'Hoewel de wetenschappelijke gemeenschap nog steeds unaniem is in haar oordeel over de pseudowetenschap van Kirkegaard en aanverwanten, vinden hun ideeën steeds meer hun weg tot een breder publiek en zelfs tot de academische mainstream', schrijft Pieter Beck.

New paper alert 🚀 Our organism-wide single-cell ATAC-seq atlas of mammalian aging is now out in @science.org, led by our fantastic graduate student Ziyu Lu from @rockefeller.edu! www.science.org/doi/10.1126/...

We wrote a perspective "How to build the regulatory genome: a constructionist guide to the cis-regulatory code", out in Development yesterday. Title says it all. Find it here: journals.biologists.com/dev/article/...

Surely it's not a good idea to train users to give their admin details to repeated unrequested vague popups that don't even show any indication in the listed program itself? I generally appreciate MacOS's smooth handling of updating OSes and applications, but these have always confused me.

Can safely way this is the craziest and coolest study I have led. We chart the evolution of sheeppox virus, finding it in the Eurasian steppe ~3700 years ago, and also in a LOT of parchment from medieval Europe (made from a range of animals skins!) #aDNA

LLM companies complaining that people are stealing their stuff via distillation attacks is very, very funny.

Am I understanding this right? The standard grading scale in Denmark goes –3, 00, 02, 4, 7, 10, 12 ! This is amazing. I kinda love it. I mean I hate it. But I love it.

We;re hiring Junior Group Leaders! 🔬✨ We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment. www.nki.nl/news-events/...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

Happy birthday to one of my favourite haters, Charles Darwin

This is a very vulnerable and important essay, pointing to the fact that there are so many ways to contribute to computer science research

You did not get your #MSCA and you are upset, because you really wanted to work on somatic cell evolution on the way to malignancy with single cell data and 🧬machine learning 💻? Then get in touch! There are other ways to fund a postdoc ;-)

One of the biggest contributors to scientific scepticism among laypeople, IME, is these idiotic nutritional epi studies that come out with conflicting results every year and are uncritically picked up by credulous journos looking for clickbait. Get in the 🗑️. #episky #statsky

🧬 We're hiring a postdoc! Come chart somatic evolution with us using cutting-edge long-read & single-cell tech 🔬 Computational bio background + love for complex cancer genomics = perfect fit 📍 Leuven, Belgium 📧 jobs.vib.be/j/129915/ #postdoc #genomics #hiring

Last summer I spent 4 months working at the @alleninstitute.org as a Visiting Scientist. Recently we released some preprints about the work we collaborated on, where from new multiome atlases of CNS regions we tried to decipher underlying enhancer logic with CREsted (among many other things). (1/n)

research haikus, you say?? www.andrewheiss.com/research/

Five classes I took in uni: - Molecular Cell Biology - Advanced Statistics and R - A History of Modern Taiwan - Genome Biology - Applied Data Analysis and Visualisation

How is current genomics impacted by social, political, and ethical assumptions? @yashaddad.bsky.social and I had the pleasure of presenting this issue in our newest work (link below) #popgen #STS #STEM #philsky #HPbio

We are thrilled that our study on the evolution of gene regulation in mammalian cerebellum development – led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social – is now out in @ScienceMagazine! www.science.org/doi/10.1126/...

Paper alert! 💻 How many cells do you need to train reliable deep learning models in regulatory genomics? We asked how data quality, sequencing depth, and dataset size affect training of sequence-to-function models from scATAC-seq. Out now www.nature.com/articles/s41... (details below)

If you, as a scientist, cannot be bothered to engage in the intellectual work of science, please quit your job and leave it to someone with skill and integrity.

Last chance to register and join us in person for #EESAIBio! 🤖🧬 Attend talks, network, socialise, and experience the EMBL Heidelberg campus atmosphere! Register by 30 January: s.embl.org/ees26-02-bl Bonus: Join the TrustworthyAI4Health Workshop, organised by @elsa-ai.eu,#EESAIBioon 9 March 2026!

Applies (with minor modifications on where to post) to academia

Happy to share that our review on mammalian genome writing with Jack Atwater, Ran Brosh, Jef Boeke, @jshendure.bsky.social and Matt Maurano is now out in @cellpress.bsky.social! www.sciencedirect.com/science/arti...

Why do some worms graze on bacteria while others hunt and kill? Our study, published today in Nature, reveals how predatory aggression evolved in nematodes. Led by @gunizgozeeren.bsky.social and @leoboeger.bsky.social across the @jameslightfoot.bsky.social and @monikakscholz.bsky.social labs.

The New World asked me to speak to some British trans women about what life has been like for them over the past few years - here's what they had to say, in their own words: www.thenewworld.co.uk/marie-le-con...

