Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...

Great work from our future neighbor!

Check out this extremely cool work by @fueyoraquel.bsky.social on how human specific ERVs contribute to early development!

Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems. Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here: www.nature.com/articles/s41...

Extremely excited to share that I’m joining Columbia University @columbiauniversity.bsky.social as an Assistant Professor! We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky thawanilab.org

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...

Looking forward to this new installment of the Woods Hole Mobile DNA Meeting! Fantastic program, laid-back atmosphere, and gorgeous setting at the Marine Biological Laboratory ⛵️🪼🐋 Abstract submission closes Aug 7 but registration after that date is possible. www.eventsquid.com/event.cfm?ev...

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...

#TEsky Structural basis for the evolution of a domesticated group II intron–like reverse transcriptase to function in host cell DNA repair doi.org/10.1073/pnas...

Ready to lead pioneering research that bridges systems-level investigations of biological systems to molecular mechanism? The EMBL Molecular Systems Biology Unit in Heidelberg is hiring a Group Leader!

🦠🧍‍♀️From bacterial to human immunity. We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social www.science.org/doi/10.1126/...

The Xue lab at UC Irvine is looking for a staff scientist to support our work investigating how microbes interact and evolve in the gut microbiome! Open to a wide range of previous experience levels, see ad for more. recruit.ap.uci.edu/JPF09601

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease. www.nature.com/articles/s41...

Deeply touched and honored by the Universidad Autónoma de Madrid, my alma mater, (@uam.es) making me Doctor Honoris Causa. Thank you to the Department of Physical Chemistry for nominating me for this recognition. It was a memorable day for me and my family👩‍🎓

Like a dream, my name next to that of @isabelallende.com, and to be recognized by Universidad Internacional Menéndez Pelayo UIMP. Soon after, Irene Vallejo @irenevalmore.bsky.social will receive the same honor. I feel proud to be linked to these truly inspiring, talented women! Thank you UIMP!

Structures of vertebrate R2 retrotransposon complexes during target-primed reverse transcription and after second-strand nicking pubmed.ncbi.nlm.nih.gov/40540573/ #cryoem

Vertebrate retrotransposons are the future of gene therapy. But how do they insert their genes? 🔥🔥 Thrilled to share our new work now published with Kathy Collins, @nogaleslab.bsky.social @berkeleymcb.bsky.social where we investigate this with #cryoEM & biochemistry in 🧪 and cells! #RNAsky #TEsky

We're thrilled to share the published version of our DRT9 story, online today @nature.com! Congratulations to all authors! www.nature.com/articles/s41...

Our review article on the recent progress in understanding the mechanism of LINE element propagation in eukaryotes is out! Please check it out. #TEsky #RNAsky #RT #cryoEM

It is finally (FINALLY) out! We characterized Kathy Collin's super cool OTTR protocol for tRNA and tRF cloning, showing that it is comparable (mim-tRNA-seq, maybe nano-tRNA -seq and LIDAR) or superior (everything else) to the best protocols in the literature. elifesciences.org/articles/77616

Amazing work @mayavoichek.bsky.social and team!

We did it! We caught Starship #transposons moving between #fungal species in the lab, including between species separated by ~100my. We think Starships are a mediator of HGT in fungi, akin to conjugative elements in bacteria. Check out the preprint. www.biorxiv.org/content/10.1...

Telomeric transposons are pervasive in linear bacterial genomes | Science www.science.org/doi/10.1126/...