire to appease a vengeful ruler that’s different. That’s autocracy at work.

In addition to whatever this says about wellness, it also speaks to where the audience is perceived to be - it looks like if you want to reach most people impactfully, you need high impact video clips; suspect @zekeemanuel.bsky.social will likely add Youtube, also some kind of podcast...

Move over Peter Attia and @hubermanlab.com -- looks like @zekeemanuel.bsky.social is leaping (energetically...) into the wellness influencer space! LI announcement -> linkedin.com/posts/zeke-e... cc @erictopol.bsky.social @alicecallahan.bsky.social @euanashley.bsky.social

@jvl.bsky.social Quite possibly the only non-shitty thing I've seen all day/week/etc. cc @sonnybunch.bsky.social

IT'S OFFICIAL: Connecticut, Maine, Massachusetts, New Jersey, New York State, Pennsylvania, Rhode Island and New York City have formed the Northeast Public Health Collaborative. The collaborative will issue their own vaccine recommendations and coordinate public health efforts.

For anyone who, like me, grew up on Woody Allen (and can place lines like "The moose...mingled" & characters like Virgil Starkwell, his interview with Bari Weiss on @thefp.com Honestly pcast will prove, like so many of his films, irresistible - www.thefp.com/p/woody-alle... .

Yeah but it'll be like $29/share with the fees bsky.app/profile/tech...

Loved this reflective @thebulwark.com essay, “right piece, wrong puzzle” by @jvl.bsky.social. open.substack.com/pub/thebulwa... Connects to themes of contingency I discussed here timmermanreport.com/2024/08/two-... & persisting amid contingency (MCU origin) here timmermanreport.com/2024/05/succ...

Wisdom bombs on AI and informatics from the inimitable Zak Kohane @harvardmed.bsky.social - always elevating, often sobering, invariably humane.

Another nice @bostonglobe.com article by @bethteitell.bsky.social, this time about the protein maximizing craze -> www.bostonglobe.com/2025/09/15/l.... Excellent perspective on the science (or lack..) from @erictopol.bsky.social , here: open.substack.com/pub/erictopo... . This, too, will pass…

It sounds like UK suffered a few recent, acute hits; situation in Boston is portrayed w bleak accuracy in Globe article you link to below - not just the downsizing that's documented, but perhaps more concerning: the massive hit to the usual sense of optimism here - all despite v promising science.

Ensembl Beta 13 is live! Check it out to see if your favourite species made the list-mine did! The Mountain Clouded Yellow was just added (beta.ensembl.org/species/fbf7...) #Genomics #OpenAccessData

White tailed kite (Elanus leucurus) at #YoloBypass this AM. #birds

What a great new Timmerman Report piece by Joseph Kannarkat and Yuxuan Bo about @fda.gov initial efforts to use genAI, via a tool called Elsa. The authors explain w unusual clarity how it was initially applied & where it might be most gainfully applied. timmermanreport.com/2025/09/leve...

Great way to start day-morning jog while listening to fascinating new ep of Ground Truths pcast w @erictopol.bsky.social interviewing Shana Kelley about her v promising new work on molecular sensors (among other areas of exploration): erictopol.substack.com/p/biosensors... @cziscience.bsky.social