Nucleoid structure and dynamics influence natural chromosomal transformation in Bacillus subtilis: the role of EbfC url: academic.oup.com/nar/article/...

New paper from the Voss lab! RLip, a secreted lipase, helps pathogenic Rickettsia thrive inside host cells. Grateful our work in the Goley lab building a R. parkeri transposon library could support this discovery. 🦠 🔬 journals.plos.org/plosone/arti...

New PubPeer comment on "Efficacy of oral folinic acid supplementation in children with autism spectrum disorder: a randomized double-blind, placebo-controlled trial" (Panda et al, 2024). Concerns about significant errors. #folinicacid #leucovorin, #autism pubpeer.com/publications...

In #mBio, dive into story behind the 1989 discovery of Helicobacter pylori CagA, the first tumorigenic bacterial protein. This article recounts the early steps in the investigative process and relates some of the unexpected discoveries that ensued. asm.social/2C1

If you want to get started, here's a tutorial that I made: github.com/JoachimGoedh... Reach out if you have questions or want advice!!

2025 #LaskerAward winner Lucy Shapiro asked: How do living organisms translate information from a linear genetic code into three-dimensional structures? And with that, she broke open a new field. 🧪 @pnas.org #Lasker2025 #systemsbiology

www.the-scientist.com/lasker-award... 🧪 #devbio #LaskerAward #Lasker2025 #LaskerLaureate

Some awesome, fundamental work here: Lucy Shapiro, on bacterial cell differentiation, Dirk Görlich and Steve McKnight on IDRs & protein gels in nuclear pores and biomolecular condensates, & Michael Welsh, Jesús González & Paul Negulescu, (overdue) for bench to bedside work on cystic fibrosis 🧪 1/2

This year's Lasker Awards went to scientists who studied the wiring diagram of life, a new state of biological matter, and a potent treatment for cystic fibrosis. Here's my story with Gina Kolata. Gift link: nyti.ms/4mZlH1F

Regulation by RNAs might be even more extensive than we thought. Many enzymes and other proteins not previously considered as RNA-binding proteins do seem to fall into this class & might have their activity regulated by RNA. www.cell.com/cell/fulltex...

New in JB: Gbolahan, Saxena et al. link membrane stress, the Rcs stress-response pathway and a block in chromosomal replication to the targeting of the DnaA initiator, likely via the ClpP protease. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology

Our newest preprint on bioRxiv ‪@biorxivpreprint.bsky.social "Divergent Rickettsia species exhibit distinct mechanisms of actin-based motility" reveals surprising evolutionary flexibility in the mechanisms of Rickettsia actin-based motility www.biorxiv.org/content/10.1...

journals.plos.org/plosgenetics... #microsky

The 2024 rankings of bacterial threats

🚨 Job alert 🚨 I’m recruiting two postdoctoral research associates to join my lab at KCL to study how #Klebsiella pneumoniae regulates virulence factor expression during infection! #klebclub Mol Micro: tinyurl.com/mtrwtx5e Infection: tinyurl.com/2s3u8ca2 Deadline: 21st September.

#microsky We challenge the long-standing view that peptidoglycan alone protects cells from bursting. Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria. 📄 www.nature.com/articles/s41...

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...

Update on North American tick-borne diseases and how to diagnose them Kyle Rodino, Eli Theel, Bobby Pritt journals.asm.org/doi/10.1128/...

#phage #phagesky A bacterial host factor confines phage localization for excluding the infected compartment through cell division: www.cell.com/cell-reports...

Excited to share our new paper in @cellreports.bsky.social that reshapes our understanding of chromosome organization's deep evolutionary roots! Our work dives into the origins of the machinery that structures our very genomes. 🔗: doi.org/10.1016/j.ce... #Genomics #Evolution #CellBiology #LECA

Very happy to share that a large part of my thesis work is out today: B. subtilis uses the second messenger c-di-AMP to modulate its turgor pressure in response to the state of its cell envelope. www.nature.com/articles/s41...

Ancient remains reveal how a pathogen began to use lice—not ticks—to infect humans, according to a new study in Science. scim.ag/3Zbkri6

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

I know you all know this, but apparently it needs to be said that basic science is a NECESSARY PRECURSOR to translational science

"Why don't you buy a new centrifuge" Because everyone knows that any appliances in that shade of yellow will outlive you and your entire family, look at it

"This prompted us to name this family the Bacterial elongated entwined Rail-like protein (BeeR)." yeah right 🍻 doi.org/10.1073/pnas...

