Andrew Lin
@andrewclin.bsky.social
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Neuroscientist studying olfaction
pinned post!
Excited to share our latest work - expressing the bacterial sodium channel in fly Kenyon cells surprisingly *decreases* their excitability, thanks partly to decreased endogenous sodium channels. This prevents learning and decreases odor-evoked calcium influx
doi.org/10.1113/JP28...
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Ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells
Abstract figure legend: We tested the effects of expressing the bacterial voltage-gated sodium channel NaChBac in the Kenyon cells of the Drosophila memory centre, the mushroom body. NaChBac expressi...
https://doi.org/10.1113/JP288790
22 days ago
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HaDi MaBouDi
16 days ago
NIBAI 2025 Workshop on the Nature of Intelligence was held in Sheffield, bringing together over 70 participants from diverse backgrounds in neuroscience, animal cognition, philosophy, and AI. Thanks to
@asab.org
the
@sheffielduni.bsky.social
, and
@devjoni.bsky.social
for sponsoring this event.
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Ariel K. Frame
19 days ago
First episode is out! I spoke with Professor James Marshall
@sheffielduni.bsky.social
@opteran.bsky.social
about his research on modelling the
#brain
of
#bees
and implications for
#ai
. Take a listen!
#neuroscience
#sciencecommunication
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Timothy O'Leary
18 days ago
We all know that correlation doesn't imply causation. So we took some correlations and tested if they were causal. Here's what happened:
www.cell.com/cell-reports...
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An optical brain-machine interface reveals a causal role of posterior parietal cortex in goal-directed navigation
Relating neural circuitry to behavior is challenging due to closed loop interactions between neural activity, actions, and sensations. Sorrell et al. present evidence for a causal role of mouse PPC in...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00633-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124725006333%3Fshowall%3Dtrue
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Excited to share our latest work - expressing the bacterial sodium channel in fly Kenyon cells surprisingly *decreases* their excitability, thanks partly to decreased endogenous sodium channels. This prevents learning and decreases odor-evoked calcium influx
doi.org/10.1113/JP28...
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Ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells
Abstract figure legend: We tested the effects of expressing the bacterial voltage-gated sodium channel NaChBac in the Kenyon cells of the Drosophila memory centre, the mushroom body. NaChBac expressi...
https://doi.org/10.1113/JP288790
22 days ago
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Andrew Lin
Adrien Peyrache
5 months ago
🚨new paper alert Blind mice use stereo olfaction, comparing smells between nostrils, to maintain a stable sense of direction. Blocking this ability disrupts their internal compass. Kudos to
@kasumbisa.bsky.social
! Another cool chapter of the Trenholm-Peyrache collab😉
www.nature.com/articles/s41...
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Stereo olfaction underlies stable coding of head direction in blind mice - Nature Communications
Stereo olfaction involves comparing odor differences between the two nostrils. Here, using neuronal recordings and a behavioral test, the authors demonstrate that blind mice use stereo olfaction to fo...
https://www.nature.com/articles/s41467-025-58847-7
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Andrew Lin
7 months ago
2024 marked the 10-year anniversary of the FENS-Kavli Network of Excellence. We warmly invite you to explore the 10-Year Report, showcasing its impact on science, mentoring, outreach, advocacy, and personal achievements.
@fens.org
@kavlifoundation.bsky.social
fenskavlinetwork.org/fkne-10-year...
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Andrew Lin
7 months ago
Excited to have this study out today (on my birthday and 'tines day no less!). Here we resolve input-specific mechanisms of homeostatic plasticity! Congrats Jerry, Kaikai, and team!
www.science.org/doi/10.1126/...
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Distinct input-specific mechanisms enable presynaptic homeostatic plasticity
Input-specific mechanisms that achieve the homeostatic control of synaptic function are resolved using a botulinum neurotoxin.
https://www.science.org/doi/10.1126/sciadv.adr0262
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Andrew Lin
Wanhe Li
8 months ago
Dear All, I believe that this thread will become one of my most important contributions to the fly field (I hope I will make other contributions)! Here, I introduce the Soy Milk Machine Fly Food Method, a.k.a., DeepCook!#Drosophila#NewPI
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Andrew Lin
8 months ago
Excited to share our new preprint: How does the fly mushroom body support odour categorisation and discrimination? 🧠✨ Dive into Ivy Chan's
@ivychanchiwai.bsky.social
findings on how neural circuits enable complex olfactory processing in flies. Check it out here:
www.biorxiv.org/content/10.1...
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Odour representations supporting ethology-relevant categorisation and discrimination in the Drosophila mushroom body
Neural representations of sensory stimuli serve multiple distinct purposes, from the rapid recognition of familiar environments, to the precise identification of individual salient cues. In the insect...
https://www.biorxiv.org/content/10.1101/2025.01.25.634657v1
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Richard Benton
8 months ago
New pre-print: an one-stop shop for everything you wanted to know about the fly olfactory system:
www.biorxiv.org/content/10.1...
