We would like to bring our EVOLVE consortium with its PhD positions to your attention again! Sharing is also much appreciated.

Currently, there's a lot of interest in quantitative models that would help us understand and predict features of the complex cellular systems that underlie human health and disease - think about virtual cells, for example. On can trace some of these ideas back to the early days of systems biology.

Kickking off the second day our @bcbhubcsic.bsky.social meeting with scientific sesions with Victor Sánchez Gaya, presenting POSTRE, a tool to predict the funcional impact of pstructural variants @hitseq.bsky.social @ibv-csic.bsky.social @csic-vaact.bsky.social

Next, Ana Martinez and Carmen Gil from @cib-csic.bsky.social presenting how to use a consortium of AI tools for drug design, with múltiple applicatons in the clínic @bcbhubcsic.bsky.social @csic-vaact.bsky.social #2AsambleaBCBHub

Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to [email protected]. See lnkd.in/dVVk4N3s. #microsky

🚨 The latest study from #NatureCommunications, led by Pasquale Piccolo, systematically evaluated AAV-mediated liver transduction across different fibrosis models.

The #Nextflow #Training week has begun! 🎉 New to Nextflow or need a guided intro? Watch the brand new on-demand walkthrough videos for the "Hello Nextflow" course, and learn at your own pace! hubs.la/Q03b2-Rk0

Quantifying Metagenomic Strain Associations from Microbiomes with Anpan www.biorxiv.org/content/10.1... 🧬🖥️🧪 #Rstats 📦 github.com/biobakery/an...

Common gynaecological disorders linked to raised heart and cerebrovascular disease risk "They include polycystic ovary syndrome, endometriosis, heavy or irregular periods" heart.bmj.com/content/earl...

PLOS has issued a statement on recent US Executive Orders and scientific integrity. We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry. plos.io/3D4O8cH

Is this real? I published it again on Brain @brain1878.bsky.social 😆 Truly appreciate the leadership of @rrust.bsky.social on this great project (>300 refs!)🫡👇 The blood–brain barrier: a help & a hindrance #Aging #Stroke #Neurodegeneration Crossing #BBB 😎 academic.oup.com/brain/advanc...

In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine had no signs of relapse after three years. Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.

A paper in Nature Methods presents Segment Anything for Microscopy, a tool for segmentation and tracking in multidimensional microscopy data. https://go.nature.com/3QiRonW

Our gut microbiome and its metabolites have key interactions with our immune response to cancer and success from cancer immunotherapy. Nice perspective @jclinical-invest.bsky.social www.jci.org/articles/vie...

Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted www.nature.com/articles/s4...

What is the mechanistic link between the NLRP3 #inflammasome, #autophagy & inflammatory #bowel disease (IBD)? This study shows that VANGL2 reduces #IBD progression by recruiting the ubiquitin ligase MARCH8 to regulate NLRP3 activation via OPTN-mediated autophagy 🧪 @plosbiology.org plos.io/42FTqFO

I have big news: @ellis.eu has launched its 2nd major research center, @ellisfinland.bsky.social! I have agreed to start as founding director & the first call for PI positions is open. This is a major opportunity for outstanding researchers, join us! ellisinstitute.fi/PI-recruit

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🚨 PhD in Bioinformatics & Gene Regulation 🚨 Join the Bioinformatics in Life Science (BiLS) initiative through a multidisciplinary project to unravel gene regulation from DNA to proteins, co-supervised by E. Valen @jonnings.bsky.social and me! www.jobbnorge.no/en/available...

In @science.org today, the discovery of the neuroimmune itch-scratch circuit. And why scratching can makes things worse www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

The feasibility of patching a severely damaged heart with stem cells as a bridge to transplant, actualized in a 46-year-old woman @nature.com www.nature.com/articles/s41... www.nature.com/articles/d41...

#Liver #metabolism is divided between pericentral & periportal zones, but what are the broader consequences of this zonation? This study shows that proper liver zonation, regulated by R-spondin3, contributes to systemic glucose metabolism & body composition 🧪 @plosbiology.org plos.io/3PR0E2a

We hope other labs find it as useful as we do! Given that it's free, we also hope it can be used in teaching labs, which are often low resourced. Congratulations to all authors! #zebrafish 🧠🧪🧬 bmcbioinformatics.biomedcentral.com/articles/10....

Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵

We are hiring! We have a fully-funded 2-year T32 post-doc slot to study spatial biology in lung regeneration. Background in data visualization useful but not required. If you’re interested or know of anyone, please get in touch or pass along! RaredonLab.com Description & teasers attached:

Proximal Ascending aorta is made of #SmoothMuscleCell of dual lineage origins Luminal side: Wnt1+ #CardiacNeuralCrest Abluminal side: Mef2c+ #SecondHeartField Their transcript profiles by scRNAseq + snATACseq👇 #AortaEd #ATVB 2024 @ahajournals.bsky.social www.ahajournals.org/doi/10.1161/...

