Each of these companies should be free to fire employees for performance. That can be subjective! No one is entitled to million-dollar paychecks for big news & entertainment jobs. But when decisions are made to hire and fire to appease a vengeful ruler that’s different. That’s autocracy at work.

In addition to whatever this says about wellness, it also speaks to where the audience is perceived to be - it looks like if you want to reach most people impactfully, you need high impact video clips; suspect @zekeemanuel.bsky.social will likely add Youtube, also some kind of podcast...

Move over Peter Attia and @hubermanlab.com -- looks like @zekeemanuel.bsky.social is leaping (energetically...) into the wellness influencer space! LI announcement -> linkedin.com/posts/zeke-e... cc @erictopol.bsky.social @alicecallahan.bsky.social @euanashley.bsky.social

@jvl.bsky.social Quite possibly the only non-shitty thing I've seen all day/week/etc. cc @sonnybunch.bsky.social

IT'S OFFICIAL: Connecticut, Maine, Massachusetts, New Jersey, New York State, Pennsylvania, Rhode Island and New York City have formed the Northeast Public Health Collaborative. The collaborative will issue their own vaccine recommendations and coordinate public health efforts.

For anyone who, like me, grew up on Woody Allen (and can place lines like "The moose...mingled" & characters like Virgil Starkwell, his interview with Bari Weiss on @thefp.com Honestly pcast will prove, like so many of his films, irresistible - www.thefp.com/p/woody-alle... .

Yeah but it'll be like $29/share with the fees bsky.app/profile/tech...

Loved this reflective @thebulwark.com essay, “right piece, wrong puzzle” by @jvl.bsky.social. open.substack.com/pub/thebulwa... Connects to themes of contingency I discussed here timmermanreport.com/2024/08/two-... & persisting amid contingency (MCU origin) here timmermanreport.com/2024/05/succ...

Wisdom bombs on AI and informatics from the inimitable Zak Kohane @harvardmed.bsky.social - always elevating, often sobering, invariably humane.

Another nice @bostonglobe.com article by @bethteitell.bsky.social, this time about the protein maximizing craze -> www.bostonglobe.com/2025/09/15/l.... Excellent perspective on the science (or lack..) from @erictopol.bsky.social , here: open.substack.com/pub/erictopo... . This, too, will pass…

It sounds like UK suffered a few recent, acute hits; situation in Boston is portrayed w bleak accuracy in Globe article you link to below - not just the downsizing that's documented, but perhaps more concerning: the massive hit to the usual sense of optimism here - all despite v promising science.

Ensembl Beta 13 is live! Check it out to see if your favourite species made the list-mine did! The Mountain Clouded Yellow was just added (beta.ensembl.org/species/fbf7...) #Genomics #OpenAccessData

White tailed kite (Elanus leucurus) at #YoloBypass this AM. #birds

What a great new Timmerman Report piece by Joseph Kannarkat and Yuxuan Bo about @fda.gov initial efforts to use genAI, via a tool called Elsa. The authors explain w unusual clarity how it was initially applied & where it might be most gainfully applied. timmermanreport.com/2025/09/leve...

Great way to start day-morning jog while listening to fascinating new ep of Ground Truths pcast w @erictopol.bsky.social interviewing Shana Kelley about her v promising new work on molecular sensors (among other areas of exploration): erictopol.substack.com/p/biosensors... @cziscience.bsky.social

Osprey doing the Osprey Strut - seen near Davis, CA #birds

Central Park edit bench. Bright-winged flyer.

Saw this on my Peloton this am, reinforced idea of real fitness->longevity pivot, as I recently discussed in @bostonglobe.com drive.google.com/file/d/1rfga.... There are good data behind lifestyle interventions, but health/flourishing=more than performance metrics: also connection, purpose, agency.

Nails it.

I found this to be the most worthwhile pcast ep I've listened to in maybe ever-so much earned perspective shared by @bhorowitz.bsky.social @a16z.bsky.social -touching on a range of topics, from leadership to bubbles to the "fat tail of human behavior"-exceptional. podcasts.apple.com/us/podcast/b...

1/4 New McKinseyoverview of geroscience ("healthspan science"), focusing on biopharma aspects. In short: early days, promising green shoots, stakeholder alignment & consortia formation could be catalytic (& implicitly, ofc: they're poised to do this) www.mckinsey.com/mhi/our-insi...

Love this graf from @katieroiphe.bsky.social @wsj.com piece on what she took away from getting into strength training; for one: enhanced sense of agency. wsj.com/lifestyle/fitn… For more on agency & health, I’ve organized a few useful resources here: kindwellhealth.com/reading-resour���

1/4 Loved @wsj.com @katieroiphe.bsky.social on why she enjoys strength training; she describes as "the rush of mastery" and a "startling sense of accomplishment." This sounds a lot like Seligman's concept of agency, a key driver of health & flourishing... www.wsj.com/lifestyle/fi...