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An integrated anatomical, functional and evolutionary view of the Drosophila olfactory system
The Drosophila melanogaster olfactory system is one of the most intensively studied parts of the nervous system in any animal. Composed of ~60 independent olfactory neuron classes, with several associ...
https://www.biorxiv.org/content/10.1101/2025.01.16.632927v1
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Blake Richards
8 months ago
This article shows that "non-responsive" neurons can still add to the Fisher Info about object location in the midbrain of weakly electric fish:
www.jneurosci.org/content/45/3...
Brings me back to one of my usual bugbears in
#neuroscience
, i.e. don't judge a cell's function by its tuning curve! 🧪
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Nonresponsive Neurons Improve Population Coding of Object Location
Understanding how heterogeneous neural populations represent sensory input to give rise to behavior remains a central problem in systems neuroscience. Here we investigated how midbrain neurons within ...
https://www.jneurosci.org/content/45/3/e1068242024
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Andrew Lin
Junior European Drosophila Investigators
9 months ago
Dear Droso peeps, we re-announce the upcoming JEDI meeting that will take place at Château du Feÿ from June 3rd to 5th in 2025. You'll find a prelim program
flies-jedi.github.io/projects/202...
We're hoping to gather about 45 of more or less young droso PI to reboot the community. -> Register Now!
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Junior European Drosophila Investigators | JEDI meeting 2025
first post COVID19 meeting
https://flies-jedi.github.io/projects/2025JEDImeeting/
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Andrew Lin
Markus Meister
9 months ago
The unbearable slowness of being: Humans still clock in at just 10 bits/s. Even after peer review :) Share link:
authors.elsevier.com/a/1kHVa3BtfH...
. ArXiv:
arxiv.org/abs/2408.10234
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https://authors.elsevier.com/a/1kHVa3BtfH9BQG
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Rory Coleman
10 months ago
Sharing my new paper again since moving from the other place 🙂 We shed light on some of the most rapidly evolving animal behaviors—those surrounding mating.
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A modular circuit coordinates the diversification of courtship strategies - Nature
Peripheral and central circuit adaptations can be flexibly coordinated in Drosophila, and such a modular circuit organization may facilitate the evolution of mate recognition systems by allowing novel...
https://www.nature.com/articles/s41586-024-08028-1#citeas
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Carlotta Martelli
10 months ago
There is an open PhD position in our Lab! In collaboration with the lab of
@manuperisse.bsky.social
we will study how flies evaluate negative experiences based on context. More info here:
mrtlllab.uni-mainz.de/we-are-hiring/
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We are hiring! - mrtlllab
We are hiring! Are you passionate about neuroscience and eager to understand how the brain processes negative experiences? The mrtllab is looking for a driven PhD candidate to study the neural mechani...
https://mrtlllab.uni-mainz.de/we-are-hiring/
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Andrew Lin
Eyal Rozenfeld
10 months ago
1/ 🧠 Ever wondered how different types of learning coexist in our brains? Spoiler: Sometimes, they don’t! Our new study flips the script on what we thought about memory and learning in Drosophila. Dive in for a surprising twist! 🧵👇
www.science.org/doi/10.1126/...
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Andrew Lin
10 months ago
1/ How do animals integrate different forms of learning? Our
@eyalrozenfeld.bsky.social
new study in Science Advances shows that active mechanisms prevent the co-formation of competing memories. Here’s what we found! 🧵👇
science.org/doi/10.1126/...
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Andrew Lin
Carolina Rezaval
10 months ago
New from Shiko Parnas' lab: Classical & operant learning in *Drosophila* rely on distinct neuronal pathways, challenging current paradigms! Unstoppable
www.science.org/doi/10.1126/...
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Neuronal circuit mechanisms of competitive interaction between action-based and coincidence learning
Parallel and interfering neuronal circuits are responsible for operant and classical learning.
https://www.science.org/doi/10.1126/sciadv.adq3016
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Andrew Lin
Moita Lab
10 months ago
Thrilled to present our latest BioRXiv on brain/body interactions during defensive freezing behaviour! (
www.biorxiv.org/content/10.1...
). You might think that a frozen animal has, well, frozen muscle activity, right? Wrong! Underneath the still surface of a fly, something in the legs is beating… 🧵
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Katrin Vogt
10 months ago
I digested two nature papers
@natureportfolio.bsky.social
@crezaval.bsky.social
@MikeCrickmore about flexible integration and decision-making in Drosophila courtship and mating. Out came this dispatch for
@currentbiology.bsky.social
:
authors.elsevier.com/a/1kCED_LsQS...
Enjoy reading!
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https://authors.elsevier.com/a/1kCED_LsQSQEUI
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Lucas C Parra
10 months ago
But injecting noise on the weights of quiescent neurons can:
www.nature.com/articles/s41...
So a bit of random homeostatic plasticity should do the trick.