📣 We are hiring! Join Yoshiji Lab at McGill University Dept of Human Genetics in Montreal, Canada! yoshiji-lab.org/joinus ✅Fully Funded Positions • 2 MSc Students • 1 PhD Student • 1 Postdoc ✅Goal: Using human genetics and multi-omics for drug target discovery and precision medicine

Divalent siRNA for prion disease https://www.biorxiv.org/content/10.1101/2024.12.05.627039v1

In this week's @science.org from @lucksmith.bsky.social and colleagues @mskcancercenter.bsky.social | Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing #RNA #microRNA #miRNA #siRNA #argonaute🧬🧪 www.science.org/doi/10.1126/...

RNA gene therapies offer hope for millions with high cholesterol "Base editing, antisense oligonucleotides and siRNA therapies that target low-density lipoprotein and the genes encoding molecules that regulate it are being tested in several clinical trials." www.nature.com/articles/d41...

DMS-MapSeq Analysis of Antisense Oligonucleotide Binding to lncRNA PANDA https://www.biorxiv.org/content/10.1101/2023.10.22.563486v1

We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer 🧬💊! Preprint led by Disha #chemsky 🧪 @uclchemistry.bsky.social @oxfordchemistry.bsky.social chemrxiv.org/engage/chemr...

My research center is hiring a data analyst! If you've got a masters, a background in microbiome work, an interest in making life better for children going forward, come work with us! #microsky jobs.jhu.edu/job/Baltimor...

Targeted decontamination of sequencing data with CLEAN https://www.biorxiv.org/content/10.1101/2023.08.05.552089v3 🧬🖥️🧪 Nextflow: https://github.com/rki-mf1/clean

I am preparing a talk on #openscience and looking for examples/studies quantifying non-openness, closed workflows, data code etc. Like this one on Excel errors in gene names per journal #science Can you recommend other good example?

Cell Storage Conditions Impact Single-Cell Proteomic Landscapes pubs.acs.org/doi/10.... --- #proteomics #prot-paper

Yup. Microsoft automatically switched me to the $99.99/year version with Spicy Autocomplete. You have to go all the way through "cancel subscription" to be presented these options and get the $69.99/year one you actually chose.

Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning A technical paper on a newly developed method to follow the distribution of nanocarriers, such as LNPs, liposomes and adenoviruses, through the body of mice. www.nature.com/artic... 1/15

A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...

My PhD adviser Liliana Florea has developed a Coursera course "Bioinformatics Methods for Transcrptomics". A great resource to learn cutting-edge short- and long-read RNA-seq data analysis techniques: www.coursera.org/learn/bioinf...

A Review in Nature Reviews Microbiology explores the pathways linking the gut and the brain and examines the microbial, endocrine and neural mechanisms involved in the gut microbiota-brain axis and their impact on gastrointestinal and neuropsychiatric health. https://go.nature.com/3DSeS0d 🔒

Our first paper on BlueSky!! Remarkable work published in @currentbiology.bsky.social from Jing Xie, Javad Najafi and others, on how cell shape affects mitotic spindle positioning forces in embryos, by impacting cytoplasm flows. @ijmonod.bsky.social www.sciencedirect.com/science/arti...

Here is a growing list of conferences and schools in gene regulation for 2025 generegulation.org/conferences-.... You can order/filter this list by the date, deadline, location. Please reply here to suggest new events* *should be specific to gene regulation

The viridis palettes are great perceptually uniform color maps for #dataviz, but sometimes at the extremes they're too pale/dark. With ggplot and #rstats, though, you can truncate the palette to avoid the paler colors. I wrote a little guide for how datavizf24.classes.andrewheiss.com/news/2024-12...

🚨 New blog post! 🚨 If you want to learn about: 🎨 How to define colours in R 📊 Choosing palettes for plots 🛠️ Generating your own colours Read this ➡️ nrennie.rbind.io/blog/colours... #DataViz #RStats #ggplot2 #RLadies

We're hiring! #database #science #jobs 🧪🔬🧬 lilly.wd5.myworkdayjobs.com/en-US/LLY/jo...

Bumping this once more. One of the benefits of IT:U is the very generous in-house base funding, consisting of recurrent positions for post-docs and PhDs, not just as a part of a startup package. Get in touch if you want to know more details.

Eleven quick tips for properly handling tabular data doi.org/10.1371/jour...

It was good seeing this coming out in preprint and great to see it published. Excellent work by Antoni Beltran (not on bluesky?) @benlehner.bsky.social etc.

First 🦋 post! Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental #glial biology to #stem cells and #tumor biology. rdcu.be/d5ADz A 🧵