Proud to kick-off #HetCCI, a DFG-funded research consortium in Germany (Priority Programme #SPP2493 on heterotypic cell-cell interactions in epithelia). Follow us if interested in how epithelial cells interact with non-epithelial tissues in different settings! Webpage will follow asap. #cellbiology

Online now: FGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression

🗣️ Are alpha cells and glucagon needed for islet function and glucose homeostasis? This topic is currently being discussed at the EISG conference in Malmö. Mark Huising is chairing the debate with Pedro Herrera, Caroline Bonner, Patrik Rorsman, and Sarah Richardson. @huisinglab.bsky.social #EISG2025

Fantastic symposium on circuit function last week here at CIPMM. Thanks to our guests Kristina Lippmann, Magdalene Schlesiger, Fiona Muellner and @juliaveit.bsky.social for sharing their latest on synaptic function, interneuron & pyramidal cell networks and long-range communication.

Cysteine restriction, by depleting GSH and CoA, exerts a maximal impact on weight loss, metabolism and stress signalling and is proposed as a strategy to combat a range of metabolic disorders @nature.com www.nature.com/articles/s41...

Are you based in the U.S. 🇺🇸 or Canada 🇨🇦 and thinking of doing research in Europe? ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields. Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik #ChooseEurope

New Faraday Fellowships for international applicants moving to the UK Up to £4 million per researcher over 5-10 years Fast-track option for mid-career researchers looking to relocate to the UK

Check out our new preprint "Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis" featuring Ca2+ imaging and timelapse imaging of human T1D insulitis. Very proud of this massive effort by first-author @molliehuber.bsky.social www.biorxiv.org/content/10.1...

New Professor position at Saarland University for Cell Physiology!

We are looking for a new colleague in the biology department at Saarland University! We are looking for excellent Cell Biologists / Cell Physiologists for a W2 tenure track W3 professorship in 'Dynamics of Biological Systems'. Please share! jobs.zeit.de/jobs/w2-prof...

New study on novel translation factor EIF2A led by Panzhinskiy as a collaboration between @jimjohnsonsci.bsky.social lab, Jan lab & @bruceverchere.bsky.social lab UBC Life Sciences Institute. Thanks Breakthrough T1D Canada for funding this project #DiabetesResearch link.springer.com/article/10.1...

Animal experiments in Germany are becoming increasingly bureaucratic, expensive, and difficult to conduct. There is currently a campaign supporting ethical and regulated animal experimentation, while also advocating for the preservation of research freedom.

Monitoring subcellular NADP redox state with NAPstar biosensors @riemerlab.bsky.social @morganlab-saarland.bsky.social @jan-oleniemeier.bsky.social www.sciencedirect.com/science/arti...

Canadian scientist Daniel Drucker among winners of prestigious Breakthrough Prize for discovery of hormone used in anti-obesity drugs, by @ivansemeniuk.bsky.social www.theglobeandmail.com/canada/artic... via @theglobeandmail.com #WeightLoss #diabetes

Congrats @danieljdrucker.bsky.social!! breakthroughprize.org/News/91

Job alert: Join us in Mainz as Max Planck Research Group Leader (W2) in Molecular Design ...and make your own research dreams happen on de novo design, generative models, proteins, materials ... tinyurl.com/r2xjxnuk @mpip-mainz.mpg.de

Here we report that individual leader and hub beta cells are stable in vivo, regulated by glycemic status and acutely by GLP-1RA. #LuisDelgadillo www.biorxiv.org/content/10.1...

Electrophysiological characterization reveals more complexity for islet α-cell heterogeneity #islets diabetesjournals.org/diabetes/art...

RNA-seq analysis and experimental exploration show that TMEM55A-mediated PI5P signalling regulates #alphacell actin depolymerisation and #glucagon secretion. #islets, #diabetes link.springer.com/article/10.1... 🔓 @xiongliu.bsky.social @bcellorg.bsky.social

🧪 Scientists have created the first map of mitochondria throughout the entire brain https://go.nature.com/42j9YCV

My first PhD student just defended his thesis! Congratulations Dr. Carlein 😍

Here it is proposed that halofuginone, a FDA–approved anti-scleroderma and antiprotozoal drug, is a promising anti-#obesity agent acting via FGF-21 and GDF-15 in preclinical mouse and pig models www.science.org/doi/10.1126/...

Analysis of the direct cardioprotective effects of semaglutide on human and mouse cardiomyocytes ex vivo with a focus on ion currents, signal transduction, and contractility onlinelibrary.wiley.com/doi/10.1002/...

One of my first memories of my daughter is a mental image of her being grievously harmed. No one told me such intrusive thoughts are nearly universal after giving birth. That and more of the best from @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪

"Weight loss of 10–15% by any means soon after onset of type 2 #diabetes is highly likely to bring about #remission of diabetes. This knowledge of the cause of type 2 diabetes is of immediate relevance to clinical management" www.thelancet.com/journals/lan... #obesity #weightloss

The apical-basal polarity status of multipotent endocrine progenitors identified as a critical epithelial feature that determines their fate into the alpha or beta cell lineages #islets www.cell.com/developmenta...

#EveryCellIsAnImmuneCell! June Round &friends show @science.org that in early life bacteria & fungi cooperate to expand insulin producing β islets via macrophage infiltration & that recognition of commensal yeast cell wall can protects against diabetes in adults! www.science.org/doi/10.1126/...

Shipments out. Supporting 20 research projects across Canada, North America, Europe and Asia. We have room for more. Give us a shout if you need islets, pancreas, intestine, adipose…. for research. https://www.bcell.org/faqs.html