An intact human heart, rendered transparent. Because disease doesn't happen in 2D. Whole-organ tissue clearing and light-sheet microscopy reveal coronary vessels (magenta) and atherosclerotic plaques (gold) across the intact organ. More at: shorturl.at/iqTBh 🫀🔬 #FluorescenceFriday!

Annual killifish continue to surprise us: they make neutrophils before almost every other cell type, even before gastrulation. Neutrophils usually arise from the lateral plate mesoderm (forming in cyan), but in killifish they are already patrolling around the embryo in gold. tinyurl.com/killiphil

🧬 🧪Our RNA velocity benchmark is out in PLOS Comp Biol We tested 5 methods on mouse & zebrafish data. They often disagree (just 1/100 driver genes shared 😬). A hypothesis tool, not ground truth. Open access 👉 doi.org/10.1371/jour... Led by the brilliant Sarah Ancheta (not on bsky)

I definitely could have used this in prior work - awesome!

May 29th. If you're in Paris, mark your calendars. Lock your pipettes. TELL YOUR cHAIR. RUN FOR YOUR LIVES 🧪🐟

It’s out! 🐟 We compared three regeneration superstars—axolotl, zebrafish, and Polypterus—to ask how animals regrow limbs and fins. We find shared core processes, and other programs fine-tuned by evolution in surprising, lineage-specific ways. tinyurl.com/mpftkn7y

This is a very thoughtful way of working as a group to determine boundaries on AI use within a lab and I completely agree with their conclusions based on my own experience testing LLM tools!

My lab’s study of behavioral development 🐠 has long faced a roadblock: how do you follow an individual’s development if you can’t identify who’s who? How do you identify a juvenile fish the size of a grain of rice? Here, we share two safe, effective tagging methods! doi.org/10.1002/jez.... 🧪 (1/5)

Pleased to say that Jonas Hartmann (bs-less) and I have finally released DySTrack (“diss track”) - Dynamic Sample Tracking. It’s a Python-based, modular tool that brings smart microscopy to everyday imaging on commercial systems. Preprint: www.biorxiv.org/content/10.6... [1/6]

Hmmm on a test image I generated using Gemini, it even did a pretty good job of simulating gaussian noise.

Very cool work!

Saving for my axon guidance lecture next year! Beautiful!

So how did it go? NIH made 43 DP2 awards, the lowest number in a decade. I really wish Director Bhattacharya would spend doing his actual job rather than badmouthing the agency he is charged to lead and spouting platitudes on podcasts and elsewhere. 6/7

Zara was a star, a cherished friend, and an untiring advocate. I wish she had the chance to stay here with us and help create a brighter future, but she already gave us so much in her time here. I'm glad she will be honored in the next cohort of LE fellows ❤️

Live visualization of extracellular matrix dynamics during development and regeneration in zebrafish https://www.biorxiv.org/content/10.1101/2025.11.02.686082v1

I need to get some better frames now that I'm a big kid (supposedly) but finally got my collection of Bob Goldstein prints in my office! There's a Clare Waterman one out of view too!

I'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n unc.peopleadmin.com/postings/307...

It is time to recognize research software as a valuable scientific contribution in itself, beyond a tool — and to support it go.nature.com/438X8qS

Seventies Susumu Ohno vibes! Fashion goes in circles.

Here's a movie from the 3D neuroimaging paper - this is the telencephalon of a 19 month old tg(kdrl:mCherry, mpeg1:eGFP) fish. We use imaris to strip the top layer (the skin and skull) off the projection so we can see just the tissue beneath the skull. This was taken with a Bruker 2P+ multiphoton.

We are so excited to include these new Fellows-to-Faculty Fellows in the Simons Foundation fold!

Want to image the adult zebrafish brain? Here's a nifty design that I made with the help of a talented master's student, Corey Steinhauser. Supporting files here! morgridge.org/research/lab...

Whoa - neuronal ciliary proteome! Tons to dig into here - different from kidney cilia proteome (perhaps unsurprising) and enriched for many postsynaptic proteins, strengthening previous suggestions of cilia as postsynaptic signaling structures. @nachury.bsky.social www.biorxiv.org/content/10.1...