1/4 Short 🧵on my latest TR piece timmermanreport.com/2025/09/can-... on biopharma's view of the AI "productivity paradox" @dereklowe.bsky.social

1/4 Short 🧵on my latest TR piece timmermanreport.com/2025/09/can-... on biopharma's view of the AI "productivity paradox" @dereklowe.bsky.social

In my latest TR column, I discuss AI's productivity paradox-a challenge that, as @johncassidysays.bsky.social recently reviewed @newyorker.com, is hardly unique to biopharma. I also explain why I prefer implementation pulled by lead users, vs pushed by mgmt: timmermanreport.com/2025/09/can-...

Huge thanks to Geoffrey Ginsburg for the idea for the symposium and to fellow Glaswegian Stephen Kingsmore for co-chairing. At the following session, we enjoyed a lively discussion on the future of AI in healthcare. Atul and his legacy will not soon be forgotten. ❤️

I had the honor of remembering and celebrating our friend Atul Butte today at a special symposium at the AGBT Precision Health meeting in San Diego. I shared the stage with superstars Chris Longhurst, Marina Sirota, Lucila Ohno-Machado, and Bimal Chaudhari.

I like this.

Miles' Law: where you stand depends upon where you sit (or walk/ride?)

[email protected] @amandacarpenter.bsky.social When we contemplate how Trump has acquired so much power, given opportunity of Congress to check it, what's staggering is that it seems to boil down to... "mean tweets," highlighting the underappreciated sting of what psychologists call "social pain."

Next stop: Kilimanjaro 2026 for Damon Runyon Cancer Research Foundation Meet the team of biotech leaders raising $1 million for cancer research and hiking up the highest peak in Africa. timmermanreport.com/2025/09/next...

Interesting and believable

More radicalism from Scott: we should deploy established high effective medicines to avoid preventable disease and associated morbidity and mortality. Wild!

Fascinating new @wsj.com op-ed from Shlomo Klapper suggesting @anthropic.com's recent lawsuit settlement after it seemed to be winning was strategically brilliant, with parallels to Russia ceding Moscow to Napoleon (w Open AI playing role of France in scenario...) www.wsj.com/opinion/anth...

This @bethteitell.bsky.social captures in excruciating detail what’s pretty much the antithesis of the value set I hope we’ve instilled in our teen daughters…. Ugh. www.bostonglobe.com/2025/09/08/l...

One unexpected gap in Gina Kolata obit for David Baltimore is his leadership of the Whitehead Inst - while now it seems somewhat eclipsed (physically as well as in terms of impact) by @broadinstitute.org when founded w Baltimore at helm, it was the white hot center of molbio in town.

btw - this is an incredible compliment for David Baltimore from the brilliant geneticist David Botstein (he's the guy from whom Eric Lander initially learned genetics)

So much respect for this man - for his impact on the world and on my small life.

Brilliant, joyful, embarrassingly accurate, via Rachel Feintzeig @nytimes.com 🐶 www.nytimes.com/2025/09/07/o...

Probably the most positive (& potentially most delicious-sounding) recent occurrence not on my 2025 bingo card - dark chocolate bar from health policy guru @zekeemanuel.bsky.social cc @ashishkjha.bsky.social @meganranney.bsky.social @matthewherper.bsky.social

Characteristically well put-together @wsj.com feature on science, personalities, deep pocketed investors & tech entrepreneurs fueling the longevity boom-by Amy D Marcus (busy week!) Alex Janin Shane Shifflett www.wsj.com/health/welln... -good pairing w recent @tadfriend.bsky.social @newyorker.com

Pascal's wager for billionaires?

Characteristically well put-together @wsj.com feature on science, personalities, deep pocketed investors & tech entrepreneurs fueling the longevity boom-by Amy D Marcus (busy week!) Alex Janin Shane Shifflett www.wsj.com/health/welln... -good pairing w recent @tadfriend.bsky.social @newyorker.com

Bird watching at @thefp.com t.co/hbvZpmJq2X @phylogenomics.bsky.social

Imagine, for example, if RFKJr was replaced by the Florida SG - not sure that would improve things very much...

For biomed/health policy Bluesky: if RFKJr should be exited from HHS, curious who you think is most likely to be nominated in his place. Wonder if it will be one of the folks he's already installed at NIH or FDA, or if someone like Scott G has a chance, or Senator Cassidy, or someone else entirely?

The idea that as a country we're re-litigating benefits of vaccination for horrific+preventable (through vaccination!) disease represents such an appalling waste of time & energy & trust that seems like it could be applied so much more productively to almost anything else. @cmyeaton.bsky.social

It might be love+appreciation of nature, & state of mind from spending time in it, that offers last best hope of bringing us together. Consider N Kristoff's "Take a hike!" www.nytimes.com/2025/08/23/o... & J Rosen @thefp.com "Just look up!" www.thefp.com/p/just-look-... @phylogenomics.bsky.social

Me, @wsj.com: It is often impossible for an org to determine, in advance, whether an innovative team is working on a hit or a flop. As the late Harvard researcher Judah Folkman used to tell his students: ‘If your idea succeeds, everybody says you’re persistent. If it doesn’t, you’re obstinate.’