We wrote a review of representation learning methods of single-cell RNA-seq data, where we compare factor models, autoencoders, contrastive learning, and foundation models 🎉 rnajournal.cshlp.org/content/earl...

Yesterday it was cows using tools, today its penguins using satellite imagery.

🗜️⚡ If you use gzip/gunzip a lot in your pipelines, switch to the faster"libdeflate" versions instead! They use modern CPU capabilities to achieve a 2-3x speedup. libdeflate is in conda, and "libdeflate-gzip" and "libdeflate-gunzip" are drop-in replacements. #unix github.com/ebiggers/lib...

Access to high-quality human genomics data can be a major barrier for bioinformatics learners, so I wanted to write a quick post plugging the 1000 genomes project as a source of practice data!

I think there is an opportunity for some kind of education here that doesn’t currently exist. Learning about basic software engineering concepts without even touching a line of code, so that you know what to ask Claude to do. But idk. Maybe the best way to learn swe concepts is to do some swe.

Some vibe-coding thoughts: I think the zero-coding-experience vibe coders miss how much of what impresses them when Claude produces what they perceive to be a fully functional app comes from the ready-built frameworks that enable the construction of such apps just by writing some boilerplate.

I don’t think we should have ceded control quite so quickly and without so much as a fight.

The Murphy Lab did our annual retreat this week. This year's theme was using AI (what it's good and bad for). I wanted to be open-minded to make sure we are not missing something we should be using it for, so we did a few exercises to test, and had presentations.

BREAKING: The controversial hepatitis B vaccine trial in Guinea-Bissau has been *cancelled,* I can now report. A senior official with Africa CDC confirmed the cancellation and said GB officials are working to make sure any research is conducted ethically: www.theguardian.com/us-news/2026...

📱Is the origin of animals comparable to the origin of the smartphones? Yes! See our new review in @embojournal.org where we show how important it was the new "Operating System" (animalOS)for animals to evolve! with @ricardsole.bsky.social, Nick and Elena @ibe-barcelona.bsky.social @csic.es @prbb.org

wikipedia turns 25 today! the last unenshittified major website! backbone of online info! triumph of humanity! powered by urge of unpaid randos to correct each other! somehow mostly reliable! "good thing wikipedia works in practice, because it sure doesn't work in theory" - old wiki adage

We tackle this challenge in human neural development. We generate two multiome atlases: on neural tube organoids and on a 4 p.c.w. human embryo. The organoids recapitulate human embryonic development strikingly well. DeepNeuralTube S2F models recover most known cell type-specific TF binding motifs.

TF-MINDI is out! A new method to learn cis-regulatory codes through rich embeddings of TF binding sites. TF-MINDI decomposes motif neighbourhoods, and works downstream of any sequence-to-function deep learning model. We deeply study the enhancer code in human neural development, check out the thread

Een half miljoen... Hoe is dit ooit nog haalbaar voor starters?

The department of Philosophy and Moral Sciences at Ghent University is proud to present a lecture series on the topic of eugenics. As philosophers and ethicists, we are concerned about the revival and normalization of eugenic discourse. humanitiesacademie.ugent.be/eugenics

New preprint from the lab and wonderful work by Seppe de Winter: System-wide extraction of cis-regulatory rules from sequence-to-function models in human neural development www.biorxiv.org/content/10.6...

Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version? I made an app you might like: adamkucharski.github.io/pdf2plot/ It all started a few years ago... 🧵

1. Excited to share CONCORD, out in @NatureBiotech, an ML framework for single-cell analysis addressing integration, dimensionality reduction, and denoising in one go by @qinzhu1.🔗 www.nature.com/articles/s41... Check out this CONCORD model of worm development resolving differentiation trajectories:

Join us at the Flanders Nanopore Day conference on April 17th in Antwerp, organized together with @nanoporetech.com! Details are available at nanoporeflanders.be, including registration (free), abstract submission, and project prizes with free PromethION sequencing for two selected projects.

In Flanders, fear of foreigners (sorry, "city problems") trumps plans to reduce traffic and emissions

We are looking for a new colleague in the lab of @jdemeul.bsky.social! If you are looking for a Postdoctoral position in Cancer Genomics,check the position here: jobso.id/pbgr

The better you’ve become at curating what the internet looks like to you, surfacing the valuable and filtering out the rest, the less it resembles what “normal people” see. It’s like using a new computer without all your personal tools and tweaks. This is obvious, but easy to lose sight of.

The robots are not coming for your jobs, but bullshitters with robots ARE competing for your jobs, and unless we decouple publishing metrics from career paths (financial gain), we are going to lose both careers and our capacity to share information. doi.org/10.1126/science.adw3000

Extremely excited & proud to share our new preprint - we provide for the first time a single cell map of the mouse brain across sex, the estrous cycle, and peripartum! Data are 🔥 👇 "Single-cell map of the female brain across reproductive transitions" www.biorxiv.org/content/10.6...