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Loss of plasticity in deep continual learning - Nature
The pervasive problem of artificial neural networks losing plasticity in continual-learning settings is demonstrated and a simple solution called the continual backpropagation algorithm is descri...
https://www.nature.com/articles/s41586-024-07711-7
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Andrew Lin
ALBA Network
10 months ago
🌟 It’s time to nominate a scientist who made outstanding contributions to promoting
#diversity
,
#equity
and
#inclusion
in neuroscience. This year, ALBA and the FENS-Kavli Scholars are targeting Europe-based students & PIs. Winner announced @
#FRM2025
(Norway, 16-19 Jun) 👉🏾
loom.ly/elEwkCE
📅 19 Dec
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Andrew Lin
Katrin Vogt
10 months ago
Excited to read the new preprint from the Ramdya lab about social behavior in fruit flies:
www.biorxiv.org/content/10.1...
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Conspecific sociability is regulated by associative learning circuits
Sociability, an animal's ease and propensity to interact with members of its own species, is a prerequisite for many important social interactions including courtship, mating, brood rearing, and colle...
https://www.biorxiv.org/content/10.1101/2024.11.25.624845v1
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Carmen Sandi
10 months ago
Neuroscientists! A key message from the ALBA Network Please help us spread the word and share this with your network!!! Nominate (self-n allowed) a mid-career neuroscientist (5+ years post-PhD) for the ALBA-Roche Research Prize for Excellence in Neuroscience! 🔎http://loom.ly/_EvQvm4 🗓️20 January 2025
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Andrew Dacks
10 months ago
First post on Bluesky! New collaborative study from Quentin Gaudry and I, led by Dr. Ahana Mallick on the role of 5-HT in modulating critical period plasticity in the antennal lobe of Drosophila. Enjoy!
www.sciencedirect.com/science/arti...
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Serotonin acts through multiple cellular targets during an olfactory critical period
Serotonin (5-HT) modulates early development during critical periods when experience drives heightened levels of plasticity in neurons. Here, we inves…
https://www.sciencedirect.com/science/article/pii/S2589004224023083
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Andrew Lin
Josh Dubnau
10 months ago
This was fun, both for the science and the wonderful collaborators. Great to have Meng-Fu (Maxwell) Shih’s final paper from my lab submitted. Starvation of flies drives foraging at night, mediated in part by transcriptional responses in a single pair of LHLK neurons.
www.biorxiv.org/content/10.1...
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Targeted single cell expression profiling identifies integrators of sleep and metabolic state
Animals modulate sleep in accordance with their internal and external environments. Metabolic cues are particularly potent regulators of sleep, allowing animals to alter their sleep timing and amount ...
https://www.biorxiv.org/content/10.1101/2024.09.25.614841v1
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Andrew Lin
Tara Spires-Jones 🌈🔬
10 months ago
Congratulations
@andrewclin.bsky.social
on winning the R Jean Bannister prize and giving a fantastic lecture here in Edinburgh
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Andrew Lin
Karla Kaun
over 1 year ago
It's an honor to co-edit a special edition of Learning & Memory on the mushroom body with Andre Fiala. Following the 1998 original by Martin Heisenberg, it starts with our editorial "What do the mushroom bodies do for the insect brain? Twenty-five years of progress"
www.kaunlab.com/post/fiala-k...
.
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Fiala & Kaun Editorial on the Mushroom Body
Dr. Andre Fiala and Dr. Karla Kaun collaborated to act as Special Guest Editors for the journal Learning & Memory on a special issue on the mushroom body to celebrate 25 years of progress since the in...
https://www.kaunlab.com/post/fiala-kaun-editorial-on-the-mushroom-body
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Check out our new review about sensory coding in the fly mushroom body, with Moshe Parnas and Julia Manoim!
learnmem.cshlp.org/content/31/5...
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Sensory encoding and memory in the mushroom body: signals, noise, and variability
Peer-reviewed scientific journal publishing basic neuroscience research in the areas of neuronal plasticity, learning and memory
https://learnmem.cshlp.org/content/31/5/a053825
over 1 year ago
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Great thread of tips for Drosophila behavioral experiments!
add a skeleton here at some point
over 1 year ago
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Postdoc position available in my lab! We study sensory coding and memory in the Drosophila mushroom body. More about us at
www.aclinlab.org
Deadline 25 March. Please spread the word!
bit.ly/LinPostdoc2024
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Research Associate at University of Sheffield
An opportunity for an academic position as a Research Associate is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.
https://bit.ly/LinPostdoc2024
over 1 year ago
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Andrew Lin
Michael Okun
almost 2 years ago
A 4-year fully funded PhD studentship (for UK and international students) is available in my lab to study the systems neuroscience of classical psychedelic compounds. Application deadline: 16-Jan. Further details:
sites.google.com/view/lcdl/me...
#neuroskyence
#compneuro
#neurojobs
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