New work from @csneeze.bsky.social explored how common additives for thermal stability analyses affected protein-drug interaction hit calling. We were surprised to see that buffer and method selection for lysates could recapitulate findings from in cell thermal stability assays!

Try this new online training game from Leandro F. Estrozi designed for newcomers in structural biology, with a focus on cryo-EM and cryo-ET map interpretation: rico.ibs.fr/helixplo...

Call for Targets: CASP17 (2026) Depositors: Help advance the frontiers of structural biology by submitting your targets

Updated travel advisory for Canadians heading to Germany and the U.K. due to the risk of polio. Get your vaccines, why, because you didn’t see what we saw when people got sick, their lives were destroyed. 🤬 This vaccine has proven effectiveness to save lives! dailyhive.com/canada/uk-ge...

Allosteric PROTACs: Expanding the Horizon of Targeted Protein Degradation | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...

Join us on 10 March for the 45th Structure Meets Function webinar. Robert Konrat of @univie.ac.at will outline their use of #NMR technologies at @cerm-cirmmp.bsky.social , and Maria Macias of @irbbarcelona.org a.org will showcase their work at @embl.org Hamburg. Register here - lnkd.in/ecTXQHZu

Why are people acting like Tourette’s makes you say racial slurs? And on top of that, acting like Black folks are supposed to just overlook this vile shit. And hearing that the UK broadcaster chose not to bleep it makes it 10X worse.

Wow.

Use RCSB PDB's Pairwise Structure Alignment tool to compare existing PDB structures or Computed Structure Models (or upload a local file) #LoveDataWeek www.rcsb.org/alignment

Cause that's what heroes do.

Every American needs to watch this:

Devastated by the loss of Catherine O'Hara. Was lucky enough, not only to work with her on Whose Line and on stage, but to chat with her at a few gatherings. Sweet, kind, humble and a genius, this is a hard one. Love to her family and all who loved her.

In light of today's news, here is a supercut of Moira Rose saying "bebe" youtu.be/w9Uw4tCRq7k?...

Catherine O'Hara & Eugene Levy performing "A Kiss At The End Of The Rainbow" from A MIGHTY WIND at the 2004 Oscars🌈💔

I couldn’t fit my Catherine O’Hara sentiments on a single Bluesky post so here’s a screen grab of what I want to say for now.

O’Hara was incredible forever, on SCTV, the Christopher Guest movies, Beetlejuice, Home Alone, etc. But she didn’t become as famous as her talent warranted until her 60s. Suddenly it was like everyone caught up to her, and she could’ve worked forever. To have her taken away at this moment? No.

She was a comic genius. So sad Catherine O'Hara has left us.

AI isn’t replacing software engineers, it’s reshaping their roles. @otfeas.bsky.social’s Dr. Qusay H Mahmoud, explains how systems thinking, ethical design, human-AI collaboration and entrepreneurial creativity matter more than ever.

SCANBIT facilitates identification of tumor cell populations in scRNAseq data using pseudobulked SNV calls https://www.biorxiv.org/content/10.64898/2026.01.27.701834v1

We benchmarked PocketVina across four widely used datasets (PDBbind, PoseBusters, Astex, DockGen), and introduce TargetDock-AI — a large-scale benchmark of >500K protein–ligand pairs with activity labels from PubChem. (5/n)

Who Was Fighting Nazi Germany And When The UK fought from the first day of the war.

Would this be tied to a specific political aim or more of a ermm fart in our general direction

Excellent overview from Wenqing Xu and Christina Woo on all their learnings about Cereblon, its native activity, and considerations for its use in targeted protein degradation! pubs.acs.org/doi/full/10....

Pour a glass of champagne AND red Bordeaux—Our newest work with GSK @scripps.edu is out in @nature.com! Here we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐 www.nature.com/articles/s41...

Special Issue on Women in Proteomics www.mcponline.org/ar... --- #proteomics #prot-paper

My first-author paper is out in @chemicalscience.rsc.org from my time in Professor Danny Huang’s laboratory @cruk-si.bsky.social. We showed that CBL can be used as a degrader E3 to target the “undruggable” eIF4E. pubs.rsc.org/en/content/a...

📝 Online now - the Review "Chemical biology approaches for protein tagging in mammalian cells" from Kaitlyn Toy, Jenna Beyer, and @gburslem.bsky.social. #SelfLabelingProteinTags #GeneticCodeExpansion #ncAAs #SplitInteins #SpatiotemporalControl Read it here 👉 authors.elsevier.com/a/1mRdq3S6Gf...

In a world first, a team of researchers at the National Institutes of Health and @emorydeptofmed.bsky.social , has successfully performed a coronary artery bypass (a normally open-heart surgery) without cutting the chest wall. #EmoryProud #EmoryMade www.nih.gov/news-events/...

A poem by Amanda Gorman For Renee Nicole Good Killed by ICE on January 7th, 2026

ACCESS Presents: Spreading Your Wings - Moving from Pediatric to Adult Healthcare Transitioning between care systems can leave survivors feeling uncertain This session explores community-informed insights and translated them into practical resources. Register: https://ow.ly/J3i050XNRnu 💛

@mark-carney.bsky.social #CRTC Please open the mobile phone market. It is unreasonable that #Canada only has 3 mobile phone companies who are on a level playing field. Every...other...country offers more affordable plans because there is more competition.

Native multi-dimensional (SEC/CZE/SID) protein complex identification and topology characterization (Native MudPIT) chemrxiv.org/engage/... --- #proteomics #prot-preprint

Protein Language Models: Applications and Perspectives pubs.acs.org/doi/10....

Mass Spectrometry Proteomics: A Key to Faster Drug Discovery pubs.acs.org/doi/ful... --- #proteomics #prot-paper

Chelsea Cornet rises to head into the bottom right corner, meeting a pinpoint free kick from Océane Hurtré. 👏 #BarclaysWSL2 #BCFCWomen

It hasn't even been twelve hours, but all three of us have been overwhelmed with requests from media for comment and I'm mostly writing this now so they'll leave me alone.

I’m just going to tell the story. Back in 2000 I was volunteering for the Gore campaign when he came along with Julia Louis-Dreyfus, Alfre Woodard and Dule Hill to a GOTV event here in MN. He ended up sitting down across from me stuffing his envelopes.

#princessbride and so many others

Let's go!!!!!!!! Blue 💙 Jays!!!!!!!!

P.tin moving westward... Watch out world Dont make the same mistake twice (wait ...I have lost count)

Engineered histones reshape chromatin in human cells [new] Engineered histones reshape chromatin. Identified variants alter structure, revealing mechanisms to drive specific states.

#gun #control #guncontrol

Not knowing early means knowing too late. Prostate cancer survivor Rensford De Haan wants other men to hear this after successful treatment through UHN's early detection program. Learn about free testing for high-risk men in Black communities in the GTA: https://bit.ly/487xTso

Cognitive decline, or does he lie so much he can’t keep it straight? Trump in 2025: “He’s a terrible Fed chair. I was surprised he was appointed.” Trump in 2017: “It is my pleasure and my honor to announce my nomination of Jerome Powell to be the next chairman of the Federal Reserve.”

Exclusive: Famed protein structure competition nears end as NIH grant money runs out | Science | AAAS www.science.org/content/arti... Am late on this ... I do hope Europe or Canada picks up the slack

GlycoNet researchers Drs. Fred West & Frank Wuest at the University of Alberta developed a new PET scan molecule that could improve imaging for breast cancer detection. The radiotracer mimics a sugar taken up by breast cancer cells. canadianglycomics.ca/new-radiotra... #glycotime