Depressing. And so, so unbearably stupid. Shortsighted and foolish. We’ve lost decades (at least) of progress.

This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again. www.nature.com/immersive/d4...

Mamdani: I am in support of abolishing ICE… I'm tired of waking up every day and seeing a new image of someone being dragged out of a car, dragged out of their home, dragged out of their life.

We’ve decided to make this story free for all readers, forever. We hope you’ll support this reporting by sharing it.

Really disappointed that @natmed.nature.com is amplifying propaganda that sets out to justify the destruction of biomedical research in the US and around the world. Just because people are in power does not mean journals should launder their credibility.

this is what it has come to for Mexican restaurants in the Twin Cities

New: We built an interactive map of every ICE contractor working with the Trump administration. readsludge.com/2026/01/16/t...

A Department of Homeland Security whistleblower has released the identities of about 4,500 ICE and Border Patrol employees Tuesday in what has been called potentially the largest agency data breach for the department.

A few months ago, ICE hired me I didn't sign and submit any paperwork. I almost certainly failed the drug test. I'm real outspoken about my opposition to the Trump administration, and I am extremely googlable And yet, there it was, in plain English. "Welcome to ICE!" My latest for Slate

A video of ICE agents conducting door-to-door searches today in Minneapolis The homeowner requests a warrant repeatedly, is told they don't require one, then is told they're getting it, then the agents storm in anyway They also point a taser at her to try and disrupt filming

at some point we're gonna have to have a real conversation about why we're still paying federal taxes to a regime that isn't using them to help anyone, but instead is using them to brutalize us

Minneapolis public schools canceled classes officials after Roosevelt High School said armed Border Patrol officers came on school property during dismissal Wednesday and began tackling people, handcuffed two staff members and released chemical weapons on bystanders www.mprnews.org/story/2026/0...

People are going to try and lure you into debates about whether Maduro was a good guy or not and the thing is, it doesn’t matter for the purposes of discussing whether violent kidnappings and extrajudicial murders by the US government are ok. No, they aren’t! End of convo.

Correctly submitting Concur travel expense reports on the first try!

The full spiked 60 Minutes CECOT package, clean & subtitled. 1/5

iCloud, Mega, and as a torrent. Archivists have uploaded the 60 Minutes episode Bari Weiss spiked.

Now seems like a swell time to point out that Frontline just released this excellent 11-minute mini-documentary about what happened inside CECOT.

Since his appointment, RFK Jr. has pursued a brutal vision of American health that several experts liken to a sort of eugenics. Kennedy has made it clear that certain deaths are acceptable or even preferable to a world where every child is vaccinated. Read more: www.theverge.com/health/66136...

Zohran: "I mean, think about when you fly.  We have made it such a difficult experience to go through TSA that there's now a financial incentive to sign up for a separate program that can move you through it quicker. We have monetized the dysfunction."

Democratic leadership didn’t want to stick their necks out for him. The GOP didn’t want him even referred to as a “Maryland man.” Sen. Chris Van Hollen, his congressional representative fought for him. And we should never forget any of this. apnews.com/article/abre...

Gov. JB Pritzker signed legislation Tuesday that bars civil immigration arrests from being made in or near courthouses, and gives residents more leeway to sue federal agents over alleged civil rights violations.

Anyone casually weighing in on this race needs to understand this.

22% fewer NIH grants

Utah’s measles outbreak, among the largest in the country, is likely to get worse. utahnewsdispatch.com/2025/12/01/u...

Only evil needs to hide in the shadows. #Pinks #Resist

Nature Sci Rep publishes incoherent AI slop. eLife publishes a paper which the reviewers didn't agree with, making all the comments and responses public with thoughtful commentary. One of these journals got delisted by Web of Science for quality concerns from not doing peer review. Guess which one?

I need everybody to read this and understand what’s going on. These are spouses of US citizens in the country legally. They have entry clearance and green cards, they’ve passed background checks and have no criminal records. ICE is taking them anyway. Gift link: www.nytimes.com/2025/11/26/u...

