New in @natmethods.nature.com: a new human stem cell model of EMT lets us watch cells transition in both 2D and 3D and shows human stem cells can undergo the transition differently depending on how they are grown. 🔗 https://doi.org/10.1038/s41592-026-03096-9

JOB ALERT 🚨The Tsai Lab at Washington University in St. Louis is hiring a Research Assistant/Lab Manager to study how tissues build reproducible patterns using #zebrafish genetics, live imaging, and quantitative analysis. To apply, email [email protected] with contents listed below #ZebrafishJobs

fluorescence fun with photoconversion new-ish adult zebrafish trunk skin immune cells in cyan, older photoconverted ones in magenta (and cyan, too, if you look closely)

happy #FluorescenceFriday from the bottom of my (stem cell colony) heart 🫀✨

🔬 For #3DThursday: a whole cleared mouse embryo imaged with DALISPIM from @lifecanvastech.bsky.social A theme from #FOM2026 + #ELMI2026 was that light microscopy innovation can come from rethinking imaging geometries, in this case an open-top inverted #lightsheet. 🎬: #syGlass v2.6.0

I'm looking for a new PhD student in Biomedical Engineering at NUS! Apply to join my team in Singapore, studying the dynamics and mechanics of collective cell organization in animal epithelial tissues. Send me your CV and a cover letter explaining your motivations via PM or email by July 22!

A new mathematical model from @flatironinstitute.org biologists explains how fruit fly sperm avoid getting tangled up: https://bit.ly/4oKB2Vx #science #biology #FlatironCCB

Finally got to see my work on exhibit at @hhmijanelia.bsky.social #sciart

Congrats @harrisonlab.bsky.social and team! Another beautiful paper, this time illustrating the role of hypoxia in coordinating coronary angiogenesis and myocardial expansion during zebrafish heart development 🧪♥️🐟 www.pnas.org/doi/10.1073/...

🎨🔬 Can techniques from the arts become tools for scientific discovery? Our new preprint introduces glass-based physical models for studying tissue mechanics, bridging art, physics, engineering, and biology! 😀 📄 arxiv.org/abs/2606.22281

Biology was never meant to be studied in 2D. One of the coolest things about my new work is being able to visualize: 🧠 Neural circuits 🩸 Vascular networks 🎯 Drug biodistribution 🎗️ Disease progression Here's a small glimpse of what we're building at @deeppiction.bsky.social 🤩🔬 #3DImaging

Researchers at #FlatironCCB are investigating how the collective movement of giant sperm in fruit flies gives rise to folded layers of motion. Read more about their new hypothesis: https://bit.ly/4oKB2Vx #science #biology

Double preprint! 👇 Check out our latest studies on timing, heterogeneity and collective behaviour (with a fun tiny bonus on evolution!) 1. www.biorxiv.org/content/10.6... 2. arxiv.org/abs/2605.13234

🐟 Nothobranchius furzeri ⏳ The African turquoise killifish lives fast and develops faster! Its embryos can enter diapause, making it a powerful model to study developmental arrest, environmental adaptation, aging, and lifespan biology 🧬✨ 📸 Image by Alexander Schier lab. #ModelMonday #DevBio #Aging

If you love imaging metadata, do I have something for you -- Search, organize, aggregate and share image data with BioFile Finder (BFF) | Nature Methods share.google/9UxsAcpaWhbu...

Our beautiful mosaic embryo made it to the cover! 🔥

This #MicroscopyMonday is a case of spontaneous axis duplication of a two days post fertilization #zebrafish embryo. Two heads and bodies share the same heart and intricate neuronal connections (orange). (Piotrowski Lab)

A ratiometric membrane tension probe based on a non-conducing TRAAK channel bearing a split HaloTag. Compares well with Flipper-TR (and no need for lifetime imaging capacity): www.biorxiv.org/content/10.6...

The zebrafish embryo is a great model of stem cell processes: zygotic genome activation and germ layer specification, within a single work day! Similar to mouse embryonic stem cells, we find transcriptional clusters undergo massive, global shifts. advanced.onlinelibrary.wiley.com/doi/10.1002/...

Zebrafish gastrulation colorfully captured by #SPIM. Credit to Dr. Gopi Shah (prev. with @mpi-cbg.de). #PrideMonth 🏳️‍🌈🐟 #ZebrafishZunday 🧪

Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?

We are thrilled to announce our new preprint from the wonderful @sorayavillaseca.bsky.social Ever wondered how cells squeeze through tiny spaces in embryos? Neural crest cells use Dynein to transport their nucleus along microtubules. Check out the preprint!! www.biorxiv.org/content/10.6...

Multi-modal comparison of primary and stem cell-derived β-cells nominates targets for maturation www.biorxiv.org/content/10.6...

🔬Des scientifiques au #lfikyoto pour éveiller la curiosité de nos élèves ! Avec « En Quête de Bio », nos élèves se sont glissés dans la peau de scientifiques pour découvrir les mystères du vivant, de la drosophile au poisson-zèbre. Merci @sfbd.bsky.social 💙🤍❤️ @michaelrera.bsky.social #biologie

✨Rare model organisms can teach us how to build a body differently. In snail embryos blastomeres can be as big as the rest of the embryo! 🐌Phrontis vibex blastula stained for tubulin (gray), phalloidin (blue) and histone (magenta). 🔬 #ModelMonday #DevBio 📸: Clemens Cabernard

🧰 New tool alert! ⚙️ #MorphoGrad, an open-source toolbox for simulating reaction–diffusion systems in 1D and 2D tissues, with cell-to-cell parameter heterogeneity & graphical user interface. No heavy coding required. Explore complex morphogen gradient models interactively. doi.org/10.1016/j.xp...