Maximising imaging volumes of expanded tissues for inverted fluorescence microscopy https://www.biorxiv.org/content/10.1101/2025.09.12.675899v1

Trying to stay hopeful and see joy in these times, and I thought this was lovely.

This is so sad. I'm so sorry fly friends. Solidarity from team fish. 💔

It looks like as a signatory to the UN Florence Agreement, if you 1) buy an item as a nonprofit or educational institution, 2) from a signatory country, 3) can demonstrate it is for research purposes, and/or 4) the item is not made in the US in significant quantities, you can import duty-free!

The NIH’s 2024 budget of just under $37B generated $95B in economic activity in 2024 alone. 99.4% of new pharmaceuticals approved from 2010-2019 came from NIH-funded research. I’m hard pressed to think of anything that generates as much direct economic benefit as our NIH did before they destroyed it

From @aaas.org check-in with Sudip Parikh: a letter by 14 Republican senators urge the Office of Management and Budget to release NIH funding. If this includes your state (AL, ME, WV, SC, KY, KS, AR, PA, NC, IN, AK), Sudip recommends contacting & thanking them for being American science leaders.

This is an excellent article on the termination of all federal funding at Harvard. This visualization shows all of the terminated programs that were supposed to train the next generation of scientists. www.nytimes.com/interactive/...

The #SCIMaP team announces a major update: an analysis of the economic impacts of the White House's NIH FY26 budget. Bottom-line, we estimate $46B in total economic loss, 202K lost jobs, and impacts in communities nationwide. Interactive map and shareable report: scienceimpacts.org/fy26 a 🧵

I've been a bit quiet lately because I've been working on a new project - I had a baby in May and am enjoying my maternity leave! 🐣 Baby and I are doing great! Lots to adjust to for us both, but we are learning!

The Stephen Katz R01 has been expired early. This was a critical funding opportunities for early stage PIs to foster taking their talents to new, big, important problems. Why?

Just got news that @hhmi.org decided to not review Hanna Gray fellowship applications. I am sorry but that’s fucked up. People spent months working in those. So now you disadvantaged these candidates even more. They could have used the time to advance their research instead.

Here are #NSF education and advocacy talking points. #SaveNSF (Shared with permission - CC0; no attribution required)

New paper dropped: journals.plos.org/plosbiology/...

Navigate, now available on PubMed. pmc.ncbi.nlm.nih.gov/articles/PMC...

Ok y'all false alarm, I went into work and turduckened my work computer to log in to my home computer and was able to get imaris to display properly. Weird glitch - absolutely no idea what happened.

Just in case anyone else has had this niche experience: Can't see Imaris display on a computer with a floating license I'm remoting into from home. It's just a white screen. Feels like a security update? (I've been able to do this in the past).

ACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n

🧵🧪”Paying taxes can feel like money lost. In truth, it is money shared. When we fund the NIH, we are betting on ourselves and on one another. We are saying that every American life is worth saving, whether that life sits next door or across the country.”

Anatomical and Molecular Characterization of the Zebrafish Meninges https://www.biorxiv.org/content/10.1101/2025.04.09.646894v1

Hey @drlizhaynes.bsky.social Thanks for representing! (Not tattooed myself but respect the art of self expression :)) www.nature.com/articles/d41...

For the cost of the commerical system that I bought in 2013 and I have no use for 99% of its features, you can make like 10 custom, purpose-built microscopes. LEDs are cheap, cameras are cheap, software is free.

Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.

We're tracking the number of international students whose visas have been revoked by the State Department. We've confirmed over 300 so far and there are likely many more. Get in touch if you've got information you'd like to share with us www.insidehighered.com/news/global/...

Kate is incredible!! You will learn so much and have a ton of fun.

If you train people in ImageJ, Fiji, whatever, even if it isn't your day job, please let us know, and please share this post! Thanks a ton, we really appreciate it. (2/2) forms.gle/C8dUpg8qZkbD... #bioimaging #microscopy #bioimageanalysis

🚨 Not a drill: NSF GRFP results are NOW OUT!!!!! But...good news and bad news. 👍 I'm *thrilled* for the grad students for whom getting this award will be life-changing, esp now. 👎 # of fellowships went down by 51% (1000 this year vs. 2036 last year) See here: www.research.gov/grfp/Awardee...