🚨New paper out! #MicroSky Studying obligate predators like Bdellovibrio bacteriovorus is tricky—essential genes for predation are also essential for survival. We expanded its genetic toolbox: 🧬promoters to fine-tune expression 🧬IPTG-inducible system 🧬CRISPRi for rapid knockdown bit.ly/46GUn2c 1/4

Combination of large-scale phylogenomic analysis, mouse lethality experiments and bacterial growth assays shows sheds light on how a pandemic clone of Vibrio parahaemolyticus was able to spread worldwide www.nature.com/articles/s41...

tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa 🦠👏High-throughput tRNA epitranscriptome profiling using mass spec on P. aeruginosa transposon insertion library and links with metabolic networks #microsky #rnasky doi.org/10.1093/nar/...

New preprint! We characterise the small, regulatory RNA Arp which controls DNA uptake and twitching motilty in A. baumannii. Led by our Dr Fergal Hamrock @hamrockfergal.bsky.social and in collaboration with @westermannlab.bsky.social and Mike Gebhardt's lab!

Evolution of hunt, kill, devour in a Vibrio ecospecies Great paper 'Molassodon' - genetically distinct ecospecies from typical V. parahaemolyticus, it has evolved a predatory strategy that devour other bacteria in viscous environments @campy-bara.bsky.social www.biorxiv.org/content/10.1...

#NatMicroPicks Vibrio in competition! 🦠💉 An orphan T6SS effector in non-toxigenic Vibrio cholerae targets susceptible strains by disrupting ion balance, shaping Vibrio population dynamics and offering a model for precision antimicrobials. #MicroSky www.cell.com/cell-host-mi...

Happy to share the preprint from here in Shanghai, together with @danielfalush.bsky.social, as well as with team Zhizhou Jia, Huqi Wen, and Zhe Xie! www.biorxiv.org/content/10.1...

3'UTR-derived small RNA couples acid resistance to metabolic reprogramming of Salmonella within macrophages https://www.biorxiv.org/content/10.1101/2025.06.06.658255v1

Quality over quantity: Small RNA pauses translation elongation to lift protein activity: Molecular Cell www.cell.com/molecular-ce...

Quality over quantity: Small RNA pauses translation elongation to lift protein activity

I'm happy to share the first publication from my lab @hoerlab.bsky.social, now out in @narjournal.bsky.social! I take a look at the biology of RNA phages, focusing on how meta-omics methods are discovering new RNA phage families and bacterial defense strategies. #PhageSky doi.org/10.1093/nar/...

Grant opportunity! 200K USD for 3 years from CAS-ANSO program. Apply by May 20th. Details in here: www.anso.org.cn/programmes/S...

Where science meets culture 🔬🎭 At the Vogel Foundation Dr Eckernkamp’s 25th anniversary gala at the Mainfranken Theater, #HIRI director Jörg Vogel emphasized the vital role of culture for cutting-edge research. Congrats & thank you for supporting our science! ➡️ www.helmholtz-hiri.de/en/newsroom/...

📅🖍️ Mark your calendars: The #HIRI & the Shanghai #RNA Club will host @rnasociety.bsky.social’s next RNA Collaborative Seminar on March 12. HIRI group leader @jenshoer.bsky.social will discuss “Insights into the role of RNA in bacterial immunity and phage replication.” us02web.zoom.us/webinar/regi...

It is finally out! Muntathar Al-Shimary, @doudna-lab.bsky.social , @cresslab.bsky.social and I present a gene knockdown tool that works in diverse bacteriophages: CRISPRi through antisense RNA Targeting (CRISPRi-ART)! Check it out @naturemicrobiol.bsky.social www.nature.com/articles/s41...

🅲🅾🅾🅻 🆃🅴🅲🅷🅽🅾🅻🅾🅶🆈 “Bacterial-MERFISH” provides ~1000-fold volumetric expansion of individual cells, charts gene expression in hundreds of thousands of cells, deciphering bacterial single-cell heterogeneity, intracellular transcriptome organization, and bacterial adaptation to µm-scale niches in vivo

My collaborators in Shanghai discovered that Within-host evolution of a transcriptional regulator contributes to the establishment of chronic Pseudomonas aeruginosa infection: Cell Reports www.cell.com/cell-reports...

Bacterial small RNA promotes gut colonization | EurekAlert! www.eurekalert.org/news-release...