Chahare, N., Imamura, C., & Nerurkar, N. (2026). Morphometric analysis reveals that the chick cranial neural tube expands as an active shell [Preprint]. bioRxiv. doi.org/10.64898/202... #EpithelialMechanics

The many faces of the developing zebrafish 🌕🌖🌗🌘🌑🌒🌓🌔 #FluorescenceFriday

Pleased to say that Jonas Hartmann (bs-less) and I have finally released DySTrack (“diss track”) - Dynamic Sample Tracking. It’s a Python-based, modular tool that brings smart microscopy to everyday imaging on commercial systems. Preprint: www.biorxiv.org/content/10.6... [1/6]

Microtubules (green) fighting retrograde actin flow (magenta) in a neuronal growth cone videoed through a TIRF microscope. #CellBiology

Here the published version of our work on uncoupling different types of tissue phase transitions during development! Find out more on how contact surface tension-driven rigidity transitions trigger tricellular junction formation and initiate epithelial organization! @natphys.nature.com

⚡ Our paper is now out in @natphys.nature.com ! This version now includes a detailed molecular characterisation of the optogenetic perturbations, new insights on the relevance of tricellular junctions for tissue morphology, and beautiful light-sheet timelapses. 🔬 www.nature.com/articles/s41...

☕ @nicolettapetridou.bsky.social & co report a feedback loop between Nodal signaling and tissue phase transitions in zebrafish #embryos. Nodal alters adhesion, triggering tissue rigidification and reduced porosity, which limits its diffusion and speeds up Lefty expression. go.nature.com/4vgBYmo

Oncologists and researchers at the ASCO 2026 conference give a standing ovation after the experimental drug daraxonrasib nearly doubles survival in a metastatic pancreatic cancer trial! #AGoodPlace Source: www.reddit.com/r/Damnthatsi...

Hello #world, meet 1,000× Expansion Microscopy. A small gel would grow to the size of an Olympic swimming pool, while amino-acid-scale distances become visible with ordinary light microscopy. Led by Helena Hu from @eboyden3.bsky.social's lab, in collab with us. Story: www.biorxiv.org/content/10.6...

This #FluorescenceFriday banger is one of our first ever fish movies and a huge part of why I instantly fell in love with the model: a living embryo expressing GFP in its beating heart!!!!

🔬⚙️💻 Excited to share #OptiCell3D, our new image-based framework for inferring cell mechanical properties with high precision from 3D microscopy. www.biorxiv.org/content/10.6... #ComputationalBiology #CellBiology #Biophysics #OpenSource

You're a devbio and stem cell enthusiast in Vienna? Come meet the community at #DevStem26 @istaresearch.bsky.social on June 16th! Only 3 days left to register & submit your abstract! Free registration 👇 devstem.pages.ist.ac.at

@drsusanna.bsky.social paper is now out in its final form. Relative to the original preprint, we now show additional mutant data and a better way to display heat maps of gene activation. www.cell.com/current-biol...

AI-agents write code for us, fix errors and try out other algorithms - tasks we data scientists do on a daily basis. But they can do it in parallel, all steps fully automatically. Check out %%alice & sand-bob #opensource! haesleinhuepf.github.io/sand-bob/exa...

How do sperm and egg fuse? Surprisingly, we still don’t fully know… Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together. We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion. tinyurl.com/34cm4xat Read on! 🧵👇

𝗔𝗿𝗲 𝘆𝗼𝘂 𝗰𝘂𝗿𝗶𝗼𝘂𝘀 𝗮𝗯𝗼𝘂𝘁 𝗵𝗼𝘄 𝗹𝗶𝗴𝗵𝘁 𝗺𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝗲𝘀 𝗮𝗰𝘁𝘂𝗮𝗹𝗹𝘆 𝘄𝗼𝗿𝗸 𝗮𝗻𝗱 𝘄𝗵𝘆 𝘁𝗵𝗲𝘆 𝗺𝗮𝘁𝘁𝗲𝗿 𝘀𝗼 𝗺𝘂𝗰𝗵 𝗶𝗻 𝗹𝗶𝗳𝗲 𝘀𝗰𝗶𝗲𝗻𝗰𝗲𝘀? If so, I recommend diving into this FREE microscopy course 👉 www.ibiology.org/online-biology-courses/microscopy-series/

#Lightsheet imaging of early #zebrafish development. Credit to @loicaroyer.bsky.social. #ZebrafishZunday 🧪

The heart of a zebrafish embryo photographed through a microscope. (Ventricle: Left; Atrium: Right). The nuclei of both the heart cells and blood cells are shown. "What? Red blood cells do not have nuclei!", you say. So human centric of you...... #CellBiology

New preprint from my lab! Will Anderson developed a transgenic #zebrafish ubiquitously expressing an optogenetic FGF/ERK activator. We're having a lot of fun with it and think you will too! www.biorxiv.org/content/10.6...

Please check out our new preprint! Together with @sarathomasy.bsky.social and led by DVM/PhD candidate Raneesh Ramarapu, we used 3D imaging + quantitative analysis to show how the corneal endothelium maintains a stable layer and refines hexagonal packing during development.

“If it is not nearly impossible, it is not worth it”

All you ever wanted to know about how to analyse the nematic nature of cellular tissues is right here 👀👇🏼! Bonus #1: we did it for many cell types and uncovered unexpected defect behavior 🐌 Bonus #2: for theoreticians looking for parameter values for your simulation🧑🏼‍💻 tinyurl.com/2s399yen

Dutch film-maker Jan van IJken condensed 4 weeks of development in a salamander embryo (Mesotriton alpestris) into a 6 minute video, presented here sped up to 1 minute. You can see gastrulation at ~the 10s mark, forming the gut, then limbs & in a moment, the heart just *begins* beating.