Great Paper by @vslioy.bsky.social on genomic plasticity of salmonella pathogenicity islands: the link between chromosome 3D and their expression! Huge effort, great work! Here is the preprint! www.biorxiv.org/content/10.1...

Newest preprint from our lab. Congratulations to all authors!

Polyphosphate: The “Dark Matter” of Bacterial Chromatin Structure onlinelibrary.wiley.com/doi/10.1111/... #jcampubs

#weekendreading 🔬 Mitochondria sense bacterial lactate and drive release of neutrophil extracellular traps @cellpress.bsky.social #microsky www.cell.com/cell-host-mi...

An antisense RNA regulates production of DnaA and affects sporulation in Bacillus subtilis https://www.biorxiv.org/content/10.1101/2025.02.18.638791v1

The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility https://www.biorxiv.org/content/10.1101/2025.02.21.639583v1

CHECK IT OUT 🦠 A team led by MBL scientists reveals that symbiotic bacteria often accompany protists in the ocean’s upper layer. Their research could help scientists understand infections in humans. Read more: bit.ly/4b4YPsq 📷: Camille Poirier & David Needham, Worden Lab

A҉L҉T҉R҉U҉I҉S҉T҉I҉C҉ ҉Z҉O҉M҉B҉I҉E҉ ҉B҉A҉C҉T҉E҉R҉I҉A҉🦠🧟 Fascinating Nat Comm paper Martin Cann Lab Durham UK Dead bacteria encode post-mortem protein catabolism via Lon protease—provides nutrients promoting growth of surviving bacteria No benefit of Lon to live bacteria to account for this www.nature.com/articles/s41...

Despite EVERYTHING, research and researchers will still matter.

A special Bluetorial about one of my mentors Ruth Kirschstein Among Ruth Kirschstein’s many contributions to American science was the development and expansion of programs intended to increase participation of people from groups underrepresented in biomedical research.

🅲🅾🅾🅻 🆃🅴🅲🅷🅽🅾🅻🅾🅶🆈 “Bacterial-MERFISH” provides ~1000-fold volumetric expansion of individual cells, charts gene expression in hundreds of thousands of cells, deciphering bacterial single-cell heterogeneity, intracellular transcriptome organization, and bacterial adaptation to µm-scale niches in vivo

I have a big ask. My 9yo son is autistic and he’s been raising a betta fish he named Kevin. Yesterday He asked if he could “share a photo of Kevin with the whole world“. I don’t know if this will work, but a dad’s gotta try. Like and share if that’s your thing. Kevin says hi! 🐟👋

Fun fact: if you're buying from a creator on etsy, you can reduce their etsy selling fees from 6.5% to 2.5% by ordering via 'shopname.etsy.com' instead of 'etsy.com/shopname' or searching from the main site. It costs you the same but the creator makes more

A lot of work in this article about Brucella’s Omp25 and the interaction with multiple TLRs. Beautiful images and I’m a sucker for a two-hybrid system 😍. 🔬 www.jbc.org/article/S002...

Pseudomonas can be so cool and slimy! 🦠 🔬 doi.org/10.1128/jb.0...

Great recent work from Sanika Vaidya and Knut Drescher Lab Mammalian innate immunity recognizes bacterial cell wall peptidoglycan (PG) via TLR2 Turns out multiple bacteria also sense PG from their lysed compatriots as a danger signal to trigger biofilm formation! www.nature.com/articles/s41...

Latest from Baumeister & @lottesogaard.bsky.social labs: The PomXYZ complex and its role in bacterial cell division. www.pnas.org/doi/10.1073/... #teamtomo #cryoET #cryoEM

🦠🧫🧪 www.nature.com/articles/s41...

40 years ago all of Genbank was published in print form by NAR. The same format today would require over 4 light seconds of shelf space. To a year of progress in 2025.

“If your dreams do not scare you, they are not big enough” Ellen Johnson Sirleaf

Officially a doctor. I had a great time back in Lexington seeing my friends and family. I’m grateful for everyone who made this possible. 💙🤍

Led by Chih-Ming Tsai + Irshad Hasham, a fascinating new JCI paper from the George Liu Lab at UCSD Pediatrics shows that in mice who have previous Staphylococcus aureus (SA) exposure, B cells secrete abundant IL-10 when challenged with the SA antigens for a second time (in a vaccine) Thread🧵 1 of 2

To celebrate the closing of my first year as a PI, I present the drastically miss-sized things I have ordered next to what I was trying to order, a thread. #sciencesky #neuroskyence #neuroscience Up first...Rosie the wrench. Silver lining torque is amazing and we now have a lab mascot.