🌟 Check out the latest preprint from our center 🌟 This work brings us one step closer to gaining a deeper understanding of gene expression regulation - a core mission of our center 🧬 🧫 If you want to know more about CGEN visit our website: cgen.ku.dk @dg.dk @ucph.bsky.social

Extremely proud to share the impressive work done by Anouk Olthof et al. on how cells maintain healthy levels of RNAPII, and how they respond when levels are too low. Fascinating stuff, we think www.biorxiv.org/content/10.1...

It is my pleasure to share with you the latest from @jsvejstrup.bsky.social lab, where we look at how the reduction of RNAPII levels has a severe, yet organized transcriptional response in the cell.

Registration and abstract submission is open for the 10th annual Danish RNA Society meeting 🇩🇰 - this year in Aarhus! Deadline is October 1st danish-rna-society.nemtilmeld.dk/8/

If you like transcription regulation and its mechanisms, this WIP list is for you. I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list. go.bsky.app/8vTgeXB

Excited to share that our latest story on Restrictor is out now in @genesdev.bsky.social!! Big thank you to my fellow co-first author Hanneke, Karen @adelmanlab.bsky.social and co-authors Nathalie and Allison!

When sun hits you, what does it *hit*? It rockets into your RNA, and the sound of colliding ribosomes and potholed RNA signals to your body to do something: produce a sunburn. My latest for @quantamagazine.bsky.social. www.quantamagazine.org/rna-is-the-c...

Very important comment for the community! This summarizes essential controls to use when performing ChIP-seq and to check when reviewing. Thank you to the authors www.nature.com/articles/s41...

Excited to share our preprint reporting a completely new approach to study kinase signaling: ProKAS. ProKAS is based on a tandem array of peptide sensors with barcodes for multiplexed, spatial and kinetic applications. We applied it to DDR kinases. Please share. www.biorxiv.org/content/10.1...

We just posted a preprint about a death mechanism that we find truly surprising. When you turn off transcription, cells die (duh!)... but did you know this happens due to loss of Pol II itself, not loss of Pol II activity!?! preprint here and a thread (1/n): www.biorxiv.org/content/10.1... 🧪

The first paper from our lab is online! A wonderful collaboration with @scottbscience.bsky.social lab. We discover that Pol II is extensively regulated by Ubiquitin at the beginning of the transcription cycle! www.cell.com/molecular-ce...

🧪🧬 Pre-print of our CUT&RUN protocol is out NOW! This comprehensive #protocol includes all the tips and tricks for assay optimization used by our scientists, making it a key read for kit users and home-brew #CUT&RUN users alike. What makes it special? (1/n) www.biorxiv.org/content/10.1...

Time for our first post here 🥳 Our latest paper is online 🙌 We show that UV activates the ribotoxic stress response, which causes inflammation, cell death and thickening in skin. Read about a role for the RSR separate from DNA damage signaling in response to sunburn: ✨☀️ www.cell.com/molecular-ce...

As you make have seen, there is a special issue of JMB on "Controlling Transcription Elongation and Termination: More Than a Means to An End" curated by my colleague here at Pitt Karen Arndt and by Steve Buratowski from Harvard Medical School 🧪🧵 1/ www.sciencedirect.com/science/arti...

Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)

What happens when you overexpress one subunit of the RNA Pol II? Well, it depends on the subunit, but all deregulate transcription and induce genome instability @agagambus.bsky.social www.biorxiv.org/content/10.1...

This is a very cool paper that I will add to my Mol Bio course. Specific tRNA recruitment of mRNA degradation complex to ribosome through the P site tRNA interactions with CCR4-NOT complex 1/ www.science.org/doi/10.1126/...

Our latest discovery of “lowest recorded temperature for eukaryotic cell motility” going all the way down to -15deg C. Come for the crazy cold Arctic & stay for diatoms. Will write longer thread - but enjoy video below of diatoms gliding on frozen ice surfaces. Congrats @zqing.bsky.social & team.

So excited to share this preprint! The culmination of my postdoctoral works in the Strahl lab and the start of work in my own. In this study, we systematically show PHRF1 to bind the N-terminus of H3 and regulate splicing and DDR. 1/

Putting together packs of transcription and Chromatin people - Nominate others to add! go.bsky.app/5zgpZfg