A friend from college texted me asking for advice and this was my first and immediate response.

If you're a professor at Texas A&M, you'll need to receive written authorization from the university president before discussing this incident on campus.

Congratulations to Joe Felsenstein on being awarded the 2026 Mendel Medal by the Genetics Society! genetics.org.uk/medals-and-p...

If you have tenure at Texas A&M and aren't maliciously emailing the president a dozen times every day to ask if you can say this or you can say that, then what's the point in having tenure?

New preprint! It turns out you can integrate arrays with super high efficiency using PhiC31. www.biorxiv.org/content/10.1...

Stoked to share our latest work entitled: “Large-scale discovery of neural enhancers for cis-regulation therapies” shorturl.at/H3Qww This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon. Bluetorial below.

A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - @jshendure.bsky.social @troymcdiarmid.bsky.social @uwgenome.bsky.social go.nature.com/49eTPCu

Senate Democrats voting to dismantle the ACA to avoid any problems with their Thanksgiving travel is tragically on brand.

It’s time

Make males live more than 400% longer and prevent sexual disfunction late in life?! We're down with it. Our latest preprint: Disruption of the insulin signaling pathway in C. elegans dramatically increases male longevity and enhances reproductive health late in life. www.biorxiv.org/content/10.1...

Finally watched Zohran Mamdani's victory speech and I almost fuckin cried. I got real goosebumps. This is what we need. Stop listening to the loudest and most out-of-touch pundits screaming about moving to the centre. Be bold and unrelenting in caring about each other. TURN THE VOLUME UP!

Thrilled to share I’ve started my lab at Dartmouth’s Geisel School of Medicine! We focus on mapping cellular trajectories & TF networks in development and Mendelian disorders, exploring new therapies. Join us—postdocs, grads, and scientists welcome! sites.dartmouth.edu/qiulab/

Between grants getting politically targeted and my lab’s building getting literally fucking bombed, 2025 is going great thanks

Sad day for the folks who staked their reputations on lab leak conspiracy theories. www.telegraph.co.uk/global-healt...

“Salt Lake County health officials say it’s probable they have found the county’s first measles case since a national outbreak…They say “probable” because the person officials believe is infected has declined to be tested or take part in an investigation, the Salt Lake County Health Department said”

I'm shaking almost too hard to type. I entered SLC airport and heard screams and cries for help. I could see people gathered around, watching. I sped over to discover this woman face down on the floor, four grown men pushing her down, while she cried "HELP ME" and pled for her child.

The Python Software Foundation was recommended for a $1.5M grant from the National Science Foundation. The terms of the award said PSF could not work on DEI, whether or not the grant funding was used for it. PSF therefore declined the funding. Science suffers, but commitment to core values remains

Today @anthropic.com released PubMed integration for Claude. No hallucinations. Just real science, real data. As a beta tester, this has been game changing— a supercharged research tool. Here are 6 prompts that will transform how you search the literature. A 🧵 www.anthropic.com/news/claude-...

WOW! Our survey of scientists who stopped using Twitter and started using Bluesky is now the #1 most-shared on social media article in the history of the journal Integrative and Comparative Biology! Thanks for reading it, everyone! @sicbjournals.bsky.social doi.org/10.1093/icb/... 🧪

As a science communicator who built my professional career out of understanding "Science Twitter": I'm confident Bluesky will be the scientific community's social media home for a while Tell your friends at #ASHG25 to get over here, whether they're on X or not!

Against Publishing: universonline.nl/nieuws/2025/... Preprints are read, shared, and cited, yet still dismissed as incomplete until blessed by a publisher. I argue that the true measure of scholarship lies in open exchange, not in the industry’s gatekeeping of what counts as published.

Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here: www.biorxiv.org/content/10.1...

Kristi Noem’s America, folks. That poor dog. That poor family.